Lupus anticoagulant activities of murine monoclonal antibodies to liposomal phosphatidylinositol phosphate.

abstract：:Monoclonal anti-dermatan sulphate antibodies were produced with hybridization after immunizing BALB/c mice with dermatan sulphate (DS). These antibodies were tested for cross-reactivity to double-stranded DNA (dsDNA) and heat-denatured DNA (ssDNA). Five clones had binding activity to DS, dsDNA and ssDNA in enzyme-link...

journal_title：Clinical and experimental immunology

authors： Ohnishi K,Sagawa A,Nakabayashi T,Ohmoto A,Megumi,Yoshikawa M,Watanabe I,Mukai M,Yasuda I,Nakagawa S

更新日期：1989-01-01 00:00:00

abstract：:Ten out of 20 (50%) 17-week-old female NOD/WEHI mice developed an acute form of autoimmune diabetes when injected with two large doses of cyclophosphamide (CY), given at 14-day intervals. If these mice were treated under a prophylactic regimen with 2.5 mg/kg body weight per day of the novel immunosuppressant deoxysper...

journal_title：Clinical and experimental immunology

authors： Nicoletti F,Borghi MO,Meroni PL,Barcellini W,Fain C,Di Marco R,Menta R,Schorlemmer HU,Bruno G,Magro G

更新日期：1993-02-01 00:00:00

abstract：:Hybridization of peripheral blood lymphocytes from patients with rheumatoid arthritis has yielded 14 monoclonal antibodies which react with cultured human epithelial cells. Immunofluorescence staining identifies at last five different types of antibody. Solid phase immunosorbent assays show a variety of cross-reaction...

journal_title：Clinical and experimental immunology

authors： Haskard DO,Gul V,Morgan A,Kataaha P,Staines NA,Archer JR

更新日期：1985-09-01 00:00:00

abstract：:The IL-15 triggering effect of gliadin is not exclusive to coeliac disease (CD) patients, whereas the secondary response is CD specific. We have studied the expression of the IL-15 receptor, and the IL-15 response upon stimulation, in non-CD and CD patients, and the possible existence of a lower immunological threshol...

journal_title：Clinical and experimental immunology

authors： Bernardo D,Garrote JA,Allegretti Y,León A,Gómez E,Bermejo-Martin JF,Calvo C,Riestra S,Fernández-Salazar L,Blanco-Quirós A,Chirdo F,Arranz E

更新日期：2008-10-01 00:00:00

abstract：:Asthma is a chronic inflammatory disease affecting the airways. Increased levels of T cells are found in the lungs after the induction of an allergic-like inflammation in rats, and flow cytometry studies have shown that these levels are reduced in CD26-deficient rats. However, the precise anatomical sites where these ...

journal_title：Clinical and experimental immunology

authors： Schade J,Schmiedl A,Kehlen A,Veres TZ,Stephan M,Pabst R,von Hörsten S

更新日期：2009-10-01 00:00:00

abstract：:Our aims were to identify the differential expression of microRNA (miR)-155, as well as to explore the possible regulatory effects of miR-155 on the differentiation and function of T helper type 17 (Th17) cells in atopic dermatitis (AD). The Th17 cell percentage and expression levels of miR-155, retinoic acid-related ...

journal_title：Clinical and experimental immunology

authors： Ma L,Xue HB,Wang F,Shu CM,Zhang JH

更新日期：2015-07-01 00:00:00

abstract：:This study examined the expression of the inhibitory receptor, leucocyte-associated immunoglobulin (Ig)-like receptor-1 (LAIR-1) in fibroblast-like synoviocytes (FLS) in rheumatoid arthritis (RA) patients to investigate its potential role in the modulation of inflammatory cytokines, matrix metalloproteinases (MMPs) an...

journal_title：Clinical and experimental immunology

authors： Zhang Y,Wang S,Dong H,Yi X,Zhang J,Liu X,Zhuang R,Ding Y

更新日期：2018-05-01 00:00:00

abstract：:Tumour necrosis factor (TNF)-alpha and interferon (IFN)-gamma exert detrimental effects in organ-specific autoimmune disease, while both destructive and protective roles have been demonstrated for interleukin (IL)-10, IL-4 and IL-5. We examined the production of these cytokines by peripheral blood mononuclear cells (P...

journal_title：Clinical and experimental immunology

authors： Nielsen CH,Hegedüs L,Rieneck K,Moeller AC,Leslie RG,Bendtzen K

更新日期：2007-02-01 00:00:00

abstract：:An expanded T cell subpopulation (CD8+ Leu-7+) has previously been reported in the peripheral blood of patients with Crohn's disease. This subpopulation of T cells was associated with a 'covert suppressor' function, particularly in patients with mild/early Crohn's disease, suppressing immunoglobulin production in vitr...

journal_title：Clinical and experimental immunology

authors： Deem RL,Targan SR,Niederlehner A,Shanahan F

更新日期：1990-06-01 00:00:00

abstract：:A positive Mitsuda skin test for delayed type hypersensitivity to Mycobacterium leprae is associated with a high level of protection against lepromatous leprosy, while the value of tuberculin sensitivity in leprosy is less pronounced. Cutaneous lymphocytes, isolated from the Mitsuda reaction of a PPD-positive individu...

