Age involution in the normal human adult thymus.

abstract：:We previously demonstrated that high levels of IL-6/sIL-6R complexes are present in sera of patients with systemic juvenile idiopathic arthritis (s-JIA) and that the amount of IL-6 estimated in the IL-6/sIL-6R complexes is markedly higher than that measured by the B9 assay. Here, we show that two additional bioassays,...

journal_title：Clinical and experimental immunology

authors： Pignatti P,Ciapponi L,Galle P,Hansen MB,Massa M,Meazza C,Paonessa G,Novick D,Ciliberto G,Martini A,De Benedetti F

更新日期：2003-02-01 00:00:00

abstract：:Members of the European Society for Immunodeficiencies (ESID) and other colleagues have updated the multi-stage expert-opinion-based diagnostic protocol for non-immunologists incorporating newly defined primary immunodeficiency diseases (PIDs). The protocol presented here aims to increase the awareness of PIDs among d...

journal_title：Clinical and experimental immunology

authors： de Vries E,European Society for Immunodeficiencies (ESID) members.

更新日期：2012-01-01 00:00:00

abstract：:The molecular basis of common variable immunodeficiency (CVID) is undefined, and diagnosis requires exclusion of other diseases including X-linked lymphoproliferative disease (XLP). This rare disorder of immunedysregulation presents typically after Epstein-Barr virus infection and results from defects in the SAP (SLAM...

journal_title：Clinical and experimental immunology

authors： Eastwood D,Gilmour KC,Nistala K,Meaney C,Chapel H,Sherrell Z,Webster AD,Davies EG,Jones A,Gaspar HB

更新日期：2004-09-01 00:00:00

abstract：:The chemotactic responsiveness of peripheral blood monocytes was evaluated in three groups of subjects: 32 patients with multiple myeloma, 27 subjects with benign monoclonal gammapathy, and 64 normal controls. Monocyte chemotactic responsiveness was significantly depressed both in multiple myeloma patients (P less tha...

journal_title：Clinical and experimental immunology

authors： Dammacco F,Miglietta A,Ventura MT,Bonomo L

更新日期：1982-02-01 00:00:00

abstract：:Using in situ hybridization, we analysed the immunoglobulin repertoire expressed by the B cells present in myasthenia gravis thymuses from four patients. B cells, mostly in activated state, were clustered in germinal centres, in which multiple isotypes were identified. A majority of cells expressed IgG as compared wit...

journal_title：Clinical and experimental immunology

authors： Guigou V,Emilie D,Berrih-Aknin S,Fumoux F,Fougereau M,Schiff C

更新日期：1991-02-01 00:00:00

abstract：:The human body is populated by a large number of microorganisms and exist in symbiosis with these immensely diverse communities, which are suggested to influence health and disease. The microbiota plays an essential role in the maturation and function of the immune system. The prevalence of atopic diseases has increas...

journal_title：Clinical and experimental immunology

authors： Nibbering B,Ubags NDJ

更新日期：2020-01-01 00:00:00

abstract：:Asthma is a chronic inflammatory disease affecting the airways. Increased levels of T cells are found in the lungs after the induction of an allergic-like inflammation in rats, and flow cytometry studies have shown that these levels are reduced in CD26-deficient rats. However, the precise anatomical sites where these ...

journal_title：Clinical and experimental immunology

authors： Schade J,Schmiedl A,Kehlen A,Veres TZ,Stephan M,Pabst R,von Hörsten S

更新日期：2009-10-01 00:00:00

abstract：:Glucocorticoid hormones (GCH) regulate, through the apoptotic process, the negative selection of immature T cells in the thymus. Because apoptosis seems to occur also in the maintenance of peripheral tolerance, we have investigated whether GCH may induce apoptosis in human mature lymphocytes. Peripheral blood lymphocy...

journal_title：Clinical and experimental immunology

authors： Lanza L,Scudeletti M,Puppo F,Bosco O,Peirano L,Filaci G,Fecarotta E,Vidali G,Indiveri F

更新日期：1996-03-01 00:00:00

abstract：:Immunoglobulin variable region heavy chain (IgVH ) somatic gene diversification is instrumental in the transformation process that characterizes hepatitis C virus (HCV)-related B cell lymphoproliferative disorders. However, the extent to which activation-induced cytidine deaminase (AID), an enzyme essential for IgV ge...

journal_title：Clinical and experimental immunology

authors： Russi S,Dammacco F,Sansonno S,Pavone F,Sansonno D

更新日期：2015-12-01 00:00:00

abstract：:The CXC chemokines, monokine induced by interferon (IFN)-gamma (MIG) (CXCL9), IFN-gamma-induced protein 10 (IP-10) (CXCL10) and IFN-inducible T cell alpha chemoattractant (I-TAC) (CXCL11), are known to attract CXCR3- (CXCR3A and CXCR3B) T lymphocytes. We investigated MIG, IP-10 and I-TAC mRNAs expression by semi-quant...

