当前位置： SCI文献检索 > CLINICAL AND EXPERIMENTAL IMMUNOLOGY期刊下所有文献 > CD4-CD8- T cells bearing invariant Valpha24JalphaQ TCR alpha-chain are decreased in patients with atopic diseases.

CD4-CD8- T cells bearing invariant Valpha24JalphaQ TCR alpha-chain are decreased in patients with atopic diseases.

Abstract：

:Atopic disorders are caused by disregulated activation of T helper 2 (Th2) cells that produce IL-4 and IL-5. Because the presence of IL-4 potently augments the differentiation of naive T cells into Th2 cells, it is important to seek the cell population which provides IL-4 for naive T cells. Recently, a unique subpopulation of T cells, natural killer (NK) T cells, has been shown to produce a large amount of IL-4 upon activation, suggesting their regulatory role in initiation of Th2 cell differentiation. To determine whether NK T cells play a regulatory role in human Th2 cell-mediated atopic diseases, we analysed the frequency of invariant Valpha24JalphaQ CD4-CD8- double-negative (DN) T cells, human NK T cells, in patients with atopic asthma and atopic dermatitis. We also studied cytokine production from Valpha24+ Vbeta11+ DN T cells, which comprise most of Valpha24JalphaQ DN T cells. We found that the invariant Valpha24JalphaQ DN T cells were greatly diminished in patients with asthma and atopic dermatitis. On the other hand, there was no significant difference in Valpha24+ CD4+ T cells possessing invariant Valpha24JalphaQ TCR between healthy subjects and atopic patients. We also found that Valpha24+ Vbeta11+ DN T cells from healthy subjects predominantly produced interferon-gamma (IFN-gamma) but not IL-4 upon activation. These results suggest that NK T cells may not be essential for human atopic disease and that the disappearance of NK T cells, most of which produce IFN-gamma, may be involved in the pathogenesis of atopic diseases.

journal_name

Clin Exp Immunol

journal_title

Clinical and experimental immunology

authors

Oishi Y,Sakamoto A,Kurasawa K,Nakajima H,Nakao A,Nakagawa N,Tanabe E,Saito Y,Iwamoto I

doi

10.1046/j.1365-2249.2000.01157.x

subject

Has Abstract

pub_date

2000-03-01 00:00:00

pages

404-11

issue

3

eissn

0009-9104

issn

1365-2249

pii

cei1157

journal_volume

119

pub_type

杂志文章

相关文献

CLINICAL AND EXPERIMENTAL IMMUNOLOGY文献大全
  • Oxazolone and ethanol induce colitis in non-obese diabetic-severe combined immunodeficiency interleukin-2Rγ(null) mice engrafted with human peripheral blood mononuclear cells.

    abstract：:Oxazolone-induced colitis in mice has become a recognized model to study the efficacy of therapeutics targeting the immunological response underlying the development of inflammatory bowel disease. However, this model cannot be used when therapeutics designed to address human targets do not interact with the respective...

    journal_title：Clinical and experimental immunology

    pub_type： 杂志文章

    doi：10.1111/cei.12057

    authors： Nolte T,Zadeh-Khorasani M,Safarov O,Rueff F,Gülberg V,Herbach N,Wollenberg A,Mueller T,Siebeck M,Wolf E,Gropp R

    更新日期：2013-05-01 00:00:00

  • Autoantibodies to duodenal gastric-inhibitory-peptide (GIP) cells and to secretin (S) cells in patients with coeliac disease, tropical sprue and maturity-onset diabetes.

    abstract：:The presence of autoantibodies detected by immunofluorescence to single endocrine cells, of human duodenum is described in three groups of patients and two control groups. Of 173 coeliac cases, four had GIP cell antibodies, one had secretin cell antibodies and twenty-one reacted with both cell types. Of twelve tropica...

