Prevention of cyclophosphamide-induced diabetes in the NOD/WEHI mouse with deoxyspergualin.

Abstract:

:Ten out of 20 (50%) 17-week-old female NOD/WEHI mice developed an acute form of autoimmune diabetes when injected with two large doses of cyclophosphamide (CY), given at 14-day intervals. If these mice were treated under a prophylactic regimen with 2.5 mg/kg body weight per day of the novel immunosuppressant deoxyspergualin (DSP) the onset of diabetes was completely prevented. Moreover, DSP-treated animals showed reduced signs of pancreatic insulitis, had lower percentages of splenic lymphoid cells (SLC) expressing IL-2 receptors and Ly-6C antigens on their surfaces, and these cells released lower amounts of interferon-gamma (IFN) when stimulated in vitro. These data, providing evidence for the capacity of DSP to protect NOD/WEHI mice from experimental autoimmune diabetes and to modulate histo-immunological pathogenic pathways, indicate DSP as a drug of potential interest in the treatment of human insulin-dependent diabetes mellitus.

journal_name

Clin Exp Immunol

authors

Nicoletti F,Borghi MO,Meroni PL,Barcellini W,Fain C,Di Marco R,Menta R,Schorlemmer HU,Bruno G,Magro G

doi

10.1111/j.1365-2249.1993.tb05888.x

subject

Has Abstract,Author List Incomplete

pub_date

1993-02-01 00:00:00

pages

232-6

issue

2

eissn

0009-9104

issn

1365-2249

journal_volume

91

pub_type

杂志文章
  • Immunological effects of insulin-like growth factor-I--enhancement of immunoglobulin synthesis.

    abstract::In addition to its activity as a metabolic hormone and a regulator of somatic growth, insulin-like growth factor-I (IGF-I) has cytokine-like activities on lymphoid cells. A 14-day infusion of recombinant human (rh)IGF-I increased lymphocyte numbers in all the peripheral lymphoid organs examined. This increase was appa...

    journal_title:Clinical and experimental immunology

    pub_type: 杂志文章

    doi:10.1111/j.1365-2249.1994.tb06534.x

    authors: Robbins K,McCabe S,Scheiner T,Strasser J,Clark R,Jardieu P

    更新日期:1994-02-01 00:00:00

  • An altered repertoire of T cell receptor V gene expression by rheumatoid synovial fluid T lymphocytes.

    abstract::The pattern of T cell receptor V gene expression by lymphocytes from rheumatoid synovial fluid and paired peripheral blood samples was compared using a polymerase chain reaction (PCR)-based assay. Eight rheumatoid arthritis (RA) patients who had varying durations of disease (from 2 to 20 years) were studied. In all pa...

    journal_title:Clinical and experimental immunology

    pub_type: 杂志文章

    doi:10.1111/j.1365-2249.1992.tb05865.x

    authors: Lunardi C,Marguerie C,So AK

    更新日期:1992-12-01 00:00:00

  • Effect of 12,13-phorbol dibutyrate and ionomycin on defective B cells in common variable immunodeficiency.

    abstract::Secretion of IgM and IgG in vitro by B cells from patients with common variable immunodeficiency (CVI) has been used to classify the disease into three groups. On stimulation with anti-IgM and IL-2, group A patients' cells fail to secrete IgM or IgG, group B patients' cells secrete no IgG and significantly lower level...

    journal_title:Clinical and experimental immunology

    pub_type: 杂志文章

    doi:10.1111/j.1365-2249.1992.tb03020.x

    authors: Franz A,Bryant A,Webster AD,Farrant J

    更新日期:1992-03-01 00:00:00

  • Remission of experimental autoimmune hepatitis is associated with antigen-specific and non-specific immunosuppression.

    abstract::Experimental autoimmune hepatitis (EAH) is an animal model for autoimmune hepatitis. The disease is T cell-mediated and runs a subacute course, with maximal disease activity around week four after disease induction and a slow ensuing recovery. The aim of the present study was to investigate the immunoregulatory mechan...

    journal_title:Clinical and experimental immunology

    pub_type: 杂志文章

    doi:10.1111/j.1365-2249.1993.tb05995.x

    authors: Lohse AW,Meyer zum Büschenfelde KH

    更新日期:1993-10-01 00:00:00

  • Mechanisms of action of intravenous immune globulin in immune-mediated diseases.

