Neoplastic thymic epithelial cells of human thymoma support T cell development from CD4-CD8- cells to CD4+CD8+ cells in vitro.

abstract：:Incubation with thymosin fraction 5, (TMS F5 at 300 micrograms/ml) a partially purified thymic factor, reduced the steroid binding activity of human infant thymocytes from 9.6 +/- 2.1 fmole/ml to 5.0 +/- 2.0 fmole/ml. The glucocorticoid receptor activity in normal infant thymocytes was found to be 2,146 +/- 726 (s.d.)...

journal_title：Clinical and experimental immunology

authors： Ma DD,Ho AH,Hoffbrand AV

更新日期：1984-02-01 00:00:00

abstract：:Studies in humans and murine disease models have clearly shown dietary fish oil to possess anti-inflammatory properties, apparently mediated by the n-3 polyunsaturated fatty acids, eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA). To determine the mechanisms by which dietary EPA and DHA modulate mouse T-cell...

journal_title：Clinical and experimental immunology

authors： Arrington JL,Chapkin RS,Switzer KC,Morris JS,McMurray DN

更新日期：2001-09-01 00:00:00

abstract：:Complement activation may play an important role in renal injury associated with glomerular deposition of IgA immune complexes. The ability of naturally occurring human IgA immune complexes (IgA-IC) and covalently cross-linked human IgA oligomers (X-IgA) to activate complement were examined in vitro and in vivo. Large...

journal_title：Clinical and experimental immunology

authors： Imai H,Chen A,Wyatt RJ,Rifai A

更新日期：1988-09-01 00:00:00

abstract：:Cyclosporin (CsA) is widely used in the treatment of renal disease and transplantation, which are often complicated by alterations of lipid metabolism. Both chronic administration of CsA and hyperlipidaemia have been shown to evoke an early macrophage influx and have progressively led to glomerular and interstitial sc...

journal_title：Clinical and experimental immunology

authors： Di Paolo S,Grandaliano G,Gesualdo L,Ranieri E,Schena FP

更新日期：1999-08-01 00:00:00

abstract：:The effector arm of the mucosal immune system comprises lymphocytes scattered at intraepithelial and lamina propria levels. Intraepithelial lymphocytes (IEL) are a large population of oligoclonal resting cells which exhibit phenotypic and functional characteristics of cytolytic T cells when activated. Several mechanis...

journal_title：Clinical and experimental immunology

authors： Ciccocioppo R,Di Sabatino A,Parroni R,D'alò S,Pistoia MA,Doglioni C,Cifone MG,Corazza GR

更新日期：2000-05-01 00:00:00

abstract：:The effects of 2.5-40 mg/kg nandrolone decanoate (ND) on the development and growth of mononuclear cell infiltrations in the submandibular glands of NZB/W (B/W) mice have been studied using a quantitative histological method. Injections with ND for 9 months, once every 3 weeks, starting at 4 weeks of age, reduced the ...

journal_title：Clinical and experimental immunology

authors： Schot LP,Verheul HA,Schuurs AH

更新日期：1984-09-01 00:00:00

abstract：:Myotonic dystrophy (MyD), an autosomal dominant neuromuscular disease with multisystem abnormalities, is associated with hypercatabolism of IgG. The hypercatabolism is not related to structural abnormalities of the IgG molecule in MyD but appears to be due to a derangement of the serum IgG concentration-fractional cat...

journal_title：Clinical and experimental immunology

authors： Banerjee D,McClintock J,Silver MM,Hudson AJ

更新日期：1982-12-01 00:00:00

abstract：:Severe acute respiratory syndrome (SARS) is a new disease which has spread rapidly and widely. We wished to know whether evaluation of in vitro cytokine production could contribute to improved understanding of disease pathogenesis and to better patient management. Numbers of unstimulated and mitogen-stimulated cytokin...

