Circulating immune complexes in six patients with trichinosis.

abstract：:In Helicobacter pylori gastritis gastric epithelium plays a central role in the innate immunity to H. pylori. However, epithelial receptors interacting with H. pylori have been poorly characterized so far. Recently a new triggering receptor expressed on myeloid cells-1 (TREM-1) has been identified on human neutrophils...

journal_title：Clinical and experimental immunology

authors： Schmausser B,Endrich S,Beier D,Moran AP,Burek CJ,Rosenwald A,Rieckmann P,Müller-Hermelink HK,Eck M

更新日期：2008-04-01 00:00:00

abstract：:Anti-citrullinated peptide antibodies (ACPA) are highly specific for rheumatoid arthritis (RA). However, the predominant B cell epitopes have not yet been defined. The aim of this study was to examine the reactivity of ACPA against different peptides derived from citrullinated proteins and to investigate whether or no...

journal_title：Clinical and experimental immunology

authors： Goules JD,Goules AV,Tzioufas AG

更新日期：2013-10-01 00:00:00

abstract：:CVID is a primary immune disorder in which hypogammaglobulinaemia may be associated with a number of T cell defects including lymphopenia, anergy, impaired lymphocyte proliferation and deficient cytokine secretion. In this study we show that T cells of CVID subjects, in comparison with control T cells, undergo spontan...

journal_title：Clinical and experimental immunology

authors： Di Renzo M,Zhou Z,George I,Becker K,Cunningham-Rundles C

更新日期：2000-06-01 00:00:00

abstract：:The Fc receptor mediated antibody-dependent cell-mediated cytotoxicity (ADCC) and phagocytosis induced by bispecific antibody (BsAb) to the high-affinity Fc receptor for IgG (Fc gamma RI) and to human red blood group antigen RhD were studied in vitro, using human mononuclear leucocytes as effector cells. The results w...

journal_title：Clinical and experimental immunology

authors： Deramoudt EX,Gilard C,Lepine N,Alonso JM,Romet-Lemonne JL

更新日期：1992-08-01 00:00:00

abstract：:Monoclonal antibodies reacting with thyroid microsomes have been described. In this report, we present evidence that some of these monoclonal antibodies (MoAb) MAH C3 and perhaps MAH C6 are directed towards the thyroid microsomal antigen towards which microsomal autoantibodies from Hashimoto patients are directed. Imm...

journal_title：Clinical and experimental immunology

authors： Banga JP,Mirakian R,Hammond L,Pryce G,Bidey S,Bottazzo F,Weetman AP,McGregor AM,Roitt IM

更新日期：1986-06-01 00:00:00

abstract：:A method for the isolation of complement-fixing immune complexes from human serum and the separation of antigen from antibody is described. In order to isolate the complexes, we used soluble bovine conglutinin in a three-step procedure: (1) serum containing immune complexes is reacted with conglutinin in the presence ...

journal_title：Clinical and experimental immunology

authors： Gupta RC,Tan EM

更新日期：1981-10-01 00:00:00

abstract：:Suppression of the lymphocyte response to concanavalin A (Con A), phytohaemagglutinin (PHA) and protein A from Staphylococcus aureus (SpA) by Con A-induced suppressor cells was measured in twenty-four patients with recently active-recovering multiple sclerosis (MS), twelve with inactive MS and twenty-three healthy con...

journal_title：Clinical and experimental immunology

authors： Gonzalez RL,Dau PC,Spitler LE

更新日期：1979-04-01 00:00:00

abstract：:Serum cytokine levels and peripheral T cell subpopulations of HIV-1-infected patients before, during and after active visceral leishmaniasis (VL) were analysed and compared with appropriate controls. At VL diagnosis, co-infected patients showed higher serum levels of interferon-gamma (IFN-gamma) than matched HIV-1 con...

journal_title：Clinical and experimental immunology

authors： Medrano FJ,Rey C,Leal M,Cañavate C,Rubio A,Sánchez-Quijano A,Alvar J,Lissen E

更新日期：1998-12-01 00:00:00

abstract：:Monocytes and endothelial cells were stimulated in co-culture with allogeneic lymphocytes to produce thromboplastin (TPL). The induction was biphasic, an early response (8-24 h) was greatly augmented by cyclosporin A (CS) (0.5-5 micrograms/ml) whereas the late response (day 3-4) was inhibited. Prednisolone inhibited b...

journal_title：Clinical and experimental immunology

authors： Carlsen E,Gaudernack G,Filion-Myklebust C,Pettersen KS,Prydz H

更新日期：1989-06-01 00:00:00

abstract：:Serum from 98 Thai adults infected with Plasmodium falciparum were examined for the presence of autoantibodies. Malarial containing antibodies sera were also revealed positive for anti-nuclear antibodies with fluorescence speckled pattern, anti-smooth muscle antibodies, anti-mitochondria antibodies and rheumatoid fact...

