Cellular cooperation in lymphocyte activation. II. Cooperative response of human peripheral T and B lymphocytes to rabbit anti-human beta 2-microglobulin.

abstract：:Previous studies have shown that the efficiency of phagocytosis is a function of cell cycle and that phagocytosis promotes cell cycle progression. Because phagocytosis is dependent on cellular receptors we hypothesized that Fcgamma receptors (FcgammaR) and complement receptors (CR) expression varied with cell cycle. C...

journal_title：Clinical and experimental immunology

authors： Luo Y,Cook E,Fries BC,Casadevall A

更新日期：2006-08-01 00:00:00

abstract：:In order to evaluate the impact of induction and increase target antigen expression on immunotoxin potency, we measured the potentiating effect of recombinant immune interferon-gamma (rIFN-gamma) on the cytotoxicity of an anti HLA-DR ricin A-chain immunotoxin (2G5 RTA-IT) on the myeloid cell line ML-3. After 48 h of i...

journal_title：Clinical and experimental immunology

authors： Chiron M,Jaffrezou JP,Carayon P,Bordier C,Roubinet F,Xavier C,Brandely M,Laurent G

更新日期：1990-11-01 00:00:00

abstract：:Peptide immunotherapy is being explored to modulate varied disease states; however, the mechanism of action remains poorly understood. In this study, we investigated the ability of a subcutaneous peptide immunization schedule to induce of CD4(+) CD25(+) T regulatory cells. DO11.10 T cell receptor (TCR) transgenic mice...

journal_title：Clinical and experimental immunology

authors： Dahlberg PE,Schartner JM,Timmel A,Seroogy CM

更新日期：2007-08-01 00:00:00

abstract：:Human T-cell lines (MOLT-4 and SOMMER-T) were injected into rabbits and monkeys (stumptail and squirrel monkeys). Rabbit anti-MOLT serum was absorbed with human liver and cultured B cells. Absorbed anti-MOLT serum was cytotoxic to lymphocytes of baboons and stumptail monkeys. Rabbit anti-MOLT and SOMMER-T sera after a...

journal_title：Clinical and experimental immunology

authors： Takada A,Babbitt H,Hayata I,Takada Y

更新日期：1976-04-01 00:00:00

abstract：:Comparisons of the results obtained in a study of fifty-two patients with genitourinary malignancies using three assays to monitor the thymus-dependent immune system (delayed cutaneous hypersensitivity to DNCB, PHA-induced lymphocyte blastogenesis, and peripheral blood E rosette-forming lymphocyte counts) yielded stat...

journal_title：Clinical and experimental immunology

authors： Catalona WJ,Tarpley JL,Potvin C,Chretien PB

更新日期：1975-02-01 00:00:00

abstract：:Cryostat sections of dermal lesions from 30 untreated leprosy patients were studied by indirect immunofluorescence using monoclonal antibodies defining T cell subsets and Ia like antigens. Most lymphocytes in leprosy lesions were positive for OKT3 and Ia like antigens indicating thereby the presence of activated T cel...

journal_title：Clinical and experimental immunology

authors： Narayanan RB,Bhutani LK,Sharma AK,Nath I

更新日期：1983-03-01 00:00:00

abstract：:This report describes the presence of a T lymphocyte subpopulation in germinal centres of lymph follicles. This subpopulation is defined by reactivity with Leu 7 antibody, in addition to OKT11, OKT1, OKT3 and OKT4 positivity. The functional activity of this T lymphocyte subpopulation is a matter of discussion and has ...

journal_title：Clinical and experimental immunology

authors： Poppema S,Visser L,De Leij L

更新日期：1983-12-01 00:00:00

abstract：:Sensorineural hearing loss is a common problem in the otolaryngologist's practice, with autoimmune disease of the inner ear being one possible cause. The restoration of auditory function in some patients following immunosuppressive therapy has created a desire to define and understand this disease better. Because of t...

journal_title：Clinical and experimental immunology

authors： Gloddek B,Rogowski M,Reiss G,Arnold W

更新日期：1994-07-01 00:00:00

abstract：:Features of tissue damage in invasive amoebiasis, in particular polymorphonuclear neutrophil (PMN) degranulation and vasculitis, bear resemblance to that seen in Wegener's granulomatosis, the latter being associated with the presence of anti-neutrophil cytoplasmic antibodies (ANCA). We therefore tested sera from patie...

journal_title：Clinical and experimental immunology

authors： Pudifin DJ,Duursma J,Gathiram V,Jackson TF

更新日期：1994-07-01 00:00:00

abstract：:Studies of human mucosal lymphoid follicles are rare and have been limited to children's Peyer's patches, which are visible at endoscopy. We investigated lymphoid follicles in ileum biopsies of 87 patients and surgical colon specimens from 66 cancer patients, and examined phenotype and function of isolated follicular ...

