Interaction of human platelets with particle-adherent aggregated IgG: description of the experimental system and role of C1q and monomeric IgG.

abstract：:Th1 cell-induced anti-mycobacterial immunity is lost during a progressive Mycobacterium tuberculosis infection in a susceptible host. This study was designed to test the mechanism of the loss of anti-mycobacterial cell-mediated immune response. We demonstrate that M. tuberculosis infection results in increased Fas exp...

journal_title：Clinical and experimental immunology

authors： Das G,Vohra H,Saha B,Agrewala JN,Mishra GC

更新日期：1999-02-01 00:00:00

abstract：:Silicosis is a chronic progressive granulomatous and fibrotic lung disease caused by inhaled silica. Although the causative agent is known, the pathogenesis, especially the immunologic response, is not well understood. We examined two important components of cell-mediated immune responses in the lungs of rats with sil...

journal_title：Clinical and experimental immunology

authors： Struhar DJ,Harbeck RJ,Gegen N,Kawada H,Mason RJ

更新日期：1989-08-01 00:00:00

abstract：:By immunological screening of a cDNA library derived from protoscoleces of Echinococcus granulosus with IgE from patients with cystic echinococcosis (CE) and allergic manifestations, we isolated a protein identical to E. granulosus cyclophilin. The protein, named EA21, has close homology with Malassezia furfur cycloph...

journal_title：Clinical and experimental immunology

authors： Ortona E,Vaccari S,Margutti P,Delunardo F,Rigano R,Profumo E,Buttari B,Rasool O,Teggi A,Siracusano A

更新日期：2002-04-01 00:00:00

abstract：:Bone marrow (BM) lymphocytes were obtained by sucrose density gradient centrifugation of the nucleated cells from adult human BM. BM was obtained from rib sections removed routinely during thoracotomy from thirteen patients with a localized lung tumour and from two other patients without tumour (mean age 47 years). Th...

journal_title：Clinical and experimental immunology

authors： De Gast GC,Platts-Mills TA

更新日期：1979-10-01 00:00:00

abstract：:Infants respond to antigen by making antibody that is generally of low affinity for antigen. Somatic hypermutation of immunoglobulin genes, and selection of cells expressing mutations with improved affinity for antigen, are the molecular and cellular processes underlying the maturation of antibody affinity. We have re...

journal_title：Clinical and experimental immunology

authors： Ridings J,Dinan L,Williams R,Roberton D,Zola H

更新日期：1998-10-01 00:00:00

abstract：:Human polymorphonuclear cells (PMN) were found to adhere to a novel model of blood vessel wall-associated IgG. The internal surfaces of cellulose acetate hollow fibres, of comparable internal diameter to small blood vessels, were coated with normal serum human IgG, heat-aggregated IgG (HAIgG), laminin or fibrinogen. U...

journal_title：Clinical and experimental immunology

authors： D'Arrigo C,Candal-Couto JJ,Greer M,Veale DJ,Woof JM

更新日期：1995-04-01 00:00:00

abstract：:The immunopathology of patch test reactions to aeroallergens in patients with atopic dermatitis (AD) has been compared to that of contact sensitivity reactions to nickel in non-atopic individuals. Both reactions were found to exhibit equivalent erythema and induration on gross examination at 48 h. Four millimetre punc...

journal_title：Clinical and experimental immunology

authors： Buckley C,Ivison C,Poulter LW,Rustin MH

更新日期：1993-03-01 00:00:00

abstract：:Anti-proteinase 3 antibodies are a subgroup of anti-neutrophil cytoplasmic antibodies (ANCA), and we have established an ELISA for their detection using high performance liquid chromatography (HPLC)-purified protein. This assay is sensitive and specific: inhibition studies have shown that despite the homology between ...

journal_title：Clinical and experimental immunology

authors： Jennings JG,Chang L,Savige JA

更新日期：1994-02-01 00:00:00

abstract：:We have demonstrated that mannose-binding lectin (MBL) recognizes various slow-growing, pathogenic mycobacteria [Mycobacterium tuberculosis (MTB), M. bovis, M. kansasii, M. gordonae] as well as non-pathogenic M. smegmatis. Recognition resulted in activation of the lectin pathway (LP) of complement and an enhancement o...

journal_title：Clinical and experimental immunology

authors： Bartlomiejczyk MA,Swierzko AS,Brzostek A,Dziadek J,Cedzynski M

更新日期：2014-11-01 00:00:00

abstract：:In vitro IgG synthesis by peripheral blood mononuclear cells (PBM) from patients with chronic liver disease (CLD) was studied. In addition, the effect of pokeweed mitogen (PWM), polyadenylic-polyuridylic acid complexes (poly A:U) and thymosin fraction 5 on IgG synthesis was determined. Unstimulated cultures of PBM fro...

