T cell subsets in leprosy lesions: in situ characterization using monoclonal antibodies.

Abstract:

:Cryostat sections of dermal lesions from 30 untreated leprosy patients were studied by indirect immunofluorescence using monoclonal antibodies defining T cell subsets and Ia like antigens. Most lymphocytes in leprosy lesions were positive for OKT3 and Ia like antigens indicating thereby the presence of activated T cells. Maximal numbers of these cells were seen in localized paucibacillary tuberculoid leprosy lesions in close association with epithelioid cells. A decline in their numbers was observed over the leprosy spectrum with a marked reduction in disseminated, multi-bacillary, lepromatous leprosy where only scattered OKT3+ cells were visualized. OKT4 and OKT8 positive cells defining T cell subsets, were frequently found within the OKT3+ lymphocytes throughout the leprosy spectrum. The ratio of OKT4+/OKT8+ cells ranged from 1.2 to 5.0 in tuberculoid and from 0.2 to 1.0 in lepromatous lesions. Macrophages in the granulomas stained intensely with anti-Ia antisera. Ia like antigens were expressed to the same degree on macrophages with or without intracellular acid fast bacilli.

journal_name

Clin Exp Immunol

authors

Narayanan RB,Bhutani LK,Sharma AK,Nath I

subject

Has Abstract

pub_date

1983-03-01 00:00:00

pages

421-9

issue

3

eissn

0009-9104

issn

1365-2249

journal_volume

51

pub_type

杂志文章
  • An islet cell antibody negative form of insulin-dependent diabetes mellitus (IDD) associated with HLA antigens A9 and Bw16.

    abstract::One hundred and sixty-six unrelated children and adolescents having growth-onset, insulin-dependent diabetes mellitus (IDD) were studied for pancreatic-cytoplasmic islet cell antibodies (ICA) at various times from the diagnosis of the disease. A strong association between HLA antigens A9 and Bw16 and an absence of ICA...

    journal_title:Clinical and experimental immunology

    pub_type: 杂志文章

    doi:

    authors: Mustonen A,Ilonen J,Akerblom HK,Tiilikainen A

    更新日期:1982-04-01 00:00:00

  • Functional behaviour and immunological phenotype of circulating B lymphocytes in multiple myeloma. Studies with pokeweed mitogen.

    abstract::Peripheral blood B lymphocytes, depleted of adherent cells, from 10 patients with multiple myeloma were cultured in the presence of PWM with autologous or donor T lymphocytes. The results show that: (1) co-cultures with allogeneic T lymphocytes produced more plasma cells than those with autologous ones; (2) the kappa/...

    journal_title:Clinical and experimental immunology

    pub_type: 杂志文章

    doi:

    authors: Gobbi M,Caligaris-Cappio F,Campana D,Tazzari PL,Bergui L,Cavo M,Tura S

    更新日期:1984-12-01 00:00:00

  • Delayed disease progression in HIV-2: the importance of TRIM5α and the retroviral capsid.

    abstract::HIV-2 is thought to have entered the human population in the 1930s through cross-species transmission of SIV from sooty mangabeys in West Africa. Unlike HIV-1, HIV-2 has not led to a global pandemic, and recent data suggest that HIV-2 prevalence is declining in some West African states where it was formerly endemic. A...

    journal_title:Clinical and experimental immunology

    pub_type: 杂志文章,评审

    doi:10.1111/cei.13280

    authors: Boswell MT,Rowland-Jones SL

    更新日期:2019-06-01 00:00:00

  • Distinct delta T cell receptor repertoires in monozygotic twins concordant for coeliac disease.

    abstract::One of the hallmarks of coeliac disease, both active and treated, is an increased number and proportion of gamma/delta intraepithelial T lymphocytes in the small intestinal mucosa, and an increased number of gamma/delta T cells in the small intestinal mucosa of coeliac disease patients has been associated with the inh...

    journal_title:Clinical and experimental immunology

    pub_type: 杂志文章

    doi:10.1046/j.1365-2249.1997.d01-887.x

    authors: Holtmeier W,Rowell DL,Nyberg A,Kagnoff MF

    更新日期:1997-01-01 00:00:00

  • Increased sensitivity to natural killing in Raji cells is due to effector recognition of molecules appearing on target cell membranes following EBV cycle induction.

