Human monoclonal antibodies for the immunological characterization of a highly conserved protein domain of the hepatitis C virus glycoprotein E1.

abstract：:The aim of this study was to evaluate prospectively cytokine levels and disease activity in juvenile idiopathic arthritis (JIA) patients treated with and without tumour necrosis factor (TNF)-α inhibitors. TNF-α inhibitor-naive JIA subjects were followed prospectively for 6 months. Cytokine levels of TNF-α, interleukin...

journal_title：Clinical and experimental immunology

authors： Walters HM,Pan N,Lehman TJ,Adams A,Kalliolias GD,Zhu YS,Santiago F,Nguyen J,Sitaras L,Cunningham-Rundles S,Walsh TJ,Toussi SS

更新日期：2016-06-01 00:00:00

abstract：:Human IgD myeloma proteins are shown to have a high carbohydrate content (9-18%) and to exhibit the same heterogeneity in carbohydrate content and composition as myeloma protein of the other immunoglobulin classes. All IgD proteins studied contain N-acetylgalactosamine which is contained in a carbohydrate moiety attac...

journal_title：Clinical and experimental immunology

authors： Jefferis R,Butwell AJ,Clamp JR

更新日期：1975-11-01 00:00:00

abstract：:CBA/KlJms-lprcg/lprcg mice with a novel mutation producing systemic lymphoproliferation were investigated for their serological and histological characteristics. The mutant mice showed elevated levels of serum immunoglobulin, C1q-binding immune complexes and antibodies to nuclear antigens such as dsDNA and ssDNA and p...

journal_title：Clinical and experimental immunology

authors： Kimura M,Mohri H,Shimada K,Wakabayashi T,Kanai Y,Matsuzawa A

更新日期：1990-01-01 00:00:00

abstract：:The aim of this study was to provide proof-of-concept for quantitative and qualitative label-free detection of immune complexes through myeloid cells with imaging surface plasmon resonance. Surface plasmon resonance imaging was first applied to monitor the binding of human sera from healthy and rheumatoid arthritis (R...

journal_title：Clinical and experimental immunology

authors： Szittner Z,Bentlage AE,Rovero P,Migliorini P,Lóránd V,Prechl J,Vidarsson G

更新日期：2016-07-01 00:00:00

abstract：:Recognition of the protein A-like activity of some strains of group A streptococci has thrown doubt on much previous work suggesting antigenic cross-reactions between these streptococci and mammalian tissues. The strains used in our previous studies have now been examined by the mixed reverse passive antiglobulin reac...

journal_title：Clinical and experimental immunology

authors： Kingston D

更新日期：1981-10-01 00:00:00

abstract：:Monocytes and endothelial cells were stimulated in co-culture with allogeneic lymphocytes to produce thromboplastin (TPL). The induction was biphasic, an early response (8-24 h) was greatly augmented by cyclosporin A (CS) (0.5-5 micrograms/ml) whereas the late response (day 3-4) was inhibited. Prednisolone inhibited b...

journal_title：Clinical and experimental immunology

authors： Carlsen E,Gaudernack G,Filion-Myklebust C,Pettersen KS,Prydz H

更新日期：1989-06-01 00:00:00

abstract：:We have studied both the humoral and cell mediated immune systems of 23 children with beta-thalassaemia major. In children who had not been splenectomized, a 3-fold expansion in the number of circulating B cells and a modest polyclonal gammopathy was present. Of these patients 70% had decreased numbers of circulating ...

journal_title：Clinical and experimental immunology

authors： Dwyer J,Wood C,McNamara J,Williams A,Andiman W,Rink L,O'Connor T,Pearson H

更新日期：1987-06-01 00:00:00

abstract：:Peripheral blood natural killer (NK) activity was analysed from 32 asthma patients and 13 control donors. Male patients and female patients with atopic asthma had significantly stronger NK activity against the leukaemic cell line K-562. Fractionation of patient mononuclear cells by discontinuous density gradient centr...

journal_title：Clinical and experimental immunology

authors： Timonen T,Stenius-Aarniala B

更新日期：1985-01-01 00:00:00

abstract：:Cardiomyopathy is the most severe outcome of Chagas disease, causing more than 12 000 deaths/year. Immune cells participate in cardiomyopathy development either by direct tissue destruction, or by driving inflammation. We have shown that CD4- CD8- [double-negative (DN)] T cells are major sources of inflammatory and an...

journal_title：Clinical and experimental immunology

authors： Passos LSA,Magalhães LMD,Soares RP,Marques AF,Nunes MDCP,Gollob KJ,Dutra WO

更新日期：2017-10-01 00:00:00

abstract：:Systemic lupus erythematosus (SLE) is a systemic autoimmune disease associated with aberrant activation of T and B lymphocytes for the production of inflammatory cytokines and autoreactive antibodies. Animal studies of SLE have indicated that Toll-like receptors (TLR) are important in the pathogenesis of murine lupus....