    journal_title：Clinical and experimental immunology

    pub_type： 杂志文章

    doi：

    authors： Mirakian R,Bottazzo GF,Doniach D

    更新日期：1980-07-01 00:00:00

  • Effects of therapy with highly active anti-retroviral therapy (HAART) and IL-2 on CD4+ and CD8+ lymphocyte apoptosis in HIV+ patients.

    abstract：:The kinetics and effects of in vivo spontaneous apoptosis and activation-induced cell death (AICD) upon CD4+ and CD8+ lymphocyte subsets and CD4 naive cell numbers were studied in HIV+ subjects with CD4 pretreatment values > 200/mm3, who were subsequently treated for 48 weeks with HAART alone or in combination with si...

    journal_title：Clinical and experimental immunology

    pub_type： 临床试验,杂志文章,随机对照试验

    doi：10.1046/j.1365-2249.2000.01187.x

    authors： Caggiari L,Zanussi S,Bortolin MT,D'andrea M,Nasti G,Simonelli C,Tirelli U,De Paoli P

    更新日期：2000-04-01 00:00:00

  • Minimal persistent inflammation in allergic rhinitis: implications for current treatment strategies.

    abstract：:Patients with allergic rhinitis have traditionally been placed into 'seasonal' and 'perennial' categories, which do not account for the subclinical inflammatory state that exists in many patients. In subjects with seasonal and perennial allergic rhinitis, even subthreshold doses of allergen have been found to cause in...

    journal_title：Clinical and experimental immunology

    pub_type： 杂志文章,评审

    doi：10.1111/j.1365-2249.2009.04017.x

    authors： Canonica GW,Compalati E

    更新日期：2009-12-01 00:00:00

  • Lupus anticoagulant activities of murine monoclonal antibodies to liposomal phosphatidylinositol phosphate.

    abstract：:Four murine monoclonal antibodies having high levels of activity against phosphatidyl-inositol phosphate (PIP) were tested for lupus anticoagulant activity. The antibodies showed different degrees of potency in a modified partial thromboplastin time test (APTT) that used dilutions of either bovine brain extract (Throm...

    journal_title：Clinical and experimental immunology

    pub_type： 杂志文章

    doi：

    authors： Alving BM,Banerji B,Fogler WE,Alving CR

    更新日期：1987-08-01 00:00:00

  • A human suppressor lymphocyte subpopulation identified by a heteroantiserum.

    abstract：:A rabbit antiserum has been prepared using peripheral mononuclear cells from a patient with common variable hypogammaglobulinaemia (CVH) who had demonstrable suppressor cells in vitro. This antiserum (anti-Ck), after absorption with pooled normal glass-non-adherent cells and platelets, showed selective reactivity with...

    journal_title：Clinical and experimental immunology

    pub_type： 杂志文章

    doi：

    authors： Rizzoli AJ,Bankhurst AD

    更新日期：1981-12-01 00:00:00

  • Low mannose-binding lectin (MBL) levels in neonates with pneumonia and sepsis.

    abstract：:We investigated whether deficiency of mannose-binding lectin (MBL), a component of innate immunity, is associated with neonatal pneumonia and sepsis during the first 72 h, i.e. early onset, and during the first month after birth. In 88 neonatal intensive care patients (71 premature), MBL2 genotype and MBL plasma level...

    journal_title：Clinical and experimental immunology

    pub_type： 杂志文章

    doi：10.1111/j.1365-2249.2007.03479.x

    authors： Frakking FN,Brouwer N,van Eijkelenburg NK,Merkus MP,Kuijpers TW,Offringa M,Dolman KM

    更新日期：2007-11-01 00:00:00

  • Haemoglobin content of multilayer E rosettes is a parameter of activated human T lymphocytes.

    abstract：:In stimulated cultures, a proportion of human T lymphocytes form multilayer rosettes with sheep red blood cells (SRBC) and they can be easily separated from common E rosettes by velocity sedimentation. We have developed a simplified method for harvesting multilayer rosettes and quantifying them. Practical applications...

