Effect of nandrolone decanoate on Sjögren's syndrome like disorders in NZB/NZW mice.

Abstract:

:The effects of 2.5-40 mg/kg nandrolone decanoate (ND) on the development and growth of mononuclear cell infiltrations in the submandibular glands of NZB/W (B/W) mice have been studied using a quantitative histological method. Injections with ND for 9 months, once every 3 weeks, starting at 4 weeks of age, reduced the number and total area of infiltrations in submandibular glands of female and castrated male B/W mice. Since ND has relatively weak virilizing properties, this substance may be useful for the treatment of Sjögren's syndrome in humans.

journal_name

Clin Exp Immunol

authors

Schot LP,Verheul HA,Schuurs AH

subject

Has Abstract

pub_date

1984-09-01 00:00:00

pages

571-4

issue

3

eissn

0009-9104

issn

1365-2249

journal_volume

57

pub_type

杂志文章
  • H-ferritin and proinflammatory cytokines are increased in the bone marrow of patients affected by macrophage activation syndrome.

    abstract::Macrophage activation syndrome (MAS) is hyperinflammatory life-threatening syndrome, associated typically with high levels of serum ferritin. This is an iron storage protein including heavy (H) and light (L) subunits, categorized on their molecular weight. The H-/L subunits ratio may be different in tissues, depending...

    journal_title:Clinical and experimental immunology

    pub_type: 杂志文章

    doi:10.1111/cei.13057

    authors: Ruscitti P,Cipriani P,Di Benedetto P,Liakouli V,Berardicurti O,Carubbi F,Ciccia F,Guggino G,Triolo G,Giacomelli R

    更新日期:2018-02-01 00:00:00

  • Factors affecting the glomerular protein leak after polyclonal activation in the HgCl2-induced model of anti-GBM disease in the brown Norway rat.

    abstract::The administration of the polyclonal activator HgCl2 (1 mg/kg i.p.) to Brown Norway (BN) rats on days 0, 2, 4 and 7 resulted in the cyclical production of anti-glomerular basement membrane (GBM) antibodies, the first peak of which occurred at day 14 with a smaller peak at day 26. Glomerular anti-GBM antibody levels we...

    journal_title:Clinical and experimental immunology

    pub_type: 杂志文章

    doi:

    authors: Savige JA,Lockwood CM

    更新日期:1987-12-01 00:00:00

  • CD5-positive B cells after T cell depleted bone marrow transplantation.

    abstract::CD5 is an antigen normally found on T cells and on a minority subpopulation of B cells in fetal spleen and tonsil and on the majority of cells in B-chronic lymphocytic leukaemia. Recent reports described the occurrence of large numbers of CD5-positive B cells in the peripheral blood after bone marrow transplantation (...

    journal_title:Clinical and experimental immunology

    pub_type: 杂志文章

    doi:

    authors: Drexler HG,Brenner MK,Wimperis JZ,Gignac SM,Janossy G,Prentice HG,Hoffbrand AV

    更新日期:1987-06-01 00:00:00

  • Serum cytokines elevated during gluten-mediated cytokine release in coeliac disease.

    abstract::Cytokines have been extensively studied in coeliac disease, but cytokine release related to exposure to gluten and associated symptoms has only recently been described. Prominent, early elevations in serum interleukin (IL)-2 after gluten support a central role for T cell activation in the clinical reactions to gluten ...

    journal_title:Clinical and experimental immunology

    pub_type: 临床试验,杂志文章,多中心研究

    doi:10.1111/cei.13369

    authors: Goel G,Daveson AJM,Hooi CE,Tye-Din JA,Wang S,Szymczak E,Williams LJ,Dzuris JL,Neff KM,Truitt KE,Anderson RP

    更新日期:2020-01-01 00:00:00

  • The CD8+ Leu-7+ subset of T cells in Crohn's disease: distinction between cytotoxic and covert suppressor functions.

    abstract::An expanded T cell subpopulation (CD8+ Leu-7+) has previously been reported in the peripheral blood of patients with Crohn's disease. This subpopulation of T cells was associated with a 'covert suppressor' function, particularly in patients with mild/early Crohn's disease, suppressing immunoglobulin production in vitr...