journal_title：Clinical and experimental immunology

authors： Wong CK,Wong PT,Tam LS,Li EK,Chen DP,Lam CW

更新日期：2010-01-01 00:00:00

abstract：:Transmembrane activator and calcium modulator and cyclophilin ligand interactor-immunoglobulin (TACI-Ig) is a human fusion protein that binds and neutralizes both B lymphocyte stimulator (BLyS), a cytokine shown to be a key regulator of B cell maturation, proliferation and survival, and a proliferation-inducing ligand...

journal_title：Clinical and experimental immunology

authors： Wang D,Chang Y,Wu Y,Zhang L,Yan S,Xie G,Qin Q,Jin J,Wang W,Fang J,Wei W

更新日期：2011-02-01 00:00:00

abstract：:Breakpoint cluster region-Abelson murine leukaemia viral oncogene homologue 1 (BCR-ABL1), encoded by the Philadelphia (Ph) chromosome, is the characteristic of chronic myeloid leukaemia (CML) and a subset of acute lymphoblastic leukaemia (ALL). We demonstrated that expression of the Ik6 transcript, which lacked exons ...

journal_title：Clinical and experimental immunology

authors： Dong Y,Liu F,Wu C,Li S,Zhao X,Zhang P,Jiao J,Yu X,Ji Y,Zhang M

更新日期：2016-09-01 00:00:00

abstract：:Mixed cryoglobulinaemia (MC) is a disorder characterized by the presence of large amounts of cryoprecipitating IgM-IgG complexes. An immune complex glomerulonephritis develops in one third of all patients, but its occurrence does not seem related to the amount of cryoglobulins in the sera, nor to their complement-fixi...

journal_title：Clinical and experimental immunology

authors： Dolcher MP,Marchini B,Sabbatini A,Longombardo G,Ferri C,Riente L,Bombardieri S,Migliorini P

更新日期：1994-05-01 00:00:00

abstract：:Our aims were to identify the differential expression of microRNA (miR)-155, as well as to explore the possible regulatory effects of miR-155 on the differentiation and function of T helper type 17 (Th17) cells in atopic dermatitis (AD). The Th17 cell percentage and expression levels of miR-155, retinoic acid-related ...

journal_title：Clinical and experimental immunology

authors： Ma L,Xue HB,Wang F,Shu CM,Zhang JH

更新日期：2015-07-01 00:00:00

abstract：:Supernatants of concanavalin A (Con A)-activated human spleen cells have been previously shown to inhibit polyclonal immunoglobulin (Ig) biosynthesis by pokeweed mitogen (PWM)-stimulated human spleen and peripheral blood mononuclear cells. In the present study, hydrocortisone was added at the beginning of in vitro cul...

journal_title：Clinical and experimental immunology

authors： Ilfeld D,Krakauer RS

更新日期：1982-04-01 00:00:00

abstract：:Tumour necrosis factor (TNF)-alpha and interferon (IFN)-gamma exert detrimental effects in organ-specific autoimmune disease, while both destructive and protective roles have been demonstrated for interleukin (IL)-10, IL-4 and IL-5. We examined the production of these cytokines by peripheral blood mononuclear cells (P...

journal_title：Clinical and experimental immunology

authors： Nielsen CH,Hegedüs L,Rieneck K,Moeller AC,Leslie RG,Bendtzen K

更新日期：2007-02-01 00:00:00

abstract：:Antigens present in the products released by the larval stage of schistosome (SRP-A) were shown to induce a strong cytotoxic and protective IgE response both in the rat and the monkey. T cell lines and clones specific for SRP-A or 26 kD antigens which are the main target of the cytotoxic IgE have been derived. The pas...

journal_title：Clinical and experimental immunology

authors： Damonneville M,Velge F,Verwaerde C,Pestel J,Auriault C,Capron A

更新日期：1987-08-01 00:00:00

abstract：:Intravenous injection of t-butyl hydroperoxide rapidly killed Plasmodium vinckei in mice, and caused haemolysis. The same dose seemed harmless to unparasitized mice. Many parasites disintegrated inside circulating erythrocytes, so parasite death was not simply a passive consequence of haemolysis. Injection of desferri...

journal_title：Clinical and experimental immunology

authors： Clark IA,Hunt NH,Cowden WB,Maxwell LE,Mackie EJ

更新日期：1984-06-01 00:00:00

abstract：:Anaphylaxis denotes an immediate hypersensitivity reaction to allergen, exclusively mediated by IgE antibodies. However, IgE antibodies do not explain all the syndromes that are encountered. We investigated potent IgG-mediated anaphylaxis in CD40-deficient mice that lack the immunoglobulin class switching for T cell-d...

journal_title：Clinical and experimental immunology

authors： Wakayama H,Hasegawa Y,Kawabe T,Saito H,Kikutani H,Shimokata K

更新日期：1998-11-01 00:00:00

abstract：:There is growing speculation about the meaning of reported imbalances in subpopulations of T lymphocytes in patients with chronic lymphocytic leukaemia (CLL). This study compared two techniques for producing T cell enriched subpopulations from both patients with CLL and normal individuals and the effects of these tech...

