An islet cell antibody negative form of insulin-dependent diabetes mellitus (IDD) associated with HLA antigens A9 and Bw16.

abstract：:Systemic lupus erythematosus (SLE) is an autoimmune disease characterized by extensive immune response, including over-activation of T and B cell development of pathogenic autoantibodies, organ damage induced by the formation and deposition of immune complex and the abnormal elevation of type I interferon. Semaphorin5...

journal_title：Clinical and experimental immunology

authors： Du Y,Wu X,Chen M,Wang W,Xv W,Ye L,Wu D,Xue J,Sun W,Luo J,Wu H

更新日期：2017-05-01 00:00:00

abstract：:Nickel (Ni), the main cause of contact allergy to metals, induces in vitro production of both Th1- and Th2-type cytokines in peripheral blood mononuclear cells (PBMC) from allergic subjects. Because the knowledge of the cellular immune response to other metals involved in contact allergy has been limited, we investiga...

journal_title：Clinical and experimental immunology

authors： Minang JT,Areström I,Troye-Blomberg M,Lundeberg L,Ahlborg N

更新日期：2006-12-01 00:00:00

abstract：:A method is described which can be used to quantitate class II MHC antigens (HLA-DR) expressed by cells within tissue sections. A mouse anti-human HLA-DR monoclonal antibody is directly conjugated to the fungal enzyme glucose oxidase. The enzyme, in the presence of its substrate can be used to reduce tetrazolium salts...

journal_title：Clinical and experimental immunology

authors： Collings LA,Tidman N,Poulter LW

更新日期：1985-07-01 00:00:00

abstract：:Mannose-binding lectin (MBL) is an innate immune molecule present in blood and some mucosal tissues, which can influence microbial attachment and inflammatory responses of host cells during infection. In this study MBL was found to be present at a low concentration in semen samples in the range 1.2-24.9 ng/ml. Co-incu...

journal_title：Clinical and experimental immunology

authors： Wing JB,Jack DL,Lee ME,Pacey AA,Kinghorn GR,Read RC

更新日期：2009-09-01 00:00:00

abstract：:In a previous work we have demonstrated that in patients exhibiting a late allergic reaction (LAR), alveolar macrophages (AM) collected 18 h after bronchial allergen challenge produced high levels of IL-6 and tumour necrosis factor-alpha (TNF) which is known to up-regulate the endothelial cell expression of adhesion m...

journal_title：Clinical and experimental immunology

authors： Lassalle P,Gosset P,Delneste Y,Tsicopoulos A,Capron A,Joseph M,Tonnel AB

更新日期：1993-10-01 00:00:00

abstract：:It has been suggested that the increase in C3 and C4 levels in jejunal perfusates of patients with Crohn's disease (CD) results from local intestinal synthesis of complement. The present study evaluated the expression of these complement genes in inflamed tissues from patients with CD. Surgically resected specimens fr...

journal_title：Clinical and experimental immunology

authors： Laufer J,Oren R,Goldberg I,Horwitz A,Kopolovic J,Chowers Y,Passwell JH

更新日期：2000-04-01 00:00:00

abstract：:Cytokines have been extensively studied in coeliac disease, but cytokine release related to exposure to gluten and associated symptoms has only recently been described. Prominent, early elevations in serum interleukin (IL)-2 after gluten support a central role for T cell activation in the clinical reactions to gluten ...

journal_title：Clinical and experimental immunology

authors： Goel G,Daveson AJM,Hooi CE,Tye-Din JA,Wang S,Szymczak E,Williams LJ,Dzuris JL,Neff KM,Truitt KE,Anderson RP

更新日期：2020-01-01 00:00:00

abstract：:In normal subjects, factor B and C3b inactivator (KAF) levels were linearly related (r = 0-71); factor B levels in subjects with low normal levels of KAF were significantly lower than in those with high normal levels of KAF. This relationship is postulated to be the result of modulation by the level of KAF of the avai...

journal_title：Clinical and experimental immunology

authors： Forristal J,Iitaka K,Vallota EH,West CD

更新日期：1977-04-01 00:00:00

abstract：:Peripheral blood leucocytes from multiple sclerosis (MS) patients and from normal individuals were tested for their interferon (IFN) producing capacity after stimulation in vitro with various lectins and viruses. The lectins, Con A, PHA and PWM, induced IFN-gamma. In a kinetic study, the response to Con A revealed its...

journal_title：Clinical and experimental immunology

authors： Vervliet G,Carton H,Meulepas E,Billiau A

更新日期：1984-10-01 00:00:00

abstract：:Coeliac disease (CD) is described as an autoimmune enteropathy associated with the presence of IgG and IgA antigliadin and antitransglutaminase autoantibodies. While of diagnostic significance, the role of these autoantibodies in the immunopathogenesis of CD is elucidated. An inappropriate T cell immune response to gl...

journal_title：Clinical and experimental immunology

authors： Cremata JA,Sorell L,Montesino R,Garcia R,Mata M,Cabrera G,Galvan JA,Garcia G,Valdes R,Garrote JA