    journal_title:Clinical and experimental immunology

    pub_type: 杂志文章

    doi:10.1111/j.1365-2249.1990.tb03298.x

    authors: Deem RL,Targan SR,Niederlehner A,Shanahan F

    更新日期:1990-06-01 00:00:00

  • Adverse reactions to nitrofurantoin in relation to cellular and humoral immune responses.

    abstract::Eighteen patients showing hypersensitivity to nitrofurantoin with symptoms like sudden fever, malaise, cough, pleuritis, leucocytosis and sometimes eosinophilia were analysed for immune reactions, i.e. lymphocyte transformation and specific antibodies. In addition, thirty-three individuals treated with the drug but wi...

    journal_title:Clinical and experimental immunology

    pub_type: 杂志文章

    doi:

    authors: Bäck O,Lidén S,Ahlstedt S

    更新日期:1977-06-01 00:00:00

  • Glucocorticoid inhibition of adjuvant arthritis synovial macrophage nitric oxide production: role of lipocortin 1.

    abstract::Nitric oxide (NO) is a mediator of inflammatory injury which is inhibited by glucocorticoids and is implicated in rheumatoid (RA) and adjuvant arthritis (AA). The glucocorticoid-induced anti-inflammatory molecule lipocortin 1 is expressed in RA synovium, but the effects of lipocortin 1 on synovial inflammation have be...

    journal_title:Clinical and experimental immunology

    pub_type: 杂志文章

    doi:10.1046/j.1365-2249.1998.00438.x

    authors: Yang YH,Hutchinson P,Santos LL,Morand EF

    更新日期:1998-01-01 00:00:00

  • Human monocytes have prothrombin cleaving activity.

    abstract::A proportion of human monocytes form long needles of fibrin on their surfaces when they are briefly exposed to human plasma. A number of coagulation factor deficient plasmas (II, V, VII, VIII, von Willebrand, IX, X, XI and XII) were tested for their ability to promote formation of this fibrin. Monocytes failed to make...

    journal_title:Clinical and experimental immunology

    pub_type: 杂志文章

    doi:

    authors: Hogg N

    更新日期:1983-09-01 00:00:00

  • Functional platelet-derived growth factor-beta (PDGF-beta) receptor expressed on early B-lineage precursor cells.

    abstract::Growth and maturation of B lymphocytes from stem cells require a series of complex processes that are dependent at least in part on growth factors. Uncontrolled expression of receptors from these early growth factors may contribute to a leukaemogenesis of such early B cell progenitors. We show here that early pre-pre-...

    journal_title:Clinical and experimental immunology

    pub_type: 杂志文章

    doi:10.1111/j.1365-2249.1995.tb03799.x

    authors: Trink B,Wang G,Shahar M,Meydan N,Roifman CM

    更新日期:1995-11-01 00:00:00

  • Interleukin-2 treatment reverses effects of cAMP-responsive element modulator α-over-expressing T cells in autoimmune-prone mice.

    abstract::Systemic autoimmune diseases, such as systemic lupus erythematosus (SLE), are often characterized by a failure of self-tolerance and result in an uncontrolled activation of B cells and effector T cells. Interleukin (IL)-2 critically maintains homeostasis of regulatory T cells (T(reg)) and effector T cells in the perip...

    journal_title:Clinical and experimental immunology

    pub_type: 杂志文章

    doi:10.1111/cei.12629

    authors: Ohl K,Wiener A,Schippers A,Wagner N,Tenbrock K

    更新日期:2015-07-01 00:00:00

  • IgG-mediated anaphylaxis via Fc gamma receptor in CD40-deficient mice.

    abstract::Anaphylaxis denotes an immediate hypersensitivity reaction to allergen, exclusively mediated by IgE antibodies. However, IgE antibodies do not explain all the syndromes that are encountered. We investigated potent IgG-mediated anaphylaxis in CD40-deficient mice that lack the immunoglobulin class switching for T cell-d...

    journal_title:Clinical and experimental immunology

    pub_type: 杂志文章

    doi:10.1046/j.1365-2249.1998.00717.x

    authors: Wakayama H,Hasegawa Y,Kawabe T,Saito H,Kikutani H,Shimokata K

    更新日期:1998-11-01 00:00:00

  • In vivo effects of a single infusion of theophylline on human peripheral blood lymphocytes.