    abstract::Previous studies demonstrated that NK resistant Epstein-Barr virus (EBV) carrying human lymphoblastoid cell lines become sensitive to NK cell-mediated destruction following induction of the viral cycle by superinfection with the P3HR-1 substrain of EBV or chemicals. In the present report we analysed the cellular membr...

    journal_title:Clinical and experimental immunology

    pub_type: 杂志文章

    doi:

    authors: Blazar BA,Fitzgerald J,Sutton L,Strome M

    更新日期:1983-10-01 00:00:00

  • Plasma cytokine response to surgical stress in schizophrenic patients.

    abstract::Schizophrenic patients are reported to have immunological dysfunction, however, the immune response to surgery in schizophrenic patients remains unclear. We measured plasma interleukin-6 (IL-6), interleukin-8 (IL-8) and tumour necrosis factor-alpha (TNF-alpha) before, during and after colectomy, hemicolectomy and sigm...

    journal_title:Clinical and experimental immunology

    pub_type: 杂志文章

    doi:10.1046/j.1365-2249.2001.01581.x

    authors: Kudoh A,Sakai T,Ishihara H,Matsuki A

    更新日期:2001-07-01 00:00:00

  • The effects of Mycobacteria vaccae derivative on allergen-specific responses in children with atopic dermatitis.

    abstract::The capacity of microbial products to inhibit allergic inflammation make them logical candidates for novel therapies in allergic diseases such as atopic dermatitis. To assess the effects of intradermal Mycobacterium vaccae derivative on allergen-specific immune responses in children with moderate to severe atopic derm...

    journal_title:Clinical and experimental immunology

    pub_type: 杂志文章

    doi:10.1111/j.1365-2249.2011.04371.x

    authors: Dunstan JA,Brothers S,Bauer J,Hodder M,Jaksic MM,Asher MI,Prescott SL

    更新日期:2011-06-01 00:00:00

  • Systemic inflammation alters the inflammatory response in experimental lipopolysaccharide-induced meningitis.

    abstract::Experiments to evaluate the effect of the level and duration of endotoxaemia on the meningeal inflammatory response were performed in order to determine if systemic inflammation alters meningitis. Rabbits received either saline or Escherichia coli O111:B4 lipopolysacharide (LPS) intravenously at various doses (1, 3 or...

    journal_title:Clinical and experimental immunology

    pub_type: 杂志文章

    doi:10.1111/j.1365-2249.2006.03255.x

    authors: O'Reilly T,Ostergaard C,Vaxelaire J,Zak O

    更新日期:2007-01-01 00:00:00

  • Common variable immunodeficiency revisited: normal generation of naturally occurring dendritic cells that respond to Toll-like receptors 7 and 9.

    abstract::Patients with common variable immunodeficiency (CVID) have reduced numbers and frequencies of dendritic cells (DCs) in blood, and there is also evidence for defective activation through Toll-like receptors (TLRs). Collectively, these observations may point to a primary defect in the generation of functional DCs. Here,...

    journal_title:Clinical and experimental immunology

    pub_type: 杂志文章

    doi:10.1111/cei.12239

    authors: Taraldsrud E,Fevang B,Aukrust P,Beiske KH,Fløisand Y,Frøland S,Rollag H,Olweus J

    更新日期:2014-03-01 00:00:00

  • The expression of CD18 is increased on Trisomy 21 (Down syndrome) lymphoblastoid cells.

    abstract::The monoclonal antibody (MAB) 60.3 reacts with the beta chain (CD18) of lymphocyte function associated antigen (LFA-1), encoded by a gene on chromosome 21. We have used 60.3 to measure the expression of CD18 on lymphoblastoid cell-lines derived from persons with Trisomy 21 (Down syndrome) by quantitative fluorescence ...

    journal_title:Clinical and experimental immunology

    pub_type: 杂志文章

    doi:

    authors: Taylor GM,Williams A,D'Souza SW,Fergusson WD,Donnai D,Fennell J,Harris R

    更新日期:1988-02-01 00:00:00

  • Human lymphocyte subpopulations effect of epinephrine.

    abstract::The effect of administration of 0-2 mg of epinephrine (Parke-Davis) on circulatory lymphocytes was investigated in fifteen normal subjects. Blood samples were taken prior to, 10 and 20 min after, subcutaneous injections. Thymus-derived (T) cells were assayed by sheep red blood cell rosettes, bone marrow-derived (B) ce...

