Interferon-gamma induces HLA-DR expression by thyroid epithelium.

abstract：:Growth and maturation of B lymphocytes from stem cells require a series of complex processes that are dependent at least in part on growth factors. Uncontrolled expression of receptors from these early growth factors may contribute to a leukaemogenesis of such early B cell progenitors. We show here that early pre-pre-...

journal_title：Clinical and experimental immunology

authors： Trink B,Wang G,Shahar M,Meydan N,Roifman CM

更新日期：1995-11-01 00:00:00

abstract：:The secondary antibody response to 5.0 microgram flagellin was studied by haemagglutination in 132 healthy or convalescent subjects given a primary challenge with 5.0 microgram flagellin from 1 to 44 months previously. The peak titre, expressed as total antibody, occurred at 2 weeks and was mainly immunoglobulin (Ig)G...

journal_title：Clinical and experimental immunology

authors： Whittingham S,Buckley JD,Mackay IR

更新日期：1978-11-01 00:00:00

abstract：:We have previously demonstrated that immune platelet destruction observed in an AIDS-free HIV-infected patient was associated with the presence of a cross-reactive antibody recognizing both HIV-glycoprotein (gp)120 and platelet gpIIIa (CD61). We have now investigated the presence of such antibodies in other HIV-infect...

journal_title：Clinical and experimental immunology

authors： Bettaieb A,Oksenhendler E,Duedari N,Bierling P

更新日期：1996-01-01 00:00:00

abstract：:Nerve growth factor (NGF) regulates B cell activation and differentiation and is an autocrine survival factor for memory B lymphocytes. We have reported recently that the number of memory B cells is reduced during HIV-1 infection. In this study we evaluated whether alteration in the NGF supply was involved in memory B...

journal_title：Clinical and experimental immunology

authors： Titanji K,Nilsson A,Mörch C,Samuelsson A,Sönnerborg A,Grutzmeier S,Zazzi M,De Milito A

更新日期：2003-05-01 00:00:00

abstract：:The aetiology of sarcoidosis, an inflammatory granulomatous multi-system disorder, is unclear. It is thought to be the product of an unknown exogenous antigenic stimulus and an endogenous genetic susceptibility. Toll-like receptors (TLR) are signal molecules essential for the cellular response to bacterial cell wall c...

journal_title：Clinical and experimental immunology

authors： Pabst S,Baumgarten G,Stremmel A,Lennarz M,Knüfermann P,Gillissen A,Vetter H,Grohé C

更新日期：2006-03-01 00:00:00

abstract：:The possibility that shared idiotypes may be present on antibodies of different specificities was explored using sera from 13 patients with systemic lupus erythematosus. Eleven sera had anti-DNA and seven carried the 16/6 idiotype (ID). Two of the sera with 16/6 ID also had lymphocytotoxic antibodies, the activity of ...

journal_title：Clinical and experimental immunology

authors： Lydyard PM,Isenberg D,de Sousa B,Mackenzie L,Cooke A

更新日期：1987-03-01 00:00:00

abstract：:To identify and measure the spontaneous cell-mediated cytotoxicity of natural killer cells, we used the lysis of an established lymphoblastoid cell line as target in a 4-hr 51Cr-release assay. Mononuclear cell suspensions of the peripheral blood of thirty-four patients with Crohn's disease (group CD), eleven patients ...

journal_title：Clinical and experimental immunology

authors： Auer IO,Ziemer E,Sommer H

更新日期：1980-10-01 00:00:00

abstract：:The relationship between allergic airway inflammation and pneumococcal pneumonia is not well understood. We assessed susceptibility to experimental pneumococcal pneumonia in mice with and without allergic airway inflammation. Susceptibility to pneumococcal pneumonia was evaluated by challenging mice with a bioluminesc...

journal_title：Clinical and experimental immunology

authors： Kang CI,Rouse MS,Patel R,Kita H,Juhn YJ

更新日期：2009-06-01 00:00:00

abstract：:Reconstitution of Semliki forest virus infected nude mice with spleen cells from their immunocompetent nu/+ litter mates resulted in an abolition of the otherwise persistent brain virus, production of anti-SFV IgG, and development of normally absent brain pathology. The brain pathological changes, including demyelinat...

journal_title：Clinical and experimental immunology

authors： Fazakerley JK,Amor S,Webb HE

更新日期：1983-04-01 00:00:00

abstract：:To investigate the possible role of IL-6 in the activation of the autoimmune process in systemic lupus erythematosus (SLE), we serially measured concentrations of IL-6, IgG, and anti-dsDNA antibodies before and during exacerbations in patients with SLE. In addition, we serially related the IL-6 response to the generat...