journal_title：Clinical and experimental immunology

authors： Roberts PP,Dockrell HM,McAdam KP

更新日期：1988-06-01 00:00:00

abstract：:Several studies in murine systems have suggested a role of apoptosis in the pathogenesis of leishmaniasis. However, the role of apoptosis in visceral leishmaniasis in man has not been explored. In this study, we show that patients with visceral leishmaniasis demonstrate significant dysregulation of Fas and Fas ligand....

journal_title：Clinical and experimental immunology

authors： Eidsmo L,Wolday D,Berhe N,Sabri F,Satti I,El Hassan AM,Sundar S,Chiodi F,Akuffo H

更新日期：2002-11-01 00:00:00

abstract：:Patients with functional deficiency of C1-inhibitor (C1-INH) suffer from recurrent acute attacks (AA) of localized oedema associated with activation of the contact system, complement and fibrinolysis. To unravel further the role of coagulation and fibrinolysis in the pathophysiology of C1-INH deficiency, we performed ...

journal_title：Clinical and experimental immunology

authors： van Geffen M,Cugno M,Lap P,Loof A,Cicardi M,van Heerde W

更新日期：2012-03-01 00:00:00

abstract：:One hundred and sixty-six unrelated children and adolescents having growth-onset, insulin-dependent diabetes mellitus (IDD) were studied for pancreatic-cytoplasmic islet cell antibodies (ICA) at various times from the diagnosis of the disease. A strong association between HLA antigens A9 and Bw16 and an absence of ICA...

journal_title：Clinical and experimental immunology

authors： Mustonen A,Ilonen J,Akerblom HK,Tiilikainen A

更新日期：1982-04-01 00:00:00

abstract：:Human mononuclear leucocytes (MNL) or the adherent fraction (monocytes) produced tumour necrosis factor-alpha (TNF-alpha) (by ELISA) in culture when stimulated with killed Staphylococcus aureus. The bisbenzylisoquinoline alkaloid, tetrandrine inhibited the capacity of MNL and monocytes to produce TNF-alpha at a concen...

journal_title：Clinical and experimental immunology

authors： Ferrante A,Seow WK,Rowan-Kelly B,Thong YH

更新日期：1990-05-01 00:00:00

abstract：:We serially monitored cell surface antigen expression on mononuclear cells in peripheral blood isolated from patients with Kawasaki disease (KD), and found, for the first time, that a markedly increased number of CD4+CD8+ T lymphocytes was present in some of the patients (11 of the 24 cases). The cases of five of thes...

journal_title：Clinical and experimental immunology

authors： Hirao J,Sugita K

更新日期：1998-02-01 00:00:00

abstract：:Type 1 diabetes (T1D) is an autoimmune disease caused by the T cell-mediated destruction of the pancreatic insulin-producing beta cells. Currently there are no widely accepted and standardized assays available to analyse the function of autoreactive T cells involved in T1D. The development of such an assay would great...

journal_title：Clinical and experimental immunology

authors： Mannering SI,Wong FS,Durinovic-Belló I,Brooks-Worrell B,Tree TI,Cilio CM,Schloot NC,Mallone R,Immunology of Diabetes Society T-Cell Workshop Committee.

更新日期：2010-11-01 00:00:00

abstract：:It has earlier been reported that the human monoclonal antibody (MoAb 33G2) and polyclonal antibodies reactive with Pf332 may interfere in vitro with the erythrocytic cycle of Plasmodium falciparum at two potential target sites for protective antibodies, indicating that the antigen may constitute an important target f...

journal_title：Clinical and experimental immunology

authors： Iqbal J,Perlmann P,Greenwood BM,Berzins K

更新日期：1993-10-01 00:00:00

abstract：:Cytoplasmic free Ca2+ concentration and influx of 86Rb+ (K+ analogue) were determined during the first minutes after stimulation of neoplastic human B cells and B cell lines by antibodies to surface Ig. The Ca2+ concentration increased in the great majority of samples (41 of 48). All of four B cell lines also responde...

journal_title：Clinical and experimental immunology

authors： Heikkilä R,Ruud E,Funderud S,Godal T

更新日期：1985-03-01 00:00:00

abstract：:We describe two brothers with marked leucopenia, lymphopenia, no immunologicl response to infections (no Ig production, negative PHA response and very low number of T and B lymphocytes in peripheral blood) and hypocellular marrow. They died at 12 and 8 days of life with infection (E. coli and Klebsiella, respectively)...

journal_title：Clinical and experimental immunology

authors： Español T,Compte J,Alvarez C,Tallada N,Laverde R,Peguero G

更新日期：1979-12-01 00:00:00

abstract：:Human thymic stromal lymphopoietin (TSLP) promotes CD4(+) T-cell proliferation both directly and indirectly through dendritic cell (DC) activation. Although human TSLP-activated DCs induce CD8(+) T-cell proliferation, it is not clear whether TSLP acts directly on CD8(+) T cells. In this study, we show that human CD8(+...