    abstract::It has recently been proposed that theophylline activates T suppressor systems in vivo and this evidence is further supported by the ability of the drug to attenuate the allograft rejection in humans and in experimental animals. In this study the acute effects of aminophylline on human peripheral blood lymphocyte (PBL...

    journal_title:Clinical and experimental immunology

    pub_type: 杂志文章

    doi:

    authors: Pardi R,Zocchi MR,Ferrero E,Ciboddo GF,Inverardi L,Rugarli C

    更新日期:1984-09-01 00:00:00

  • Effect of rituximab on B cell phenotype and serum B cell-activating factor levels in patients with thrombotic thrombocytopenic purpura.

    abstract::Autoantibodies inhibiting the activity of the metalloproteinase, ADAMTS13 (a disintegrin and metalloproteinase with a thrombospondin type 1 motif, member 13), underlie the pathogenesis of thrombotic thrombocytopenic purpura (TTP). Rituximab (RTX) combined with plasma-exchange (PEX) is an effective treatment in TTP. Pa...

    journal_title:Clinical and experimental immunology

    pub_type: 杂志文章

    doi:10.1111/cei.12472

    authors: Becerra E,Scully MA,Leandro MJ,Heelas EO,Westwood JP,De La Torre I,Cambridge G

    更新日期:2015-03-01 00:00:00

  • Influence of the Ity/Lsh/Bcg gene on the development of suppressor cell precursors in the early phase of the infection of mice with Mycobacterium lepraemurium.

    abstract::In vitro inducible suppressor cell precursors were detected in the spleen of BALB/c but not in DBA/2 mice infected intraperitoneally with 10(8) Mycobacterium lepraemurium bacilli, thus suggesting that their development is genetically controlled. Two pairs of mouse strains congenic at the Ity/Lsh/Bcg locus (BALB/c-C.D2...

    journal_title:Clinical and experimental immunology

    pub_type: 杂志文章

    doi:10.1111/j.1365-2249.1994.tb06545.x

    authors: Gosselin D,Turcotte R,Lemieux S

    更新日期:1994-05-01 00:00:00

  • Sequential autoantigenic determinants of the small nuclear ribonucleoprotein Sm D shared by human lupus autoantibodies and MRL lpr/lpr antibodies.

    abstract::Autoantibodies directed against the Sm proteins of the spliceosome complex are found in approximately 25% of systemic lupus erythematosus (SLE) patients sera. To determine which regions of the Sm D polypeptide are involved in the lupus autoimmune response, binding to overlapping octapeptides of Sm D has been evaluated...

    journal_title:Clinical and experimental immunology

    pub_type: 杂志文章

    doi:10.1111/j.1365-2249.1994.tb05507.x

    authors: James JA,Mamula MJ,Harley JB

    更新日期:1994-12-01 00:00:00

  • Features of the immune response to DNA in mice II. Participation of B and T cells.

    abstract::The respective roles of thymus-derived and bone marrow-derived lymphocytes in the immune response to DNA was investigated in mice reconstituted with various cell populations using cell transfers. A helper effect of thymus-derived cells in the immune response to DNA was suggested by experiments performed in athymic nud...

    journal_title:Clinical and experimental immunology

    pub_type: 杂志文章

    doi:

    authors: Fournié GJ,Lambert PH,Bankhurst AD,Miescher PA

    更新日期:1976-10-01 00:00:00

  • Human anti-mouse antibody response to the injection of murine monoclonal antibodies against IL-6.

    abstract::We analysed human anti-mouse antibodies (HAMA) in 12 patients (six with multiple myeloma (MM) and six with metastatic renal cell carcinoma (MRCC) who were treated with B-E8, an IgG1 MoAb against IL-6. Efficiency of the treatment was evidenced by the drop in the serum levels of C-reactive protein (CRP), the in vivo pro...

    journal_title:Clinical and experimental immunology

    pub_type: 杂志文章

    doi:10.1111/j.1365-2249.1994.tb06145.x

    authors: Legouffe E,Liautard J,Gaillard JP,Rossi JF,Wijdenes J,Bataille R,Klein B,Brochier J

    更新日期:1994-11-01 00:00:00

  • Effect of protein deprivation on immunoregulatory cells in the rat mucosal immune response.

    abstract::Secretory IgA antibody responses such as those directed against respiratory and enteric pathogens, may be impaired in protein-calorie malnutrition. In previous studies using a rat model of the mucosal immune response to cholera toxin, as little as 2 weeks of severe protein deprivation markedly impaired mucosal anti-to...

