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Effects of activin A on IgE synthesis and cytokine production by human peripheral mononuclear cells.

Abstract：

:Activin A not only stimulates the synthesis and release of pituitary follicle-stimulating hormone, but exerts various effects on haematopoietic cells, embryos, and fibroblasts. In the present study we have examined effects of activin A on IgE synthesis and cytokine production by peripheral blood mononuclear cells (PBMC) in normal humans. When PBMC were cultured in the presence of IL-4, activin A significantly augmented IgE production induced by IL-4. Activin A did not affect, however, IgE production from highly purified B cells when they were stimulated with anti-CD40 MoAb and IL-4. The fact that in the latter condition IgE synthesis was T cell- and monocyte-independent indicated that activin A does not directly influence B cells for IgE synthesis. Rather, production as well as gene expression of IL-6, which is known to enhance IgE synthesis by purified monocytes, was induced by activin A alone. In addition, activin A induced other monokines such as IL-1 and tumour necrosis factor (TNF)-alpha from monocytes. In contrast, activin A neither induced nor augmented the production of TNF-beta or interferon-gamma (IFN-gamma), both of which are known to be exclusively generated by T cells. These data indicate that activin A plays a certain role in physiological functions for monocytes in normal humans.

journal_name

Clin Exp Immunol

journal_title

Clinical and experimental immunology

authors

Yamashita N,Nakajima T,Takahashi H,Kaneoka H,Mizushima Y,Sakane T

doi

10.1111/j.1365-2249.1993.tb06003.x

subject

Has Abstract

pub_date

1993-10-01 00:00:00

pages

214-9

issue

1

eissn

0009-9104

issn

1365-2249

journal_volume

94

pub_type

杂志文章

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