journal_title：Clinical and experimental immunology

authors： Akamatsu T,Watanabe N,Kido M,Saga K,Tanaka J,Kuzushima K,Nishio A,Chiba T

更新日期：2008-10-01 00:00:00

abstract：:This study evaluates the correlation between natural killer (NK) cell function and human immunodeficiency virus (HIV)-1 disease progression in 133 untreated HIV-1 positive Chinese subjects, including 41 former plasma donors (FPDs) and 92 men who have sex with men, and 35 HIV-negative controls. Flow cytometry was used ...

journal_title：Clinical and experimental immunology

authors： Jia M,Li D,He X,Zhao Y,Peng H,Ma P,Hong K,Liang H,Shao Y

更新日期：2013-01-01 00:00:00

abstract：:Adjuvant arthritis in Lewis rats is a model of T cell-mediated autoimmune arthritis resembling human rheumatoid arthritis. A nonapeptide from the 65-kD heat-shock protein of Mycobacterium bovis BCG, amino acid sequence 180-188, has been described to carry the dominant immunogenic epitope(s) for both arthritis-protecti...

journal_title：Clinical and experimental immunology

authors： Yang XD,Gasser J,Feige U

更新日期：1990-08-01 00:00:00

abstract：:Cells from the peripheral blood of patients with B cell chronic lymphocytic leukaemia (B-CLL) and acute lymphoblastic leukaemia (ALL) were examined for the expression of MHC class II antigens, using a number of monoclonal antibodies (MoAb) including L243 (anti-DR) and TU22 (anti-DQ). There was wide variation in expres...

journal_title：Clinical and experimental immunology

authors： Guy K,Docherty LJ,Dewar AE

更新日期：1986-02-01 00:00:00

abstract：:Kawasaki disease (KD) is an acute febrile illness of early childhood, in which the activation of monocytes/macrophages plays a central role in the development of vasculitis during the acute stage of disease. In this study we investigated peripheral blood T cells of 10 patients with KD, focusing on the Th1 and Th2 imba...

journal_title：Clinical and experimental immunology

authors： Matsubara T,Katayama K,Matsuoka T,Fujiwara M,Koga M,Furukawa S

更新日期：1999-06-01 00:00:00

abstract：:Anaphylaxis denotes an immediate hypersensitivity reaction to allergen, exclusively mediated by IgE antibodies. However, IgE antibodies do not explain all the syndromes that are encountered. We investigated potent IgG-mediated anaphylaxis in CD40-deficient mice that lack the immunoglobulin class switching for T cell-d...

journal_title：Clinical and experimental immunology

authors： Wakayama H,Hasegawa Y,Kawabe T,Saito H,Kikutani H,Shimokata K

更新日期：1998-11-01 00:00:00

abstract：:Schizophrenic patients are reported to have immunological dysfunction, however, the immune response to surgery in schizophrenic patients remains unclear. We measured plasma interleukin-6 (IL-6), interleukin-8 (IL-8) and tumour necrosis factor-alpha (TNF-alpha) before, during and after colectomy, hemicolectomy and sigm...

journal_title：Clinical and experimental immunology

authors： Kudoh A,Sakai T,Ishihara H,Matsuki A

更新日期：2001-07-01 00:00:00

abstract：:Serum and salivary responses of 95 infants to either a standard (4 x 10(4) plaque-forming units (PFU), 47 neonates) or a high dose (4 x 10(5) PFU, 48 neonates) of tetravalent reassortant rhesus rotavirus vaccine (administered at 2 days and at 6 weeks of age) were evaluated in a double-blind clinical trial. Serum and s...

journal_title：Clinical and experimental immunology

authors： Friedman MG,Segal B,Zedaka R,Sarov B,Margalith M,Bishop R,Dagan R

更新日期：1993-05-01 00:00:00

abstract：:Lymphocyte and neutrophil locomotion were studied in 23 patients with well defined, primary immunodeficiencies. These included eight patients with common variable immune deficiency, three patients with X-linked agammaglobulinaemia, two patients with the Wiskott-Aldrich syndrome, three patients with ataxia telangiectas...

journal_title：Clinical and experimental immunology

authors： Van Epps DE,El-Naggar A,Ochs HD

更新日期：1983-09-01 00:00:00

abstract：:Lymphocytes and plasma cells in the peripheral blood and bone marrow of patients with multiple myeloma, benign monoclonal gammopathy and Waldenström's macroglobulinaemia were investigated for their cytoplasmic immunoglobulin distribution. Anti-idiotypic sera were used as markers for monoclonality. Double-wavelength fl...

journal_title：Clinical and experimental immunology

authors： Van Camp B,Reynaert P,Broodtaerts L

更新日期：1981-04-01 00:00:00

abstract：:This study tested the hypothesis that pregnant female baboons exhibit increased levels of various inflammatory mediators in serum resulting from ligature-induced periodontitis, and that these profiles would relate to periodontal disease severity/extent in the animals. The animals were sampled at baseline (B), mid-preg...

journal_title：Clinical and experimental immunology

authors： Ebersole JL,Steffen MJ,Holt SC,Kesavalu L,Chu L,Cappelli D

更新日期：2010-12-01 00:00:00