Specific antibody-dependent killing of Toxoplasma gondii by normal macrophages.

abstract：:Normal, but not tolerant, adult thymocytes prevented particulate antigen inducing tolerance in differentiating B lymphocytes. This was demonstrated by measuring the emergence of responsive B cells (identified by their allotype) developing from a foetal liver innoculum in irradiated hosts with or without the addition o...

journal_title：Clinical and experimental immunology

authors： Elson CJ

更新日期：1978-10-01 00:00:00

abstract：:Coeliac disease (CD) is described as an autoimmune enteropathy associated with the presence of IgG and IgA antigliadin and antitransglutaminase autoantibodies. While of diagnostic significance, the role of these autoantibodies in the immunopathogenesis of CD is elucidated. An inappropriate T cell immune response to gl...

journal_title：Clinical and experimental immunology

authors： Cremata JA,Sorell L,Montesino R,Garcia R,Mata M,Cabrera G,Galvan JA,Garcia G,Valdes R,Garrote JA

更新日期：2003-09-01 00:00:00

abstract：:Cellular sensitization to rabbit liver specific lipoprotein (RLSP) has been investigated using a lymphocyte transformation test in patients with chronic active hepatitis (CAH). A stimulation index greater than 2 was recorded in twenty out of twenty-five cases (eight of ten HBsAg positive and twelve of fiteen HBsAg neg...

journal_title：Clinical and experimental immunology

authors： Ortona L,Laghi V,Cauda R,Nervo P

更新日期：1979-11-01 00:00:00

abstract：:Isoelectric focusing of serial bleeds from patients with Hashimoto's thyroiditis was carried out and thyroglobulin (Tg) autoantibodies visualized using 125I-labelled Tg followed by autoradiography. Although the spectrotype of these antibodies was polyclonal and varied from patient to patient, each individual's spectro...

journal_title：Clinical and experimental immunology

authors： Delves PJ,Roitt IM

更新日期：1988-03-01 00:00:00

abstract：:It is generally accepted that multiple sclerosis (MS) is mediated by autoreactive T cells and that myelin basic protein (MBP) is one of the target autoantigens. The T-cell response to MBP has been analysed extensively, largely through the use of T-cell lines (TCL) and T-cell clones (TCC), and to date, three immunodomi...

journal_title：Clinical and experimental immunology

authors： Mazza G,Ponsford M,Lowrey P,Campbell MJ,Zajicek J,Wraith DC

更新日期：2002-06-01 00:00:00

abstract：:A 3.5 year old boy with X-linked severe combined immunodeficiency disease (SCID), who had been in laminar flow isolation throughout his life, developed a B cell tumour producing up to 3008 mg/dl of an IgM kappa paraprotein 1 month after infusion of both liver and thymus cells from a fetal donor and 6 months after the ...

journal_title：Clinical and experimental immunology

authors： Shirley LR,Buckley RH,Borowitz MJ,Welt SI,Kostyu DD

更新日期：1982-06-01 00:00:00

abstract：:The circulating and cervical B cell responses to Chlamydia trachomatis plasmid protein pgp3 were characterized in children and adults with ocular or genital chlamydial infection using the enzyme-linked immunospot assay (ELISPOT) and ELISA. No pgp3-specific ASCs were detected in healthy controls, but predominantly IgA ...

journal_title：Clinical and experimental immunology

authors： Ghaem-Maghami S,Ratti G,Ghaem-Maghami M,Comanducci M,Hay PE,Bailey RL,Mabey DC,Whittle HC,Ward ME,Lewis DJ

更新日期：2003-06-01 00:00:00

abstract：:To elucidate the in vivo mechanisms involved in the impairment in pulmonary defence as the result of treatment with glucocorticoids, we established fatal pneumonia with bacteraemia in dexamethasone (DEX)-treated mice by means of an intratracheal challenge of Pseudomonas aeruginosa. An increased neutrophil influx was o...

journal_title：Clinical and experimental immunology

authors： Satoh S,Oishi K,Iwagaki A,Senba M,Akaike T,Akiyama M,Mukaida N,Atsushima KM,Nagatake T

更新日期：2001-11-01 00:00:00

abstract：:Human cartilage gp-39 (HC gp-39) is a well-known autoantigen in rheumatoid arthritis (RA). However, the exact localization, fluctuation and function of HC gp-39 in RA are unknown. Therefore, using a glucose-6-phosphate isomerase (GPI)-induced model of arthritis, we investigated these aspects of HC gp-39 in arthritis. ...

journal_title：Clinical and experimental immunology

authors： Tanaka Y,Matsumoto I,Inoue A,Umeda N,Takai C,Sumida T

更新日期：2014-08-01 00:00:00

abstract：:Ultrastructural study of mucosal eosinophils in a case of eosinophilic gastroenteritis involving stomach, duodenum and ileum showed an altered structure in ulcerated duodenal areas. The electron core density of eosinophil granules was inverted or disappeared and tubulovesicular structures occurred. Using immunogold st...