journal_title：Clinical and experimental immunology

authors： Mutchnick MG,Lederman HM,Missirian A,Johnson AG

更新日期：1981-02-01 00:00:00

abstract：:Female Hartley guinea-pigs were immunized with N-phthaloylated ox insulin (96% NA1,NB1,NB29-triphthaloyl ox insulin) using H. pertussis as adjuvant. Haptenic antibody, which was found in antisera taken 20 days after secondary immunization, was assessed for cross-reaction with a series of N-acylated ox insulins. Cross-...

journal_title：Clinical and experimental immunology

authors： Hollins PJ,Nathan MM

更新日期：1978-03-01 00:00:00

abstract：:The intestinal population of gamma delta T cell receptor (TCR)-bearing cells was characterized with regard to V delta and V gamma subtype expression. For this purpose, we utilized V gene-specific PCR of mRNA prepared from intestinal biopsies. Predominant expression of the V delta 1 subtype was demonstrated in the smal...

journal_title：Clinical and experimental immunology

authors： Bucht A,Söderström K,Esin S,Grunewald J,Hagelberg S,Magnusson I,Wigzell H,Grönberg A,Kiessling R

更新日期：1995-01-01 00:00:00

abstract：:Two facts support the definition of idiopathic thrombocytopenic purpura (ITP) as an immune disorder. First, antibodies against platelets, which often appear after a viral infection, provoke the increased elimination of these cells. Viral disease may change the complex immune response of the host at different levels. I...

journal_title：Clinical and experimental immunology

authors： Imbach PA

更新日期：1994-07-01 00:00:00

abstract：:Up to 20% of Crohn's disease (CD) patients respond poorly to glucocorticoids (GC). A product of an alternative splicing of the glucocorticoid receptor (GR) premRNA, GRbeta, may play a role as a dominant inhibitor of the glucocorticoid response. Increasing evidence suggests that inflammatory cytokines such as interleuk...

journal_title：Clinical and experimental immunology

authors： Towers R,Naftali T,Gabay G,Carlebach M,Klein A,Novis B

更新日期：2005-08-01 00:00:00

abstract：:The emerging role of interleukin (IL)-17 as a hallmark proinflammatory cytokine of the adaptive immune system, produced primarily by a new T helper cell subset termed 'Th17', has received considerable attention. Differentiation of Th17 cells is driven by the simultaneous presence of transforming growth factor-beta and...

journal_title：Clinical and experimental immunology

authors： Nalbandian A,Crispín JC,Tsokos GC

更新日期：2009-08-01 00:00:00

abstract：:Skin nuclear speckled IgG deposition was noted in seven patients. The patients' clinical courses satisfied at least four of the preliminary criteria of the American Rheumatism Association for the diagnosis of systemic lupus erthematosus (SLE). Examination of approximately 700 additional biopsies from patiets with SLE,...

journal_title：Clinical and experimental immunology

authors： Shu S,Provost T,Croxdale MB,Reichlin M,Beutner EH

更新日期：1977-02-01 00:00:00

abstract：:Serum cytokine levels and peripheral T cell subpopulations of HIV-1-infected patients before, during and after active visceral leishmaniasis (VL) were analysed and compared with appropriate controls. At VL diagnosis, co-infected patients showed higher serum levels of interferon-gamma (IFN-gamma) than matched HIV-1 con...

journal_title：Clinical and experimental immunology

authors： Medrano FJ,Rey C,Leal M,Cañavate C,Rubio A,Sánchez-Quijano A,Alvar J,Lissen E

更新日期：1998-12-01 00:00:00

abstract：:Human bronchoalveolar lavage (BAL) macrophages were obtained from normal human volunteers and infected with an AIDS-associated strain of Mycobacterium avium. Infected cells were exposed to purified envelope glycoprotein (gp120) from HIV-1 or to the recombinant non-glycosylated gp120 fragments PBI-RF and PBI-IIIB. Nati...

journal_title：Clinical and experimental immunology

authors： Denis M

更新日期：1994-10-01 00:00:00

abstract：:Donor-specific CTL present within the cardiac allograft during a rejection episode are distinct from those that populate the cardiac allograft in the absence of rejection. Whereas the former generally have a high avidity for donor cells, the latter mainly have a low avidity for donor cells. This observation made us re...

journal_title：Clinical and experimental immunology

authors： Van Emmerik NE,Daane CR,Knoop CJ,Hesse C,Vaessen LM,Balk AH,Mochtar B,Claas FH,Weimar W

更新日期：1997-12-01 00:00:00

abstract：:The c-Jun N-terminal kinase (JNK) participates in intracellular signalling cascades that mediate inflammatory responses. Therefore, the JNK signalling may be involved in gastric injury and inhibition of this pathway may form the basis of a new strategy for the treatment of gastric injury. The aim of this study was to ...

journal_title：Clinical and experimental immunology

authors： Mitsuyama K,Tsuruta O,Matsui Y,Harada K,Tomiyasu N,Suzuki A,Takaki K,Masuda J,Handa K,Satoh Y,Bennett BL,Toyonaga A,Sata M