journal_title：Clinical and experimental immunology

authors： Junker Y,Bode H,Wahnschaffe U,Kroesen A,Loddenkemper C,Duchmann R,Zeitz M,Ullrich R

更新日期：2009-05-01 00:00:00

abstract：:The frequency and specificity of antibodies to native and denatured collagens were evaluated in systemic sclerosis (SSc) and in primary Raynaud's phenomenon (PRP) by direct and competitive ELISA. Antibodies reactive with denatured collagen type I (CI) were found in 43% of the SSc sera, and anti-CIV and anti-CV in 31%....

journal_title：Clinical and experimental immunology

authors： Riente L,Marchini B,Dolcher MP,Puccetti A,Bombardieri S,Migliorini P

更新日期：1995-11-01 00:00:00

abstract：:Neutrophils are often exclusively considered as a first-line innate immune defence, able to rapidly kill or trap pathogens and causing in case of over-activation tissue damage. In the female reproductive tract, however, the presence and activity of neutrophils seems to be tightly regulated. Major players in orchestrat...

journal_title：Clinical and experimental immunology

authors： Hahn S,Hasler P,Vokalova L,van Breda SV,Lapaire O,Than NG,Hoesli I,Rossi SW

更新日期：2019-10-01 00:00:00

abstract：:Disseminated infection with virulent Mycobacterium avium in C57Bl/6 (B6) mice leads to severe lymphocyte depletion in secondary lymphoid organs. In this study, we found an up-regulation of caspase-8 activity in spleen cell extracts from M. avium 25291-infected B6 mice compared to non-infected mice. The activation of t...

journal_title：Clinical and experimental immunology

authors： Borges M,Rosa GT,Appelberg R

更新日期：2011-06-01 00:00:00

abstract：:The regulation of cytokine production and T cell proliferation by other cytokines is mandatory in mediating inflammatory responses but the full understanding is far from complete. We have previously reported increased production of IL-2 and IL-2 receptors (IL-2R) in IgA nephropathy. The present study was undertaken to...

journal_title：Clinical and experimental immunology

authors： Lai KN,Leung JC,Li PK,Lui SF

更新日期：1991-08-01 00:00:00

abstract：:The programmed death-1 (PD-1) receptor ligands, PD-L1 and PD-L2, are co-stimulatory molecules that contribute to the negative regulation of T lymphocyte activation. It is still unclear whether there is correlation between PD-L1 or PD-L2 and tumour-infiltrating dendritic cells (TIDCs) in cutaneous squamous cell carcino...

journal_title：Clinical and experimental immunology

authors： Jiao Q,Liu C,Li W,Li W,Fang F,Qian Q,Zhang X

更新日期：2017-06-01 00:00:00

abstract：:The secretion of PGE2 from monocytes of newly diagnosed patients with Hodgkin's disease (HD) was compared to that of patients in remission, who were not receiving either chemotherapy or radiotherapy, and normal controls. We found that monocyte monolayers of some patients, both newly diagnosed and those in remission, s...

journal_title：Clinical and experimental immunology

authors： Passwell J,Levanon M,Davidsohn J,Ramot B

更新日期：1983-01-01 00:00:00

abstract：:In vivo studies in rats demonstrated that the binding of a highly cationic antigen (cationized human IgG, pI greater than 9.5) to glomerular polyanion could be significantly reduced by prior application of a small polycation, protamine sulfate. The degree of inhibition was dose dependent and the highest dose used, 4 m...

journal_title：Clinical and experimental immunology

authors： Oite T,Shimizu F,Batsford SR,Vogt A

更新日期：1986-05-01 00:00:00

abstract：:Two facts support the definition of idiopathic thrombocytopenic purpura (ITP) as an immune disorder. First, antibodies against platelets, which often appear after a viral infection, provoke the increased elimination of these cells. Viral disease may change the complex immune response of the host at different levels. I...

journal_title：Clinical and experimental immunology

authors： Imbach PA

更新日期：1994-07-01 00:00:00

abstract：:T helper (Th) responses are mediated in part by immunoregulatory cytokines and the signals delivered by the costimulatory CD28-B7 pathway. In this study, we have investigated the relationship between the regulation of B7 isoform expression on antigen-presenting cells from HIV+ individuals and the production of Th cyto...

journal_title：Clinical and experimental immunology

authors： Kumar A,Angel JB,Aucoin S,Creery WD,Daftarian MP,Cameron DW,Filion L,Diaz-Mitoma F

更新日期：1999-07-01 00:00:00

abstract：:Two models of murine graft-versus-host disease (GVHD) were studied with respect to autoantibody production and development of systemic lupus erythematosus (SLE) like disease. One model was induced by injection of (B10.A(4R) x B10.A(2R]F1 mice with parental (B10.A(4R] spleen and lymph node cells (groups I GVHD), the ot...

