Evidence that the Mitsuda reaction to Mycobacterium leprae can be mediated by lymphocytes responsive to Mycobacterium tuberculosis.

Abstract:

:A positive Mitsuda skin test for delayed type hypersensitivity to Mycobacterium leprae is associated with a high level of protection against lepromatous leprosy, while the value of tuberculin sensitivity in leprosy is less pronounced. Cutaneous lymphocytes, isolated from the Mitsuda reaction of a PPD-positive individual not previously exposed to M. leprae, were cloned with Dharmendra lepromin and analysed for antigen specificity. Thirteen lepromin-responsive cell lines were derived, with greater than 95% certainty that the number of true clones was at least five and the number of functionally monoclonal lines at least seven. All lepromin-responsive clones proliferated in response to PPD as well, implying that PPD-responsive cells can fulfill the helper T cell function required for the in vivo Mitsuda reaction.

journal_name

Clin Exp Immunol

authors

Roberts PP,Dockrell HM,McAdam KP

subject

Has Abstract

pub_date

1988-06-01 00:00:00

pages

390-3

issue

3

eissn

0009-9104

issn

1365-2249

journal_volume

72

pub_type

杂志文章
  • Short-term simvastatin treatment has no effect on plasma cytokine response in a human in vivo model of low-grade inflammation.

    abstract::Statins reduce plasma cholesterol, but clinical trials and in vitro studies indicate that they might also possess anti-inflammatory properties. The effect of simvastatin on circulating cytokines and leucocytes was evaluated in a human in vivo model of low-grade inflammation. Thirty young healthy male participants rece...

    journal_title:Clinical and experimental immunology

    pub_type: 杂志文章,随机对照试验

    doi:10.1111/j.1365-2249.2006.03042.x

    authors: Erikstrup C,Ullum H,Pedersen BK

    更新日期:2006-04-01 00:00:00

  • Splenic regulation of the murine pulmonary lymph node response.

    abstract::Exposure to intratracheal immunization and aerosolization with soluble antigen plus murmayl-dipeptide (MDP) induces the development of plaque-forming cells in the pulmonary draining lymph nodes of two of three inbred mouse strains. Splenectomy before immunization led to a heightened plaque-forming cell response in the...

    journal_title:Clinical and experimental immunology

    pub_type: 杂志文章

    doi:

    authors: Allen EM,Abramoff P,Fink JN,Calvanico NJ

    更新日期:1987-08-01 00:00:00

  • Human monoclonal antibodies for the immunological characterization of a highly conserved protein domain of the hepatitis C virus glycoprotein E1.

    abstract::Although both envelope glycoproteins of the hepatitis C virus, E1 and E2/NS1, show a high degree of sequence variation, the E1 protein includes a well conserved domain, which may be functionally important. We have analysed the human B cell response to a peptide fragment from amino acid residues 314-330 (EP3) covering ...

    journal_title:Clinical and experimental immunology

    pub_type: 杂志文章

    doi:10.1111/j.1365-2249.1995.tb08351.x

    authors: Siemoneit K,Cardoso Mda S,Koerner K,Wölpl A,Kubanek B

    更新日期:1995-08-01 00:00:00

  • IL-6-induced anaemia in rats: possible pathogenetic implications for anemia observed in chronic inflammations.

    abstract::Anaemia of chronic disease (ACD) is frequently found in rheumatoid arthritis (RA). In the pathogenesis of ACD both cytokines, such as tumour necrosis factor-alpha (TNF-alpha), IL-1 and IL-6 as well as a relative deficiency of erythropoietin (EPO), are thought to play a key role. In the present study the role of IL-6 i...

    journal_title:Clinical and experimental immunology

    pub_type: 杂志文章

    doi:10.1046/j.1365-2249.1996.d01-622.x

    authors: Jongen-Lavrencic M,Peeters HR,Rozemuller H,Rombouts WJ,Martens AC,Vreugdenhil G,Pillay M,Cox PH,Bijser M,Brutel G,Breedveld FC,Swaak AJ

    更新日期:1996-02-01 00:00:00

  • Beta-2-glycoprotein I expression on monocytes is increased in anti-phospholipid antibody syndrome and correlates with tissue factor expression.

    abstract::It is well known that monocytes may play an active role in thrombogenesis, since they may express on their surface tissue factor, the major initiator of the clotting cascade. The results of this investigation demonstrate beta-2-glycoprotein I (beta2-GPI) mRNA expression by human peripheral blood monocytes, indicating ...