journal_title：Clinical and experimental immunology

authors： Spronk PE,ter Borg EJ,Limburg PC,Kallenberg CG

更新日期：1992-10-01 00:00:00

abstract：:Glucocorticoid hormones (GCH) regulate, through the apoptotic process, the negative selection of immature T cells in the thymus. Because apoptosis seems to occur also in the maintenance of peripheral tolerance, we have investigated whether GCH may induce apoptosis in human mature lymphocytes. Peripheral blood lymphocy...

journal_title：Clinical and experimental immunology

authors： Lanza L,Scudeletti M,Puppo F,Bosco O,Peirano L,Filaci G,Fecarotta E,Vidali G,Indiveri F

更新日期：1996-03-01 00:00:00

abstract：:Natural killer (NK) cytotoxic activity was simultaneously investigated in bone marrow mononuclear cells (BMMC) and peripheral blood lymphocytes (PBL) from nine Hodgkin's disease (HD) and 15 non-Hodgkin lymphoma (NHL) untreated patients. Twenty-five PBL samples and seven bone marrow specimens from healthy individuals w...

journal_title：Clinical and experimental immunology

authors： Caldera LH,Leon-Ponte M,Acquatella G,Bianco NE,Blanca I

更新日期：1992-04-01 00:00:00

abstract：:We report a study on immunoregulation of in vitro antibody to hepatitis B surface antigen (anti-HBs) synthesis induced by pokeweed mitogen (PWM) from peripheral blood mononuclear cells (PBMC) in chronic hepatitis B surface antigen (HBsAg) carriers and in 'high responders', (anti-HBs RIA ratio greater than or equal to ...

journal_title：Clinical and experimental immunology

authors： Barnaba V,Valesini G,Levrero M,Zaccari C,Van Dyke A,Falco M,Musca A,Balsano F

更新日期：1985-05-01 00:00:00

abstract：:For 'the total population of patients with sepsis, sepsis syndrome or SIRS', the question of whether intravenous immune globulin (IVIG) reduces mortality is neither proved nor disproved. For the sepsis subgroups 'postoperative sepsis with a sepsis score more than 19' and 'endotoxaemic, early septic shock', a significa...

journal_title：Clinical and experimental immunology

authors： Werdan K,Pilz G

更新日期：1996-05-01 00:00:00

abstract：:Anti-neutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV) is a group of autoimmune diseases, including granulomatosis with polyangiitis (GPA) and microscopic polyangiitis (MPA). It is not known why ANCA develop, but it has been shown that they participate in pathogenesis by activating polymorphonuclear n...

journal_title：Clinical and experimental immunology

authors： Ohlsson SM,Pettersson Å,Ohlsson S,Selga D,Bengtsson AA,Segelmark M,Hellmark T

更新日期：2012-10-01 00:00:00

abstract：:The lymphocyte stimulation test has been standardized in a normal human population using four virus cell-associated antigens (VCAA): human embryonic lung cells infected with the LEC and Norrby strains of measles virus, mumps virus, and vaccinia virus. Following 1 week of treatment with the immunopotentiating drug leva...

journal_title：Clinical and experimental immunology

authors： Dau PC,Johnson KP,Spitler LE

更新日期：1976-11-01 00:00:00

abstract：:Anti-tubulin antibodies were studied in normal human serum either maintained at neutral pH to measure the free antibody activity (FAA) or treated at pH 2.8 to measure the total antibody activity (TAA): FAA + the antibody activity in the form of immune complexes (ICAA). Anti-tubulin antibody activities were assessed by...

journal_title：Clinical and experimental immunology

authors： Bernier-Valentin F,Rabilloud R,Rousset B

更新日期：1988-02-01 00:00:00

abstract：:Summary The interaction between stroma and blood cells in the human spleen has received little attention, despite their well-defined roles during blood cell development in bone marrow. We have reported previously that human spleen-derived fibroblasts display a differentiated myofibroblast phenotype and constitutively ...

journal_title：Clinical and experimental immunology

authors： Briard D,Azzarone B,Brouty-Boyé D

更新日期：2005-05-01 00:00:00

abstract：:IL-1 acts on many cells as an inflammatory mediator. Its two forms, IL-1 alpha and IL-1 beta, are regulated differentially within hyperproliferative inflammatory skin conditions, such as psoriasis. While IL-1 alpha is down-regulated within psoriatic lesions, the levels of IL-1 beta are increased. However, some investi...

journal_title：Clinical and experimental immunology

authors： Schön M,Behmenburg C,Denzer D,Schön MP

更新日期：2001-03-01 00:00:00

abstract：:Vulnerability to Streptococcus pneumoniae is most pronounced in children. The microbial virulence factors and the features of the host immune response contributing to this phenomenon are not completely understood. In the current study, the humoral immune response to separated Strep. pneumoniae surface proteins and the...

journal_title：Clinical and experimental immunology

authors： Lifshitz S,Dagan R,Shani-Sekler M,Grossman N,Fleminger G,Friger M,Nebenzahl YM