journal_title：Clinical and experimental immunology

authors： Boonpucknavig S,Ekapanyakul G

更新日期：1984-10-01 00:00:00

abstract：:The immunoregulatory role of histamine is presumably mediated by specific receptors on the plasma membrane of lymphocytes. However, using murine spleen cells and a whole cell assay commonly applied in hormone receptor studies, specific histamine receptors with an affinity higher than that of non-specific binding could...

journal_title：Clinical and experimental immunology

authors： Wang Y,Kristensen F,Joncourt F,Slauson DO,De Weck AL

更新日期：1983-11-01 00:00:00

abstract：:Cell-mediated cytotoxicity (CTX) of meningioma patients was assessed postoperatively by a [3H]proline microcytotoxicity test. Autologous and allogeneic tumour cells were used for prelabelling with isotope and peripheral blood lymphocytes added in a ratio of 200:1. After 60 hg the plates were washed and residual CMP co...

journal_title：Clinical and experimental immunology

authors： Pees HW,Seidel B

更新日期：1976-05-01 00:00:00

abstract：:Here we describe the presence of IgG antibodies, in the sera of patients presenting with insulin-dependent diabetes mellitus (IDDM), that react in Western blots with a 60-kD protein (Mr 60K) from rat hepatic microsomal extracts. Sera from 60 IDDM patients were screened and 31.6% were positive for the Mr 60K band. This...

journal_title：Clinical and experimental immunology

authors： Pehuet-Figoni M,Alvarez F,Bach JF,Chatenoud L

更新日期：2000-11-01 00:00:00

abstract：:Protein kinases mediate protein phosphorylation, which is a fundamental component of cell signalling, with crucial roles in most signal transduction cascades: from controlling cell growth and proliferation to the initiation and regulation of immunological responses. Aberrant kinase activity is implicated in an increas...

journal_title：Clinical and experimental immunology

authors： Patterson H,Nibbs R,McInnes I,Siebert S

更新日期：2014-04-01 00:00:00

abstract：:Common variable immunodeficiency (CVID) is the name given to a clinically heterogeneous group of hypogammaglobulinaemic immunodeficiency states. Bronchiectasis is a feature of this disease and is believed to be the result of recurrent bacterial infection affecting the respiratory tract. Bronchiectasis is also a featur...

journal_title：Clinical and experimental immunology

authors： Sansom ME,Ferry BL,Sherrell ZP,Chapel HM

更新日期：2002-12-01 00:00:00

abstract：:Ten out of 20 (50%) 17-week-old female NOD/WEHI mice developed an acute form of autoimmune diabetes when injected with two large doses of cyclophosphamide (CY), given at 14-day intervals. If these mice were treated under a prophylactic regimen with 2.5 mg/kg body weight per day of the novel immunosuppressant deoxysper...

journal_title：Clinical and experimental immunology

authors： Nicoletti F,Borghi MO,Meroni PL,Barcellini W,Fain C,Di Marco R,Menta R,Schorlemmer HU,Bruno G,Magro G

更新日期：1993-02-01 00:00:00

abstract：:Serum activity of the adenosine deaminase (ADA) isozyme, ADA2, has been reported to be elevated during various disease states. Macrophages have been suggested as the cellular source of extracellular ADA activity because they are one of the only cell types in which intracellular ADA2 activity has been measured, but ext...

journal_title：Clinical and experimental immunology

authors： Conlon BA,Law WR

更新日期：2004-10-01 00:00:00

abstract：:Intraepithelial lymphocytes (IELs) can be identified among epithelial cells in systemic mucosal tissues. Although intestinal IELs play a crucial role in mucosal immunity, their bronchial counterparts have not been well studied. The purpose of this study was to determine the immunological functions of human bronchial I...

journal_title：Clinical and experimental immunology

authors： Hirosako S,Goto E,Fujii K,Tsumori K,Hirata N,Tsumura S,Kamohara H,Kohrogi H

更新日期：2009-02-01 00:00:00

abstract：:To elucidate the in vivo mechanisms involved in the impairment in pulmonary defence as the result of treatment with glucocorticoids, we established fatal pneumonia with bacteraemia in dexamethasone (DEX)-treated mice by means of an intratracheal challenge of Pseudomonas aeruginosa. An increased neutrophil influx was o...

journal_title：Clinical and experimental immunology

authors： Satoh S,Oishi K,Iwagaki A,Senba M,Akaike T,Akiyama M,Mukaida N,Atsushima KM,Nagatake T

更新日期：2001-11-01 00:00:00

abstract：:A study was conducted to quantify soluble IL-2 receptor (sIL-2R) levels in sera of 57 chronic plaque psoriasis patients and correlate these measurements with disease activity and the number of IL-2R-positive (CD25+) lymphocytes in lesional biopsies of 11 cyclosporin A (CsA) and 13 psoralen plus ultraviolet radiation (...

journal_title：Clinical and experimental immunology

authors： Duncan JI,Horrocks C,Ormerod AD,Powles AV,Whiting PH,Fry L,Thomson AW

更新日期：1991-08-01 00:00:00

abstract：:Interstitial mononuclear cell infiltration in rats during the development of autoimmune Heymann nephritis (HN) was studied using the fine-needle aspiration biopsy (FNAB) technique. The results were compared with those obtained by immunohistochemical studies of infiltrating T helper (T-h) and T suppressor/cytotoxic (T-...

