Abstract:
:To identify and measure the spontaneous cell-mediated cytotoxicity of natural killer cells, we used the lysis of an established lymphoblastoid cell line as target in a 4-hr 51Cr-release assay. Mononuclear cell suspensions of the peripheral blood of thirty-four patients with Crohn's disease (group CD), eleven patients with inflammatory bowel disease other than CD or ulcerative colitis (group D) and forty-five healthy subjects matched for both age and sex with the patients were studied. Depletion of phagocytic, plastic-adherent cells ('purified suspensions') led to a significant increase of the natural killer cell activity as compared with unseparated suspensions. This was seen to occur in all groups. In CD patients the natural killer cell activity was significantly below normal levels in both unseparated and 'purified' suspensions. This was independent of disease duration. In 'purified' suspensions the natural killer cell activity was inversely related to the disease activity. In group D the natural cytotoxicity was significantly lower in unseparated suspensions than that in healthy controls. In 'purified' suspensions it was still slightly lower than in healthy controls.
journal_name
Clin Exp Immunoljournal_title
Clinical and experimental immunologyauthors
Auer IO,Ziemer E,Sommer Hsubject
Has Abstractpub_date
1980-10-01 00:00:00pages
41-9issue
1eissn
0009-9104issn
1365-2249journal_volume
42pub_type
杂志文章abstract::The kinetics of the cellular and humoral responses of 30 recipients of hepatitis B vaccine were studied. All individuals exerted an HBsAg blastogenic response sometime throughout the study period but the maximum response was detected on day 28 and 56. The removal of CD8+ cells enhanced significantly the HBsAg response...
journal_title:Clinical and experimental immunology
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abstract::A subpopulation of human B lymphocytes forms rosettes with mouse erythrocytes through a glycoprotein-dependent bond. Further studies of this bond show that the lymphocyte receptor is not immunoglobulin, although the binding of antisera or staphylococci to surface immunoglobulin inhibits the formation of mouse rosettes...
journal_title:Clinical and experimental immunology
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更新日期:1979-06-01 00:00:00
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journal_title:Clinical and experimental immunology
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journal_title:Clinical and experimental immunology
pub_type: 杂志文章,评审
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journal_title:Clinical and experimental immunology
pub_type: 杂志文章
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journal_title:Clinical and experimental immunology
pub_type: 杂志文章
doi:
更新日期:1986-05-01 00:00:00
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pub_type: 杂志文章
doi:10.1111/j.1365-2249.2008.03743.x
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journal_title:Clinical and experimental immunology
pub_type: 杂志文章
doi:
更新日期:1989-08-01 00:00:00
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journal_title:Clinical and experimental immunology
pub_type: 杂志文章
doi:
更新日期:1998-02-01 00:00:00
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journal_title:Clinical and experimental immunology
pub_type: 杂志文章
doi:10.1046/j.1365-2249.2000.01286.x
更新日期:2000-08-01 00:00:00
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journal_title:Clinical and experimental immunology
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doi:
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journal_title:Clinical and experimental immunology
pub_type: 杂志文章
doi:
更新日期:1978-10-01 00:00:00
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journal_title:Clinical and experimental immunology
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journal_title:Clinical and experimental immunology
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journal_title:Clinical and experimental immunology
pub_type: 杂志文章
doi:10.1111/j.1365-2249.2009.04013.x
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journal_title:Clinical and experimental immunology
pub_type: 杂志文章
doi:
更新日期:1977-03-01 00:00:00
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journal_title:Clinical and experimental immunology
pub_type: 杂志文章
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journal_title:Clinical and experimental immunology
pub_type: 杂志文章
doi:
更新日期:1989-03-01 00:00:00
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journal_title:Clinical and experimental immunology
pub_type: 杂志文章
doi:
更新日期:1983-12-01 00:00:00
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journal_title:Clinical and experimental immunology
pub_type: 杂志文章
doi:
更新日期:1987-03-01 00:00:00
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journal_title:Clinical and experimental immunology
pub_type: 杂志文章
doi:10.1111/j.1365-2249.2010.04277.x
更新日期:2011-01-01 00:00:00