    journal_title:Clinical and experimental immunology

    pub_type: 杂志文章

    doi:

    authors: Yu DT,Clements PJ

    更新日期:1976-09-01 00:00:00

  • Regulation of the in vitro monoclonal immunoglobulin production in cultures of peripheral blood mononuclear cells and bone marrow cells from myeloma patients mediated by T cell dependent mitogens.

    abstract::In vitro monoclonal immunoglobulin (mIg) production of cultured tumour cells--prepared from the bone marrow (BM) or from the peripheral blood (PB) of 40 multiple myeloma (MM) patients, 16 patients with monoclonal gammopathy of undetermined significance and two patients with M. Waldenström--was measured with an enzyme-...

    journal_title:Clinical and experimental immunology

    pub_type: 杂志文章

    doi:

    authors: Peest D,Gasch S,Thiele C,Bartels B,Brunkhorst U,Dallmann I,Hoffmann M,Schedel I,Deicher H

    更新日期:1986-07-01 00:00:00

  • Allelic family-specific humoral responses to merozoite surface protein 2 (MSP2) in Gabonese residents with Plasmodium falciparum infections.

    abstract::Merozoite surface protein 2 (MSP2) expressed by Plasmodium falciparum asexual blood stages has been identified as a promising vaccine candidate. In order to explore allelic family-specific humoral responses which may be responsible for parasite neutralization during natural infections, isolates from individuals with e...

    journal_title:Clinical and experimental immunology

    pub_type: 杂志文章

    doi:10.1046/j.1365-2249.2002.01904.x

    authors: Ekala MT,Jouin H,Lekoulou F,Mercereau-Puijalon O,Ntoumi F

    更新日期:2002-08-01 00:00:00

  • Contrasting activity of cytosin-guanosin dinucleotide oligonucleotides in mice with experimental colitis.

    abstract::Intestinal inflammation in inflammatory bowel disease (IBD) and experimental models of colitis is characterized by a dysregulated intestinal immune response with elevated levels of Th1 cytokines. The luminal flora has been implicated as a major factor contributing to the initiation and perpetuation of inflammation in ...

    journal_title:Clinical and experimental immunology

    pub_type: 杂志文章

    doi:10.1046/j.1365-2249.2003.02288.x

    authors: Obermeier F,Dunger N,Strauch UG,Grunwald N,Herfarth H,Schölmerich J,Falk W

    更新日期:2003-11-01 00:00:00

  • Complement-induced mixed aggregation of T and B lymphocytes and myeloid cells and the effect of adjuvant.

    abstract::Complement induces mixed aggregation of murine spleen cells bearing C3 receptors. In the present studies, we show with immunofluorescent techniques that these aggregates are formed by T and B lymphocytes and myeloid cells, B cells constituting the predominant component in normal mice. There are striking changes in the...

    journal_title:Clinical and experimental immunology

    pub_type: 杂志文章

    doi:

    authors: Arnaiz-Villena A,Roitt IM

    更新日期:1975-07-01 00:00:00

  • Isolation of human anti-c-erbB-2 Fabs from a lymph node-derived phage display library.

    abstract::An immunoglobulin phage display library constructed from a tumour-associated pericolic lymph node was panned against the extracellular domain of the oncoprotein c-erbB-2. Sixteen independent clones were confirmed as positive binders based on ELISA analysis of soluble Fabs. Nucleotide sequencing demonstrated that the V...

    journal_title:Clinical and experimental immunology

    pub_type: 杂志文章

    doi:10.1046/j.1365-2249.1997.4161316.x

    authors: Clark MA,Hawkins NJ,Papaioannou A,Fiddes RJ,Ward RL

    更新日期:1997-07-01 00:00:00

  • Disturbance of the Epstein-Barr virus-host balance in rheumatoid arthritis patients: a quantitative study.

    abstract::Rheumatoid arthritis (RA), seronegative spondyloarthropathy (SA) and osteoarthritis (OA) patients receiving no steroid or disease-modifying therapy have been monitored, along with healthy controls, for their prevailing level of Epstein-Barr virus (EBV) infection using four independent indices of the EBV-host balance, ...

    journal_title:Clinical and experimental immunology

    pub_type: 杂志文章

    doi:

    authors: Yao QY,Rickinson AB,Gaston JS,Epstein MA

    更新日期:1986-05-01 00:00:00

  • Hydroxychloroquine potentiates Fas-mediated apoptosis of rheumatoid synoviocytes.