    abstract::Intravenous immune globulin (IVIG) exhibits a number of immunomodulatory properties that are mediated by the Fe portion of IgG and by the spectrum of variable (V) regions contained in the immune globulin preparations. Five predominant and non-exclusive mechanisms of action have been proposed to account for the immunom...

    journal_title:Clinical and experimental immunology

    pub_type: 杂志文章,评审

    doi:

    authors: Mouthon L,Kaveri SV,Spalter SH,Lacroix-Desmazes S,Lefranc C,Desai R,Kazatchkine MD

    更新日期:1996-05-01 00:00:00

  • Specific in vivo and in vitro antibody response to tetanus toxoid immunization.

    abstract::Booster immunization of normal individuals with soluble tetanus toxoid (TT) produced significant levels of plasma anti-tetanus IgG and IgM detectable by an enzyme linked immunosorbent assay (ELISA). Similar changes in circulating anti-TT antibody were found in mice following primary immunization. There was. however, n...

    journal_title:Clinical and experimental immunology

    pub_type: 杂志文章

    doi:

    authors: Ershler WB,Moore AL,Hacker MP

    更新日期:1982-09-01 00:00:00

  • Reduced blood BDCA-2+ (lymphoid) and CD11c+ (myeloid) dendritic cells in systemic lupus erythematosus.

    abstract::Type 1 IFN is thought to be implicated in the autoimmune process of SLE. Plasmacytoid dendric cells (DC), which are natural IFN-alpha producing cells, play a pivotal epipathogenic role in SLE. The present study was undertaken to investigate the phenotypic characteristics of peripheral blood DC in SLE patients in compa...

    journal_title:Clinical and experimental immunology

    pub_type: 杂志文章

    doi:10.1111/j.1365-2249.2005.02897.x

    authors: Migita K,Miyashita T,Maeda Y,Kimura H,Nakamura M,Yatsuhashi H,Ishibashi H,Eguchi K

    更新日期:2005-10-01 00:00:00

  • Regulation of IL-2 beta receptor expression and beta-chain mRNA by human thymocytes.

    abstract::The high affinity form of the human IL-2 receptor (IL-2R) has two known components, the IL-2R alpha (p55) and the IL-2R beta chain (p75). We have previously shown that recombinant IL-2 (rIL-2) could induce the expression of the alpha-chain (p55) on T cells and thymocytes, and increase this expression following subopti...

    journal_title:Clinical and experimental immunology

    pub_type: 杂志文章

    doi:10.1111/j.1365-2249.1992.tb06429.x

    authors: Reem GH,Han X,Marcelli A

    更新日期:1992-01-01 00:00:00

  • Immunomodulatory effects of the tobacco-specific carcinogen, NNK, on alveolar macrophages.

    abstract::Lung cancer is strongly associated with cigarette smoking. More than 20 lung carcinogens have been identified in cigarette smoke and one of the most abundant is 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK). We hypothesized that NNK modulates alveolar macrophage (AM) mediator production, thus contributing to ca...

    journal_title:Clinical and experimental immunology

    pub_type: 杂志文章

    doi:10.1046/j.1365-2249.2003.02142.x

    authors: Therriault MJ,Proulx LI,Castonguay A,Bissonnette EY

    更新日期:2003-05-01 00:00:00

  • Cellular aspects of selective IgA deficiency.

    abstract::Five patients with no detectable serum IgA (less than 20 mug/ml) and one patient with low serum IgA were compared to normal subjects. The number of circulating E-RFC was normal as was the lymphocyte DNA synthesis induced by PHA, Con A, and streptokinase-streptodornase. The patients had normal numbers of IgA-bearing ly...

    journal_title:Clinical and experimental immunology

    pub_type: 杂志文章

    doi:

    authors: Delespesse G,Gausset P,Cauchie C,Govaerts A

    更新日期:1976-05-01 00:00:00

  • Viruses and type 1 diabetes: ignorance acquires a better vocabulary.

    abstract::The hypothesis that a virus might in some way be involved in the causation of type 1 diabetes has a long history, but decades of research have failed to resolve the issue beyond reasonable doubt. Viruses could potentially play a primary role in the pathogenesis of type 1 diabetes by initiating autoimmunity, a secondar...

    journal_title:Clinical and experimental immunology

    pub_type:

    doi:10.1111/j.1365-2249.2011.04553.x

    authors: Gale EA

    更新日期:2012-04-01 00:00:00

  • The effect of cortisone acetate on pulmonary lesions in a rabbit model of hypersensitivity pneumonitis (cortisone and hypersensitivity pneumonitis).

