MC(1) receptors are constitutively expressed on leucocyte subpopulations with antigen presenting and cytotoxic functions.

abstract：:Neutrophil phagocytosis and killing of Candida albicans were examined using a radiometric assay in 25 patients with insulin-dependent diabetes and 17 controls under various in vitro metabolic conditions. Glucose was present at 5, 10 and 50 mM, beta-hydroxybutyrate at 1, 5 and 20 mM and glucose with beta-hydroxybutyrat...

journal_title：Clinical and experimental immunology

authors： Wilson RM,Reeves WG

更新日期：1986-02-01 00:00:00

abstract：:One hundred and sixty-six unrelated children and adolescents having growth-onset, insulin-dependent diabetes mellitus (IDD) were studied for pancreatic-cytoplasmic islet cell antibodies (ICA) at various times from the diagnosis of the disease. A strong association between HLA antigens A9 and Bw16 and an absence of ICA...

journal_title：Clinical and experimental immunology

authors： Mustonen A,Ilonen J,Akerblom HK,Tiilikainen A

更新日期：1982-04-01 00:00:00

abstract：:A growing body of evidence points to autophagy as an essential component in the immune response to tuberculosis. Autophagy is a direct mechanism of killing intracellular Mycobacterium tuberculosis and also acts as a modulator of proinflammatory cytokine secretion. In addition, autophagy plays a key role in antigen pro...

journal_title：Clinical and experimental immunology

authors： Ní Cheallaigh C,Keane J,Lavelle EC,Hope JC,Harris J

更新日期：2011-06-01 00:00:00

abstract：:Previous studies demonstrated that NK resistant Epstein-Barr virus (EBV) carrying human lymphoblastoid cell lines become sensitive to NK cell-mediated destruction following induction of the viral cycle by superinfection with the P3HR-1 substrain of EBV or chemicals. In the present report we analysed the cellular membr...

journal_title：Clinical and experimental immunology

authors： Blazar BA,Fitzgerald J,Sutton L,Strome M

更新日期：1983-10-01 00:00:00

abstract：:CBA/KlJms-lprcg/lprcg mice with a novel mutation producing systemic lymphoproliferation were investigated for their serological and histological characteristics. The mutant mice showed elevated levels of serum immunoglobulin, C1q-binding immune complexes and antibodies to nuclear antigens such as dsDNA and ssDNA and p...

journal_title：Clinical and experimental immunology

authors： Kimura M,Mohri H,Shimada K,Wakabayashi T,Kanai Y,Matsuzawa A

更新日期：1990-01-01 00:00:00

abstract：:Stress known to stimulate sympathetic activity, as well as the hypothalamic-pituitary-adrenal axis (HPA), produces a significant increase in adrenomedullin (AdM) levels, suggesting a regulatory or protective role for AdM in countering HPA activation that follows a variety of stressors. Stressors can modulate the secre...

journal_title：Clinical and experimental immunology

authors： Yildirim NC,Yurekli M

更新日期：2010-07-01 00:00:00

abstract：:We describe a system for studying the interaction of human, single donor platelets and aggregated human IgG adherent to erythrocyte stroma (ES/Agg IgG) and report the role of monomeric IgG and C1q in this interaction. Monomeric IgG inhibits platelet aggregation by the ES/Agg IgG and acts on the platelet surface. Compl...

journal_title：Clinical and experimental immunology

authors： Vollertsen RS,McDuffie FC,Bowie EJ

更新日期：1983-05-01 00:00:00

abstract：:Biologically significant levels of IL-2 activity were produced by isolated lamina propria mononuclear cells (LPMC) from normal intestine (n = 12), cancer-bearing colons (n = 35) and inflammatory bowel disease (IBD) affected tissue (n = 12). The levels of IL-2 produced were similar for all three sources of LPMC (normal...

journal_title：Clinical and experimental immunology

authors： Pullman WE,Doe WF

更新日期：1992-04-01 00:00:00

abstract：:Graves' disease (GD) is characterized by the presence of autoantibodies against the TSH-receptor (TSH-R) which are pathogenic and, upon binding to the receptor, trigger intracellular signal transduction. The autoantibodies are oligoclonal and as they are responsible for disease activity, their characterization would l...

journal_title：Clinical and experimental immunology

authors： Van Der Heijden JH,De Bruin TW,Glaudemans KA,De Kruif J,Banga JP,Logtenberg T

更新日期：1999-11-01 00:00:00

abstract：:In order to study T-cell function related to the production of autoimmune nephropathy, we immunized random-bred mice, homozygous athymic nude (nu/nu) mice and heterozygous hairy (nu/+) mice with human glomeruli contained in Freund's complete adjuvant. The random-bred and heterozygous hairy mice developed circulating a...