    journal_title：Clinical and experimental immunology

    pub_type： 杂志文章

    doi：

    authors： Abuaf N,Leynadier F,Luce H,Dry J

    更新日期：1981-04-01 00:00:00

  • Functional behaviour and immunological phenotype of circulating B lymphocytes in multiple myeloma. Studies with pokeweed mitogen.

    abstract：:Peripheral blood B lymphocytes, depleted of adherent cells, from 10 patients with multiple myeloma were cultured in the presence of PWM with autologous or donor T lymphocytes. The results show that: (1) co-cultures with allogeneic T lymphocytes produced more plasma cells than those with autologous ones; (2) the kappa/...

    journal_title：Clinical and experimental immunology

    pub_type： 杂志文章

    doi：

    authors： Gobbi M,Caligaris-Cappio F,Campana D,Tazzari PL,Bergui L,Cavo M,Tura S

    更新日期：1984-12-01 00:00:00

  • A monoclonal IgM smooth muscle antibody reactive with fibroblast stress fibres produced by immunization with Treponema pallidum.

    abstract：:A monoclonal IgM smooth muscle antibody secreted by a hybrid (MMI-1) of mouse plasmacytoma NS-1 with spleen cells from mouse immunized with Treponema pallidum was detected by indirect immunofluorescence tests on frozen tissue sections and on acetone fixed monolayers of rat and human fibroblasts. The antibody did not r...

    journal_title：Clinical and experimental immunology

    pub_type： 杂志文章

    doi：

    authors： Strugnell RA,Underwood JR,Clarke FM,Pedersen JS,Chalmers PJ,Faine S,Toh BH

    更新日期：1983-06-01 00:00:00

  • The ABA-1 allergen of the nematode Ascaris suum: epitope stability, mass spectrometry, and N-terminal sequence comparison with its homologue in Toxocara canis.

    abstract：:ABA-1 is a major allergen of nematode parasites of the genus Ascaris which includes the large roundworms of humans and pigs, A. lumbricoides and A. suum, respectively. The allergen was purified from A. suum by immunoaffinity chromatography for immunochemical examination. The IgE antibody repertoire is under MHC contro...

    journal_title：Clinical and experimental immunology

    pub_type： 杂志文章

    doi：10.1111/j.1365-2249.1993.tb05958.x

    authors： Christie JF,Dunbar B,Kennedy MW

    更新日期：1993-04-01 00:00:00

  • Translational mini-review series on the immunogenetics of gut disease: immunogenetics of coeliac disease.

    abstract：:Recent advances in immunological and genetic research in coeliac disease provide new and complementary insights into the immune response driving this chronic intestinal inflammatory disorder. Both approaches confirm the central importance of T cell-mediated immune responses to disease pathogenesis and have further beg...

    journal_title：Clinical and experimental immunology

    pub_type： 杂志文章,评审

    doi：10.1111/j.1365-2249.2008.03704.x

    authors： Dubois PC,van Heel DA

    更新日期：2008-08-01 00:00:00

  • Inhibition of immune reactions in vivo by liposome associated transforming growth factor (TGF) type beta 1.

    abstract：:In view of its potent inhibitory capacity on immune cells in culture, we wished to determine the ability of transforming growth factor (TGF) beta 1 to down-regulate immune responses in vivo. Preliminary experiments suggested that, at the doses used, systemic injection of soluble TGF beta 1 could not affect bacterial-i...

    journal_title：Clinical and experimental immunology

    pub_type： 杂志文章

    doi：10.1111/j.1365-2249.1991.tb02965.x

    authors： Strassmann G,Bertolini DR,Eidelman O

    更新日期：1991-12-01 00:00:00

  • Interleukin-2 treatment reverses effects of cAMP-responsive element modulator α-over-expressing T cells in autoimmune-prone mice.

    abstract：:Systemic autoimmune diseases, such as systemic lupus erythematosus (SLE), are often characterized by a failure of self-tolerance and result in an uncontrolled activation of B cells and effector T cells. Interleukin (IL)-2 critically maintains homeostasis of regulatory T cells (T(reg)) and effector T cells in the perip...

