T cell subpopulations in CLL: methods of T cell enrichment artificially alter proportions of OKT4 and OKT8 positive cells.

abstract：:Antigens present in the products released by the larval stage of schistosome (SRP-A) were shown to induce a strong cytotoxic and protective IgE response both in the rat and the monkey. T cell lines and clones specific for SRP-A or 26 kD antigens which are the main target of the cytotoxic IgE have been derived. The pas...

journal_title：Clinical and experimental immunology

authors： Damonneville M,Velge F,Verwaerde C,Pestel J,Auriault C,Capron A

更新日期：1987-08-01 00:00:00

abstract：:Psoriasis is a chronic, inflammatory, hyperproliferative skin disease, in which autoimmunity plays a great role. Natural killer T cells (NK T cells), are suggested to be involved in the pathogenesis of different autoimmune diseases. To examine the involvement of CD3+CD56+ NK T cells in the pathogenesis of psoriasis, w...

journal_title：Clinical and experimental immunology

authors： Koreck A,Surányi A,Szöny BJ,Farkas A,Bata-Csörgö Z,Kemény L,Dobozy A

更新日期：2002-01-01 00:00:00

abstract：:The possibility that the peanut agglutinin (PNA) receptor and/or its co-ordinate structures on the surface of leukaemia cells might be recognized by lectin free crude interleukin-2 (IL-2) activated human peripheral blood lymphocytes (LAK) was investigated. Analysis was undertaken of the correlation between the sensiti...

journal_title：Clinical and experimental immunology

authors： Gotoh YI,Minegishi M,Yamaguchi Y,Konno T,Tada K

更新日期：1984-09-01 00:00:00

abstract：:Schizophrenic patients are reported to have immunological dysfunction, however, the immune response to surgery in schizophrenic patients remains unclear. We measured plasma interleukin-6 (IL-6), interleukin-8 (IL-8) and tumour necrosis factor-alpha (TNF-alpha) before, during and after colectomy, hemicolectomy and sigm...

journal_title：Clinical and experimental immunology

authors： Kudoh A,Sakai T,Ishihara H,Matsuki A

更新日期：2001-07-01 00:00:00

abstract：:Recently, naturally occurring antibodies to IFN-alpha were discovered in a few systemic lupus erythematosus (SLE) and cancer patients; however, in most patients monitored for anti-IFN antibodies before treatment, no antibodies were found. In an attempt to explain the 'IFN-blocking effect' that we observed in all serum...

journal_title：Clinical and experimental immunology

authors： Ross C,Hansen MB,Schyberg T,Berg K

更新日期：1990-10-01 00:00:00

abstract：:CD4+CD25+ T regulatory cells may play a role in the different clinical presentations of chronic hepatitis C virus (HCV) infection by suppressing CD4+ T cell responses. Peripheral CD4+CD25+ T cells from chronic HCV carriers with normal and abnormal alanine aminotransferase (ALT) were analysed for specificity and effect...

journal_title：Clinical and experimental immunology

authors： Bolacchi F,Sinistro A,Ciaprini C,Demin F,Capozzi M,Carducci FC,Drapeau CM,Rocchi G,Bergamini A

更新日期：2006-05-01 00:00:00

abstract：:The possible role of cytokines in leprosy reactions was investigated by analysing the levels of tumour necrosis factor (TNF) and interleukin-1 (IL-1) in serum samples from 39 leprosy patients, 22 of them presenting either type I (upgrading) or type II (ENL) reactions. Fifty per cent of the patients showed elevated con...

journal_title：Clinical and experimental immunology

authors： Sarno EN,Grau GE,Vieira LM,Nery JA

更新日期：1991-04-01 00:00:00

abstract：:Reduced microbial exposure in early life may contribute to the increase of atopic diseases in 'westernized' societies but the underlying mechanisms remain elusive. The objective of this study was to examine how exposure to bacterial lipopolysaccharide (LPS) during early antigen encounter might influence the maturation...

journal_title：Clinical and experimental immunology

authors： Haddeland U,Sletten GB,Brandtzaeg P,Nakstad B

更新日期：2005-02-01 00:00:00

abstract：:Epstein-Barr (EB) virus serology was correlated with the results of immunological investigations of three inherited immunodeficiency diseases, in an attempt to understand the immune mechanisms controlling EB virus infection. In nine patients with Wiskott-Aldrich syndrome (WAS), the constant lack of anti-EB virus assoc...

journal_title：Clinical and experimental immunology

authors： Vilmer E,Lenoir GM,Virelizier JL,Griscelli C

更新日期：1984-02-01 00:00:00

abstract：:2-Chlorodeoxyadenosine (cladribine, CdA) is an immunosuppressive drug that is licensed to treat hairy cell leukaemia, and has been shown recently to have beneficial effects in patients with multiple sclerosis (MS). The therapeutic effects of CdA have been suggested to be mediated partly through its potent toxicity tow...