journal_title：Clinical and experimental immunology

authors： Jones BM,Ma ES,Peiris JS,Wong PC,Ho JC,Lam B,Lai KN,Tsang KW

更新日期：2004-03-01 00:00:00

abstract：:Dysregulation of apoptosis, particularly in the Fas/Fas ligand (FasL) pathway, is considered to be involved in the pathogenesis of autoimmune diseases such as systemic lupus erythematosus (SLE). Recently, a soluble decoy receptor, termed decoy receptor 3 (DcR3), that binds FasL and inhibits FasL-induced apoptosis, has...

journal_title：Clinical and experimental immunology

authors： Otsuki T,Tomokuni A,Sakaguchi H,Aikoh T,Matsuki T,Isozaki Y,Hyodoh F,Ueki H,Kusaka M,Kita S,Ueki A

更新日期：2000-02-01 00:00:00

abstract：:The CCL2/CCR2 chemokine/receptor axis directs the chemotaxis of infiltrating monocytes/macrophages and T cells and plays a pivotal role in tissue damage and fibrosis in kidney diseases. The eradication of the activated leucocytes should diminish the production of inflammatory mediators, limit tissue damage and amelior...

journal_title：Clinical and experimental immunology

authors： McIntosh LM,Barnes JL,Barnes VL,McDonald JR

更新日期：2009-02-01 00:00:00

abstract：:In this paper we describe the clinical and molecular features of a new case (GOR) of homozygous human TAP2 deficiency, analysing the phenotype and function of NK cells. The patient presented from infancy with recurrent sinopulmonary infections; a selective IgG2 deficiency, negative antibody response to polysaccharide ...

journal_title：Clinical and experimental immunology

authors： Matamoros N,Milà J,Llano M,Balas A,Vicario JL,Pons J,Crespí C,Martinez N,Iglesias-Alzueta J,López-Botet M

更新日期：2001-08-01 00:00:00

abstract：:Human cartilage gp-39 (HC gp-39) is a well-known autoantigen in rheumatoid arthritis (RA). However, the exact localization, fluctuation and function of HC gp-39 in RA are unknown. Therefore, using a glucose-6-phosphate isomerase (GPI)-induced model of arthritis, we investigated these aspects of HC gp-39 in arthritis. ...

journal_title：Clinical and experimental immunology

authors： Tanaka Y,Matsumoto I,Inoue A,Umeda N,Takai C,Sumida T

更新日期：2014-08-01 00:00:00

abstract：:The F1 hybrid mouse strain, from B10Q and DBA/1 parentals (the QD strain), is highly susceptible to induction of type II collagen-induced arthritis, an experimental model for rheumatoid arthritis. Males are more susceptible than females. Oophorectomy enhances susceptibility to arthritis and treatment with physiologica...

journal_title：Clinical and experimental immunology

authors： Jansson L,Holmdahl R

更新日期：1992-09-01 00:00:00

abstract：:Autoreactivity to heat shock protein 60 (Hsp60) has been implicated in the pathogenesis and regulation of chronic inflammation, especially in autoimmune diseases. In transplantation, there is a lack of information regarding the cytokine profile and specificity of cells that recognize self-Hsp60 as well as the kinetics...

journal_title：Clinical and experimental immunology

authors： Caldas C,Luna E,Spadafora-Ferreira M,Porto G,Iwai LK,Oshiro SE,Monteiro SM,Fonseca JA,Lemos F,Hammer J,Ho PL,Kalil J,Coelho V

更新日期：2006-10-01 00:00:00

abstract：:To elucidate the in vivo mechanisms involved in the impairment in pulmonary defence as the result of treatment with glucocorticoids, we established fatal pneumonia with bacteraemia in dexamethasone (DEX)-treated mice by means of an intratracheal challenge of Pseudomonas aeruginosa. An increased neutrophil influx was o...

journal_title：Clinical and experimental immunology

authors： Satoh S,Oishi K,Iwagaki A,Senba M,Akaike T,Akiyama M,Mukaida N,Atsushima KM,Nagatake T

