当前位置： SCI文献检索 > CLINICAL AND EXPERIMENTAL IMMUNOLOGY期刊下所有文献 > A restricted T cell response to myelin basic protein (MBP) is stable in multiple sclerosis (MS) patients.

A restricted T cell response to myelin basic protein (MBP) is stable in multiple sclerosis (MS) patients.

Abstract：

:The close resemblance of MS to the animal model experimental autoimmune encephalomyelitis (EAE) has provided compelling data sustaining a pathogenic role of circulating T cells reactive against MBP. T cell antigen receptor (TCR) usage in EAE is commonly considered restricted; nevertheless, dynamic changes of TCR usage correlate with the course of EAE, resulting in a limited repertoire during early stages of disease activity followed by the recruitment of other T cells reactive against new determinants. Although a broader TCR repertoire mediates the response to MBP in humans, a restricted intraindividual heterogeneity may occur in some MS patients. In the present study we characterize the response to MBP in MS subjects with relapsing remitting disease from two sampling time points 12 months apart. MBP-specific T cell lines (TCL) were first generated from eight MS individuals and two healthy subjects. New TCL were obtained after 12 months from one control and three MS patients whose response, at the first time point, was directed against a single epitope. Interestingly, these three subjects had a stable and mild disease. Few TCL obtained at two time points from the MS individuals recognized the same immunodominant epitope and shared identical TCR Vbeta sequences. In the control we could not detect a restriction of the repertoire. These findings suggest that in some MS patients with benign disease a predominant T cell response to a single determinant may be detectable at different moments and is mediated by clonally expanded populations.

journal_name

Clin Exp Immunol

journal_title

Clinical and experimental immunology

authors

Uccelli A,Giunti D,Salvetti M,Ristori G,Fenoglio D,Abbruzzese,Mancardi G

doi

10.1046/j.1365-2249.1998.00457.x

subject

Has Abstract

pub_date

1998-01-01 00:00:00

pages

186-92

issue

1

eissn

0009-9104

issn

1365-2249

journal_volume

111

pub_type

杂志文章

相关文献

CLINICAL AND EXPERIMENTAL IMMUNOLOGY文献大全
  • Tissue factor over-expression in platelets of patients with anti-phospholipid syndrome: induction role of anti-β2-GPI antibodies.

    abstract：:Anti-phospholipid syndrome (APS) is characterized by arterial and/or venous thrombosis and pregnancy morbidity. It is well known that in these patients thrombosis may be the result of a hypercoagulable state related to anti-β2-glycoprotein I (β2-GPI) antibodies. Moreover, platelets may play a role in thrombotic manife...

    journal_title：Clinical and experimental immunology

    pub_type： 杂志文章

    doi：10.1111/cei.13248

    authors： Capozzi A,Manganelli V,Riitano G,Recalchi S,Truglia S,Alessandri C,Longo A,Garofalo T,Misasi R,Valesini G,Conti F,Sorice M

    更新日期：2019-04-01 00:00:00

  • Serum cytokines elevated during gluten-mediated cytokine release in coeliac disease.

    abstract：:Cytokines have been extensively studied in coeliac disease, but cytokine release related to exposure to gluten and associated symptoms has only recently been described. Prominent, early elevations in serum interleukin (IL)-2 after gluten support a central role for T cell activation in the clinical reactions to gluten ...

    journal_title：Clinical and experimental immunology

    pub_type： 临床试验,杂志文章,多中心研究

    doi：10.1111/cei.13369

    authors： Goel G,Daveson AJM,Hooi CE,Tye-Din JA,Wang S,Szymczak E,Williams LJ,Dzuris JL,Neff KM,Truitt KE,Anderson RP

    更新日期：2020-01-01 00:00:00

  • CARD11 blockade suppresses murine collagen-induced arthritis via inhibiting CARD11/Bcl10 assembly and T helper type 17 response.

    abstract：:The scaffold protein caspase recruitment domain-containing protein 11 (CARD11) is implicated in the regulation of inflammation and autoimmunity. The present study aimed to explore the role of CARD11 in the pathogenesis of rheumatoid arthritis (RA). Mice with collagen-induced arthritis (CIA) were treated with either CA...

    journal_title：Clinical and experimental immunology

    pub_type： 杂志文章

    doi：10.1111/cei.12275

    authors： Wang H,Zhao J,Zhang H,Huang Y,Wang S,Tu Q,Yang N

    更新日期：2014-05-01 00:00:00

  • A single administration of human adipose tissue-derived mesenchymal stromal cells (MSC) induces durable and sustained long-term regulation of inflammatory response in experimental colitis.