journal_title：Clinical and experimental immunology

authors： Torpier G,Colombel JF,Mathieu-Chandelier C,Capron M,Dessaint JP,Cortot A,Paris JC,Capron A

更新日期：1988-12-01 00:00:00

abstract：:Pre-eclampsia is an endothelial disorder and TNF-alpha has fundamental effects on endothelial cells by several means, including altering the balance between oxidant and anti-oxidant, changing the pattern of prostaglandin production and affecting expression of several cell surface components. To determine whether TNF-a...

journal_title：Clinical and experimental immunology

authors： Chen G,R Wilson,Wang SH,Zheng HZ,Walker JJ,McKillop JH

更新日期：1996-04-01 00:00:00

abstract：:Cell-bound helper and suppressor factors, on lymphocytes from Rhesus monkeys, were assayed by the indirect immunofluorescent method, using F(ab')2 fragments of rabbit antisera to antigen specific secreted helper and suppressor factors. The rabbit antisera recognize the function related to the 'constant' region of secr...

journal_title：Clinical and experimental immunology

authors： Lehner T,Lamb JR,Kontiainen S

更新日期：1982-03-01 00:00:00

abstract：:Hyperlipidaemia accompanies chronic renal disease either as a consequence of the renal dysfunction or as part of generalized metabolic derangements. Under both situations, the lipid profile is characterized by accumulation of triglyceride-rich lipoproteins (TGRLs). This lipid profile is recognized as a risk factor for...

journal_title：Clinical and experimental immunology

authors： Saja MF,Cook HT,Ruseva MM,Szajna M,Pickering MC,Woollard KJ,Botto M

更新日期：2018-06-01 00:00:00

abstract：:Factor H is an abundant plasma glycoprotein that plays a critical role in the regulation of the complement system in plasma and in the protection of host cells and tissues from damage by complement activation. Several recent studies have described the association of genetic variations of the complement factor H gene (...

journal_title：Clinical and experimental immunology

authors： de Córdoba SR,de Jorge EG

更新日期：2008-01-01 00:00:00

abstract：:We have recently demonstrated that peripheral blood monocytes from patients with multiple sclerosis (MS) have a defect in stimulating autologous and allogeneic T lymphocytes. This defect was found to correlate with disease activity. In this report we demonstrate that prothymosin alpha (ProT alpha), a rat thymus fracti...

journal_title：Clinical and experimental immunology

authors： Reclos GJ,Baxevanis CN,Sfagos C,Papageorgiou C,Tsokos GC,Papamichail M

更新日期：1987-11-01 00:00:00

abstract：:There are few studies assessing the pathogenicity of human monoclonal anti-DNA antibodies. The use of SCID mice avoids the problem of rejection of the human hybridoma cells thus allowing in vivo assessment of human immunoglobulins. Using electron microscopy we have shown that the human IgG anti-dsDNA monoclonal antibo...

journal_title：Clinical and experimental immunology

authors： Mason LJ,Ravirajan CT,Latchman DS,Isenberg DA

更新日期：2001-10-01 00:00:00

abstract：:Diesel exhaust particles (DEP) are known to modulate the production of cytokines associated with acute and chronic respiratory symptoms and allergic respiratory disease. Tolerance is an important mechanism through which the immune system can maintain nonresponsiveness to common environmental antigens. We examined the ...

journal_title：Clinical and experimental immunology

authors： Pacheco KA,Tarkowski M,Sterritt C,Negri J,Rosenwasser LJ,Borish L

更新日期：2001-12-01 00:00:00

abstract：:Diagnosis of perinatal infection in the newborn is difficult; there may be few clinical signs and current tests are slow or non-specific. Detection of organisms, antigen or specific antibody to common pathogens often requires repeat samples and does not give immediate results. Haematological parameters, although relie...

journal_title：Clinical and experimental immunology

authors： Hodge S,Hodge G,Flower R,Han P

更新日期：1998-07-01 00:00:00

abstract：:Booster immunization of normal individuals with soluble tetanus toxoid (TT) produced significant levels of plasma anti-tetanus IgG and IgM detectable by an enzyme linked immunosorbent assay (ELISA). Similar changes in circulating anti-TT antibody were found in mice following primary immunization. There was. however, n...

journal_title：Clinical and experimental immunology

authors： Ershler WB,Moore AL,Hacker MP

更新日期：1982-09-01 00:00:00

abstract：:Previous studies have shown that the efficiency of phagocytosis is a function of cell cycle and that phagocytosis promotes cell cycle progression. Because phagocytosis is dependent on cellular receptors we hypothesized that Fcgamma receptors (FcgammaR) and complement receptors (CR) expression varied with cell cycle. C...