更新日期：2002-02-01 00:00:00

abstract：:The structural characteristics of autologous red blood cell (ARBC) receptors on human peripheral blood lymphocytes (PBL) induced by phytohaemagglutinin (PHA) were examined. Tunicamycin, which is known to be a blocker of the protein glycosylation of N-glycosidic type glycoprotein, significantly inhibited the production...

journal_title：Clinical and experimental immunology

authors： Hyodo S,Kishi T,Kashiwa H,Kittaka E,Suzawa T,Tanaka Y,Sakano T,Usui T

更新日期：1984-07-01 00:00:00

abstract：:Based on what is known about the biology of HIV-1 vertical transmission, the HIV burden of the mother, maternal immune factors and the integrity of the placental barrier are likely to play major roles. We therefore sought to determine whether the presence of antibodies in sera from 47 HIV-1-infected mothers, including...

journal_title：Clinical and experimental immunology

authors： Mabondzo A,Rouvier P,Raoul H,Le Naour R,Courpotin C,Hervé F,Parnet-Mathieu F,Lasfargues G,Dormont D

更新日期：1995-12-01 00:00:00

abstract：:Autoantibodies inhibiting the activity of the metalloproteinase, ADAMTS13 (a disintegrin and metalloproteinase with a thrombospondin type 1 motif, member 13), underlie the pathogenesis of thrombotic thrombocytopenic purpura (TTP). Rituximab (RTX) combined with plasma-exchange (PEX) is an effective treatment in TTP. Pa...

journal_title：Clinical and experimental immunology

authors： Becerra E,Scully MA,Leandro MJ,Heelas EO,Westwood JP,De La Torre I,Cambridge G

更新日期：2015-03-01 00:00:00

abstract：:Lewis rats were immunized with bee venom allergen in Freund's complete adjuvant (FCA) or with FCA only. Animals immunized with bee venom developed specific IgG antibodies but no specific IgE antibodies were detected. Lymphocytes from lymph nodes when cultured with antigen in vitro showed an increased stimulation index...

journal_title：Clinical and experimental immunology

authors： Schneider H,Urbanek R

更新日期：1984-08-01 00:00:00

abstract：:The NOD mouse is a model of human juvenile type I diabetes mellitus. As in humans and in the BB rat model, the development of diabetes in NOD mice is accompanied by evident manifestations of cell-mediated and humoral autoimmunity. Beside autoantibodies directed at putative islet cell antigens, NOD sera contain antibod...

journal_title：Clinical and experimental immunology

authors： Lehuen A,Altman J,Bach JF,Carnaud C

更新日期：1990-09-01 00:00:00

abstract：:Type 1 diabetes (T1D) is often considered the prototype organ-specific autoimmune disease in clinical immunology circles. The key disease features - precise destruction of a single endocrine cell type occurring on a distinct genetic and autoimmune background - have been unravelled in recent years to such an extent tha...

journal_title：Clinical and experimental immunology

authors： Staeva-Vieira T,Peakman M,von Herrath M

更新日期：2007-04-01 00:00:00

abstract：:The presence of autoantibodies detected by immunofluorescence to single endocrine cells, of human duodenum is described in three groups of patients and two control groups. Of 173 coeliac cases, four had GIP cell antibodies, one had secretin cell antibodies and twenty-one reacted with both cell types. Of twelve tropica...

journal_title：Clinical and experimental immunology

authors： Mirakian R,Bottazzo GF,Doniach D

更新日期：1980-07-01 00:00:00

abstract：:A comparative and quantitative study of the tissue distribution of brain-thymus shared antigens was carried out using rabbit antisera to rat, dog and human brain homogenates, assayed on rat, dog and human thymus cells, respectively. Quantitative absorption analyses with eleven different tissues showed that the tissue ...

journal_title：Clinical and experimental immunology

authors： Dalchau R,Fabre JW

更新日期：1979-03-01 00:00:00

abstract：:Recently markers of endothelial cell activation or injury gained increasing interest as serological parameters of disease activation in vasculitides. Among these, soluble serum thrombomodulin, ICAM-1, VCAM-1 and E-selectin are of particular interest. However, only thrombomodulin showed the expected close correlation. ...

journal_title：Clinical and experimental immunology

authors： Boehme MW,Raeth U,Scherbaum WA,Galle PR,Stremmel W

更新日期：2000-01-01 00:00:00

abstract：:Experimental autoimmune uveitis (EAU) is an organ-specific autoimmune disease and has served as a model of certain ocular inflammatory conditions in man. The present study was aimed at separating the effects of MHC and non-MHC genes on the development of EAU in the rat. EAU-susceptible LEW (RT1l), EAU-resistant WKAH (...

journal_title：Clinical and experimental immunology

authors： Hirose S,Ogasawara K,Natori T,Sasamoto Y,Ohno S,Matsuda H,Onoé K

更新日期：1991-12-01 00:00:00