    journal_title：Clinical and experimental immunology

    pub_type： 杂志文章

    doi：10.1111/cei.12629

    authors： Ohl K,Wiener A,Schippers A,Wagner N,Tenbrock K

    更新日期：2015-07-01 00:00:00

  • Metabolic fate of monovalent and multivalent antibodies of Heymann nephritis following formation of surface immune complexes on glomerular epithelial cells.

    abstract：:Heymann nephritis of the rat has several similarities to human idiopathic membranous glomerulo-nephropathy, and therefore serves as an animal model for study of the human disease. The disease process in the rat is initiated by autoantibodies forming in situ immune deposits on the surface of the glomerular epithelial c...

    journal_title：Clinical and experimental immunology

    pub_type： 杂志文章

    doi：10.1111/j.1365-2249.1993.tb08209.x

    authors： Singh AK,Kasinath BS

    更新日期：1993-12-01 00:00:00

  • Virus-specific cytotoxic T cell responses are associated with immunity of the cottontop tamarin to Epstein-Barr virus (EBV).

    abstract：:The cytotoxic responses of peripheral blood lymphocytes from cottontop tamarins to in vitro restimulation with autologous lymphoblastoid cell lines (LCL) were assayed. Lymphocytes from immune tamarins that had recovered from EBV challenge developed potent cytotoxicity for natural killer (NK) cell targets and for autol...

    journal_title：Clinical and experimental immunology

    pub_type： 杂志文章

    doi：10.1046/j.1365-2249.1996.d01-607.x

    authors： Wilson AD,Shooshstari M,Finerty S,Watkins P,Morgan AJ

    更新日期：1996-02-01 00:00:00

  • 5,7-dihydroxy-3,4,6-trimethoxyflavone inhibits the inflammatory effects induced by Bacteroides fragilis enterotoxin via dissociating the complex of heat shock protein 90 and I kappaB alpha and I kappaB kinase-gamma in intestinal epithelial cell culture.

    abstract：:Enterotoxin produced by enterotoxigenic Bacteroides fragilis (BFT) has been associated with mucosal inflammation and diarrhoeal diseases. In this study, the anti-inflammatory molecular mechanism of 5,7-dihydroxy-3,4,6-trimethoxyflavone (eupatilin) was characterized in an HT-29 intestinal epithelial cell line stimulate...

    journal_title：Clinical and experimental immunology

    pub_type： 杂志文章

    doi：10.1111/j.1365-2249.2008.03849.x

    authors： Kim JM,Lee DH,Kim JS,Lee JY,Park HG,Kim YJ,Oh YK,Jung HC,Kim SI

    更新日期：2009-03-01 00:00:00

  • Effects of activin A on IgE synthesis and cytokine production by human peripheral mononuclear cells.

    abstract：:Activin A not only stimulates the synthesis and release of pituitary follicle-stimulating hormone, but exerts various effects on haematopoietic cells, embryos, and fibroblasts. In the present study we have examined effects of activin A on IgE synthesis and cytokine production by peripheral blood mononuclear cells (PBM...

    journal_title：Clinical and experimental immunology

    pub_type： 杂志文章

    doi：10.1111/j.1365-2249.1993.tb06003.x

    authors： Yamashita N,Nakajima T,Takahashi H,Kaneoka H,Mizushima Y,Sakane T

    更新日期：1993-10-01 00:00:00

  • Emerging viruses and current strategies for vaccine intervention.

    abstract：:During the past decade several notable viruses have suddenly emerged from obscurity or anonymity to become serious global health threats, provoking concern regarding their sustained epidemic transmission in immunologically naive human populations. With each new threat comes the call for rapid vaccine development. Inde...