    journal_title:Clinical and experimental immunology

    pub_type: 杂志文章

    doi:10.1046/j.1365-2249.2003.02180.x

    authors: Conti F,Sorice M,Circella A,Alessandri C,Pittoni V,Caronti B,Calderaro C,Griggi T,Misasi R,Valesini G

    更新日期:2003-06-01 00:00:00

  • The effect of cell death in the initiation of lupus nephritis.

    abstract::Cell death and the release of chromatin have been demonstrated to activate the immune system producing autoantibodies against nuclear antigens in patients with systemic lupus erythematosus (SLE). Apoptosis, necrosis, necroptosis, secondary necrosis, autophagy and the clearance of dying cells by phagocytosis are proces...

    journal_title:Clinical and experimental immunology

    pub_type: 杂志文章,评审

    doi:10.1111/cei.12417

    authors: Fenton K

    更新日期:2015-01-01 00:00:00

  • Differential activation of the immune system by virulent Streptococcus pneumoniae strains determines recovery or death of the host.

    abstract::Streptococcus pneumoniae infection may result in asymptomatic carriage, mucosal or invasive disease. We hypothesize that self-limiting or fatal disease outcome follows infection with S. pneumoniae differential activation of the host immune response. BALB/c and C57BL/6 mice were inoculated intranasally with S. pneumoni...

    journal_title:Clinical and experimental immunology

    pub_type: 杂志文章

    doi:10.1046/j.1365-2249.2003.02261.x

    authors: Mizrachi-Nebenzahl Y,Lifshitz S,Teitelbaum R,Novick S,Levi A,Benharroch D,Ling E,Dagan R

    更新日期:2003-10-01 00:00:00

  • Functional deficiency of complement factor D in a monozygous twin.

    abstract::An adult twin with recurrent bacterial infections was found to have a partial functional deficiency of complement factor D. Full restoration of alternative pathway activity and zymosan- or cobra venom factor-induced consumption of C3 and B was found after reconstitution of patient's serum with purified D. Family studi...

    journal_title:Clinical and experimental immunology

    pub_type: 杂志文章

    doi:

    authors: Kluin-Nelemans HC,van Velzen-Blad H,van Helden HP,Daha MR

    更新日期:1984-12-01 00:00:00

  • Characterization of immunological depression in mice exposed to normobaric oxygen.

    abstract::Immunological cell functions were evaluated during 24, 48 and 96 h O2 exposure in C57Bl/6 mice. A normobaric O2 exposure resulted in depression of delayed type hypersensitivity (DTH) to oxazolone and Staphylococcus aureus antigens. This effect was proportional to the duration of O2 exposure. The antibody response of s...

    journal_title:Clinical and experimental immunology

    pub_type: 杂志文章

    doi:

    authors: Levacher-Place M,Gougerot-Pocidalo MA,Rouveix B,Kraus L,Pocidalo JJ

    更新日期:1983-11-01 00:00:00

  • Cytokines in synovial fluid. I. The presence of biologically active and immunoreactive IL-1.

    abstract::Using a sensitive IL-1-dependent T cell clone we estimated interleukin 1 (IL-1)-like activity in a variety of synovial fluids (SF). Although we demonstrate that SF contains potent inhibitors of endogenous and exogenous IL-1 we were able to estimate that samples from rheumatoid arthritis, osteoarthritis and other arthr...

    journal_title:Clinical and experimental immunology

    pub_type: 杂志文章

    doi:

    authors: Hopkins SJ,Humphreys M,Jayson MI

    更新日期:1988-06-01 00:00:00

  • Inhibition of immune reactions in vivo by liposome associated transforming growth factor (TGF) type beta 1.

    abstract::In view of its potent inhibitory capacity on immune cells in culture, we wished to determine the ability of transforming growth factor (TGF) beta 1 to down-regulate immune responses in vivo. Preliminary experiments suggested that, at the doses used, systemic injection of soluble TGF beta 1 could not affect bacterial-i...

    journal_title:Clinical and experimental immunology

    pub_type: 杂志文章

    doi:10.1111/j.1365-2249.1991.tb02965.x

    authors: Strassmann G,Bertolini DR,Eidelman O

    更新日期:1991-12-01 00:00:00

  • Influence of the mouse Bcg, Tbc-1 and xid genes on resistance and immune responses to tuberculosis infection and efficacy of bacille Calmette-Guérin (BCG) vaccination.