journal_title：Clinical and experimental immunology

authors： Grönhagen-Riska C,Honkanen E,von Willebrand E,Tikkanen I,Miettinen A,Holthöfer H,Törnroth T

更新日期：1987-11-01 00:00:00

abstract：:Post-kala-azar dermal leishmaniasis (PKDL) is a chronic dermal complication that occurs usually after recovery from visceral leishmaniasis (VL). The disease manifests into macular, papular and/or nodular clinical types with mono- or polymorphic presentations. Here, we investigated differences in immunological response...

journal_title：Clinical and experimental immunology

authors： Kaushal H,Bras-Gonçalves R,Avishek K,Kumar Deep D,Petitdidier E,Lemesre JL,Papierok G,Kumar S,Ramesh V,Salotra P

更新日期：2016-07-01 00:00:00

abstract：:When MRL/lpr (H-2k) spleen cells were intraperitoneally injected into C.B-17-scid/scid (severe combined immunodeficient (SCID)) (H-2d) mice, the SCID (SCID-MRL/lpr) mice manifested a severe wasting syndrome with weight loss, splenic atrophy, and lymphoid cell infiltration in the liver and lung, as seen in lpr-GVHD. In...

journal_title：Clinical and experimental immunology

authors： Hosaka N,Nagata N,Miyashima S,Ikehara S

更新日期：1994-06-01 00:00:00

abstract：:The mechanism of action of methotrexate (MTX) in autoimmune diseases (AID) is unclear. A pro-apoptotic effect has been demonstrated in mitogen-stimulated peripheral blood mononuclear cells (PBMC), but studies employing conventional antigens have disputed a pro-apoptotic effect. CD4+ T helper (Th) cells play a signific...

journal_title：Clinical and experimental immunology

authors： Nielsen CH,Albertsen L,Bendtzen K,Baslund B

更新日期：2007-05-01 00:00:00

abstract：:Vaccination against meningococcal serogroup B is recommended for patients with a complement deficiency; however, although immunogenicity in this patient group has been shown, efficacy has not yet been established. In this study, we collected serum from children with a complement deficiency in the alternative pathway o...

journal_title：Clinical and experimental immunology

authors： van den Broek B,van Els CACM,Kuipers B,van Aerde K,Henriet SS,de Groot R,de Jonge MI,Langereis JD,van der Flier M

更新日期：2019-12-01 00:00:00

abstract：:Specific assays for 5'-nucleotidase, adenosine diphosphatase (ADPase) and Mg2+-dependent adenosine triphosphatase (Mg2+-ATPase) have been optimized for human lymphocytes and their subcellular localizations determined by sucrose density gradient centrifugation. 5'-Nucleotidase was localized solely to the plasma membran...

journal_title：Clinical and experimental immunology

authors： Smith GP,Shah T,Webster AD,Peters TJ

更新日期：1982-08-01 00:00:00

abstract：:Sarcoidosis is a systemic, inflammatory disorder, which in a proportion of patients runs a chronic progressive course despite immunosuppressive treatment. Therapeutic granulocyte and monocyte apheresis (GMA) has been shown to be an effective treatment option for other systemic inflammatory disorders, but has not yet b...

journal_title：Clinical and experimental immunology

authors： Olsen HH,Muratov V,Cederlund K,Lundahl J,Eklund A,Grunewald J

更新日期：2014-09-01 00:00:00

abstract：:Human red cells (RBC) coated with IgG anti-D are cleared from the circulation to the spleen by macrophages which express IgG receptors (Fcgamma R). Polymorphisms of Fcgamma RIIa and Fcgamma RIIIa affect IgG binding in vitro, and may alter the efficiency of clearance of immune complexes in vivo. In a RBC clearance stud...

journal_title：Clinical and experimental immunology

authors： Kumpel BM,De Haas M,Koene HR,Van De Winkel JG,Goodrick MJ

更新日期：2003-04-01 00:00:00

abstract：:We analysed human anti-mouse antibodies (HAMA) in 12 patients (six with multiple myeloma (MM) and six with metastatic renal cell carcinoma (MRCC) who were treated with B-E8, an IgG1 MoAb against IL-6. Efficiency of the treatment was evidenced by the drop in the serum levels of C-reactive protein (CRP), the in vivo pro...

journal_title：Clinical and experimental immunology

authors： Legouffe E,Liautard J,Gaillard JP,Rossi JF,Wijdenes J,Bataille R,Klein B,Brochier J

更新日期：1994-11-01 00:00:00

abstract：:Interferons play an important, but incompletely understood role in HIV-related disease. We investigated the effect of HAART on plasma levels of IFN-alpha, IFN-gamma, neopterin and interferon-inducible protein 10 (IP-10) in 41 HIV-infected patients during 78 weeks of therapy. At baseline HIV-infected patients had raise...

journal_title：Clinical and experimental immunology

authors： Stylianou E,Aukrust P,Bendtzen K,Müller F,Frøland SS

更新日期：2000-03-01 00:00:00