Abstract：
:Natural killer (NK) cells mediate host defense against infections and are regulated by interleukin 2 (IL-2) and other factors. We studied NK cell function in burn patients using a 51Cr release assay with K562 target cells. We found that peripheral blood lymphocytes from burn patients had depressed NK activity (target cell lysis = 22.0 +/- 3.1% vs 39.8 +/- 3.2% in healthy volunteers, P less than 0.001) and also a lower response to IL-2 (28.9 +/- 3.8% vs 53.2 +/- 4.3%, P less than 0.001). Thirteen burn patients were randomly assigned to receive either standard therapy or 5 days of intravenous polymyxin B in addition to standard therapy. After 2 weeks, the patients not receiving polymyxin B had a significant decline in peripheral blood NK activity (P less than 0.01) and response to IL-2 (P less than 0.05), while no decline in NK cell activity was seen in patients who received polymyxin B. Sera from burn patients was found to suppress the NK activity of lymphocytes from healthy adults by 5-75%. After using affinity chromatography to remove endotoxin, the sera from burn patients no longer suppressed NK cell activity. Circulating endotoxin appears to be involved in the suppression of NK activity in burn patients.
journal_name
Clin Exp Immunoljournal_title
Clinical and experimental immunologyauthors
Bender BS,Winchurch RA,Thupari JN,Proust JJ,Adler WH,Munster AMsubject
Has Abstractpub_date
1988-01-01 00:00:00pages
120-5issue
1eissn
0009-9104issn
1365-2249journal_volume
71pub_type
临床试验,杂志文章,随机对照试验abstract：:Heavy C3 glomerular deposits were observed in rabbits injected intravenously with C5 streptococcal vaccine. Immunoglobulin deposits appeared later in a few rabbits. Although some data favour the presence of circulating immune complexes during the course of this glomerulonephritis, no evidence for their initiating role...
journal_title：Clinical and experimental immunology
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abstract：:The role of suppressive anti-retroviral therapy (ART) in eliciting restoration of dysregulated immune function remains unclear in HIV-1 infection. Also, due to tailoring of therapeutic regimens towards HIV-1, this possible impairment of therapy may be even more pronounced in HIV-2 and dual (HIV-D) infection. Thus, we ...
journal_title：Clinical and experimental immunology
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abstract：:Autoreactivity to heat shock protein 60 (Hsp60) has been implicated in the pathogenesis and regulation of chronic inflammation, especially in autoimmune diseases. In transplantation, there is a lack of information regarding the cytokine profile and specificity of cells that recognize self-Hsp60 as well as the kinetics...
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pub_type： 杂志文章
doi：
更新日期：1978-10-01 00:00:00
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pub_type： 杂志文章,评审
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journal_title：Clinical and experimental immunology
pub_type： 杂志文章
doi：
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pub_type： 杂志文章
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pub_type： 杂志文章
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更新日期：1990-08-01 00:00:00
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pub_type： 杂志文章
doi：
更新日期：1980-09-01 00:00:00
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journal_title：Clinical and experimental immunology
pub_type： 杂志文章
doi：
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doi：
更新日期：1984-07-01 00:00:00
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doi：
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pub_type： 杂志文章
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journal_title：Clinical and experimental immunology
pub_type： 杂志文章
doi：
更新日期：1979-10-01 00:00:00
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doi：
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pub_type： 杂志文章
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doi：
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更新日期：1993-08-01 00:00:00
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pub_type： 杂志文章
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