    abstract：:Current therapies for inflammatory bowel diseases (IBD) are aimed at controlling the exacerbated response in the gut, but no treatment is fully effective for many refractory patients. Mesenchymal stromal cells (MSC) are multi-potent cells with regulatory immunosuppressive activity that may control inflammatory disease...

    journal_title：Clinical and experimental immunology

    pub_type： 杂志文章

    doi：10.1111/cei.13262

    authors： Alves VBF,de Sousa BC,Fonseca MTC,Ogata H,Caliári-Oliveira C,Yaochite JNU,Rodrigues Júnior V,Chica JEL,da Silva JS,Malmegrim KCR,Pernomian L,Cardoso CR

    更新日期：2019-05-01 00:00:00

  • IgD production and other lymphocyte functions in HIV infection: immaturity and activation of B cells at different clinical stages.

    abstract：:T and B cell function, in particular IgD production in vitro, were studied across the spectrum of HIV infection in homosexual men and compared with seronegative homosexual and heterosexual male controls. Proliferation to phytohaemagglutinin (PHA) was reduced most strikingly in symptomatic HIV infection; it was also im...

    journal_title：Clinical and experimental immunology

    pub_type： 杂志文章

    doi：

    authors： Rogers LA,Forster SM,Pinching AJ

    更新日期：1989-01-01 00:00:00

  • Idiopathic histaminergic angioedema without wheals: a case series of 31 patients.

    abstract：:Idiopathic histaminergic acquired angioedema (IH-AAE) is a common cause of recurrent angioedema without wheals. It is a mast cell-mediated disease thought to belong to the same clinical entity as chronic urticaria (CU). The objective of this study was to describe the clinical and epidemiological characteristics of IH-...

    journal_title：Clinical and experimental immunology

    pub_type： 杂志文章

    doi：10.1111/cei.12789

    authors： Faisant C,Boccon-Gibod I,Mansard C,Dumestre Perard C,Pralong P,Chatain C,Deroux A,Bouillet L

    更新日期：2016-07-01 00:00:00

  • Anti-proteinase 3 antibodies, their characterization and disease associations.

    abstract：:Anti-proteinase 3 antibodies are a subgroup of anti-neutrophil cytoplasmic antibodies (ANCA), and we have established an ELISA for their detection using high performance liquid chromatography (HPLC)-purified protein. This assay is sensitive and specific: inhibition studies have shown that despite the homology between ...

    journal_title：Clinical and experimental immunology

    pub_type： 杂志文章

    doi：10.1111/j.1365-2249.1994.tb06519.x

    authors： Jennings JG,Chang L,Savige JA

    更新日期：1994-02-01 00:00:00

  • The influence of DNA size on the binding of antibodies to DNA in the sera of normal human subjects and patients with systemic lupus erythematosus (SLE).

    abstract：:To elucidate antibody recognition of DNA in normal and aberrant immunity, the binding of sera of normal human subjects (NHS) and patients with SLE was tested with mammalian and bacterial DNA varying in size. Klebsiella pneumoniae (KP) and calf thymus (CT) single-stranded DNA (ssDNA) were investigated as model antigens...

    journal_title：Clinical and experimental immunology

    pub_type： 杂志文章

    doi：10.1046/j.1365-2249.1999.00875.x

    authors： Pisetsky DS,Gonzalez TC

    更新日期：1999-05-01 00:00:00

  • Interleukin-1 beta enhances and interferon-gamma suppresses activin A actions by reciprocally regulating activin A and follistatin secretion from bone marrow stromal fibroblasts.

    abstract：:Activin A is a multi-functional cytokine with a potent stimulation on erythroid cell differentiation in the bone marrow. The actions of activin A are determined by a balance of the levels of activin A and its inhibitor, follistatin (FS). However, the regulation of its actions in the bone marrow has been unclear. Here ...

    journal_title：Clinical and experimental immunology

    pub_type： 杂志文章

    doi：10.1046/j.1365-2249.2001.01644.x

    authors： Abe M,Shintani Y,Eto Y,Harada K,Fujinaka Y,Kosaka M,Matsumoto T

    更新日期：2001-10-01 00:00:00

  • Progressive cellular immune impairment leading to development of AIDS: two-year prospective study of HIV infection in drug addicts.

    abstract：:We have studied immunological, serological and clinical abnormalities in 264 HIV-positive and HIV-negative drug abusers. Ninety percent of the 264 drug addicts (mean age 26 +/- 0.8 years) were found to have HIV antibodies and there was a significant increase (P less than 0.01) in the frequency of HIV antibody positivi...

