Evidence that the Mitsuda reaction to Mycobacterium leprae can be mediated by lymphocytes responsive to Mycobacterium tuberculosis.

Abstract:

:A positive Mitsuda skin test for delayed type hypersensitivity to Mycobacterium leprae is associated with a high level of protection against lepromatous leprosy, while the value of tuberculin sensitivity in leprosy is less pronounced. Cutaneous lymphocytes, isolated from the Mitsuda reaction of a PPD-positive individual not previously exposed to M. leprae, were cloned with Dharmendra lepromin and analysed for antigen specificity. Thirteen lepromin-responsive cell lines were derived, with greater than 95% certainty that the number of true clones was at least five and the number of functionally monoclonal lines at least seven. All lepromin-responsive clones proliferated in response to PPD as well, implying that PPD-responsive cells can fulfill the helper T cell function required for the in vivo Mitsuda reaction.

journal_name

Clin Exp Immunol

authors

Roberts PP,Dockrell HM,McAdam KP

subject

Has Abstract

pub_date

1988-06-01 00:00:00

pages

390-3

issue

3

eissn

0009-9104

issn

1365-2249

journal_volume

72

pub_type

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