更新日期：2006-01-01 00:00:00

abstract：:We have reported recently that mouse liver NK cells and NK1 x 1+ T cells were activated by bacterial superantigens via the IL-12 production from Kupffer cells. In the present study, we examined the effect of staphyloccoccal enterotoxin A (SEA) on human T cells with NK cell markers, CD56 or CD57 (NK-type T cells). Afte...

journal_title：Clinical and experimental immunology

authors： Ami K,Ohkawa T,Koike Y,Sato K,Habu Y,Iwai T,Seki S,Hiraide H

更新日期：2002-06-01 00:00:00

abstract：:In humans and in laboratory animals, administration of a single does of glucocorticosteroids induces a rapid and transient decrease in the numbers of peripheral blood lymphocytes through a redistribution of circulating lymphocytes. This lymphocytopenic effect is an important factor in the immunosuppressive capacity of...

journal_title：Clinical and experimental immunology

authors： Bloemena E,Weinreich S,Schellekens PT

更新日期：1990-06-01 00:00:00

abstract：:Peripheral blood leucocytes from multiple sclerosis (MS) patients and from normal individuals were tested for their interferon (IFN) producing capacity after stimulation in vitro with various lectins and viruses. The lectins, Con A, PHA and PWM, induced IFN-gamma. In a kinetic study, the response to Con A revealed its...

journal_title：Clinical and experimental immunology

authors： Vervliet G,Carton H,Meulepas E,Billiau A

更新日期：1984-10-01 00:00:00

abstract：:T cells from systemic lupus erythematosus (SLE) patients display a wide array of anomalies in peripheral immune tolerance mechanisms. The role of ubiquitin ligases such as Cbl-b has been described recently in these phenomena. However, its role in resistance to suppression phenotype in SLE has not been characterized, w...

journal_title：Clinical and experimental immunology

authors： Romo-Tena J,Rajme-López S,Aparicio-Vera L,Alcocer-Varela J,Gómez-Martín D

更新日期：2018-01-01 00:00:00

abstract：:An expanded T cell subpopulation (CD8+ Leu-7+) has previously been reported in the peripheral blood of patients with Crohn's disease. This subpopulation of T cells was associated with a 'covert suppressor' function, particularly in patients with mild/early Crohn's disease, suppressing immunoglobulin production in vitr...

journal_title：Clinical and experimental immunology

authors： Deem RL,Targan SR,Niederlehner A,Shanahan F

更新日期：1990-06-01 00:00:00

abstract：:HAART may increase CD4+ T cell counts despite a persistently detectable HIV load. The impact of HAART on apoptosis, which may play a role in the disease process in HIV-infected patients, has not been extensively studied. We performed a study to compare the level of spontaneous T cell apoptosis and anti-retroviral trea...

journal_title：Clinical and experimental immunology

authors： Roger PM,Breittmayer JP,Arlotto C,Pugliese P,Pradier C,Bernard-Pomier G,Dellamonica P,Bernard A

更新日期：1999-12-01 00:00:00

abstract：:The proliferative responses to stimulation with phytohaemagglutinin (PHA) in cultures of lymphocytes from newly calved and non-pregnant cattle were compared. Lymphocyte cultures from newly calved cows were seen to respond less to PHA than cultures from the non-pregnant cows. It is suggested that this depression in res...

journal_title：Clinical and experimental immunology

authors： Wells PW,Burrells C,Martin WB

更新日期：1977-07-01 00:00:00

abstract：:The monoclonal antibody HNK-1 identifies a subpopulation of lymphocytes containing almost all of the natural killer (NK) and antibody-dependent killer (K) cell activity. Using an immunoperoxidase technique on frozen tissue sections of human spleen, tonsil and lymph node we have demonstrated that cells identified by th...

journal_title：Clinical and experimental immunology

authors： Ritchie AW,James K,Micklem HS

更新日期：1983-03-01 00:00:00

abstract：:The aim of this study was to investigate the diagnostic value of using the copy number of propionibacterial rRNA as a biomarker for sarcoidosis. Ribosomal RNA of Propionibacterium acnes and P. granulosum was measured by real-time quantitative reverse transcription-polymerase chain reaction (RT-PCR) using formalin-fixe...

journal_title：Clinical and experimental immunology

authors： Zhou Y,Wei YR,Zhang Y,Du SS,Baughman RP,Li HP

更新日期：2015-09-01 00:00:00

abstract：:The contribution of circulating anti-La(SS-B) antibody to the hypergammaglobulinaemia seen in primary Sjögren's syndrome is unknown. In this study levels of anti-La(SS-B) antibody directed against three immunodominant epitopes of the anti-La(SS-B) autoantigen were measured by ELISA in 84 anti-La(SS-B)+ sera using puri...

journal_title：Clinical and experimental immunology

authors： Gordon TP,Greer M,Reynolds P,Guidolin A,McNeilage LJ

更新日期：1991-09-01 00:00:00