    journal_title：Clinical and experimental immunology

    pub_type： 杂志文章

    doi：

    authors： Fernandez-Cruz E,Fernandez AM,Gutierrez C,Garcia-Montes M,de la Morena MT,Rodriguez-Villanueva J,Longo N,Zabay JM

    更新日期：1988-05-01 00:00:00

  • Immune complexes and antibodies to BCG in sera from patients with mycobacterial infections.

    abstract：:We have examined the prevalence of circulating immune complexes in sera from patients with mycobacterial infections. Sera from 68 percent of patients with active M. tuberculosis and 58 percent of patients with M. intracellulare infections had significantly elevated Clq binding activity (Clq-BA). In general there was a...

    journal_title：Clinical and experimental immunology

    pub_type： 杂志文章

    doi：

    authors： Carr RI,Chakraborty AK,Brunda MJ,Davidson PT,Damle PB,Hardtke MA,Gilbride KJ,Minden P

    更新日期：1980-03-01 00:00:00

  • A defective Th1 response of the spleen in the initial phase may explain why splenectomy helps prevent a Listeria infection.

    abstract：:Listeria monocytogenes (Listeria) are known to grow and proliferate in the liver while a splenectomy induces host resistance against a Listeria infection despite the fact that a splenectomy inhibits the Th1 response. Therefore, the mechanism by which a splenectomy helps to prevent the growth of Listeria still remains ...

    journal_title：Clinical and experimental immunology

    pub_type： 杂志文章

    doi：10.1111/j.1365-2249.2005.02735.x

    authors： Kuranaga N,Kinoshita M,Kawabata T,Shinomiya N,Seki S

    更新日期：2005-04-01 00:00:00

  • Imatinib inhibits CSF1R that stimulates proliferation of rheumatoid arthritis fibroblast-like synoviocytes.

    abstract：:In this study, we aimed to explore the effects of imatinib on the proliferation of rheumatoid arthritis synovial cell (RA-FLS) and inflammatory responses by regulating CSF1R. Differential genes were screened via microarray analysis, followed by being analysed through the weighted co-expression network (WGCNA) network,...

    journal_title：Clinical and experimental immunology

    pub_type： 杂志文章

    doi：10.1111/cei.13220

    authors： Hu X,Tang J,Hu X,Bao P,Pan J,Ou Y,Deng W,Liang Y

    更新日期：2019-02-01 00:00:00

  • Epitope mapping of an HLA-B27 monoclonal antibody that also reacts with a 35-kD bacterial outer-membrane protein.

    abstract：:Ye-3 is an HLA-B27-specific murine monoclonal antibody recognizing the heat-modifiable protein of Enterobacteriaceae. Here we used recombinant hybrid molecules between the HLA-B7 and HLA-B27 antigens to delineate the epitope recognized by Ye-3. Results of these experiments indicated that the segment of HLA-B*2705 span...

    journal_title：Clinical and experimental immunology

    pub_type： 杂志文章

    doi：10.1111/j.1365-2249.1990.tb05397.x

    authors： Toubert A,Hamachi M,Raffoux C,Park MS,Yu DT

    更新日期：1990-10-01 00:00:00

  • Cytokine responses in acute and persistent human parvovirus B19 infection.

    abstract：:The aim of this study was to characterize the proinflammatory and T helper (Th)1/Th2 cytokine responses during acute parvovirus B19 (B19) infection and determine whether an imbalance of the Th1/Th2 cytokine pattern is related to persistent B19 infection. Cytokines were quantified by multiplex beads immunoassay in seru...

    journal_title：Clinical and experimental immunology

    pub_type： 杂志文章

    doi：10.1111/j.1365-2249.2006.03286.x

    authors： Isa A,Lundqvist A,Lindblom A,Tolfvenstam T,Broliden K

    更新日期：2007-03-01 00:00:00

  • Spontaneous lymphocyte proliferation and depressed cellular immunity in Hodgkin's disease.

    abstract：:Patients with Hodgkin's disease have increased numbers of spontaneously proliferating circulating lymphocytes. In order to test the relationship between this phenomenon and the in vitro mitogenic response, both spontaneous lymphocyte proliferation and the response to stimulation with phytohaemagglutinin were quantifie...

    journal_title：Clinical and experimental immunology

    pub_type： 杂志文章

    doi：

    authors： Shiftan TA,Caviles AP Jr,Mendelsohn J

    更新日期：1978-04-01 00:00:00

  • Patients with inflammatory bowel disease may have a transforming growth factor-beta-, interleukin (IL)-2- or IL-10-deficient state induced by intrinsic neutralizing antibodies.