    abstract::We have studied the role of three mouse distinct non-H-2 genes (Bcg, Tbc-1, xid) in several phenomena of antituberculosis immunity and resistance. On the basis of median survival time (MST) of mice following infection with virulent Mycobacterium tuberculosis H37Rv, Bcg gene did not control resistance to the lethal dos...

    journal_title:Clinical and experimental immunology

    pub_type: 杂志文章

    doi:10.1046/j.1365-2249.1996.d01-643.x

    authors: Nikonenko BV,Apt AS,Mezhlumova MB,Avdienko VG,Yeremeev VV,Moroz AM

    更新日期:1996-04-01 00:00:00

  • Efficacy, safety, tolerability and pharmacokinetics of a novel human immune globulin subcutaneous, 20%: a Phase 2/3 study in Europe in patients with primary immunodeficiencies.

    abstract::A highly concentrated (20%) immunoglobulin (Ig)G preparation for subcutaneous administration (IGSC 20%), would offer a new option for antibody replacement therapy in patients with primary immunodeficiency diseases (PIDD). The efficacy, safety, tolerability and pharmacokinetics of IGSC 20% were evaluated in a prospecti...

    journal_title:Clinical and experimental immunology

    pub_type: 杂志文章,多中心研究

    doi:10.1111/cei.12866

    authors: Borte M,Kriván G,Derfalvi B,Maródi L,Harrer T,Jolles S,Bourgeois C,Engl W,Leibl H,McCoy B,Gelmont D,Yel L

    更新日期:2017-01-01 00:00:00

  • Hypogalactosylation of serum IgG in patients with coeliac disease.

    abstract::Coeliac disease (CD) is described as an autoimmune enteropathy associated with the presence of IgG and IgA antigliadin and antitransglutaminase autoantibodies. While of diagnostic significance, the role of these autoantibodies in the immunopathogenesis of CD is elucidated. An inappropriate T cell immune response to gl...

    journal_title:Clinical and experimental immunology

    pub_type: 杂志文章

    doi:10.1046/j.1365-2249.2003.02220.x

    authors: Cremata JA,Sorell L,Montesino R,Garcia R,Mata M,Cabrera G,Galvan JA,Garcia G,Valdes R,Garrote JA

    更新日期:2003-09-01 00:00:00

  • Circulating cytokine balance and activation markers of leucocytes in Q fever.

    abstract::As Q fever is associated with an inflammatory syndrome, we determined circulating levels of inflammatory cytokines, cytokine antagonists, and activation markers of leucocytes in patients with acute Q fever and Q fever endocarditis. Tumour necrosis factor (TNF) and IL-6, but not IL-1beta, were markedly increased compar...

    journal_title:Clinical and experimental immunology

    pub_type: 杂志文章

    doi:10.1046/j.1365-2249.1999.00786.x

    authors: Capo C,Amirayan N,Ghigo E,Raoult D,Mege J

    更新日期:1999-01-01 00:00:00

  • Cell-mediated immunity to hepatitis B virus antigens in mice: correlation of in vivo and in vitro assays.

    abstract::Cell mediated immunity (CMI) to hepatitis B viral antigens was studied in BALB/mice after immunization with purified hepatitis B surface antigen (HBsAg), or core antigen (HBcAg), with adjuvants. The two in vitro assays for cell-mediated immunity (CMI), utilizing lymph node cells, were release of interferon after expos...

    journal_title:Clinical and experimental immunology

    pub_type: 杂志文章

    doi:

    authors: De Moerloose PA,Frazer IH,Sewell WA,Collins EJ,Mackay IR

    更新日期:1986-05-01 00:00:00

  • Regulation of IgA secretion in polyclonally induced in vitro human lymphocyte cultures: the function of T and B cells from mesenteric lymph nodes and peripheral blood.

    abstract::Human gut-associated immunoregulatory events were studied in a pokeweed mitogen (PWM)-stimulated culture system using lymphocytes obtained from the mesenteric lymph nodes (MLN) of female subjects undergoing gastroplasty for obesity. Compared with peripheral blood lymphocytes, lymphocytes obtained from MLN secreted IgG...

    journal_title:Clinical and experimental immunology

    pub_type: 杂志文章

    doi:

    authors: Pang G,Yeung S,Clancy RL,Cripps AW,Hennessy EJ,Santhanam AN

    更新日期:1986-04-01 00:00:00

  • Antibody-mediated adherence of rat eosinophils to schistosomula of Schistoma mansoni in vitro.