    journal_title：Clinical and experimental immunology

    pub_type： 杂志文章,评审

    doi：10.1111/cei.13295

    authors： Afrough B,Dowall S,Hewson R

    更新日期：2019-05-01 00:00:00

  • Polyclonal T cell elimination by prolonged immunostimulation in an experimental model.

    abstract：:An experimental model of immunological deficiency obtained by treating mice for 6 months with serum of human blood drawn from different healthy individuals has been studied. The results show that an alteration of a circulating lymphocyte population with alterations of the ratio CD4+/CD8+ appeared in mice stimulated fo...

    journal_title：Clinical and experimental immunology

    pub_type： 杂志文章

    doi：10.1111/j.1365-2249.1997.tb08315.x

    authors： Galdiero F,Galdiero M,Nuzzo I,Vitiello M,Bentivoglio C,Romano-Carratelli C

    更新日期：1997-11-01 00:00:00

  • In vitro production of IgE by human peripheral blood mononuclear cells. IV. Modulation by allergen of the spontaneous IgE antibody biosynthesis.

    abstract：:Peripheral blood lymphocytes (PBL) from a proportion of grass-sensitive patients, studied during or immediately after the grass pollination period, showed spontaneous production in vitro of grass-specific IgE antibody, whereas PBL from atopic patients sensitive to allergens other than grass pollens or non-atopic indiv...

    journal_title：Clinical and experimental immunology

    pub_type： 杂志文章

    doi：

    authors： Romagnani S,Maggi E,Del Prete GF,Almerigogna F,Biagiotti R,Giudizi MG,Ricci M

    更新日期：1982-07-01 00:00:00

  • Ketamine reduces inducible superoxide generation in human neutrophils in vitro by modulating the p38 mitogen-activated protein kinase (MAPK)-mediated pathway.

    abstract：:Many cellular stresses and inflammatory stimuli can activate p38 mitogen-activated protein kinase (MAPK), a serine/threonine kinase in the MAPK family. The different stimuli act via different receptors or signalling pathways to induce phosphorylation of the cytosolic protein p47(phox), one subunit of the nicotinamide ...

    journal_title：Clinical and experimental immunology

    pub_type： 杂志文章

    doi：10.1111/j.1365-2249.2010.04111.x

    authors： Lu HW,He GN,Ma H,Wang JK

    更新日期：2010-06-01 00:00:00

  • T cell clones from a non-leprosy exposed subject recognize the Mycobacterium leprae 18-kD protein.

    abstract：:Although Mycobacterium leprae shares many protein antigens with other mycobacterial species, there is a degree of specificity in the T cell response to the organism. This is evident in the failure of cross-protection between mycobacterial species and the specific unresponsiveness to M. leprae in lepromatous leprosy pa...

    journal_title：Clinical and experimental immunology

    pub_type： 杂志文章

    doi：10.1111/j.1365-2249.1995.tb06636.x

    authors： Adams E,Basten A,Prestidge R,Britton WJ

    更新日期：1995-10-01 00:00:00

  • Activation of the alternative complement pathway in systemic lupus erythematosus.

    abstract：:Serum factors activating the alternative pathway of complement in vitro, independent of classical pathway activation was demonstrated in six of eleven patients with systemic lupus erythematosus (SLE). These serum factors were detected by lysis of gluthathione-sensitized human erythrocytes and by C3 and factor B conver...

    journal_title：Clinical and experimental immunology

    pub_type： 杂志文章

    doi：

    authors： Wilson MR,Arroyave CM,Nakamura RM,Vaughan JH,Tan EM

    更新日期：1976-10-01 00:00:00

  • Daily subcutaneous injections of peptide induce CD4+ CD25+ T regulatory cells.

    abstract：:Peptide immunotherapy is being explored to modulate varied disease states; however, the mechanism of action remains poorly understood. In this study, we investigated the ability of a subcutaneous peptide immunization schedule to induce of CD4(+) CD25(+) T regulatory cells. DO11.10 T cell receptor (TCR) transgenic mice...