更新日期：2001-11-01 00:00:00

abstract：:Regulatory T cells (T(regs)) may inhibit immunity against cancer. Induction and expansion of T(regs) in the immunosuppressive microenvironment created by a growing tumour appear to be one of the mechanisms by which it can evade host defence. We studied the impact of CD25+ T(regs) in a B cell lymphoma model in which Ra...

journal_title：Clinical and experimental immunology

authors： Heier I,Hofgaard PO,Brandtzaeg P,Jahnsen FL,Karlsson M

更新日期：2008-05-01 00:00:00

abstract：:The balance between Type 1 and Type 2 cytokines is important for the outcome of several infectious diseases. As elderly humans show increased morbidity and mortality from infectious diseases, this study tests if ageing is associated with a change towards Type 2 dominance in T cells. Expression of IFN-gamma, and IL-4 w...

journal_title：Clinical and experimental immunology

authors： Sandmand M,Bruunsgaard H,Kemp K,Andersen-Ranberg K,Pedersen AN,Skinhøj P,Pedersen BK

更新日期：2002-01-01 00:00:00

abstract：:Immunoglobulin G (IgG) in soluble and particulate fractions of discrete tissue samples from multiple sclerosis (MS) brain was analysed. Supernatant IgG/albumin rations and particulate-bound IgG levels were highest in samples dissected from MS plaques and adjacent white matter. Acid extracts of particulate fractions fr...

journal_title：Clinical and experimental immunology

authors： Glynn P,Gilbert HM,Newcombe J,Cuzner ML

更新日期：1982-04-01 00:00:00

abstract：:During chronic inflammation, interleukin (IL)-22 expression is up-regulated in both CD4 and CD8 T cells, exerting a protective role in infections. However, in autoimmunity, IL-22 appears to have either a protective or a pathogenic role in a variety of murine models of autoimmunity and, by extrapolation, in humans. It ...

journal_title：Clinical and experimental immunology

authors： Yang GX,Sun Y,Tsuneyama K,Zhang W,Leung PS,He XS,Ansari AA,Bowlus C,Ridgway WM,Gershwin ME

更新日期：2016-08-01 00:00:00

abstract：:Traumatic injury and sepsis reduce HLA-DR expression on monocytes. This study assessed the effect of interferon-gamma (IFN-gamma) on the expression of HLA-DR on monocytes taken from severely injured patients. The mononuclear layer of each blood sample was incubated with either 500 units IFN-gamma or control media. The...

journal_title：Clinical and experimental immunology

authors： Hershman MJ,Appel SH,Wellhausen SR,Sonnenfeld G,Polk HC Jr

更新日期：1989-07-01 00:00:00

abstract：:T cells are thought to play an important regulatory role in atopic asthma. We hypothesized that human blood and BAL T cell subsets bearing various TCR-Vbeta genes might show selective differences in their cytokine profile. Peripheral blood (PB) and bronchoalveolar lavage (BAL) T cells from seven atopic asthmatic and s...

journal_title：Clinical and experimental immunology

authors： Bakakos P,Pickard C,Smith JL,Frew AJ

更新日期：2002-05-01 00:00:00

abstract：:The requirement for specificity of antibody-dependent inhibition or killing of intracellular Toxoplasma gondii trophozoites by normal mouse peritoneal macrophages was evaluated in vitro using light microscopy and autoradiography. Anti-toxoplasma antibody in the presence of 'accessory factor' rendered extracellular T. ...

journal_title：Clinical and experimental immunology

authors： Anderson SE Jr,Bautista SC,Remington JS

更新日期：1976-12-01 00:00:00

abstract：:The aim of this study was to evaluate prospectively cytokine levels and disease activity in juvenile idiopathic arthritis (JIA) patients treated with and without tumour necrosis factor (TNF)-α inhibitors. TNF-α inhibitor-naive JIA subjects were followed prospectively for 6 months. Cytokine levels of TNF-α, interleukin...

