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A monoclonal antibody with specificity for Trypanosoma cruzi, central and peripheral neurones and glia.

Abstract：

:Of 26 hybridomas secreting anti-Trypanosoma cruzi antibodies, two reacted with murine brain and spinal cord extracts but not other tissues. Both antibodies (5H7 and 3H3) had identical isotypes (IgM) and specificities as judged by western blotting. Antigens of molecular weight 58,000 and 37,000 in mouse brain and spinal cord, and 58,000 and 35,000 in T. cruzi were detected. Different tissue antigens were recognized by a previously reported T. cruzi mammalian neural tissue cross-reacting monoclonal antibody CE5; on immunofluorescence 5H7 stained some glia, and some central and peripheral neurones in rat tissue sections. Pooled sera from mice chronically infected with T. cruzi competed with binding of 5H7 to T. cruzi antigens.

journal_name

Clin Exp Immunol

journal_title

Clinical and experimental immunology

authors

Snary D,Flint JE,Wood JN,Scott MT,Chapman MD,Dodd J,Jessell TM,Miles MA

subject

Has Abstract

pub_date

1983-12-01 00:00:00

pages

617-24

issue

3

eissn

0009-9104

issn

1365-2249

journal_volume

54

pub_type

杂志文章

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