journal_title：Clinical and experimental immunology

authors： Dickinson AM,George S,Proctor SJ

更新日期：1983-11-01 00:00:00

abstract：:Citrobacter rodentium is a murine pathogen that transiently colonizes the lumen of the large intestine. C. rodentium induces colitis, but the relative importance and temporal induction of the T helper type 17 (Th17) and regulatory T cell (T(reg)) pathways in protection from the infection and inflammation have not been...

journal_title：Clinical and experimental immunology

authors： Symonds EL,Riedel CU,O'Mahony D,Lapthorne S,O'Mahony L,Shanahan F

更新日期：2009-07-01 00:00:00

abstract：:It is suggested that CD30 and CD26 are surface molecules expressed on activated Th2 and Th1 cells, respectively. We examined plasma levels of soluble CD26 (sCD26) and sCD30 in patients with atopic dermatitis (AD) when their eruptions were aggravated and in non-atopic healthy controls, and then analysed the possible co...

journal_title：Clinical and experimental immunology

authors： Katoh N,Hirano S,Suehiro M,Ikenaga K,Yamashita T,Sugawara N,Yasuno H

更新日期：2000-08-01 00:00:00

abstract：:Skin nuclear speckled IgG deposition was noted in seven patients. The patients' clinical courses satisfied at least four of the preliminary criteria of the American Rheumatism Association for the diagnosis of systemic lupus erthematosus (SLE). Examination of approximately 700 additional biopsies from patiets with SLE,...

journal_title：Clinical and experimental immunology

authors： Shu S,Provost T,Croxdale MB,Reichlin M,Beutner EH

更新日期：1977-02-01 00:00:00

abstract：:In this study, we aimed to explore the effects of imatinib on the proliferation of rheumatoid arthritis synovial cell (RA-FLS) and inflammatory responses by regulating CSF1R. Differential genes were screened via microarray analysis, followed by being analysed through the weighted co-expression network (WGCNA) network,...

journal_title：Clinical and experimental immunology

authors： Hu X,Tang J,Hu X,Bao P,Pan J,Ou Y,Deng W,Liang Y

更新日期：2019-02-01 00:00:00

abstract：:The cytotoxic functions of highly purified blood lymphocytes from patients with breast cancer were studied before and after radiotherapy. Addition of PHA or of rabbit antibodies to target cells (chicken erythrocytes) were chosen as two means of inducing lymphocyte cytotoxicity in vitro. The proportion of T and non-T-l...

journal_title：Clinical and experimental immunology

authors： Wasserman J,Melén B,Blomgren H,Glas U,Perlmann P

更新日期：1975-11-01 00:00:00

abstract：:Inflammation is an unstable state; it either resolves or persists. Inflammatory reactions often have a propensity for specific anatomical sites. Why inflammation persists with specific tissue tropism remains obscure. Increasing evidence suggests that stromal cells which define tissue architecture are the key cells inv...

journal_title：Clinical and experimental immunology

authors： Naylor AJ,Filer A,Buckley CD

更新日期：2013-01-01 00:00:00

abstract：:Proliferation of mesangial cells is a hallmark of glomerular disease, and understanding the regulatory mechanisms is critically important. The purpose of this study was to examine the relationship between mesangial cell proliferation and phosphorylated signal transducer and activator of transcription (STAT) 3 and to d...

journal_title：Clinical and experimental immunology

authors： Hirai T,Masaki T,Kuratsune M,Yorioka N,Kohno N

更新日期：2006-05-01 00:00:00

abstract：:C3b-coated immune complexes adhere to the complement receptor 1 (CR1, CD35) on human erythrocytes. This multi-valent binding might be favoured by the known clustering of CR1 and by the multiple C3b-binding sites on each CR1. The size of the CR1 clusters correlates directly with the number of CR1/erythrocytes, and the ...

journal_title：Clinical and experimental immunology

authors： Madi N,Paccaud JP,Steiger G,Schifferli JA

更新日期：1991-04-01 00:00:00

abstract：:Recombinant human deoxyribonuclease I (rhDNase) may be an effective therapeutic for the treatment of systemic lupus erythematosus (SLE). The pharmacodynamics of rhDNase in serum was investigated using two activity assays: one based on hydrolysis of a radiolabelled phage DNA and the other based on hydrolysis of human c...

journal_title：Clinical and experimental immunology

authors： Prince WS,Baker DL,Dodge AH,Ahmed AE,Chestnut RW,Sinicropi DV

更新日期：1998-08-01 00:00:00

abstract：:Using an autoimmune hepatitis model of A/J mice which was prepared with immunization by syngeneic crude liver proteins, various influences of neonatal thymectomy were studied by observations of histological liver changes, autoantibody to liver-specific membrane lipoprotein (LSP), delayed-type hypersensitivity (DTH) to...

journal_title：Clinical and experimental immunology

authors： Watanabe Y,Kawakami H,Kawamoto H,Ikemoto Y,Masuda K,Takezaki E,Nakanishi T,Kajiyama G,Takeno H

更新日期：1987-01-01 00:00:00