    abstract::Rabbits were sensitized with Micropolyspora faeni by intratracheal inoculations and later challenged with the same antigen either with or without parenteral administration of cortisone acetate prior to challenge. Animals developed anti-M. faeni serum precipitins, M. faeni-induced alveolar macrophage migration inhibiti...

    journal_title:Clinical and experimental immunology

    pub_type: 杂志文章

    doi:

    authors: Cashner FM,Schuyler MR,Salvaggio JE

    更新日期:1979-05-01 00:00:00

  • Th17 responses to pneumococcus in blood and adenoidal cells in children.

    abstract::Pneumococcal infections cause a large global health burden, and the search for serotype-independent vaccines continues. Existing conjugate vaccines reduce nasopharyngeal colonization by target serotypes. Such mucosal effects of novel antigens may similarly be important. CD4+ Th17 cell-dependent, antibody-independent r...

    journal_title:Clinical and experimental immunology

    pub_type: 杂志文章

    doi:10.1111/cei.13225

    authors: Oliver E,Pope C,Clarke E,Langton Hewer C,Ogunniyi AD,Paton JC,Mitchell T,Malley R,Finn A

    更新日期:2019-02-01 00:00:00

  • MC(1) receptors are constitutively expressed on leucocyte subpopulations with antigen presenting and cytotoxic functions.

    abstract::The expression of melanocortin MC(1) receptors on human peripheral lymphocyte subsets was analysed by flow cytometry using rabbit antibodies selective for the human MC(1) receptor and a panel of monoclonal antibodies against lymphocyte differentiation markers. The MC(1) receptor was found to be constitutively expresse...

    journal_title:Clinical and experimental immunology

    pub_type: 杂志文章

    doi:10.1046/j.1365-2249.2001.01604.x

    authors: Neumann Andersen G,Nagaeva O,Mandrika I,Petrovska R,Muceniece R,Mincheva-Nilsson L,Wikberg JE

    更新日期:2001-12-01 00:00:00

  • Monocyte chemoattractant protein-1 (MCP-1) inhibits the intestinal-like differentiation of monocytes.

    abstract::Monocytes (MO) migrating into normal, non-inflamed intestinal mucosa undergo a specific differentiation resulting in a non-reactive, tolerogenic intestinal macrophage (IMAC). Recently we demonstrated the differentiation of MO into an intestinal-like macrophage (MAC) phenotype in vitro in a three-dimensional cell cultu...

    journal_title:Clinical and experimental immunology

    pub_type: 杂志文章

    doi:10.1111/j.1365-2249.2006.03113.x

    authors: Spoettl T,Hausmann M,Herlyn M,Gunckel M,Dirmeier A,Falk W,Herfarth H,Schoelmerich J,Rogler G

    更新日期:2006-07-01 00:00:00

  • Distribution of immunoglobulin G subclasses of anti-thyroid peroxidase antibody in sera from patients with Hashimoto's thyroiditis with different thyroid functional status.

    abstract::The mechanism of disease progression in Hashimoto's thyroiditis (HT) is still unclear. Anti-thyroid peroxidase antibody (TPOAb), a diagnostic hallmark of HT, is principally of the immunoglobulin G (IgG) isotype, and it appears to be a response to thyroid injury. The aim of our study was to evaluate the distribution of...

    journal_title:Clinical and experimental immunology

    pub_type: 杂志文章

    doi:10.1111/j.1365-2249.2008.03756.x

    authors: Xie LD,Gao Y,Li MR,Lu GZ,Guo XH

    更新日期:2008-11-01 00:00:00

  • Impact of natural killer cell dose and donor killer-cell immunoglobulin-like receptor (KIR) genotype on outcome following human leucocyte antigen-identical haematopoietic stem cell transplantation.

    abstract::To define the role of quantitative graft composition and donor killer-cell immunoglobulin-like receptor (KIR) genotype in clinical outcome following unmanipulated peripheral blood stem cell transplantation (PBSCT) from human leucocyte antigen (HLA)-identical siblings, 43 consecutive transplants for haematological mali...

    journal_title:Clinical and experimental immunology

    pub_type: 杂志文章

    doi:10.1111/j.1365-2249.2007.03360.x

    authors: Clausen J,Wolf D,Petzer AL,Gunsilius E,Schumacher P,Kircher B,Gastl G,Nachbaur D

    更新日期:2007-06-01 00:00:00

  • Monoclonal anti-poly(rA) hybridoma antibodies from an autoimmune MRL/MpJ-lpr/lpr mouse.