更新日期：2003-09-01 00:00:00

abstract：:Idiopathic histaminergic acquired angioedema (IH-AAE) is a common cause of recurrent angioedema without wheals. It is a mast cell-mediated disease thought to belong to the same clinical entity as chronic urticaria (CU). The objective of this study was to describe the clinical and epidemiological characteristics of IH-...

journal_title：Clinical and experimental immunology

authors： Faisant C,Boccon-Gibod I,Mansard C,Dumestre Perard C,Pralong P,Chatain C,Deroux A,Bouillet L

更新日期：2016-07-01 00:00:00

abstract：:The serum levels of TGF-beta1, measured by solid-phase ELISA, were determined to be significantly augmented in patients with both relapsing remitting (RR) and secondary chronic progressive (CP) MS compared with sex- and age-matched healthy controls. Moreover, in RR MS patients, the blood levels of the cytokine were fu...

journal_title：Clinical and experimental immunology

authors： Nicoletti F,Di Marco R,Patti F,Reggio E,Nicoletti A,Zaccone P,Stivala F,Meroni PL,Reggio A

更新日期：1998-07-01 00:00:00

abstract：:In the present study we attempted to clarify the effects of anti-beta 2-microglobulin (a-beta 2m) on lymphocyte activation. Neither a-beta 2m IgG fraction nor F(ab')2 had a mitogenic effect on either highly purified T or B lymphocytes alone, while their mitogenic effect was observed when T and B lymphocytes were appro...

journal_title：Clinical and experimental immunology

authors： Kin K,Kasahara T,Itoh Y,Sakurabayashi I,Kawai T,Morita K

更新日期：1979-05-01 00:00:00

abstract：:A proportion of human monocytes form long needles of fibrin on their surfaces when they are briefly exposed to human plasma. A number of coagulation factor deficient plasmas (II, V, VII, VIII, von Willebrand, IX, X, XI and XII) were tested for their ability to promote formation of this fibrin. Monocytes failed to make...

journal_title：Clinical and experimental immunology

authors： Hogg N

更新日期：1983-09-01 00:00:00

abstract：:IgE was isolated from a patient with the hyper IgE, recurrent infection syndrome by immunoadsorption on sepharose bound goat anti-human IgE. Addition of this IgE to a monolayer culture of human monocytes resulted in a dose-dependent increase in PGE2 secretion. The addition of F(ab')2 fraction of goat anti-human IgE in...

journal_title：Clinical and experimental immunology

authors： Passwell JH,Geiger B,Levanon M,Davidsohn J,Cohen BE,Ramot B

更新日期：1984-12-01 00:00:00

abstract：:In this study the antigen-presenting capacity of human peritoneal cells and the influence of continuous ambulant peritoneal dialysis (CAPD) were studied. On average 6% of the peritoneal cells were dendritic cells (DC), with no difference between CAPD and control peritoneal cells. DC were enriched by selecting for non-...

journal_title：Clinical and experimental immunology

authors： Betjes MG,Tuk CW,Struijk DG,Krediet RT,Arisz L,Beelen RH

更新日期：1993-11-01 00:00:00

abstract：:Our aims were to identify the differential expression of microRNA (miR)-155, as well as to explore the possible regulatory effects of miR-155 on the differentiation and function of T helper type 17 (Th17) cells in atopic dermatitis (AD). The Th17 cell percentage and expression levels of miR-155, retinoic acid-related ...

journal_title：Clinical and experimental immunology

authors： Ma L,Xue HB,Wang F,Shu CM,Zhang JH

更新日期：2015-07-01 00:00:00

abstract：:In fifty-seven healthy individuals a significant correlation ( r = 0.3, P < 0.05) has been found between responses of their lymphocytes to stimulation by PHA and by pooled lymphocytes in MLC. It is suggested that these tests quantitate the general status of T cell reactivity of individuals, and may be used in conjunct...

journal_title：Clinical and experimental immunology

authors： Nanra SK,Boettcher B

更新日期：1980-07-01 00:00:00

abstract：:Recent experimental data indicate a pathogenic role of complement activation in congestive heart failure (CHF). The aim of this study was to evaluate contact and complement systems activation in patients hospitalized for an acute episode of CHF. Forty-two of 80 consecutive patients admitted at our hospital with confir...

journal_title：Clinical and experimental immunology

authors： Suffritti C,Tobaldini E,Schiavon R,Strada S,Maggioni L,Mehta S,Sandrone G,Toschi-Dias E,Cicardi M,Montano N

更新日期：2017-11-01 00:00:00

abstract：:Sjögren's syndrome (SS) is an autoimmune disease characterized by T cell infiltration into the salivary and lacrimal glands (LG). Previous studies on T cell receptor (TCR) usage in the minor salivary glands (SG) have yielded controversial results. We studied TCR beta gene usage of the T cells infiltrating to LG, which...

