Decrease of CD154 intensity on peripheral CD4+ T cells in autoimmune thyroid disease.

abstract：:The risk of premature death is high in haemodialysis (HD) patients. Antibodies against cardiolipin (anti-CL) are thrombogenic in diseases such as systemic lupus erythematosus (SLE). CL is easily oxidized (Ox) and plays a role in apoptosis. In this work we studied immunoglobulin (Ig)M anti-CL and anti-OxCL in HD-patien...

journal_title：Clinical and experimental immunology

authors： Frostegård AG,Hua X,Su J,Carrero JJ,Heimbürger O,Bárány P,Stenvinkel P,Frostegård J

更新日期：2013-12-01 00:00:00

abstract：:We have studied immunological, serological and clinical abnormalities in 264 HIV-positive and HIV-negative drug abusers. Ninety percent of the 264 drug addicts (mean age 26 +/- 0.8 years) were found to have HIV antibodies and there was a significant increase (P less than 0.01) in the frequency of HIV antibody positivi...

journal_title：Clinical and experimental immunology

authors： Fernandez-Cruz E,Fernandez AM,Gutierrez C,Garcia-Montes M,de la Morena MT,Rodriguez-Villanueva J,Longo N,Zabay JM

更新日期：1988-05-01 00:00:00

abstract：:Individuals with a negative intradermal reaction to tuberculin PPD have long been described in the Mycobacterium tuberculosis exposed, immune-competent population. Here, we studied PPD-specific blood T lymphocytes from these subjects for phenotypic markers relevant to skin migration, including the expression of the sk...

journal_title：Clinical and experimental immunology

authors： Magnani ZI,Confetti C,Besozzi G,Codecasa LR,Panina-Bordignon P,Lang R,Rossi GA,Pardi R,Burastero SE

更新日期：2000-01-01 00:00:00

abstract：:PHA activated human peripheral blood mononuclear cells (MNC) were incubated with human interleukin 2 (IL-2) in the absence or in the presence of 10(-6)-10(-9) M hydrocortisone (HC). HC suppressed the proliferative response of the activated MNC to highly purified human leucocyte IL-2 in a dose dependent manner. This su...

journal_title：Clinical and experimental immunology

authors： Horst HJ,Flad HD

更新日期：1987-04-01 00:00:00

abstract：:Biologically significant levels of IL-2 activity were produced by isolated lamina propria mononuclear cells (LPMC) from normal intestine (n = 12), cancer-bearing colons (n = 35) and inflammatory bowel disease (IBD) affected tissue (n = 12). The levels of IL-2 produced were similar for all three sources of LPMC (normal...

journal_title：Clinical and experimental immunology

authors： Pullman WE,Doe WF

更新日期：1992-04-01 00:00:00

abstract：:Secretory immunoglobulin A (IgA) was determined by means of an enzyme-linked immunosorbent assay (using as capture antibody an MoAb specific for secretory component) in saliva and serum from 46 patients with IgA mesangial nephritis (IgAGN), 36 with an idiopathic nephrotic syndrome (INS), 30 with an idiopathic membrano...

journal_title：Clinical and experimental immunology

authors： Rostoker G,Terzidis H,Petit-Phar M,Meillet D,Lang P,Dubert JM,Lagrue G,Weil B

更新日期：1992-11-01 00:00:00

abstract：:Circulating immunoglobulin (Ig)G antibodies against M(2) muscarinic acetylcholine receptors (M(2) mAChR) have been implicated in Chagas' disease (ChD) pathophysiology. These antibodies bind to and activate their target receptor, displaying agonist-like activity through an unclear mechanism. This study tested the abili...

journal_title：Clinical and experimental immunology

authors： Beltrame SP,Auger SR,Bilder CR,Waldner CI,Goin JC

更新日期：2011-05-01 00:00:00

abstract：:Merozoite surface protein 2 (MSP2) expressed by Plasmodium falciparum asexual blood stages has been identified as a promising vaccine candidate. In order to explore allelic family-specific humoral responses which may be responsible for parasite neutralization during natural infections, isolates from individuals with e...

journal_title：Clinical and experimental immunology

authors： Ekala MT,Jouin H,Lekoulou F,Mercereau-Puijalon O,Ntoumi F

更新日期：2002-08-01 00:00:00

abstract：:Th1 cell-induced anti-mycobacterial immunity is lost during a progressive Mycobacterium tuberculosis infection in a susceptible host. This study was designed to test the mechanism of the loss of anti-mycobacterial cell-mediated immune response. We demonstrate that M. tuberculosis infection results in increased Fas exp...

journal_title：Clinical and experimental immunology

authors： Das G,Vohra H,Saha B,Agrewala JN,Mishra GC

更新日期：1999-02-01 00:00:00

abstract：:Whilst the mechanism by which Helicobacter pylori causes different gastroduodenal diseases is uncertain, strains producing the cytotoxin-associated protein (CagA) have greater pathogenicity. Hsps are immunogenic molecules induced by inflammatory mediators. The aim of this study was to assess pathogenicity of hsp antib...