journal_title：Clinical and experimental immunology

authors： Manousou P,Kolios G,Drygiannakis I,Koulentaki M,Pyrovolaki K,Voumvouraki A,Notas G,Bourikas L,Papadaki HA,Kouroumalis E

更新日期：2013-04-01 00:00:00

abstract：:Depression of one or more parameters of cellular and/or humoral immune responses was found in 60% of general hospital patients treated with phenytoin and 47% of patients treated with carbamazepine. Phenytoin-treated patients failed to manifest delayed hypersensitivity (DHS) reactions to common antigens, and to make an...

journal_title：Clinical and experimental immunology

authors： Sorrell TC,Forbes IJ

更新日期：1975-05-01 00:00:00

abstract：:IgE rheumatoid factor activity was found to be significantly elevated (P less than 0.01) using an ELISA assay when paired synovial fluid and sera from 13 patients with active RA were compared to ten control samples. Synovial fluid IgE RF activity was higher than predicted by diffusion alone in 7/11 (64%) of the RA syn...

journal_title：Clinical and experimental immunology

authors： Gruber B,Ballan D,Gorevic PD

更新日期：1988-02-01 00:00:00

abstract：:Insulin autoantibodies (IAA) can appear in children within months of introducing solid foods to the diet and before clinical type 1 diabetes. The aim of this study was to determine whether infant dietary antigens could be immunizing agents of IAA. To this end, IAA binding to [(125) I]insulin was competed with food pre...

journal_title：Clinical and experimental immunology

authors： Adler K,Mueller DB,Achenbach P,Krause S,Heninger AK,Ziegler AG,Bonifacio E

更新日期：2011-04-01 00:00:00

abstract：:Factor H and the FHL-1/reconectin protein are two human plasma proteins that act as important regulators of the alternative complement pathway. Each protein is encoded by a unique transcript, but both mRNAs are derived from the factor H gene by means of alternative processing. In order to address potential functional ...

journal_title：Clinical and experimental immunology

authors： Friese MA,Hellwage J,Jokiranta TS,Meri S,Müller-Quernheim HJ,Peter HH,Eibel H,Zipfel PF

更新日期：2000-08-01 00:00:00

abstract：:We studied the effects of ultraviolet B (UV-B) irradiation on cell-cell interactions using mouse lymphoma RMA cells and T cell hybridoma HTB-176.10. RMA cells act as stimulators by presenting H-2Kb surface antigens to HTB-176.10 cells, inducing IL-2 production in HTB-176.10 cells. Irradiating RMA cells with 1000J/m2 U...

journal_title：Clinical and experimental immunology

authors： Maekawa TL,Takahashi TA,Fujihara M,Akasaka J,Fujikawa S,Minami M,Sekiguchi S

更新日期：1996-08-01 00:00:00

abstract：:A number of studies done in the last 10 years demonstrate the importance of iron in regulating the expression of T lymphoid cell surface markers, in influencing the expansion of different T cell subsets and in affecting different immune cell functions in vitro. It has been argued that some of the results obtained coul...

journal_title：Clinical and experimental immunology

authors： de Sousa M

更新日期：1989-01-01 00:00:00

abstract：:Citrobacter rodentium is a murine pathogen that transiently colonizes the lumen of the large intestine. C. rodentium induces colitis, but the relative importance and temporal induction of the T helper type 17 (Th17) and regulatory T cell (T(reg)) pathways in protection from the infection and inflammation have not been...

journal_title：Clinical and experimental immunology

authors： Symonds EL,Riedel CU,O'Mahony D,Lapthorne S,O'Mahony L,Shanahan F

更新日期：2009-07-01 00:00:00

abstract：:The expression of melanocortin MC(1) receptors on human peripheral lymphocyte subsets was analysed by flow cytometry using rabbit antibodies selective for the human MC(1) receptor and a panel of monoclonal antibodies against lymphocyte differentiation markers. The MC(1) receptor was found to be constitutively expresse...

journal_title：Clinical and experimental immunology

authors： Neumann Andersen G,Nagaeva O,Mandrika I,Petrovska R,Muceniece R,Mincheva-Nilsson L,Wikberg JE

更新日期：2001-12-01 00:00:00

abstract：:Many cellular stresses and inflammatory stimuli can activate p38 mitogen-activated protein kinase (MAPK), a serine/threonine kinase in the MAPK family. The different stimuli act via different receptors or signalling pathways to induce phosphorylation of the cytosolic protein p47(phox), one subunit of the nicotinamide ...

journal_title：Clinical and experimental immunology

authors： Lu HW,He GN,Ma H,Wang JK

更新日期：2010-06-01 00:00:00

abstract：:Linomide (quinoline-3-carboxamide) is a synthetic immunomodulator that suppresses several experimental autoimmune diseases. Here we report the effects of Linomide on experimental autoimmune neuritis (EAN), a CD4+ T cell-mediated animal model of acute Guillain-Barré syndrome (GBS) in humans. EAN induced in Lewis rats b...