journal_title：Clinical and experimental immunology

authors： Singh V,Prajeeth CK,Gudi V,Bénardais K,Voss EV,Stangel M

更新日期：2013-08-01 00:00:00

abstract：:Human thymoma is a thymic epithelial cell tumour which often contains a large number of immature T cells and is frequently associated with autoimmune diseases. Since thymic epithelial cells play key roles in the development and selection of T cells in the normal thymus, we hypothesized that the neoplastic thymic epith...

journal_title：Clinical and experimental immunology

authors： Inoue M,Fujii Y,Okumura M,Takeuchi Y,Shiono H,Miyoshi S,Matsuda H,Shirakura R

更新日期：1998-06-01 00:00:00

abstract：:The aim of this study was to identify the epitopes recognized by antibodies to the asialoglycoprotein receptor, a specific hepatocyte protein, from sera of patients with autoimmune hepatitis. An ELISA test was used to detect anti-asialoglycoprotein receptor antibodies in the sera of patients with autoimmune hepatitis....

journal_title：Clinical and experimental immunology

authors： Hajoui O,Martin S,Alvarez F

更新日期：1998-09-01 00:00:00

abstract：:Although Mycobacterium leprae shares many protein antigens with other mycobacterial species, there is a degree of specificity in the T cell response to the organism. This is evident in the failure of cross-protection between mycobacterial species and the specific unresponsiveness to M. leprae in lepromatous leprosy pa...

journal_title：Clinical and experimental immunology

authors： Adams E,Basten A,Prestidge R,Britton WJ

更新日期：1995-10-01 00:00:00

abstract：:Nasal administration of microg doses of acetylcholine receptor (AChR) is effective in preventing the development of B cell-mediated EAMG in the Lewis rat, a model for human MG. In order to investigate whether nasal administration of AChR modulates ongoing EAMG, Lewis rats were treated nasally with AChR 2 weeks after i...

journal_title：Clinical and experimental immunology

authors： Shi FD,Bai XF,Li HL,Huang YM,Van der Meide PH,Link H

更新日期：1998-03-01 00:00:00

abstract：:The balance between Type 1 and Type 2 cytokines is important for the outcome of several infectious diseases. As elderly humans show increased morbidity and mortality from infectious diseases, this study tests if ageing is associated with a change towards Type 2 dominance in T cells. Expression of IFN-gamma, and IL-4 w...

journal_title：Clinical and experimental immunology

authors： Sandmand M,Bruunsgaard H,Kemp K,Andersen-Ranberg K,Pedersen AN,Skinhøj P,Pedersen BK

更新日期：2002-01-01 00:00:00

abstract：:Merozoite surface protein 2 (MSP2) expressed by Plasmodium falciparum asexual blood stages has been identified as a promising vaccine candidate. In order to explore allelic family-specific humoral responses which may be responsible for parasite neutralization during natural infections, isolates from individuals with e...

journal_title：Clinical and experimental immunology

authors： Ekala MT,Jouin H,Lekoulou F,Mercereau-Puijalon O,Ntoumi F

更新日期：2002-08-01 00:00:00

abstract：:T cells are thought to play an important regulatory role in atopic asthma. We hypothesized that human blood and BAL T cell subsets bearing various TCR-Vbeta genes might show selective differences in their cytokine profile. Peripheral blood (PB) and bronchoalveolar lavage (BAL) T cells from seven atopic asthmatic and s...

journal_title：Clinical and experimental immunology

authors： Bakakos P,Pickard C,Smith JL,Frew AJ

更新日期：2002-05-01 00:00:00

abstract：:Positive skin reactions to PPD in guinea-pigs immunized with Freund's complete adjuvant (FCA) were reversed after treatment with 10 mg/kg/day nifurtimox for 12 days. The in vitro migration of peripheral blood leucocytes from FCA-immunized guinea-pigs was inhibited with PPD, but it returned to normal values after nifur...

journal_title：Clinical and experimental immunology

authors： Lelchuk R,Cardoni RL,Levis S

更新日期：1977-12-01 00:00:00

abstract：:Studies in humans and murine disease models have clearly shown dietary fish oil to possess anti-inflammatory properties, apparently mediated by the n-3 polyunsaturated fatty acids, eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA). To determine the mechanisms by which dietary EPA and DHA modulate mouse T-cell...

journal_title：Clinical and experimental immunology

authors： Arrington JL,Chapkin RS,Switzer KC,Morris JS,McMurray DN

更新日期：2001-09-01 00:00:00

abstract：:T cells of C57BL/6J (B6) mice activated in vitro against the K and D determinants of the H-2d haplotype, and expanded in tissue culture in the presence of interleukin 2, were capable of rapidly killing lethally irradiated BALB/c recipients when injected intravenously. Mice given 10(6), 10(7) and 10(8) such T cells sur...