journal_title：Clinical and experimental immunology

authors： Bolton WK,Benton FR,Lobo PI

更新日期：1978-09-01 00:00:00

abstract：:Acute lung injury frequently develops following haemorrhage, and is characterized by increased proinflammatory cytokine levels and massive neutrophil accumulation in the lung. Blood loss produces rapid increases in tumour necrosis factor-alpha (TNF-alpha) mRNA expression among pulmonary cell populations which precede ...

journal_title：Clinical and experimental immunology

authors： Abraham E,Coulson WF,Schwartz MD,Allbee J

更新日期：1994-10-01 00:00:00

abstract：:Previous studies have shown that rabbit anti-mouse immunoglobulin sera (anti-Ig) which kill non-activated B lymphocytes in the presence of complement, are incapable of doing so when the cells are activated by antigen or mitogen into mitosis. Results reported here indicate that the resistance is not dependent on either...

journal_title：Clinical and experimental immunology

authors： Kerbel RS,Birbeck MS,Robertson D,Cartwright P

更新日期：1975-04-01 00:00:00

abstract：:Human T-cell lines (MOLT-4 and SOMMER-T) were injected into rabbits and monkeys (stumptail and squirrel monkeys). Rabbit anti-MOLT serum was absorbed with human liver and cultured B cells. Absorbed anti-MOLT serum was cytotoxic to lymphocytes of baboons and stumptail monkeys. Rabbit anti-MOLT and SOMMER-T sera after a...

journal_title：Clinical and experimental immunology

authors： Takada A,Babbitt H,Hayata I,Takada Y

更新日期：1976-04-01 00:00:00

abstract：:The precise factor responsible for the altered immunological reactivity and diminished inflammatory responses occurring in pregnancy is unknown. Recent observations implicate the pregnancy-associated alpha-2 glycoprotein (PAG). Using rosette assays for the detection of cells carrying Fc receptors and for the demonstra...

journal_title：Clinical and experimental immunology

authors： Persellin RH,Rhodes J

更新日期：1981-11-01 00:00:00

abstract：:The immunopathology of patch test reactions to aeroallergens in patients with atopic dermatitis (AD) has been compared to that of contact sensitivity reactions to nickel in non-atopic individuals. Both reactions were found to exhibit equivalent erythema and induration on gross examination at 48 h. Four millimetre punc...

journal_title：Clinical and experimental immunology

authors： Buckley C,Ivison C,Poulter LW,Rustin MH

更新日期：1993-03-01 00:00:00

abstract：:The programmed death-1 (PD-1) receptor ligands, PD-L1 and PD-L2, are co-stimulatory molecules that contribute to the negative regulation of T lymphocyte activation. It is still unclear whether there is correlation between PD-L1 or PD-L2 and tumour-infiltrating dendritic cells (TIDCs) in cutaneous squamous cell carcino...

journal_title：Clinical and experimental immunology

authors： Jiao Q,Liu C,Li W,Li W,Fang F,Qian Q,Zhang X

更新日期：2017-06-01 00:00:00

abstract：:This study aimed to examine whether acute intermittent porphyria (AIP) is associated with systemic inflammation and whether the inflammation correlates with disease activity. A case-control study with 50 AIP cases and age-, sex- and place of residence-matched controls was performed. Plasma cytokines, insulin and C-pep...

journal_title：Clinical and experimental immunology

authors： Storjord E,Dahl JA,Landsem A,Fure H,Ludviksen JK,Goldbeck-Wood S,Karlsen BO,Berg KS,Mollnes TE,W Nielsen E,Brekke OL

更新日期：2017-03-01 00:00:00

abstract：:We have examined the cell-mediated immunity (CMI) to Staphylococcus aureus (S. aureus) and Staphylococcal enterotoxin B (SEB) in peripheral blood mononuclear cells (PBMC) from children with atopic dermatitis (AD) and from non-atopic child controls by measurement of proliferative responses and production of the cytokin...

journal_title：Clinical and experimental immunology

authors： Campbell DE,Kemp AS

更新日期：1997-02-01 00:00:00

abstract：:Ageing is a very complex process, the result of the dysregulation of multiple systems interacting in many ways. A prominent change occurring with ageing is related to the architecture and functioning of the immune system, viewed commonly as detrimental and termed 'immunosenescence'. However, age-associated changes may...

journal_title：Clinical and experimental immunology

authors： Fulop T,Witkowski JM,Le Page A,Fortin C,Pawelec G,Larbi A

更新日期：2017-01-01 00:00:00

abstract：:In vivo studies in rats demonstrated that the binding of a highly cationic antigen (cationized human IgG, pI greater than 9.5) to glomerular polyanion could be significantly reduced by prior application of a small polycation, protamine sulfate. The degree of inhibition was dose dependent and the highest dose used, 4 m...