    abstract::Inadequate apoptosis may contribute to the synovial hyperplasia associated with rheumatoid arthritis (RA). The Fas-associated death domain protein (FADD)-like interleukin (IL)-1beta-converting enzyme (FLICE)-inhibitory protein (FLIP), which is an apoptotic inhibitor, has been implicated in the resistance to Fas-mediat...

    journal_title:Clinical and experimental immunology

    pub_type: 杂志文章

    doi:10.1111/j.1365-2249.2006.03070.x

    authors: Kim WU,Yoo SA,Min SY,Park SH,Koh HS,Song SW,Cho CS

    更新日期:2006-06-01 00:00:00

  • Interleukin-21 induces migration and invasion of fibroblast-like synoviocytes from patients with rheumatoid arthritis.

    abstract::Rheumatoid arthritis (RA) is a chronic inflammatory disease characterized by synovial fibroblast hyperplasia and bone erosion. Fibroblast-like synoviocytes (FLS) play a pivotal role in RA pathogenesis through aggressive migration and matrix invasion, and certain proinflammatory cytokines may affect synoviocyte invasio...

    journal_title:Clinical and experimental immunology

    pub_type: 杂志文章

    doi:10.1111/cei.12751

    authors: Xing R,Jin Y,Sun L,Yang L,Li C,Li Z,Liu X,Zhao J

    更新日期:2016-05-01 00:00:00

  • Correlation between hypersensitivity to parenteral chymopapain and the presence of IgE anti-chymopapain antibody.

    abstract::A solid phase radioimmunoassay, similar to the RAST, was developed in an attempt to predict anaphylactic reactions in patients injected with the proteolytic enzyme chymopapain, used in therapy for prolapsed intervertebral disc. The test measured the serum content of anti-chymopapain antibodies of the IgE class. Of 126...

    journal_title:Clinical and experimental immunology

    pub_type: 杂志文章

    doi:

    authors: Kapsalis AA,Stern IJ,Bornstein I

    更新日期:1978-07-01 00:00:00

  • Widespread IgE-mediated hypersensitivity in Northern Sudan to the chironomid Cladotanytarsus lewisi ('green nimitti').

    abstract::Hypersensitivity to Chironomidae (non-biting midges) has been a problem in Northern Sudan since about 1927 and is probably due to the working of dams which have produced lake-like conditions on parts of the Blue and main Niles where breeding has evidently increased. Studies were undertaken to determine whether this hy...

    journal_title:Clinical and experimental immunology

    pub_type: 杂志文章

    doi:

    authors: Kay AB,Gad El Rab MO,Stewart J,Erwa HH

    更新日期:1978-10-01 00:00:00

  • Progressive polarization towards a T helper/cytotoxic type-1 cytokine pattern during age-dependent maturation of the immune response inversely correlates with CD30 cell expression and serum concentration.

    abstract::In order to investigate the T cell cytokine profile during age-dependent maturation of the immune response, we evaluated the cytokine expression of CD4+ and CD8+ circulating cells by flow cytometric single-cell analysis after non-specific stimulation in vitro in different age groups of normal individuals, from cord bl...

    journal_title:Clinical and experimental immunology

    pub_type: 杂志文章

    doi:10.1046/j.1365-2249.1999.00977.x

    authors: Krampera M,Vinante F,Tavecchia L,Morosato L,Chilosi M,Romagnani S,Zanolin ME,Pizzolo G

    更新日期:1999-08-01 00:00:00

  • Effects of cyclosporin A on immunoglobulin production by EB virus stimulated lymphocytes.

    abstract::Cyclosporin A (Cy A) enhances immunoglobulin (Ig) production by EB virus stimulated peripheral blood lymphocytes from normal subjects with prior immunity to EB virus. In 11 normal adults, this enhancement of Ig production correlated with T cell-mediated cytotoxic regression. Cultures from normal healthy adults without...

    journal_title:Clinical and experimental immunology

    pub_type: 杂志文章

    doi:

    authors: Pereira RS,Gear AJ,Doré CJ,Webster AD

    更新日期:1983-07-01 00:00:00

  • Regulation of the primary in vitro antibody response in human peripheral blood lymphocytes: different effects of mitogen-induced and spontaneous T suppressor cells.

    abstract::The specific response of human peripheral blood lymphocyte cultures to TNP-polyacrylamide was suppressed by the addition of concanavalin A (Con A). A dose of Con A (0.5 microgram/ml) could be selected, which induced a reproducible but incomplete suppression independent of the magnitude of the anti-TNP response. Con A-...