journal_title：Clinical and experimental immunology

authors： Mizushima N,Kohsaka H,Tsubota K,Saito I,Miyasaka N

更新日期：1995-07-01 00:00:00

abstract：:The immune modulating capacity of vitamin D(3) is well-recognized. Ultra-violet (UV) exposure determines production of vitamin D(3) in vivo and varies through the course of the year, especially in temperate regions. However, it is not known whether the human innate immune response differs due to seasonality. To valida...

journal_title：Clinical and experimental immunology

authors： Khoo AL,Chai LY,Koenen HJ,Sweep FC,Joosten I,Netea MG,van der Ven AJ

更新日期：2011-04-01 00:00:00

abstract：:A full-length cDNA coding a human beta 2-glycoprotein I (beta 2-GPI) was introduced into the baculovirus genome to construct a recombinant baculovirus. Spodoptera frugiperda (Sf9) cells were infected with the recombinant baculovirus. A protein (mol. wt 43,000) reactive with anti-beta 2-GPI antisera was produced in the...

journal_title：Clinical and experimental immunology

authors： Igarashi M,Matsuura E,Igarashi Y,Nagae H,Matsuura Y,Ichikawa K,Yasuda T,Voelker DR,Koike T

更新日期：1993-07-01 00:00:00

abstract：:As Q fever is associated with an inflammatory syndrome, we determined circulating levels of inflammatory cytokines, cytokine antagonists, and activation markers of leucocytes in patients with acute Q fever and Q fever endocarditis. Tumour necrosis factor (TNF) and IL-6, but not IL-1beta, were markedly increased compar...

journal_title：Clinical and experimental immunology

authors： Capo C,Amirayan N,Ghigo E,Raoult D,Mege J

更新日期：1999-01-01 00:00:00

abstract：:T cells are thought to play an important regulatory role in atopic asthma. We hypothesized that human blood and BAL T cell subsets bearing various TCR-Vbeta genes might show selective differences in their cytokine profile. Peripheral blood (PB) and bronchoalveolar lavage (BAL) T cells from seven atopic asthmatic and s...

journal_title：Clinical and experimental immunology

authors： Bakakos P,Pickard C,Smith JL,Frew AJ

更新日期：2002-05-01 00:00:00

abstract：:Dysregulation of IL-6 synthesis is thought to play a role in the development of a number of age-related conditions, such as rheumatoid arthritis, osteoporosis, atherosclerosis, Alzheimer's disease and B cell malignancies. Recently it has been suggested that the production of IL-6 is influenced by the adrenal hormone d...

journal_title：Clinical and experimental immunology

authors： Young DG,Skibinski G,Mason JI,James K

更新日期：1999-09-01 00:00:00

abstract：:There is increasing evidence that the functional state of the immune system at birth is predictive of the kinetics of immune maturation in early infancy. Moreover, this maturation process can have a major impact on early vaccine responses and can be a key determinant of risk for communicable and non-communicable disea...

journal_title：Clinical and experimental immunology

authors： van den Biggelaar AH,Holt PG

更新日期：2010-04-01 00:00:00

abstract：:Mixtures of serum of Freund's complete adjuvant (FCA) immunized guinea-pigs and tuberculin PPD consistently inhibited the in vitro migration of peritoneal exudate cells (PEC) of normal guinea-pigs. It is shown that this inhibitory effect is due to a soluble complex between an IgG2 antibody and PPD. By separation of PP...

journal_title：Clinical and experimental immunology

authors： Kotkes P,Pick E

更新日期：1975-01-01 00:00:00

abstract：:Interleukin-6 (IL-6) is a key cytokine featuring redundancy and pleiotropic activity. It plays a central role in host defence against environmental stress such as infection and injury. Dysregulated, persistent interleukin (IL)-6 production has been implicated in the development of various autoimmune, chronic inflammat...

journal_title：Clinical and experimental immunology

authors： Mesquida M,Leszczynska A,Llorenç V,Adán A

更新日期：2014-06-01 00:00:00

abstract：:Clearance rates in the guinea pig were determined for intact guinea pig and human C1 inhibitor, the complexes of both inhibitors with human Cls, beta factor XIIa and kallikrein, and for each inhibitor cleaved at its reactive centre with trypsin. Intact human and guinea pig C1 inhibitor were cleared from the circulatio...

journal_title：Clinical and experimental immunology

authors： Malek R,Aulak KS,Davis AE 3rd

更新日期：1996-07-01 00:00:00

abstract：:The specific response of human peripheral blood lymphocyte cultures to TNP-polyacrylamide was suppressed by the addition of concanavalin A (Con A). A dose of Con A (0.5 microgram/ml) could be selected, which induced a reproducible but incomplete suppression independent of the magnitude of the anti-TNP response. Con A-...

journal_title：Clinical and experimental immunology

authors： Galanaud P,Crevon MC,Delfraissy JF,Segond P,Wallon C,Dormont J

更新日期：1979-10-01 00:00:00