journal_title：Clinical and experimental immunology

authors： Walters HM,Pan N,Lehman TJ,Adams A,Kalliolias GD,Zhu YS,Santiago F,Nguyen J,Sitaras L,Cunningham-Rundles S,Walsh TJ,Toussi SS

更新日期：2016-06-01 00:00:00

abstract：:In a family with partial or total adenine phosphoribosyl transferase (APRT) deficiency, T and B cell function was evaluated by counting rosette-forming cells, by investigating lymphocyte transformation to phytohaemagglutinin (PHA), concanavalin A (Con A) and pokeweed mitogen (PWM), by assaying serum immunoglobulins an...

journal_title：Clinical and experimental immunology

authors： Stevens WJ,Peetermans ME,Van Acker KJ

更新日期：1979-06-01 00:00:00

abstract：:Since thyroid follicular epithelial cells (thyrocytes) have been shown to express a number of functions similar to monocytes, they were further examined for their potency in secreting thymocyte-stimulating activity (TSA). Although spontaneous production of TSA could not be detected when thyrocytes were cultured in the...

journal_title：Clinical and experimental immunology

authors： Hirose W,Kawagoe M,Hara M,Kitani A,Hirose T,Norioka K,Harigai M,Nakamura H

更新日期：1987-10-01 00:00:00

abstract：:Bacillus Calmette-Guérin (BCG) remains the only available and most widely administered vaccine against Mycobacterium tuberculosis (Mtb), yet it fails to protect vaccinated individuals either from primary infection or reactivation of latent tuberculosis (TB). Despite BCG's variable efficacy against TB, the fact remains...

journal_title：Clinical and experimental immunology

authors： Siddiqui KF,Amir M,Khan N,Rama Krishna G,Sheikh JA,Rajagopal K,Agrewala JN

更新日期：2015-08-01 00:00:00

abstract：:Psoriasis is an immune-mediated inflammatory skin disease that mainly affects the skin barrier. Treatment for psoriasis mainly includes conventional immunosuppressive drugs. However, long-term treatment with global immunosuppressive agents may cause a variety of side effects, including nephrotoxicity and infections. K...

journal_title：Clinical and experimental immunology

authors： Liu C,Liu H,Lu C,Deng J,Yan Y,Chen H,Wang Y,Liang CL,Wei J,Han L,Dai Z

更新日期：2019-12-01 00:00:00

abstract：:Nephritic factor was detected in an individual whose serum showed a selective decrease in the third component of complement (C3) during and subsequent to an illness resembling disseminated gonococcal infection (DGI). As is characteristic of C3 nephritic factor (C3NeF), its activity was heat stable, was associated with...

journal_title：Clinical and experimental immunology

authors： Gewurz AT,Imherr SM,Strauss S,Gewurz H,Mold C

更新日期：1983-10-01 00:00:00

abstract：:We have investigated the expression of chemokines and their receptors in leprosy skin lesions using immunohistochemistry. Skin biopsies from 25 leprosy patients across the leprosy spectrum, 11 patients undergoing type I reversal reactions and four normal donors were immunostained by ABC peroxidase method using antibod...

journal_title：Clinical and experimental immunology

authors： Kirkaldy AA,Musonda AC,Khanolkhar-Young S,Suneetha S,Lockwood DN

更新日期：2003-12-01 00:00:00

abstract：:Mixed cryoglobulinaemia (MC) is a disorder characterized by the presence of large amounts of cryoprecipitating IgM-IgG complexes. An immune complex glomerulonephritis develops in one third of all patients, but its occurrence does not seem related to the amount of cryoglobulins in the sera, nor to their complement-fixi...

journal_title：Clinical and experimental immunology

authors： Dolcher MP,Marchini B,Sabbatini A,Longombardo G,Ferri C,Riente L,Bombardieri S,Migliorini P

更新日期：1994-05-01 00:00:00