journal_title：Clinical and experimental immunology

authors： Oite T,Shimizu F,Batsford SR,Vogt A

更新日期：1986-05-01 00:00:00

abstract：:The expression in tissue and serum of a panel of murine and human common DNA antibody idiotypes (Ids) (BEG 2, PR 4, F-423, I-402, II-28, IV-228, V-88) has been investigated. The murine V-88 Id was detected in eight out of 10 and the human BEG 2 Id in five out of 10 labial biopsies from patients with Sjögren's syndrome...

journal_title：Clinical and experimental immunology

authors： Watts RA,Ravirajan CT,Wilkinson LS,Williams W,Griffiths M,Butcher D,Horsfall AT,Staines NA,Isenberg DA

更新日期：1991-02-01 00:00:00

abstract：:There is increasing evidence that the functional state of the immune system at birth is predictive of the kinetics of immune maturation in early infancy. Moreover, this maturation process can have a major impact on early vaccine responses and can be a key determinant of risk for communicable and non-communicable disea...

journal_title：Clinical and experimental immunology

authors： van den Biggelaar AH,Holt PG

更新日期：2010-04-01 00:00:00

abstract：:During blood-stage infection of mice with a lethal variant of Plasmodium yoelii, cells in both spleen and liver became activated to reach a peak at day 5. In mice protected by vaccination, activation was accelerated after infection. The most striking difference observed was in the 10-fold greater yield of infiltrating...

journal_title：Clinical and experimental immunology

authors： Taverne J,Rahman D,Dockrell HM,Alavi A,Leveton C,Playfair JH

更新日期：1987-12-01 00:00:00

abstract：:Hybridomas producing monoclonal antibodies that bind to determinants on myelogenous leukaemia blast cells were developed using fresh leukaemia blasts as immunogens. These monoclonal antibodies were used to quantitate the amount of a variety of antigens on both leukaemia and normal blood cells in a radioimmunoassay. Th...

journal_title：Clinical and experimental immunology

authors： Ball ED,Fanger MW

更新日期：1982-06-01 00:00:00

abstract：:Characterization of cold reactive lymphocytotoxic antibodies present in sera from Thai adults with malaria revealed that the antibodies are predominantly 19S (IgM), directed against both autologous and allogeneic mononuclear cells, complement-dependent, present in titres ranging from 1:2 to 1:16, and exhibit greater l...

journal_title：Clinical and experimental immunology

authors： Gilbreath MJ,Pavanand K,MacDermott RP,Wells RA,Ussery MA

更新日期：1983-02-01 00:00:00

abstract：:In patients with reactive arthritis (ReA)/undifferentiated spondyloarthropathy (uSpA), synovial fluid mononuclear cells (SFMC) show proliferation to bacterial antigens that trigger ReA, i.e. Chlamydia, Yersinia, Campylobactor, Shigella and Salmonella species. We have shown previously that SFMC proliferate significantl...

journal_title：Clinical and experimental immunology

authors： Singh R,Shasany AK,Aggarwal A,Sinha S,Sisodia BS,Khanuja SP,Misra R

更新日期：2007-06-01 00:00:00

abstract：:We investigated whether deficiency of mannose-binding lectin (MBL), a component of innate immunity, is associated with neonatal pneumonia and sepsis during the first 72 h, i.e. early onset, and during the first month after birth. In 88 neonatal intensive care patients (71 premature), MBL2 genotype and MBL plasma level...

journal_title：Clinical and experimental immunology

authors： Frakking FN,Brouwer N,van Eijkelenburg NK,Merkus MP,Kuijpers TW,Offringa M,Dolman KM

更新日期：2007-11-01 00:00:00

abstract：:In order to establish normal reference ranges of serum immunoglobulin G subclasses for different age groups in Chinese, we measured the four IgG subclasses by radial immunodiffusion using polyclonal antisera in 350 normal healthy subjects (148 males and 202 females) recruited from the community. There was no significa...

journal_title：Clinical and experimental immunology

authors： Lau YL,Jones BM,Ng KW,Yeung CY

更新日期：1993-02-01 00:00:00

abstract：:Recent evidence has shown that microRNA-126 (miR-126) has been involved in the development and function of immune cells, which contributed to the pathogenesis of related clinical diseases. However, the potential role of miR-126 in the development and function of CD4+ T cells remains largely unknown. Here we first foun...

journal_title：Clinical and experimental immunology

authors： Chu F,Hu Y,Zhou Y,Guo M,Lu J,Zheng W,Xu H,Zhao J,Xu L

更新日期：2018-02-01 00:00:00

abstract：:Recurrent respiratory papillomatosis (RRP) is characterized by benign exophytic lesions of the respiratory tract caused by the human papillomavirus (HPV), in particular low-risk HPV6 and HPV11. Aggressiveness varies greatly among patients. Surgical excision is the current standard of care for RRP, with adjuvant therap...

journal_title：Clinical and experimental immunology

authors： Ivancic R,Iqbal H,deSilva B,Pan Q,Matrka L

更新日期：2020-02-01 00:00:00