    abstract::Eosinophils from the peritoneal washings of normal rats adhered to live or formalin-fixed schistosomula of Schistosoma mansoni in vitro, in the presence of heat-inactivated serum from infected rats. Eosinophil adherence caused permeability changes in the schistosomula as revealed by 51Cr release and methylene blue upt...

    journal_title:Clinical and experimental immunology

    pub_type: 杂志文章

    doi:

    authors: Mackenzie CD,Ramalho-Pinto FJ,McLaren DJ,Smithers SR

    更新日期:1977-10-01 00:00:00

  • Multiple sclerosis: II. Effects of prothymosin alpha on the autologous and allogeneic MLR in patients with multiple sclerosis.

    abstract::We have recently demonstrated that peripheral blood monocytes from patients with multiple sclerosis (MS) have a defect in stimulating autologous and allogeneic T lymphocytes. This defect was found to correlate with disease activity. In this report we demonstrate that prothymosin alpha (ProT alpha), a rat thymus fracti...

    journal_title:Clinical and experimental immunology

    pub_type: 杂志文章

    doi:

    authors: Reclos GJ,Baxevanis CN,Sfagos C,Papageorgiou C,Tsokos GC,Papamichail M

    更新日期:1987-11-01 00:00:00

  • Increased expression of class II antigens of the major histocompatibility complex on alveolar macrophages and alveolar type II cells and interleukin-1 (IL-1) secretion from alveolar macrophages in an animal model of silicosis.

    abstract::Silicosis is a chronic progressive granulomatous and fibrotic lung disease caused by inhaled silica. Although the causative agent is known, the pathogenesis, especially the immunologic response, is not well understood. We examined two important components of cell-mediated immune responses in the lungs of rats with sil...

    journal_title:Clinical and experimental immunology

    pub_type: 杂志文章

    doi:

    authors: Struhar DJ,Harbeck RJ,Gegen N,Kawada H,Mason RJ

    更新日期:1989-08-01 00:00:00

  • Soluble histocompatibility antigens in synovial fluids of patients with rheumatoid arthritis.

    abstract::Soluble histocompatibility antigens of the class II region have been detected in synovial fluids obtained from patients with rheumatoid arthritis. A capture immunoassay involving two monoclonal antibodies was used; interference by rheumatoid factor, which is a feature of such assays, was overcome by mild pretreatment ...

    journal_title:Clinical and experimental immunology

    pub_type: 杂志文章

    doi:10.1111/j.1365-2249.1990.tb06437.x

    authors: Stevenson FK,Douglass WA,Spellerberg MB,Walters MT,Cawley MI

    更新日期:1990-04-01 00:00:00

  • Effects of oestradiol and raloxifene on the induction and effector phases of experimental postmenopausal arthritis and secondary osteoporosis.

    abstract::Oestradiol and the selective oestrogen receptor modulator (SERM) raloxifene have been shown to ameliorate collagen-induced arthritis (CIA) in rats and in mice. One aim was to investigate if raloxifene exerts its anti-arthritic and anti-osteoporotic effects during the induction or effector phase of arthritis. A second ...

    journal_title:Clinical and experimental immunology

    pub_type: 杂志文章

    doi:10.1111/j.1365-2249.2011.04397.x

    authors: Jochems C,Islander U,Erlandsson M,Engdahl C,Lagerquist M,Ohlsson C,Nandakumar KS,Holmdahl R,Carlsten H

    更新日期:2011-07-01 00:00:00

  • Polyclonal T cell elimination by prolonged immunostimulation in an experimental model.

    abstract::An experimental model of immunological deficiency obtained by treating mice for 6 months with serum of human blood drawn from different healthy individuals has been studied. The results show that an alteration of a circulating lymphocyte population with alterations of the ratio CD4+/CD8+ appeared in mice stimulated fo...

    journal_title:Clinical and experimental immunology

    pub_type: 杂志文章

    doi:10.1111/j.1365-2249.1997.tb08315.x

    authors: Galdiero F,Galdiero M,Nuzzo I,Vitiello M,Bentivoglio C,Romano-Carratelli C

    更新日期:1997-11-01 00:00:00

  • IgG-mediated anaphylaxis via Fc gamma receptor in CD40-deficient mice.