    abstract：:Ulcerative colitis (UC) and Crohn's disease (CD) are considered to be immunologically mediated disorders that share certain features with murine models of colitis. Whether any of these models are physiologically relevant to the human condition remains controversial. The hypothesis is that increased amounts of antibodi...

    journal_title：Clinical and experimental immunology

    pub_type： 杂志文章

    doi：10.1111/j.1365-2249.2008.03802.x

    authors： Ebert EC,Panja A,Das KM,Praveen R,Geng X,Rezac C,Bajpai M

    更新日期：2009-01-01 00:00:00

  • Complement-induced mixed aggregation of T and B lymphocytes and myeloid cells and the effect of adjuvant.

    abstract：:Complement induces mixed aggregation of murine spleen cells bearing C3 receptors. In the present studies, we show with immunofluorescent techniques that these aggregates are formed by T and B lymphocytes and myeloid cells, B cells constituting the predominant component in normal mice. There are striking changes in the...

    journal_title：Clinical and experimental immunology

    pub_type： 杂志文章

    doi：

    authors： Arnaiz-Villena A,Roitt IM

    更新日期：1975-07-01 00:00:00

  • MicroRNA-155 may be involved in the pathogenesis of atopic dermatitis by modulating the differentiation and function of T helper type 17 (Th17) cells.

    abstract：:Our aims were to identify the differential expression of microRNA (miR)-155, as well as to explore the possible regulatory effects of miR-155 on the differentiation and function of T helper type 17 (Th17) cells in atopic dermatitis (AD). The Th17 cell percentage and expression levels of miR-155, retinoic acid-related ...

    journal_title：Clinical and experimental immunology

    pub_type： 杂志文章

    doi：10.1111/cei.12624

    authors： Ma L,Xue HB,Wang F,Shu CM,Zhang JH

    更新日期：2015-07-01 00:00:00

  • Piroxicam, indomethacin and aspirin action on a murine fibrosarcoma. Effects on tumour-associated and peritoneal macrophages.

    abstract：:Growth of a methylcholanthrene-induced fibrosarcoma in BALB/c mice was accompanied by an increase in the activation state of tumour-associated macrophages (TAM), as measured by their FcIgG receptor expression, phagocytic index and beta-glucuronidase levels. All of these parameters were markedly higher in TAM than in p...

    journal_title：Clinical and experimental immunology

    pub_type： 杂志文章

    doi：10.1111/j.1365-2249.1991.tb05816.x

    authors： Valdéz JC,Perdigón G

    更新日期：1991-11-01 00:00:00

  • Acute-phase protein synthesis in human hepatoma cells: differential regulation of serum amyloid A (SAA) and haptoglobin by interleukin-1 and interleukin-6.

    abstract：:Interleukin-6 (IL-6, BSF-2 or IFN-beta 2) is thought to be the major regulator of the acute-phase protein response that follows tissue injury and inflammation, with interleukin-1 (IL-1), tumour necrosis factor and more recently, LIF or HSF III, slightly stimulatory on only certain acute phase proteins. The synthesis o...

    journal_title：Clinical and experimental immunology

    pub_type： 杂志文章

    doi：10.1111/j.1365-2249.1991.tb05666.x

    authors： Raynes JG,Eagling S,McAdam KP

    更新日期：1991-03-01 00:00:00

  • Are alterations of lymphocyte subpopulations in polymicrobial sepsis and DHEA treatment mediated by the tumour necrosis factor (TNF)-alpha receptor (TNF-RI)? A study in TNF-RI (TNF-RI(-/-)) knock-out rodents.

    abstract：:Sepsis is associated with depression of T cell-dependent immune reactivity with proinflammatory cytokines, such as tumour necrosis factor (TNF)-alpha, playing an important role. Recent investigations describe an association between these immunological alterations and disturbances of the endocrine system, related most ...

    journal_title：Clinical and experimental immunology

    pub_type： 杂志文章

    doi：10.1111/j.1365-2249.2004.02598.x

    authors： Hildebrand F,Pape HC,Harwood P,Wittwer T,Krettek C,van Griensven M

    更新日期：2004-11-01 00:00:00

  • Induction of human autorosette forming cells by phorbol myristate acetate.

    abstract：:Human peripheral blood lymphocytes were examined for rosette formation with autologous erythrocytes. When normal human lymphocytes were stimulated with phorbol myristate acetate (PMA) in the presence of autologous serum, the levels of autorosette forming cells (ARFC) were strongly enhanced. Pre-culture was necessary f...

    journal_title：Clinical and experimental immunology

    pub_type： 杂志文章

    doi：

    authors： Sakano T,Hyodo S,Kittaka E,Tanaka Y,Usui T

    更新日期：1982-09-01 00:00:00

  • Levels of soluble Fc gammaRIII correlate with disease severity in sepsis.