journal_title：Clinical and experimental immunology

authors： van Dam AP,Meilof JF,van den Brink HG,Smeenk RJ

更新日期：1990-07-01 00:00:00

abstract：:C4BP has a central role in regulating the classical complement (C') pathway, but it is still uncertain whether or not it is consumed during in vivo complement activation. Attempts to demonstrate changes in C4BP plasma levels in systemic lupus erythematosus and essential mixed cryoglobulinaemia have failed, probably du...

journal_title：Clinical and experimental immunology

authors： Bergamaschini L,Miedico A,Cicardi M,Coppola R,Faioni EN,Agostoni A

更新日期：1999-05-01 00:00:00

abstract：:The capacity of human T cell subsets, CD4+ or CD8+ T cells, to produce tumour necrosis factors (TNF-alpha and TNF-beta) upon stimulation with toxic shock syndrome toxin-1 (TSST-1) and the requirement for MHC class II molecules on accessory cells (AC) in the response were investigated. The capacity of CD4+ T cells was ...

journal_title：Clinical and experimental immunology

authors： Akatsuka H,Imanishi K,Inada K,Yamashita H,Yoshida M,Uchiyama T

更新日期：1994-06-01 00:00:00

abstract：:To elucidate antibody recognition of DNA in normal and aberrant immunity, the binding of sera of normal human subjects (NHS) and patients with SLE was tested with mammalian and bacterial DNA varying in size. Klebsiella pneumoniae (KP) and calf thymus (CT) single-stranded DNA (ssDNA) were investigated as model antigens...

journal_title：Clinical and experimental immunology

authors： Pisetsky DS,Gonzalez TC

更新日期：1999-05-01 00:00:00

abstract：:Atopic disorders are caused by disregulated activation of T helper 2 (Th2) cells that produce IL-4 and IL-5. Because the presence of IL-4 potently augments the differentiation of naive T cells into Th2 cells, it is important to seek the cell population which provides IL-4 for naive T cells. Recently, a unique subpopul...

journal_title：Clinical and experimental immunology

authors： Oishi Y,Sakamoto A,Kurasawa K,Nakajima H,Nakao A,Nakagawa N,Tanabe E,Saito Y,Iwamoto I

更新日期：2000-03-01 00:00:00

abstract：:Using a sensitive IL-1-dependent T cell clone we estimated interleukin 1 (IL-1)-like activity in a variety of synovial fluids (SF). Although we demonstrate that SF contains potent inhibitors of endogenous and exogenous IL-1 we were able to estimate that samples from rheumatoid arthritis, osteoarthritis and other arthr...

journal_title：Clinical and experimental immunology

authors： Hopkins SJ,Humphreys M,Jayson MI

更新日期：1988-06-01 00:00:00

abstract：:Smokers exhibit airway inflammation and increased number of alveolar macrophages (AM), but not all develop chronic obstructive pulmonary disease (COPD). We hypothesized that AMs in COPD patients have an altered functional capacity mirrored in a different phenotype. Sixteen steroid-naive COPD patients [forced expirator...

journal_title：Clinical and experimental immunology

authors： Löfdahl JM,Wahlström J,Sköld CM

更新日期：2006-09-01 00:00:00

abstract：:Intestinal T cells have a unique state of activation and differentiation which might specifically affect or be affected by HIV infection. Lymphocyte subsets in the peripheral blood are well characterized, but our knowledge about intestinal lymphocytes in HIV infection is incomplete. We therefore analysed lymphocytes i...

journal_title：Clinical and experimental immunology

authors： Schneider T,Ullrich R,Bergs C,Schmidt W,Riecken EO,Zeitz M

更新日期：1994-03-01 00:00:00

abstract：:Human mononuclear leucocytes (MNL) or the adherent fraction (monocytes) produced tumour necrosis factor-alpha (TNF-alpha) (by ELISA) in culture when stimulated with killed Staphylococcus aureus. The bisbenzylisoquinoline alkaloid, tetrandrine inhibited the capacity of MNL and monocytes to produce TNF-alpha at a concen...

journal_title：Clinical and experimental immunology

authors： Ferrante A,Seow WK,Rowan-Kelly B,Thong YH

更新日期：1990-05-01 00:00:00

abstract：:Rheumatoid arthritis (RA) is a chronic inflammatory disease that develops as a result of the interaction between genetic and environmental risk factors. Although increasing evidence shows the importance of genes in determining the risk of RA, it is clear that environmental factors also have a vital role. Studies to da...

journal_title：Clinical and experimental immunology

authors： Colebatch AN,Edwards CJ

更新日期：2011-01-01 00:00:00

abstract：:Summary The interaction between stroma and blood cells in the human spleen has received little attention, despite their well-defined roles during blood cell development in bone marrow. We have reported previously that human spleen-derived fibroblasts display a differentiated myofibroblast phenotype and constitutively ...

journal_title：Clinical and experimental immunology

authors： Briard D,Azzarone B,Brouty-Boyé D

更新日期：2005-05-01 00:00:00