    abstract::Anaphylaxis denotes an immediate hypersensitivity reaction to allergen, exclusively mediated by IgE antibodies. However, IgE antibodies do not explain all the syndromes that are encountered. We investigated potent IgG-mediated anaphylaxis in CD40-deficient mice that lack the immunoglobulin class switching for T cell-d...

    journal_title:Clinical and experimental immunology

    pub_type: 杂志文章

    doi:10.1046/j.1365-2249.1998.00717.x

    authors: Wakayama H,Hasegawa Y,Kawabe T,Saito H,Kikutani H,Shimokata K

    更新日期:1998-11-01 00:00:00

  • Streptococci and Actinomyces induce antibodies which cross react with epithelial antigens in periodontitis.

    abstract::Perturbation of epithelial structure is a prominent but poorly understood feature of the immunopathological response to bacterial antigens which characterizes the destructive lesion of periodontitis. Western analysis of sera from 22 patients with periodontitis detected multiple antigens in extracts of epithelial cells...

    journal_title:Clinical and experimental immunology

    pub_type: 杂志文章

    doi:10.1046/j.1365-2249.2003.02088.x

    authors: Ye P,Harty DW,Chapple CC,Nadkarni MA,Carlo AA,Hunter N

    更新日期:2003-03-01 00:00:00

  • PGK1 as an immune target in Kawasaki disease.

    abstract::Kawasaki disease (KD) is an immune-mediated vasculitis with symptoms that mimic febrile illness; the immune origin has been suggested but never proved. First, cell chip technology was used to screen immune targets cells. With the indirect immunofluorescence assay we found that the HeLa cell chip could be recognized by...

    journal_title:Clinical and experimental immunology

    pub_type: 杂志文章

    doi:10.1111/cei.13204

    authors: Cui J,Zhou Y,Hu H,Zhao L,Du Z,Du H

    更新日期:2018-12-01 00:00:00

  • Generation of monoclonal anti-dermatan sulphate antibodies cross-reacting to calf thymus DNA.

    abstract::Monoclonal anti-dermatan sulphate antibodies were produced with hybridization after immunizing BALB/c mice with dermatan sulphate (DS). These antibodies were tested for cross-reactivity to double-stranded DNA (dsDNA) and heat-denatured DNA (ssDNA). Five clones had binding activity to DS, dsDNA and ssDNA in enzyme-link...

    journal_title:Clinical and experimental immunology

    pub_type: 杂志文章

    doi:

    authors: Ohnishi K,Sagawa A,Nakabayashi T,Ohmoto A,Megumi,Yoshikawa M,Watanabe I,Mukai M,Yasuda I,Nakagawa S

    更新日期:1989-01-01 00:00:00

  • Fluorescent probes to detect lymphocyte activation.

    abstract::Fluorescent probes can monitor events in lymphocytes stimulated by mitogens and antigens. Early activation is associated with conformational changes in membrane macromolecules, and has been studied by measurement of fluorescence intensity or polarization of the membrane-localizing probes ANS, NPN, DPH and TMRITC. Subs...

    journal_title:Clinical and experimental immunology

    pub_type: 杂志文章,评审

    doi:

    authors: Nairn RC,Rolland JM

    更新日期:1980-01-01 00:00:00

  • Study of antigenic sites on the asialoglycoprotein receptor recognized by autoantibodies.

    abstract::The aim of this study was to identify the epitopes recognized by antibodies to the asialoglycoprotein receptor, a specific hepatocyte protein, from sera of patients with autoimmune hepatitis. An ELISA test was used to detect anti-asialoglycoprotein receptor antibodies in the sera of patients with autoimmune hepatitis....

    journal_title:Clinical and experimental immunology

    pub_type: 杂志文章

    doi:10.1046/j.1365-2249.1998.00673.x

    authors: Hajoui O,Martin S,Alvarez F

    更新日期:1998-09-01 00:00:00

  • Mechanisms of action of intravenous immune globulin in immune-mediated diseases.

    abstract::Intravenous immune globulin (IVIG) exhibits a number of immunomodulatory properties that are mediated by the Fe portion of IgG and by the spectrum of variable (V) regions contained in the immune globulin preparations. Five predominant and non-exclusive mechanisms of action have been proposed to account for the immunom...

    journal_title:Clinical and experimental immunology

    pub_type: 杂志文章,评审

    doi:

    authors: Mouthon L,Kaveri SV,Spalter SH,Lacroix-Desmazes S,Lefranc C,Desai R,Kazatchkine MD

    更新日期:1996-05-01 00:00:00