    journal_title:Clinical and experimental immunology

    pub_type: 杂志文章

    doi:

    authors: Koster F,Pierce NF

    更新日期:1985-04-01 00:00:00

  • Immune status in Crohn's disease. V. Decreased in vitro natural killer cell activity in peripheral blood.

    abstract::To identify and measure the spontaneous cell-mediated cytotoxicity of natural killer cells, we used the lysis of an established lymphoblastoid cell line as target in a 4-hr 51Cr-release assay. Mononuclear cell suspensions of the peripheral blood of thirty-four patients with Crohn's disease (group CD), eleven patients ...

    journal_title:Clinical and experimental immunology

    pub_type: 杂志文章

    doi:

    authors: Auer IO,Ziemer E,Sommer H

    更新日期:1980-10-01 00:00:00

  • Circulating, Mycobacterium tuberculosis-specific lymphocytes from PPD skin test-negative patients with tuberculosis do not secrete interferon-gamma (IFN-gamma) and lack the cutaneous lymphocyte antigen skin-selective homing receptor.

    abstract::Individuals with a negative intradermal reaction to tuberculin PPD have long been described in the Mycobacterium tuberculosis exposed, immune-competent population. Here, we studied PPD-specific blood T lymphocytes from these subjects for phenotypic markers relevant to skin migration, including the expression of the sk...

    journal_title:Clinical and experimental immunology

    pub_type: 杂志文章

    doi:10.1046/j.1365-2249.2000.01128.x

    authors: Magnani ZI,Confetti C,Besozzi G,Codecasa LR,Panina-Bordignon P,Lang R,Rossi GA,Pardi R,Burastero SE

    更新日期:2000-01-01 00:00:00

  • Protein A-like activity and streptococcal cross-reactions.

    abstract::Recognition of the protein A-like activity of some strains of group A streptococci has thrown doubt on much previous work suggesting antigenic cross-reactions between these streptococci and mammalian tissues. The strains used in our previous studies have now been examined by the mixed reverse passive antiglobulin reac...

    journal_title:Clinical and experimental immunology

    pub_type: 杂志文章

    doi:

    authors: Kingston D

    更新日期:1981-10-01 00:00:00

  • Induction of apoptosis in monocytes and lymphocytes by serum from patients with systemic lupus erythematosus - an additional mechanism to increased autoantigen load?

    abstract::The most likely source of autoantigens in systemic lupus erythematosus (SLE) is apoptotic material. Because increased levels of circulating apoptotic cells are found in SLE we wanted to investigate the capacity of serum from patients with SLE or other autoimmune or infectious diseases and normal healthy donors (NHD) t...

    journal_title:Clinical and experimental immunology

    pub_type: 杂志文章

    doi:10.1111/j.1365-2249.2003.02386.x

    authors: Bengtsson AA,Sturfelt G,Gullstrand B,Truedsson L

    更新日期:2004-03-01 00:00:00

  • Proportions of several types of plasma and urine microparticles are increased in patients with rheumatoid arthritis with active disease.

    abstract::We analysed the proportions of different microparticles (MPs) in plasma from patients with rheumatoid arthritis (RA), and assessed their relationship with disease activity/therapy and their in-vitro effect on proinflammatory cytokine release. Blood and urine samples were obtained from 55 patients with RA (24 untreated...

    journal_title:Clinical and experimental immunology

    pub_type: 杂志文章

    doi:10.1111/cei.12598

    authors: Viñuela-Berni V,Doníz-Padilla L,Figueroa-Vega N,Portillo-Salazar H,Abud-Mendoza C,Baranda L,González-Amaro R

    更新日期:2015-06-01 00:00:00

  • Functional activity of peripheral mononuclear cells in cystic fibrosis: antibodies and plaque formation.

    abstract::Chronic pulmonary infection is known to constitute a major complication of cystic fibrosis (CF). In order to determine whether a defect of antibody formation is associated with this clinical finding, we have investigated antibody production on the cellular level by using a haemolytic plaque forming cell (PFC) assay. T...