    abstract::Three B cell hybridomas were produced by the fusion of spleen cells from a 5 month old MRL/Mp-lpr/lpr mouse with the myeloma cell line, NS-1. By competitive inhibition, all three monoclonal antibodies (MoAb) were specific for poly(rA) and were inhibited to a lesser extent by dDNA, nDNA, poly(rI) and poly(rC). Moreover...

    journal_title:Clinical and experimental immunology

    pub_type: 杂志文章

    doi:

    authors: Dang H,Fischbach M,Erdos M,Talal N

    更新日期:1985-07-01 00:00:00

  • Natural and disease-specific autoantibodies in chronic obstructive pulmonary disease.

    abstract::Autoimmunity may contribute to the pathogenesis of chronic obstructive pulmonary disease (COPD). Studies have identified disease-specific autoantibodies (DSAAbs) in COPD patients, but natural autoantibodies (NAAbs) may also play a role. Previous studies have concentrated on circulating autoantibodies, but lung-associa...

    journal_title:Clinical and experimental immunology

    pub_type: 临床试验,杂志文章,多中心研究

    doi:10.1111/cei.12565

    authors: Daffa NI,Tighe PJ,Corne JM,Fairclough LC,Todd I

    更新日期:2015-04-01 00:00:00

  • Wild isolates of Plasmodium falciparum malaria show decreased sensitivity to in vitro inhibition of parasite growth mediated by autologous host antibodies.

    abstract::Antigenic diversity in field populations of Plasmodium falciparum parasites may delay the acquisition of protective immunity to malaria, the development of which may thus require repeated exposure to infection over a prolonged period of time. In this study we show that P. falciparum parasites may vary in their sensiti...

    journal_title:Clinical and experimental immunology

    pub_type: 杂志文章

    doi:10.1111/j.1365-2249.1997.273-ce1163.x

    authors: Flyg BW,Perlmann H,Perlmann P,Esposito F,Berzins K

    更新日期:1997-02-01 00:00:00

  • T- and B-lymphocyte subpopulations in the tropical splenomegaly syndrome (TSS).

    abstract::Lymphocyte subpopulations in thirty-nine patients with the tropical splenomegaly syndrome (TSS) were studied using the E-rosette, EAC rosette and direct immunofluorescent staining techniques. In the peripheral blood a decrease in the percentage of T-lymphocytes was found which was accompanied by an increase in the per...

    journal_title:Clinical and experimental immunology

    pub_type: 杂志文章

    doi:

    authors: Fakunle YM,Oduloju AJ,Greenwood BM

    更新日期:1978-08-01 00:00:00

  • Interferon-gamma treatment increases HLA-DR expression on monocytes in severely injured patients.

    abstract::Traumatic injury and sepsis reduce HLA-DR expression on monocytes. This study assessed the effect of interferon-gamma (IFN-gamma) on the expression of HLA-DR on monocytes taken from severely injured patients. The mononuclear layer of each blood sample was incubated with either 500 units IFN-gamma or control media. The...

    journal_title:Clinical and experimental immunology

    pub_type: 杂志文章

    doi:

    authors: Hershman MJ,Appel SH,Wellhausen SR,Sonnenfeld G,Polk HC Jr

    更新日期:1989-07-01 00:00:00

  • Human monoclonal antibodies for the immunological characterization of a highly conserved protein domain of the hepatitis C virus glycoprotein E1.

    abstract::Although both envelope glycoproteins of the hepatitis C virus, E1 and E2/NS1, show a high degree of sequence variation, the E1 protein includes a well conserved domain, which may be functionally important. We have analysed the human B cell response to a peptide fragment from amino acid residues 314-330 (EP3) covering ...

    journal_title:Clinical and experimental immunology

    pub_type: 杂志文章

    doi:10.1111/j.1365-2249.1995.tb08351.x

    authors: Siemoneit K,Cardoso Mda S,Koerner K,Wölpl A,Kubanek B

    更新日期:1995-08-01 00:00:00

  • Long-term human immune system reconstitution in non-obese diabetic (NOD)-Rag (-)-γ chain (-) (NRG) mice is similar but not identical to the original stem cell donor.

    abstract::The murine immune system is not necessarily identical to it human counterpart, which has led to the construction of humanized mice. The current study analysed whether or not a human immune system contained within the non-obese diabetic (NOD)-Rag1(null) -γ chain(null) (NRG) mouse model was an accurate representation of...

