Abstract：
:The lymphokine profiles were determined in the skin lesions of the three distinct clinical forms of American cutaneous leishmaniasis (ACL), using a reverse transcriptase polymerase chain reaction (RT-PCR) and primers for various lymphokines. The message for interferon-gamma (IFN-gamma), tumour necrosis factor-beta (TNF-beta), and IL-8 was expressed in the three clinical forms of ACL. IL-1 beta mRNA was expressed in most localized (LCL) and mucocutaneous (MCL) leishmaniasis, but in only few of the diffuse cutaneous leishmaniasis (DCL). IL-2 mRNA was detected in about half of the lesions, with more prominent values for MCL. IL-4 mRNA was present in most lesions from the three clinical forms, but markedly increased in DCL. IL-5 and IL-10 mRNAs were expressed in all MCL and in half of the DCL lesions and weakly expressed in LCL lesions. IL-10 mRNA was more abundant in MCL lesions. In contrast, IL-6 and TNF-alpha mRNAs were expressed in a large number of LCL. In MCL, IL-6 mRNA was expressed in most cases and TNF-alpha mRNA in all the cases. In DCL, IL-6 mRNA was absent and TNF-alpha mRNA was weakly expressed. These results suggest that most T cells present in the MCL and DCL lesions secrete a mixture of type 1 and type 2 cytokine patterns, but in DCL granulomas type 2 cytokines predominate. In LCL the cytokine patterns show a mixture of type 1 and type 0 with a preponderance of IFN-gamma over IL-4, and low levels of IL-5 and IL-10. The lack of IL-6 and TNF-alpha mRNAs, and the low expression of IL-1 beta in DCL lesions suggest a defect in the antigen-processing cells that may account for the state of unresponsiveness in these patients.
journal_name
Clin Exp Immunoljournal_title
Clinical and experimental immunologyauthors
Cáceres-Dittmar G,Tapia FJ,Sánchez MA,Yamamura M,Uyemura K,Modlin RL,Bloom BR,Convit Jdoi
10.1111/j.1365-2249.1993.tb05931.xsubject
Has Abstractpub_date
1993-03-01 00:00:00pages
500-5issue
3eissn
0009-9104issn
1365-2249journal_volume
91pub_type
杂志文章abstract：:The aim of the study was to test whether normal rat epiphyseal chondrocytes react with monoclonal antibodies (MoAbs) detecting different markers of lymphoid cells. For this purpose, isolated chondrocyte and, for comparison, splenocyte cytosmears were exposed to a battery of different MoAbs followed by indirect immunop...
journal_title：Clinical and experimental immunology
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doi：
更新日期：1989-03-01 00:00:00
abstract：:We found that IgA is predominant among the immune deposits in the renal glomeruli of mice infected with Schistosoma mansoni, and thus conducted an analysis of the deposition of different immunoglobulin isotypes in the glomeruli throughout the course of infection in mice. Both immunofluorescent and immunoperoxidase met...
journal_title：Clinical and experimental immunology
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更新日期：1988-01-01 00:00:00
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更新日期：1984-05-01 00:00:00
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journal_title：Clinical and experimental immunology
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更新日期：1988-08-01 00:00:00
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journal_title：Clinical and experimental immunology
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pub_type： 杂志文章
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journal_title：Clinical and experimental immunology
pub_type： 杂志文章
doi：
更新日期：1980-12-01 00:00:00
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journal_title：Clinical and experimental immunology
pub_type： 杂志文章
doi：
更新日期：1985-05-01 00:00:00
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doi：
更新日期：1984-02-01 00:00:00
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pub_type： 杂志文章
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journal_title：Clinical and experimental immunology
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doi：
更新日期：1977-06-01 00:00:00
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journal_title：Clinical and experimental immunology
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journal_title：Clinical and experimental immunology
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journal_title：Clinical and experimental immunology
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更新日期：1994-07-01 00:00:00
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journal_title：Clinical and experimental immunology
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doi：
更新日期：1986-02-01 00:00:00
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journal_title：Clinical and experimental immunology
pub_type： 杂志文章
doi：
更新日期：1986-06-01 00:00:00
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journal_title：Clinical and experimental immunology
pub_type： 杂志文章
doi：
更新日期：1975-05-01 00:00:00
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journal_title：Clinical and experimental immunology
pub_type： 杂志文章
doi：
更新日期：1976-04-01 00:00:00
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journal_title：Clinical and experimental immunology
pub_type： 杂志文章
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