    abstract：:Neutrophil activation is thought to play a crucial role in the pathogenesis of sepsis. During activation, neutrophils adhere to and migrate through the endothelium. Therefore, the amount of circulating neutrophils does not adequately reflect the total amount of neutrophils that are involved in the pathophysiologic pro...

    journal_title：Clinical and experimental immunology

    pub_type： 杂志文章

    doi：10.1046/j.1365-2249.1998.00727.x

    authors： Muller Kobold AC,Zijlstra JG,Koene HR,de Haas M,Kallenberg CG,Tervaert JW

    更新日期：1998-11-01 00:00:00

  • Monocyte PGE2 secretion in Hodgkin's disease and its relation to decreased cellular immunity.

    abstract：:The secretion of PGE2 from monocytes of newly diagnosed patients with Hodgkin's disease (HD) was compared to that of patients in remission, who were not receiving either chemotherapy or radiotherapy, and normal controls. We found that monocyte monolayers of some patients, both newly diagnosed and those in remission, s...

    journal_title：Clinical and experimental immunology

    pub_type： 杂志文章

    doi：

    authors： Passwell J,Levanon M,Davidsohn J,Ramot B

    更新日期：1983-01-01 00:00:00

  • Age involution in the normal human adult thymus.

    abstract：:Thymic biopsies taken under general anaesthetic prior to partial thyroidectomy for non-toxic nodular goitre were studied with histometric techniques: evidence is presented that the tissue studied is representative of the normal adult human thymus. The pattern of age involution of the normal adult thymus is described: ...

    journal_title：Clinical and experimental immunology

    pub_type： 杂志文章

    doi：

    authors： Simpson JG,Gray ES,Beck JS

    更新日期：1975-02-01 00:00:00

  • Cell-mediated immunity to hepatitis B virus antigens in mice: correlation of in vivo and in vitro assays.

    abstract：:Cell mediated immunity (CMI) to hepatitis B viral antigens was studied in BALB/mice after immunization with purified hepatitis B surface antigen (HBsAg), or core antigen (HBcAg), with adjuvants. The two in vitro assays for cell-mediated immunity (CMI), utilizing lymph node cells, were release of interferon after expos...

    journal_title：Clinical and experimental immunology

    pub_type： 杂志文章

    doi：

    authors： De Moerloose PA,Frazer IH,Sewell WA,Collins EJ,Mackay IR

    更新日期：1986-05-01 00:00:00

  • Experimental allergic encephalomyelitis in rhesus monkeys: II. Treatment of EAE with anti-T lymphocyte subset monoclonal antibodies.

    abstract：:Experimental allergic encephalomyelitis was induced in rhesus monkeys by immunization with bovine brain homogenate emulsified in complete Freund's adjuvant. Four monkeys were treated with anti-CD4 (OKT4+4A) monoclonal antibodies after the onset of clinical signs. One monkey developed a chronic-progressive course of EA...

    journal_title：Clinical and experimental immunology

    pub_type： 杂志文章

    doi：

    authors： Van Lambalgen R,Jonker M

    更新日期：1987-05-01 00:00:00

  • Factors associated with CD4 lymphocyte counts in HIV-negative Senegalese individuals.

    abstract：:CD4+ lymphocytes are a primary target of the human immunodeficiency virus (HIV), and CD4 counts are one of the factors used to measure disease progression in HIV-positive individuals. CD4 counts vary in uninfected individuals and across populations due to a variety of demographic, environmental, immunological and gene...

    journal_title：Clinical and experimental immunology

    pub_type： 杂志文章,多中心研究

    doi：10.1111/j.1365-2249.2007.03573.x

    authors： Mair C,Hawes SE,Agne HD,Sow PS,N'doye I,Manhart LE,Fu PL,Gottlieb GS,Kiviat NB

    更新日期：2008-03-01 00:00:00

  • Relationship of granulocyte colony stimulating factor with other acute phase reactants in man.

    abstract：:The non-specific acute phase response in mice is associated with increased resistance to bacterial infection, which is critically mediated by granulocyte colony stimulating factor (G-CSF), but the behaviour of G-CSF in the human acute phase response is not known. Cardiothoracic surgery is a powerful acute phase stimul...

    journal_title：Clinical and experimental immunology

    pub_type： 杂志文章

    doi：10.1111/j.1365-2249.2005.02732.x

    authors： Noursadeghi M,Pepys MB,Gallimore R,Cohen J

    更新日期：2005-04-01 00:00:00