Effect of nandrolone decanoate on Sjögren's syndrome like disorders in NZB/NZW mice.

abstract：:The recent development of salivary proteomics has led to the identification of potential biomarkers for diagnosing patients with primary Sjögren's syndrome (pSS). Here we sought to identify differentially produced salivary metabolites from pSS patients and healthy controls (HCs) that might be used to characterize this...

journal_title：Clinical and experimental immunology

authors： Kageyama G,Saegusa J,Irino Y,Tanaka S,Tsuda K,Takahashi S,Sendo S,Morinobu A

更新日期：2015-11-01 00:00:00

abstract：:Atherosclerosis is an inflammatory response, probably to a range of initiating causes. Chronic infection with Chlamydia pneumoniae (C.pn) has been suggested as one cause, but the nature of the association is controversial, in large part due to lack of an identified mechanism to link infection with the atherosclerotic ...

journal_title：Clinical and experimental immunology

authors： Clancy R,Ren Z,Pang G,Fletcher P,D'Este C

更新日期：2006-11-01 00:00:00

abstract：:Burkholderia pseudomallei is the causative agent of melioidosis. Historically believed to be a relatively rare human disease in tropical countries, a recent study estimated that, worldwide, there are approximately 165 000 human melioidosis cases per year, more than half of whom die. The bacterium is inherently resista...

journal_title：Clinical and experimental immunology

authors： Morici L,Torres AG,Titball RW

更新日期：2019-05-01 00:00:00

abstract：:Tuberculosis (TB) is usually more severe in HIV-infected patients, and the immune derangement found in co-infected patients may differ from that in each isolated disease. Following mitogen stimulation of peripheral blood mononuclear cells (PBMC), interferon (IFN)-gamma and tumour necrosis factor (TNF)-alpha production...

journal_title：Clinical and experimental immunology

authors： de Castro Cunha RM,Kallas EG,Rodrigues DS,Nascimento Burattini M,Salomao R

更新日期：2005-06-01 00:00:00

abstract：:Atopic disorders are caused by disregulated activation of T helper 2 (Th2) cells that produce IL-4 and IL-5. Because the presence of IL-4 potently augments the differentiation of naive T cells into Th2 cells, it is important to seek the cell population which provides IL-4 for naive T cells. Recently, a unique subpopul...

journal_title：Clinical and experimental immunology

authors： Oishi Y,Sakamoto A,Kurasawa K,Nakajima H,Nakao A,Nakagawa N,Tanabe E,Saito Y,Iwamoto I

更新日期：2000-03-01 00:00:00

abstract：:The expression in tissue and serum of a panel of murine and human common DNA antibody idiotypes (Ids) (BEG 2, PR 4, F-423, I-402, II-28, IV-228, V-88) has been investigated. The murine V-88 Id was detected in eight out of 10 and the human BEG 2 Id in five out of 10 labial biopsies from patients with Sjögren's syndrome...

journal_title：Clinical and experimental immunology

authors： Watts RA,Ravirajan CT,Wilkinson LS,Williams W,Griffiths M,Butcher D,Horsfall AT,Staines NA,Isenberg DA

更新日期：1991-02-01 00:00:00

abstract：:We report a case of a combined immunodeficiency (CID) in a child affected by trichothiodystrophy (TTD) characterized by an altered response to ultraviolet (UV) light due to a defect in the XPD gene. The XPD gene encodes a subunit of the transcription factor II H (TFIIH), a complex involved in nucleotide-excision repai...

journal_title：Clinical and experimental immunology

authors： Racioppi L,Cancrini C,Romiti ML,Angelini F,Di Cesare S,Bertini E,Livadiotti S,Gambarara MG,Matarese G,Lago Paz F,Stefanini M,Rossi P

更新日期：2001-12-01 00:00:00

abstract：:A subpopulation of human B lymphocytes forms rosettes with mouse erythrocytes through a glycoprotein-dependent bond. Further studies of this bond show that the lymphocyte receptor is not immunoglobulin, although the binding of antisera or staphylococci to surface immunoglobulin inhibits the formation of mouse rosettes...

journal_title：Clinical and experimental immunology

authors： Zalewski PD,Forbes IJ

更新日期：1979-06-01 00:00:00

abstract：:Porphyromonas gingivalis cysteine proteinases (gingipains) have been associated with virulence in destructive periodontitis, a disease process that has been linked with Th2 pathways. Critical in maintaining Th2 activity is the response of B lymphocytes to environmental interleukin (IL)-4, a cytokine that also countera...

journal_title：Clinical and experimental immunology

authors： Yun LW,Decarlo AA,Collyer C,Hunter N

更新日期：2003-11-01 00:00:00

abstract：:Amino acid residues involved in the peptide binding groove of HLA-DRB1 alleles were examined in three Nigerian ethnic groups with leprosy (n = 287) and 170 controls to determine the role of DRB1 alleles in disease outcome with Mycobacterium leprae. Nine positively charged motifs and two others with neutral charge to t...

journal_title：Clinical and experimental immunology

authors： Uko GP,Lu LY,Asuquo MA,Fici D,Mahan S,Awdeh Z,Udim ER,Ding W,Umana U,Adewole T,Fraser PA