    journal_title:Clinical and experimental immunology

    pub_type: 杂志文章

    doi:10.1111/cei.12192

    authors: Harris DT,Badowski M,Balamurugan A,Yang OO

    更新日期:2013-12-01 00:00:00

  • Pre-incubation with interleukin-4 mediates a direct protective effect against the loss of pancreatic beta-cell viability induced by proinflammatory cytokines.

    abstract::Loss of pancreatic beta-cells in type I diabetes is associated with an increase in T helper 1 (Th1) proinflammatory cytokines in the islet milieu, with a concomitant reduction in Th2 anti-inflammatory cytokines. In animal models, manoeuvres designed to polarize Th1 responses towards Th2, particularly involving interle...

    journal_title:Clinical and experimental immunology

    pub_type: 杂志文章

    doi:10.1111/j.1365-2249.2007.03375.x

    authors: Kaminski A,Kaminski ER,Morgan NG

    更新日期:2007-06-01 00:00:00

  • The immunopathogenesis of fibrosis in systemic sclerosis.

    abstract::Systemic sclerosis (SSc) is an idiopathic systemic autoimmune disease. It is characterized by a triad of hallmarks: immune dysfunction, fibrosis and vasculopathy. Immune dysfunction in SSc is characterized by the activation and recruitment of immune cells and the production of autoantibodies and cytokines. How immune ...

    journal_title:Clinical and experimental immunology

    pub_type: 杂志文章,评审

    doi:10.1111/cei.13238

    authors: Brown M,O'Reilly S

    更新日期:2019-03-01 00:00:00

  • Specific activation of resting T cells against tumour cells by bispecific antibodies and CD28-mediated costimulation is accompanied by Th1 differentiation and recruitment of MHC-independent cytotoxicity.

    abstract::Specific activation of resting lymphocytes for tumour targeting can be achieved by bispecific monoclonal antibodies (bi-MoAbs) with specificity for tumour antigens and T cell-activating antigens in combination with a costimulatory anti-CD28 antibody. In this study we focus on the immunomodulatory function of an anti-C...

    journal_title:Clinical and experimental immunology

    pub_type: 杂志文章

    doi:10.1046/j.1365-2249.1997.3481245.x

    authors: Hombach A,Tillmann T,Jensen M,Heuser C,Sircar R,Diehl V,Kruis W,Pohl C

    更新日期:1997-05-01 00:00:00

  • Interferon-gamma and tumour necrosis factor-alpha production by CD4+ T and CD8+ T lymphocytes in AIDS patients with tuberculosis.

    abstract::Tuberculosis (TB) is usually more severe in HIV-infected patients, and the immune derangement found in co-infected patients may differ from that in each isolated disease. Following mitogen stimulation of peripheral blood mononuclear cells (PBMC), interferon (IFN)-gamma and tumour necrosis factor (TNF)-alpha production...

    journal_title:Clinical and experimental immunology

    pub_type: 杂志文章

    doi:10.1111/j.1365-2249.2005.02796.x

    authors: de Castro Cunha RM,Kallas EG,Rodrigues DS,Nascimento Burattini M,Salomao R

    更新日期:2005-06-01 00:00:00

  • Molecular studies and NK cell function of a new case of TAP2 homozygous human deficiency.

    abstract::In this paper we describe the clinical and molecular features of a new case (GOR) of homozygous human TAP2 deficiency, analysing the phenotype and function of NK cells. The patient presented from infancy with recurrent sinopulmonary infections; a selective IgG2 deficiency, negative antibody response to polysaccharide ...

    journal_title:Clinical and experimental immunology

    pub_type: 杂志文章

    doi:10.1046/j.1365-2249.2001.01595.x

    authors: Matamoros N,Milà J,Llano M,Balas A,Vicario JL,Pons J,Crespí C,Martinez N,Iglesias-Alzueta J,López-Botet M

    更新日期:2001-08-01 00:00:00

  • Analysis of in vitro polyclonal B cell differentiation responses to bacterial peptidoglycan and pokeweed mitogen in rheumatoid arthritis.

    abstract::To gain insight into possible determinants of in vivo polyclonal B cell activation seen in rheumatoid arthritis (RA), we enumerated immunoglobulin secreting cells appearing in cultures of peripheral blood mononuclear cells that were stimulated with pokeweed mitogen (PWM) or a newly described polyclonal B cell activato...

    journal_title:Clinical and experimental immunology

    pub_type: 杂志文章

    doi:

    authors: Pardo I,Carafa C,Dziarski R,Levinson AI

    更新日期:1984-05-01 00:00:00