journal_title：Clinical and experimental immunology

authors： Luo Y,Cook E,Fries BC,Casadevall A

更新日期：2006-08-01 00:00:00

abstract：:Studies were performed on eleven patients with inflammatory bowel disease to determine if there was an alteration in concanavalin A (Con A) induced suppressor cell activity. Similar investigations were also performed on twenty-one control subjects and five patients with other inflammatory conditions. Supressor cells w...

journal_title：Clinical and experimental immunology

authors： Hodgson HJ,Wands JR,Isselbacher KJ

更新日期：1978-06-01 00:00:00

abstract：:Patients with recurrent miscarriage (RM) show up-regulated cytotoxic natural killer (NK) cells that are suspected to play a causal role in abortion. In the present study, we investigated counter-regulating inhibitory mechanisms and compared the results in RM patients with those of healthy controls (HC), patients with ...

journal_title：Clinical and experimental immunology

authors： Zhu L,Aly M,Wang H,Karakizlis H,Weimer R,Morath C,Kuon RJ,Toth B,Ekpoom N,Opelz G,Daniel V

更新日期：2018-08-01 00:00:00

abstract：:IgG2 deficiency has been recently associated with the appearance of vasculitis. None of the 42 patients with IgG2 deficiency whom we studied has a history of vasculitis. We have also studied 56 patients with vasculitis, and found four of them with IgG2 levels below the normal range for their age. As a group, the vascu...

journal_title：Clinical and experimental immunology

authors： Jiménez A,López-Trascasa M,Fontán G

更新日期：1989-11-01 00:00:00

abstract：:The specific response of human peripheral blood lymphocyte cultures to TNP-polyacrylamide was suppressed by the addition of concanavalin A (Con A). A dose of Con A (0.5 microgram/ml) could be selected, which induced a reproducible but incomplete suppression independent of the magnitude of the anti-TNP response. Con A-...

journal_title：Clinical and experimental immunology

authors： Galanaud P,Crevon MC,Delfraissy JF,Segond P,Wallon C,Dormont J

更新日期：1979-10-01 00:00:00

abstract：:An expanded T cell subpopulation (CD8+ Leu-7+) has previously been reported in the peripheral blood of patients with Crohn's disease. This subpopulation of T cells was associated with a 'covert suppressor' function, particularly in patients with mild/early Crohn's disease, suppressing immunoglobulin production in vitr...

journal_title：Clinical and experimental immunology

authors： Deem RL,Targan SR,Niederlehner A,Shanahan F

更新日期：1990-06-01 00:00:00

abstract：:Epigenetic studies reveal how our genes (nature) are influenced by environment (nurture) leading to wide variability in clinical presentations, especially in autoimmune diseases. Patients with C1-inhibitor deficiency, even within the same family, have diverse clinical presentations that may reflect epigenetic control ...

journal_title：Clinical and experimental immunology

authors： Khan S,Longhurst H

更新日期：2020-11-01 00:00:00

abstract：:Ten patients with chronic lymphatic leukaemia (CLL) were injected with the antigen phichi174 intravenously on two occasions to test their capacity for antibody production. Nine out of ten patients failed to develop a primary response, and five out of ten failed to develop a secondary response. Only one out of the ten ...

journal_title：Clinical and experimental immunology

authors： Hamblin TJ,Jones JV,Peacock DB

更新日期：1975-07-01 00:00:00

abstract：:Immune repopulation, despite virological failure, often occurs in children under highly active anti-retroviral therapy (HAART). The aim of this study was to analyse the characteristics of immune repopulation and activation in children with and without virological response to HAART. Fourteen human immunodeficiency viru...

journal_title：Clinical and experimental immunology

authors： Anselmi A,Vendrame D,Rampon O,Giaquinto C,Zanchetta M,De Rossi A

更新日期：2007-12-01 00:00:00

abstract：:Fifty sera which gave ring-like nuclear staining in immunofluorescence on rat liver tissue sections were characterized. Using immunoprecipitation and Western blotting we showed that 10 of the sera contained antibodies to 200 kD polypeptide(s) of nuclear envelope. Clinical and biological data were available for nine of...

journal_title：Clinical and experimental immunology

authors： Lassoued K,Guilly MN,Andre C,Paintrand M,Dhumeaux D,Danon F,Brouet JC,Courvalin JC

更新日期：1988-11-01 00:00:00

abstract：:Paneth cells are important contributors to the intestinal antimicrobial barrier through synthesis and release of antimicrobial peptides and proteins. Animal studies indicate that Paneth cell numbers, location and granule morphology are altered by infection and zinc status. We examined human tissue to determine whether...

journal_title：Clinical and experimental immunology

authors： Kelly P,Feakins R,Domizio P,Murphy J,Bevins C,Wilson J,McPhail G,Poulsom R,Dhaliwal W

更新日期：2004-02-01 00:00:00