更新日期：1999-10-01 00:00:00

abstract：:Although both envelope glycoproteins of the hepatitis C virus, E1 and E2/NS1, show a high degree of sequence variation, the E1 protein includes a well conserved domain, which may be functionally important. We have analysed the human B cell response to a peptide fragment from amino acid residues 314-330 (EP3) covering ...

journal_title：Clinical and experimental immunology

authors： Siemoneit K,Cardoso Mda S,Koerner K,Wölpl A,Kubanek B

更新日期：1995-08-01 00:00:00

abstract：:We set out to discover whether antibodies to small ribonucleoprotein antigens (RNP) and to 73-kD heat shock protein (hsp 73) which have been proposed as markers of mixed connective tissue disease (MCTD) recognize different epitopes. MCTD serum was immunoadsorbed on hsp 73-coupled Sepharose and the affinity retained, a...

journal_title：Clinical and experimental immunology

authors： Appelboom T,Kahn MF,Mairesse N

更新日期：1995-06-01 00:00:00

abstract：:Perforin, one of the cytotoxic proteins of the immune system, plays a prominent role in protection against viral and bacterial infections. We investigated its expression in PBL and their CD3+, CD4+, CD8+ and CD16+ and/or CD56+ subpopulations in endurance athletes before and after a triathlon. Lymphocyte subpopulations...

journal_title：Clinical and experimental immunology

authors： Staats R,Balkow S,Sorichter S,Northoff H,Matthys H,Luttmann W,Berg A,Virchow JC

更新日期：2000-06-01 00:00:00

abstract：:Antigens present in the products released by the larval stage of schistosome (SRP-A) were shown to induce a strong cytotoxic and protective IgE response both in the rat and the monkey. T cell lines and clones specific for SRP-A or 26 kD antigens which are the main target of the cytotoxic IgE have been derived. The pas...

journal_title：Clinical and experimental immunology

authors： Damonneville M,Velge F,Verwaerde C,Pestel J,Auriault C,Capron A

更新日期：1987-08-01 00:00:00

abstract：:Previous studies of an experimental human immunoglobulin preparation for intravenous use, containing normal pooled IgM (IVIgM), have shown its beneficial therapeutic effect in experimental autoimmune diseases. The mechanisms of its immunomodulatory activity remain however, poorly understood. In the experiments reporte...

journal_title：Clinical and experimental immunology

authors： Vassilev T,Mihaylova N,Voynova E,Nikolova M,Kazatchkine M,Kaveri S

更新日期：2006-07-01 00:00:00

abstract：:Recently we reported the first known incidence of antibodies possessing catalytic sialidase activity (sialidase abzymes) in the serum of patients with multiple myeloma and systemic lupus erythematosus (SLE). These antibodies desialylate biomolecules, such as glycoproteins, gangliosides and red blood cells. Desialylati...

journal_title：Clinical and experimental immunology

authors： Tomin A,Dumych T,Tolstyak Y,Kril I,Mahorivska I,Bila E,Stoika R,Herrmann M,Kit Y,Bilyy R

更新日期：2015-01-01 00:00:00

abstract：:Phytohaemagglutinin-induced lymphocyte transformation of four healthy adults and a child with kwashiorkor was performed in the presence of plasma from nineteen patients with protein energy malnutrition and a nutritionally normal child. Marked inhibition occurred in the presence of plasma from six patients who subseque...

journal_title：Clinical and experimental immunology

authors： Heyworth B,Moore DL,Brown J

更新日期：1975-10-01 00:00:00

abstract：:The expression and up-regulation of cell adhesion molecules on a human colonic epithelial cell line HT-29, and the peripheral blood T lymphocyte proliferation responses to bacterial superantigens presented by this cell line were investigated, compared with peripheral blood monocytes. In HT-29 cells, there was constitu...

journal_title：Clinical and experimental immunology

authors： Liu ZX,Sugawara S,Hiwatashi N,Noguchi M,Rikiishi H,Kumagai K,Toyota T

更新日期：1997-06-01 00:00:00

abstract：:Th1 cell-induced anti-mycobacterial immunity is lost during a progressive Mycobacterium tuberculosis infection in a susceptible host. This study was designed to test the mechanism of the loss of anti-mycobacterial cell-mediated immune response. We demonstrate that M. tuberculosis infection results in increased Fas exp...

journal_title：Clinical and experimental immunology

authors： Das G,Vohra H,Saha B,Agrewala JN,Mishra GC

更新日期：1999-02-01 00:00:00

abstract：:HLA class II-restricted proliferative and cytotoxic T cell (CTL) responses to B cell chronic lymphocytic leukaemia (B-CLL) can be generated using autologous dendritic cells (DCs) pulsed with tumour cell lysate. In this study a number of different approaches were used to optimize further the in vitro system. First, the...