    journal_title：Clinical and experimental immunology

    pub_type： 杂志文章

    doi：10.1111/j.1365-2249.2007.03402.x

    authors： Dahlberg PE,Schartner JM,Timmel A,Seroogy CM

    更新日期：2007-08-01 00:00:00

  • Correlations among cutaneous reactivity to DNCB, PHA-induced lymphocyte blastogenesis and peripheral blood E rosettes.

    abstract：:Comparisons of the results obtained in a study of fifty-two patients with genitourinary malignancies using three assays to monitor the thymus-dependent immune system (delayed cutaneous hypersensitivity to DNCB, PHA-induced lymphocyte blastogenesis, and peripheral blood E rosette-forming lymphocyte counts) yielded stat...

    journal_title：Clinical and experimental immunology

    pub_type： 杂志文章

    doi：

    authors： Catalona WJ,Tarpley JL,Potvin C,Chretien PB

    更新日期：1975-02-01 00:00:00

  • Evidence that factors other than particular thyrotropin receptor T cell epitopes contribute to the development of hyperthyroidism in murine Graves' disease.

    abstract：:Immunization with thyrotropin receptor (TSHR)-adenovirus is an effective approach for inducing thyroid stimulating antibodies and Graves' hyperthyroidism in BALB/c mice. In contrast, mice of the same strain vaccinated with TSHR-DNA have low or absent TSHR antibodies and their T cells recognize restricted epitopes on t...

    journal_title：Clinical and experimental immunology

    pub_type： 杂志文章

    doi：10.1111/j.1365-2249.2004.02399.x

    authors： Pichurin PN,Chen CR,Nagayama Y,Pichurina O,Rapoport B,McLachlan SM

    更新日期：2004-03-01 00:00:00

  • Desialylation of dying cells with catalytically active antibodies possessing sialidase activity facilitate their clearance by human macrophages.

    abstract：:Recently we reported the first known incidence of antibodies possessing catalytic sialidase activity (sialidase abzymes) in the serum of patients with multiple myeloma and systemic lupus erythematosus (SLE). These antibodies desialylate biomolecules, such as glycoproteins, gangliosides and red blood cells. Desialylati...

    journal_title：Clinical and experimental immunology

    pub_type： 杂志文章

    doi：10.1111/cei.12312

    authors： Tomin A,Dumych T,Tolstyak Y,Kril I,Mahorivska I,Bila E,Stoika R,Herrmann M,Kit Y,Bilyy R

    更新日期：2015-01-01 00:00:00

  • Human lymphocyte markers defined by antibodies derived from somatic cell hybrids. II. A hybridoma secreting antibody against an antigen expressed by human B and null lymphocytes.

    abstract：:A hybridoma (FMC4) has been derived which secretes antibody showing selective reaction with human B lymphocytes, monocytes and some null lymphocytes. Few, if any, T lymphocytes in normal blood are stained, although stimulation of lymphocytes with PHA leads to an increase in the proportion of cells reacting with the hy...

    journal_title：Clinical and experimental immunology

    pub_type： 杂志文章

    doi：

    authors： Beckman IG,Bradley J,Brooks DA,Kupa A,McNamara PJ,Thomas ME,Zola H

    更新日期：1980-06-01 00:00:00

  • H-ferritin and proinflammatory cytokines are increased in the bone marrow of patients affected by macrophage activation syndrome.

    abstract：:Macrophage activation syndrome (MAS) is hyperinflammatory life-threatening syndrome, associated typically with high levels of serum ferritin. This is an iron storage protein including heavy (H) and light (L) subunits, categorized on their molecular weight. The H-/L subunits ratio may be different in tissues, depending...

    journal_title：Clinical and experimental immunology

    pub_type： 杂志文章

    doi：10.1111/cei.13057

    authors： Ruscitti P,Cipriani P,Di Benedetto P,Liakouli V,Berardicurti O,Carubbi F,Ciccia F,Guggino G,Triolo G,Giacomelli R

    更新日期：2018-02-01 00:00:00