journal_title：Clinical and experimental immunology

authors： Barton SG,Winrow VR,Rampton DS,Crabtree JE,Beales IL,Calam J

更新日期：1998-06-01 00:00:00

abstract：:Systemic autoimmune diseases, such as systemic lupus erythematosus (SLE), are often characterized by a failure of self-tolerance and result in an uncontrolled activation of B cells and effector T cells. Interleukin (IL)-2 critically maintains homeostasis of regulatory T cells (T(reg)) and effector T cells in the perip...

journal_title：Clinical and experimental immunology

authors： Ohl K,Wiener A,Schippers A,Wagner N,Tenbrock K

更新日期：2015-07-01 00:00:00

abstract：:The expression of melanocortin MC(1) receptors on human peripheral lymphocyte subsets was analysed by flow cytometry using rabbit antibodies selective for the human MC(1) receptor and a panel of monoclonal antibodies against lymphocyte differentiation markers. The MC(1) receptor was found to be constitutively expresse...

journal_title：Clinical and experimental immunology

authors： Neumann Andersen G,Nagaeva O,Mandrika I,Petrovska R,Muceniece R,Mincheva-Nilsson L,Wikberg JE

更新日期：2001-12-01 00:00:00

abstract：:Anti-neutrophil cytoplasmic antibodies against proteinase 3 (PR3-ANCA) are used as diagnostic tools for patients with small vessel vasculitis (AASV). We have produced chimeric mouse/human PR3 molecules and investigate changes in reactivity over time and the possible relationship between epitope specificity and clinica...

journal_title：Clinical and experimental immunology

authors： Selga D,Segelmark M,Gunnarsson L,Hellmark T

更新日期：2010-06-01 00:00:00

abstract：:Neutrophils are often exclusively considered as a first-line innate immune defence, able to rapidly kill or trap pathogens and causing in case of over-activation tissue damage. In the female reproductive tract, however, the presence and activity of neutrophils seems to be tightly regulated. Major players in orchestrat...

journal_title：Clinical and experimental immunology

authors： Hahn S,Hasler P,Vokalova L,van Breda SV,Lapaire O,Than NG,Hoesli I,Rossi SW

更新日期：2019-10-01 00:00:00

abstract：:Autoantibodies characteristic for anti-phospholipid syndrome (APS) and systemic lupus erythematosus (SLE) are anti-β2 -glycoprotein I (β2 GPI) antibodies and anti-DNA antibodies, respectively, and almost half of APS cases occur in SLE. Anti-β2 GPI antibodies are recognized to play a pivotal role in inducing a prothrom...

journal_title：Clinical and experimental immunology

authors： Virachith S,Saito M,Watanabe Y,Inoue K,Hoshi O,Kubota T

更新日期：2019-02-01 00:00:00

abstract：:Based on studies in animal models, viral infections, in particular by enteroviruses, can accelerate or halt type 1 diabetes (T1D) development. Among factors that determine the outcome are the degree of viral replication in the target organ (viral titres), the tropism of the virus for beta cells, and the precise time-p...

journal_title：Clinical and experimental immunology

authors： Filippi CM,von Herrath MG

更新日期：2010-04-01 00:00:00

abstract：:A 7 month old girl with severe combined immunodeficiency disease (SCID) received a single transfusion of peripheral blood leucocytes from her histocompatible grandfather in an attempt to achieve immunological reconstitution. There was rapid restoration of humoral and cellular immunity which has persisted undiminished ...

journal_title：Clinical and experimental immunology

authors： Polmar SH,Schacter BZ,Sorensen RU

更新日期：1986-06-01 00:00:00

abstract：:To elucidate the mechanisms of anti-DNA production, we assessed the binding of sera of normal human subjects (NHS) and patients with SLE to a panel of bacterial and mammalian DNA. Using single-stranded DNA as antigens in an ELISA, NHS showed significant binding to some but not all bacterial DNA, while lacking reactivi...

journal_title：Clinical and experimental immunology

authors： Wu ZQ,Drayton D,Pisetsky DS

更新日期：1997-07-01 00:00:00

abstract：:Antigen- and mitogen-stimulated cytokine production by peripheral blood mononuclear cells (PBMC) of 50 pregnant women and 31 age- and sex-matched non-pregnant controls were analysed to determine whether changes in cytokine production occur during normal and pathologic human gestation. The pregnant women, consecutively...

journal_title：Clinical and experimental immunology

authors： Marzi M,Vigano A,Trabattoni D,Villa ML,Salvaggio A,Clerici E,Clerici M

更新日期：1996-10-01 00:00:00

abstract：:The La/SSB autoantigen is a major target of long-term humoral autoimmunity in primary Sjögren's Syndrome (SS) and systemic lupus erythematosus. A majority of patients with linked anti-Ro60/Ro52/La responses target an NH2-terminal epitope designated LaA that is expressed on Ro/La ribonucleoprotein complexes and the sur...

journal_title：Clinical and experimental immunology

authors： Thurgood LA,Arentz G,Lindop R,Jackson MW,Whyte AF,Colella AD,Chataway TK,Gordon TP