journal_title：Clinical and experimental immunology

authors： Goddard RV,Prentice AG,Copplestone JA,Kaminski ER

更新日期：2003-01-01 00:00:00

abstract：:To elucidate the mechanisms of anti-DNA production, we assessed the binding of sera of normal human subjects (NHS) and patients with SLE to a panel of bacterial and mammalian DNA. Using single-stranded DNA as antigens in an ELISA, NHS showed significant binding to some but not all bacterial DNA, while lacking reactivi...

journal_title：Clinical and experimental immunology

authors： Wu ZQ,Drayton D,Pisetsky DS

更新日期：1997-07-01 00:00:00

abstract：:The carcinoembryonic antigen (CEA) distribution obtained after fractionation of thirty sera of patients with gastrointestinal tumours by gel filtration in Sephadex G200 was compared with that resulting from extraction of the sera with perchloric acid. In all cases gel filtration yielded a fraction of free CEA and in t...

journal_title：Clinical and experimental immunology

authors： Kapsopoulou-Dominos K,Anderer FA

更新日期：1979-07-01 00:00:00

abstract：:Coeliac disease (CD) is described as an autoimmune enteropathy associated with the presence of IgG and IgA antigliadin and antitransglutaminase autoantibodies. While of diagnostic significance, the role of these autoantibodies in the immunopathogenesis of CD is elucidated. An inappropriate T cell immune response to gl...

journal_title：Clinical and experimental immunology

authors： Cremata JA,Sorell L,Montesino R,Garcia R,Mata M,Cabrera G,Galvan JA,Garcia G,Valdes R,Garrote JA

更新日期：2003-09-01 00:00:00

abstract：:Nerve growth factor (NGF) regulates B cell activation and differentiation and is an autocrine survival factor for memory B lymphocytes. We have reported recently that the number of memory B cells is reduced during HIV-1 infection. In this study we evaluated whether alteration in the NGF supply was involved in memory B...

journal_title：Clinical and experimental immunology

authors： Titanji K,Nilsson A,Mörch C,Samuelsson A,Sönnerborg A,Grutzmeier S,Zazzi M,De Milito A

更新日期：2003-05-01 00:00:00

abstract：:An association between mannan-binding lectin (MBL) status and severity of lung function impairment in cystic fibrosis (CF) has been found in several studies, but not in others. To explore the possible basis for discrepancies in the literature, we related both MBL and L-ficolin concentrations to lung function and exami...

journal_title：Clinical and experimental immunology

authors： Muhlebach MS,MacDonald SL,Button B,Hubbard JJ,Turner ML,Boucher RC,Kilpatrick DC

更新日期：2006-08-01 00:00:00

abstract：:Hybridization of peripheral blood lymphocytes from patients with rheumatoid arthritis has yielded 14 monoclonal antibodies which react with cultured human epithelial cells. Immunofluorescence staining identifies at last five different types of antibody. Solid phase immunosorbent assays show a variety of cross-reaction...

journal_title：Clinical and experimental immunology

authors： Haskard DO,Gul V,Morgan A,Kataaha P,Staines NA,Archer JR

更新日期：1985-09-01 00:00:00

abstract：:This longitudinal study investigates the change of erythrocyte complement receptor (E-CR1) expression in patients with severe acute respiratory syndrome (SARS). Circulating E-CR1 expression was semiquantified by flow cytometric analyses in 54 SARS patients and in 212 healthy individuals as a control. Since E-CR1 expre...

journal_title：Clinical and experimental immunology

authors： Wang FS,Chu FL,Jin L,Li YG,Zhang Z,Xu D,Shi M,Wu H,Moulds JM

更新日期：2005-01-01 00:00:00

abstract：:We have developed a panel of MoAbs against four separate but overlapping epitopes on endothelial cell (EC) vascular cell adhesion molecule-1 (VCAM-1). Two of the MoAbs (1G11 and 1E5) inhibited T cell adhesion to tumour necrosis factor (TNF)-activated EC, whilst two MoAbs (1.4C3 and 6D9) did not. Using these MoAbs we h...

journal_title：Clinical and experimental immunology

authors： Wellicome SM,Kapahi P,Mason JC,Lebranchu Y,Yarwood H,Haskard DO

更新日期：1993-06-01 00:00:00

abstract：:Enterotoxin produced by enterotoxigenic Bacteroides fragilis (BFT) has been associated with mucosal inflammation and diarrhoeal diseases. In this study, the anti-inflammatory molecular mechanism of 5,7-dihydroxy-3,4,6-trimethoxyflavone (eupatilin) was characterized in an HT-29 intestinal epithelial cell line stimulate...

journal_title：Clinical and experimental immunology

authors： Kim JM,Lee DH,Kim JS,Lee JY,Park HG,Kim YJ,Oh YK,Jung HC,Kim SI

更新日期：2009-03-01 00:00:00

abstract：:Podocytes, the main target of immune complex, participate actively in the development of glomerular injury as immune cells. Dendritic cell-specific intercellular adhesion molecule-3-grabbing non-integrin (DC-SIGN) is an innate immune molecular that has an immune recognition function, and is involved in mediation of ce...

journal_title：Clinical and experimental immunology

authors： Cai M,Zhou T,Wang X,Shang M,Zhang Y,Luo M,Xu C,Yuan W

更新日期：2016-03-01 00:00:00