journal_title：Clinical and experimental immunology

authors： Zhu J,Bai XF,Hedlund G,Björk J,Bakhiet M,Van Der Meide PH,Link H

更新日期：1999-01-01 00:00:00

abstract：:Natural Killer (NK) cell activity against K562 target cells was measured in 21 female patients with primary Sjögren's syndrome (primary SS) and in 20 female normal controls matched for age. The in vitro effect of alpha-interferon (IF) and interleukin 2 (IL-2) on NK cell activity was examined and the percentage of larg...

journal_title：Clinical and experimental immunology

authors： Pedersen BK,Oxholm P,Manthorpe R,Andersen V

更新日期：1986-01-01 00:00:00

abstract：:During pathogenesis of diabetes, pancreatic islets are exposed to high levels of cytokines and other inflammatory mediators that induce deterioration of insulin-producing beta cells. Macrophage migration inhibitory factor (MIF) plays a key role in the onset and development of several immunoinflammatory diseases and al...

journal_title：Clinical and experimental immunology

authors： Stojanovic I,Saksida T,Nikolic I,Nicoletti F,Stosic-Grujicic S

更新日期：2012-08-01 00:00:00

abstract：:Vitamin D has been shown to modulate innate immune responses in vitro and ex vivo; however, human in-vivo data are lacking. At high latitudes, seasonal vitamin D deficiency is common due to alternating ultraviolet (UV)-B radiation exposure. In the present study, we investigated whether levels of 25 hydroxyvitamin D(3)...

journal_title：Clinical and experimental immunology

authors： Kox M,van den Berg MJ,van der Hoeven JG,Wielders JP,van der Ven AJ,Pickkers P

更新日期：2013-02-01 00:00:00

abstract：:Haemorrhage produces alterations in macrophage, T and B cell function. In order to better define the mechanism for the effects of blood loss on immune response, we examined function of and cytokine production by purified T cells, CD4+ and CD8+ subpopulations after blood loss. Whereas T and CD4+ cells from control, unh...

journal_title：Clinical and experimental immunology

authors： Abraham E,Chang YH

更新日期：1992-12-01 00:00:00

abstract：:Antibodies to extractable nuclear antigens (ENA) were analysed in the sera of fifty-two patients with severe rheumatoid arthritis (RA) who were divided into two categories: twenty-five with arthritis only and twenty-seven with extra-articular disease. Using haemagglutination, counterimmunoelectropheresis (CIE) and dou...

journal_title：Clinical and experimental immunology

authors： Venables PJ,Erhardt CC,Maini RN

更新日期：1980-01-01 00:00:00

abstract：:This study analyses the expression by rat lymphocytes of six renal brush border (BB) antigens defined by a set of monoclonal antibodies and demonstrates that a 90 kD protein (gp 90), synthesized by BB and glomeruli is found on the surface of T and B cells. The other antigens, including the 330 kD protein involved in H...

journal_title：Clinical and experimental immunology

authors： Van Leer EH,Moullier P,Ronco P,Verroust P

更新日期：1987-03-01 00:00:00

abstract：:Monocytes and endothelial cells were stimulated in co-culture with allogeneic lymphocytes to produce thromboplastin (TPL). The induction was biphasic, an early response (8-24 h) was greatly augmented by cyclosporin A (CS) (0.5-5 micrograms/ml) whereas the late response (day 3-4) was inhibited. Prednisolone inhibited b...

journal_title：Clinical and experimental immunology

authors： Carlsen E,Gaudernack G,Filion-Myklebust C,Pettersen KS,Prydz H

更新日期：1989-06-01 00:00:00

abstract：:Spleens of BALB/c mice with plasmacytoma contain macrophages (M phi) which were found to suppress the in vitro immune function of normal splenic cells through a diffusible factor. The suppressor activity of these macrophages was reversibly inhibited by ligands specific for the corresponding PC globulin, but not by ant...

journal_title：Clinical and experimental immunology

authors： Chen YH,Heller P

更新日期：1982-11-01 00:00:00

abstract：:IL-1 acts on many cells as an inflammatory mediator. Its two forms, IL-1 alpha and IL-1 beta, are regulated differentially within hyperproliferative inflammatory skin conditions, such as psoriasis. While IL-1 alpha is down-regulated within psoriatic lesions, the levels of IL-1 beta are increased. However, some investi...

journal_title：Clinical and experimental immunology

authors： Schön M,Behmenburg C,Denzer D,Schön MP

更新日期：2001-03-01 00:00:00

abstract：:Recently markers of endothelial cell activation or injury gained increasing interest as serological parameters of disease activation in vasculitides. Among these, soluble serum thrombomodulin, ICAM-1, VCAM-1 and E-selectin are of particular interest. However, only thrombomodulin showed the expected close correlation. ...

journal_title：Clinical and experimental immunology

authors： Boehme MW,Raeth U,Scherbaum WA,Galle PR,Stremmel W

更新日期：2000-01-01 00:00:00