    journal_title:Clinical and experimental immunology

    pub_type: 杂志文章

    doi:

    authors: Götz M,Zielinski CC,Ahmad R,Eibl M

    更新日期:1982-10-01 00:00:00

  • The binding of immunoglobulin Fc to cationic proteins.

    abstract::The interaction of cationic proteins with IgG, IgA and IgM were investigated by solid phase radioimmunoassay. All these immunoglobulins showed avid binding, IgM giving the strongest reaction, followed by IgA and then IgG. Fc fragments of IgG gave binding, but F(ab')2 fragments from the three main Ig classes did not, s...

    journal_title:Clinical and experimental immunology

    pub_type: 杂志文章

    doi:

    authors: Pambakian S,Poston RN

    更新日期:1987-05-01 00:00:00

  • Vitamin D status is not associated with inflammatory cytokine levels during experimental human endotoxaemia.

    abstract::Vitamin D has been shown to modulate innate immune responses in vitro and ex vivo; however, human in-vivo data are lacking. At high latitudes, seasonal vitamin D deficiency is common due to alternating ultraviolet (UV)-B radiation exposure. In the present study, we investigated whether levels of 25 hydroxyvitamin D(3)...

    journal_title:Clinical and experimental immunology

    pub_type: 杂志文章

    doi:10.1111/cei.12006

    authors: Kox M,van den Berg MJ,van der Hoeven JG,Wielders JP,van der Ven AJ,Pickkers P

    更新日期:2013-02-01 00:00:00

  • Secretory IgA are elevated in both saliva and serum of patients with various types of primary glomerulonephritis.

    abstract::Secretory immunoglobulin A (IgA) was determined by means of an enzyme-linked immunosorbent assay (using as capture antibody an MoAb specific for secretory component) in saliva and serum from 46 patients with IgA mesangial nephritis (IgAGN), 36 with an idiopathic nephrotic syndrome (INS), 30 with an idiopathic membrano...

    journal_title:Clinical and experimental immunology

    pub_type: 杂志文章

    doi:10.1111/j.1365-2249.1992.tb07947.x

    authors: Rostoker G,Terzidis H,Petit-Phar M,Meillet D,Lang P,Dubert JM,Lagrue G,Weil B

    更新日期:1992-11-01 00:00:00

  • BeWo trophoblast cell susceptibility to Toxoplasma gondii is increased by interferon-gamma, interleukin-10 and transforming growth factor-beta1.

    abstract::The present study aimed to investigate BeWo trophoblast cell susceptibility to Toxoplasma gondii infection under stimulation with anti-inflammatory cytokines in comparison with HeLa cells. Both cell types were submitted to different treatments with recombinant cytokines [interleukin (IL)-10 and transforming growth fac...

    journal_title:Clinical and experimental immunology

    pub_type: 杂志文章

    doi:10.1111/j.1365-2249.2007.03583.x

    authors: Barbosa BF,Silva DA,Costa IN,Mineo JR,Ferro EA

    更新日期:2008-03-01 00:00:00

  • Structural relationship of kappa-type light chains with AL amyloidosis: multiple deletions found in a VkappaIV protein.

    abstract::Two amyloidogenic Bence Jones proteins (Am37 VkappaIV and NIG1 VkappaI) and one non-amyloidogenic protein (NIG26 VkappaIII) were characterized. The protein Am37 had four deletions when compared with the translated germ-line gene sequence: two Ser residues following position 27 (27e, 27f) in CDR1 and two amino acids Pr...

    journal_title:Clinical and experimental immunology

    pub_type: 杂志文章

    doi:10.1046/j.1365-2249.1999.00939.x

    authors: Alim MA,Yamaki S,Hossain MS,Takeda K,Kozima M,Izumi T,Takashi I,Shinoda T

    更新日期:1999-12-01 00:00:00

  • Direct Coombs antiglobulin reactions in Gambian children with Plasmodium falciparum malaria. I. Incidence and class specificity.

    abstract::Gambian children with past or present Plasmodium falciparum malaria were investigated for the incidence of Coombs positivity using monospecific antisera. Approximately 50% were positive and the most frequent form of erythrocyte sensitization was with C3d. Other specificities, EIgG, EIgGC3d and EIgGC4bC3d were less com...

    journal_title:Clinical and experimental immunology

    pub_type: 杂志文章

    doi:

    authors: Facer CA,Bray RS,Brown J

    更新日期:1979-01-01 00:00:00