更新日期：2013-11-01 00:00:00

abstract：:The susceptibility of hepatocytes from patients with chronic hepatitis B to complement-dependent cytotoxicity mediated by heterologous antibodies to hepatitis B virus core (anti-HBc) and surface (anti-HBs) antigens and to hepatic asialoglycoprotein receptor was examined using a microcytotoxicity assay. The anti-HBc-in...

journal_title：Clinical and experimental immunology

authors： Michalak TI,Lau JY,McFarlane BM,Alexander GJ,Eddleston AL,Williams R

更新日期：1995-05-01 00:00:00

abstract：:Nitric oxide (NO) is a mediator of inflammatory injury which is inhibited by glucocorticoids and is implicated in rheumatoid (RA) and adjuvant arthritis (AA). The glucocorticoid-induced anti-inflammatory molecule lipocortin 1 is expressed in RA synovium, but the effects of lipocortin 1 on synovial inflammation have be...

journal_title：Clinical and experimental immunology

authors： Yang YH,Hutchinson P,Santos LL,Morand EF

更新日期：1998-01-01 00:00:00

abstract：:Oestradiol and the selective oestrogen receptor modulator (SERM) raloxifene have been shown to ameliorate collagen-induced arthritis (CIA) in rats and in mice. One aim was to investigate if raloxifene exerts its anti-arthritic and anti-osteoporotic effects during the induction or effector phase of arthritis. A second ...

journal_title：Clinical and experimental immunology

authors： Jochems C,Islander U,Erlandsson M,Engdahl C,Lagerquist M,Ohlsson C,Nandakumar KS,Holmdahl R,Carlsten H

更新日期：2011-07-01 00:00:00

abstract：:BALB/c mice made tolerant to A/J alloantigens by neonatal injection of (A/J x BALB/c)F1 spleen cells develop a host-versus-graft (HVG) disease due to the activation of donor B cells by a subset of host alloreactive helper T cells. We have investigated the effects of a single neonatal injection of the 145-2C11 anti-mou...

journal_title：Clinical and experimental immunology

authors： Wissing M,Marchant A,Moser M,Flamand V,Leo O,Abramowicz D,Urbain J,Goldman M

更新日期：1991-02-01 00:00:00

abstract：:Autoimmune Addison's disease (AAD), or primary adrenocortical insufficiency, is a classical organ-specific autoimmune disease with 160 years of history. AAD is remarkably homogeneous with one major dominant self-antigen, the cytochrome P450 21-hydroxylase enzyme, which is targeted by both autoantibodies and autoreacti...

journal_title：Clinical and experimental immunology

authors： Hellesen A,Bratland E

更新日期：2019-01-01 00:00:00

abstract：:CD4+ lymphocytes are a primary target of the human immunodeficiency virus (HIV), and CD4 counts are one of the factors used to measure disease progression in HIV-positive individuals. CD4 counts vary in uninfected individuals and across populations due to a variety of demographic, environmental, immunological and gene...

journal_title：Clinical and experimental immunology

authors： Mair C,Hawes SE,Agne HD,Sow PS,N'doye I,Manhart LE,Fu PL,Gottlieb GS,Kiviat NB

更新日期：2008-03-01 00:00:00

abstract：:In order to define the optimal conditions for detection of microbial antigens in urine, urinary HBsAg excreted during hepatitis B was chosen as a model. Using commercial kits, which mainly involve anti-discontinuous epitopes, we found urinary HBsAg in only 50% of patients with HBsAg in their sera. In contrast, with an...

journal_title：Clinical and experimental immunology

authors： Badur S,Grangeot-Keros L,Pillot J

更新日期：1992-02-01 00:00:00

abstract：:Natural killer (NK) cells mediate host defense against infections and are regulated by interleukin 2 (IL-2) and other factors. We studied NK cell function in burn patients using a 51Cr release assay with K562 target cells. We found that peripheral blood lymphocytes from burn patients had depressed NK activity (target ...

journal_title：Clinical and experimental immunology

authors： Bender BS,Winchurch RA,Thupari JN,Proust JJ,Adler WH,Munster AM

更新日期：1988-01-01 00:00:00

abstract：:Two models of murine graft-versus-host disease (GVHD) were studied with respect to autoantibody production and development of systemic lupus erythematosus (SLE) like disease. One model was induced by injection of (B10.A(4R) x B10.A(2R]F1 mice with parental (B10.A(4R] spleen and lymph node cells (groups I GVHD), the ot...

journal_title：Clinical and experimental immunology

authors： van Dam AP,Meilof JF,van den Brink HG,Smeenk RJ

更新日期：1990-07-01 00:00:00

abstract：:Activin A is a cytokine whose multiple functions have yet to be fully determined. In this study, the role of proinflammatory cytokines in regulatory control of activin A production was shown in synoviocytes and chondrocytes. Additional facets of functional inflammation-related activities of activin A were also determi...

journal_title：Clinical and experimental immunology

authors： Yu EW,Dolter KE,Shao LE,Yu J

更新日期：1998-04-01 00:00:00