journal_title：Clinical and experimental immunology

authors： Andrus L,Atkinson K,Lafferty KJ

更新日期：1982-12-01 00:00:00

abstract：:Antibody-dependent cellular cytotoxicity (ADCC) of peripheral blood lymphocytes against chicken red blood cells (ChRBC) in the presence of specific antiserum has been studied in normal subjects and in patients with acute hepatitis B and with chronic active hepatitis (CAH). ADCC was significantly reduced in patients wi...

journal_title：Clinical and experimental immunology

authors： Bortolotti F,Realdi G,Diodati G,Fattovich G

更新日期：1978-08-01 00:00:00

abstract：:We found that IgA is predominant among the immune deposits in the renal glomeruli of mice infected with Schistosoma mansoni, and thus conducted an analysis of the deposition of different immunoglobulin isotypes in the glomeruli throughout the course of infection in mice. Both immunofluorescent and immunoperoxidase met...

journal_title：Clinical and experimental immunology

authors： el-Sherif AK,Befus D

更新日期：1988-01-01 00:00:00

abstract：:Tumour necrosis factor (TNF)-alpha and interferon (IFN)-gamma exert detrimental effects in organ-specific autoimmune disease, while both destructive and protective roles have been demonstrated for interleukin (IL)-10, IL-4 and IL-5. We examined the production of these cytokines by peripheral blood mononuclear cells (P...

journal_title：Clinical and experimental immunology

authors： Nielsen CH,Hegedüs L,Rieneck K,Moeller AC,Leslie RG,Bendtzen K

更新日期：2007-02-01 00:00:00

abstract：:A subpopulation of human B lymphocytes forms rosettes with mouse erythrocytes through a glycoprotein-dependent bond. Further studies of this bond show that the lymphocyte receptor is not immunoglobulin, although the binding of antisera or staphylococci to surface immunoglobulin inhibits the formation of mouse rosettes...

journal_title：Clinical and experimental immunology

authors： Zalewski PD,Forbes IJ

更新日期：1979-06-01 00:00:00

abstract：:For 'the total population of patients with sepsis, sepsis syndrome or SIRS', the question of whether intravenous immune globulin (IVIG) reduces mortality is neither proved nor disproved. For the sepsis subgroups 'postoperative sepsis with a sepsis score more than 19' and 'endotoxaemic, early septic shock', a significa...

journal_title：Clinical and experimental immunology

authors： Werdan K,Pilz G

更新日期：1996-05-01 00:00:00

abstract：:The sera of patients with histologically proven carcinomata of the gastrointestinal tract were fractionated by gel filtration and the fractions assayed for the presence of free carcinoembryonic antigen (CEA) binding immunoglobulins and CEA immune complexes by radioimmuno-double-diffusion, using 125I-CEA as a marker. I...

journal_title：Clinical and experimental immunology

authors： Kapsopoulou-Dominos K,Anderer FA

更新日期：1979-02-01 00:00:00

abstract：:Vaccination against meningococcal serogroup B is recommended for patients with a complement deficiency; however, although immunogenicity in this patient group has been shown, efficacy has not yet been established. In this study, we collected serum from children with a complement deficiency in the alternative pathway o...

journal_title：Clinical and experimental immunology

authors： van den Broek B,van Els CACM,Kuipers B,van Aerde K,Henriet SS,de Groot R,de Jonge MI,Langereis JD,van der Flier M

更新日期：2019-12-01 00:00:00

abstract：:Autoantibodies directed against the Sm proteins of the spliceosome complex are found in approximately 25% of systemic lupus erythematosus (SLE) patients sera. To determine which regions of the Sm D polypeptide are involved in the lupus autoimmune response, binding to overlapping octapeptides of Sm D has been evaluated...

journal_title：Clinical and experimental immunology

authors： James JA,Mamula MJ,Harley JB

更新日期：1994-12-01 00:00:00

abstract：:Pre-eclampsia is an endothelial disorder and TNF-alpha has fundamental effects on endothelial cells by several means, including altering the balance between oxidant and anti-oxidant, changing the pattern of prostaglandin production and affecting expression of several cell surface components. To determine whether TNF-a...

journal_title：Clinical and experimental immunology

authors： Chen G,R Wilson,Wang SH,Zheng HZ,Walker JJ,McKillop JH

更新日期：1996-04-01 00:00:00

abstract：:Amino acid residues involved in the peptide binding groove of HLA-DRB1 alleles were examined in three Nigerian ethnic groups with leprosy (n = 287) and 170 controls to determine the role of DRB1 alleles in disease outcome with Mycobacterium leprae. Nine positively charged motifs and two others with neutral charge to t...

journal_title：Clinical and experimental immunology

authors： Uko GP,Lu LY,Asuquo MA,Fici D,Mahan S,Awdeh Z,Udim ER,Ding W,Umana U,Adewole T,Fraser PA

更新日期：1999-10-01 00:00:00