    journal_title:Clinical and experimental immunology

    pub_type: 杂志文章

    doi:

    authors: Galanaud P,Crevon MC,Delfraissy JF,Segond P,Wallon C,Dormont J

    更新日期:1979-10-01 00:00:00

  • Translational mini-review series on Toll-like receptors: Toll-like receptor ligands as novel pharmaceuticals for allergic disorders.

    abstract::Characterization of the Toll-like receptor (TLR) family and associated signalling pathways provides a key molecular basis for our understanding of the relationship between exposure to microbial products and susceptibility to immune-mediated disorders. Indeed, ligation of TLR controls innate and adaptive immune respons...

    journal_title:Clinical and experimental immunology

    pub_type: 杂志文章,评审

    doi:10.1111/j.1365-2249.2006.03296.x

    authors: Goldman M

    更新日期:2007-02-01 00:00:00

  • The influence of prednisolone on the recirculation of peripheral blood lymphocytes in vivo.

    abstract::In humans and in laboratory animals, administration of a single does of glucocorticosteroids induces a rapid and transient decrease in the numbers of peripheral blood lymphocytes through a redistribution of circulating lymphocytes. This lymphocytopenic effect is an important factor in the immunosuppressive capacity of...

    journal_title:Clinical and experimental immunology

    pub_type: 杂志文章

    doi:10.1111/j.1365-2249.1990.tb03310.x

    authors: Bloemena E,Weinreich S,Schellekens PT

    更新日期:1990-06-01 00:00:00

  • Human milk contains proteins that stimulate and suppress T lymphocyte proliferation.

    abstract::The modulatory effect of human milk proteins from colostrum and late milk on the proliferative response of human T lymphocytes activated by mitogens (OKT3 and leucoagglutinin from Phaseolus vulgaris) and alloantigens was studied. High concentrations (10-100 micrograms/ml) of crude colostral milk proteins had an inhibi...

    journal_title:Clinical and experimental immunology

    pub_type: 杂志文章

    doi:10.1111/j.1365-2249.1990.tb08113.x

    authors: Mincheva-Nilsson L,Hammarström ML,Juto P,Hammarström S

    更新日期:1990-03-01 00:00:00

  • Scleroderma fibroblasts promote migration of mononuclear leucocytes across endothelial cell monolayers.

    abstract::Perivascular infiltrates of inflammatory cells are a hallmark of lesional skin in scleroderma. We have explored the potential for scleroderma fibroblasts to modulate mononuclear leucocyte migration across endothelial cell monolayers in tissue culture, and to regulate expression of endothelial cell adhesion molecules. ...

    journal_title:Clinical and experimental immunology

    pub_type: 杂志文章

    doi:10.1046/j.1365-2249.1998.00721.x

    authors: Denton CP,Shi-Wen X,Sutton A,Abraham DJ,Black CM,Pearson JD

    更新日期:1998-11-01 00:00:00

  • A prospective controlled crossover trial of a new heat-treated intravenous immunoglobulin.

    abstract::Twenty-one patients with primary immunoglobulin deficiency were enrolled in a crossover study to test the efficacy and safety of Alphaglobin in comparison with the licensed preparations Sandoglobulin and Gamimune. There was no statistical difference in these parameters between Alphaglobin and Sandoglobulin/Gamimune. T...

    journal_title:Clinical and experimental immunology

    pub_type: 临床试验,杂志文章

    doi:10.1111/j.1365-2249.1995.tb03465.x

    authors: Zuhrie SR,Webster AD,Davies R,Fay AC,Wallington TB

    更新日期:1995-01-01 00:00:00

  • Therapeutic granulocyte and monocyte apheresis (GMA) for treatment refractory sarcoidosis: a pilot study of clinical effects and possible mechanisms of action.

    abstract::Sarcoidosis is a systemic, inflammatory disorder, which in a proportion of patients runs a chronic progressive course despite immunosuppressive treatment. Therapeutic granulocyte and monocyte apheresis (GMA) has been shown to be an effective treatment option for other systemic inflammatory disorders, but has not yet b...

    journal_title:Clinical and experimental immunology

    pub_type: 杂志文章

    doi:10.1111/cei.12360

    authors: Olsen HH,Muratov V,Cederlund K,Lundahl J,Eklund A,Grunewald J

    更新日期:2014-09-01 00:00:00