Immunoglobulin replacement therapy by self-infusion at home.

abstract：:In this study, we hypothesized that the granulomatous disorder sarcoidosis is not caused by a single pathogen, but rather results from abnormal responses of Toll-like receptors (TLRs) to conserved bacterial elements. Unsorted bronchoalveolar lavage (BAL) cells from patients with suspected pulmonary sarcoidosis and hea...

journal_title：Clinical and experimental immunology

authors： Gabrilovich MI,Walrath J,van Lunteren J,Nethery D,Seifu M,Kern JA,Harding CV,Tuscano L,Lee H,Williams SD,Mackay W,Tomashefski JF Jr,Silver RF

更新日期：2013-09-01 00:00:00

abstract：:A retrospective chart review was conducted at a single centre, capturing data on 173 primary immunodeficiency disease (PIDD) patients, including 40 obese patients, using subcutaneous administration of immunoglobulin (Ig) (SCIG) (16 or 20%) delivered by infusion pump or subcutaneous (s.c.) rapid push. Patients previous...

journal_title：Clinical and experimental immunology

authors： Shapiro R

更新日期：2013-08-01 00:00:00

abstract：:In susceptible mice, the heavy metal ion mercury is able to induce a strong immune activation, which resembles a T helper 2 (Th2) type of immune response and is characterized by a polyclonal B cell activation, formation of high levels of IgG1 and IgE antibodies, production of autoantibodies of different specificities ...

journal_title：Clinical and experimental immunology

authors： Brenden N,Rabbani H,Abedi-Valugerdi M

更新日期：2001-08-01 00:00:00

abstract：:Nitric oxide (NO) is a mediator of inflammatory injury which is inhibited by glucocorticoids and is implicated in rheumatoid (RA) and adjuvant arthritis (AA). The glucocorticoid-induced anti-inflammatory molecule lipocortin 1 is expressed in RA synovium, but the effects of lipocortin 1 on synovial inflammation have be...

journal_title：Clinical and experimental immunology

authors： Yang YH,Hutchinson P,Santos LL,Morand EF

更新日期：1998-01-01 00:00:00

abstract：:Heavy C3 glomerular deposits were observed in rabbits injected intravenously with C5 streptococcal vaccine. Immunoglobulin deposits appeared later in a few rabbits. Although some data favour the presence of circulating immune complexes during the course of this glomerulonephritis, no evidence for their initiating role...

journal_title：Clinical and experimental immunology

authors： Bellon B,Kuhn J,Ayed K,Girard JF,Druet P

更新日期：1979-08-01 00:00:00

abstract：:Th1 cell-induced anti-mycobacterial immunity is lost during a progressive Mycobacterium tuberculosis infection in a susceptible host. This study was designed to test the mechanism of the loss of anti-mycobacterial cell-mediated immune response. We demonstrate that M. tuberculosis infection results in increased Fas exp...

journal_title：Clinical and experimental immunology

authors： Das G,Vohra H,Saha B,Agrewala JN,Mishra GC

更新日期：1999-02-01 00:00:00

abstract：:Studies of human mucosal lymphoid follicles are rare and have been limited to children's Peyer's patches, which are visible at endoscopy. We investigated lymphoid follicles in ileum biopsies of 87 patients and surgical colon specimens from 66 cancer patients, and examined phenotype and function of isolated follicular ...

journal_title：Clinical and experimental immunology

authors： Junker Y,Bode H,Wahnschaffe U,Kroesen A,Loddenkemper C,Duchmann R,Zeitz M,Ullrich R

更新日期：2009-05-01 00:00:00

abstract：:Anaphylatoxins C5a and C3a and their des Arg derivatives inhibited C2 production by mononuclear phagocytes. C5a and C5adesArg which were approximately equipotent (IC50 = 10(-10) mol/l) were more effective than C3a (IC50 = 5 X 10(-8) mol/l) which was approximately 10-20-fold more potent than C3adesArg IC50 = 5 X 10(-6)...

journal_title：Clinical and experimental immunology

authors： Lappin D,Damerau B,Whaley K

更新日期：1983-11-01 00:00:00

abstract：:Anti-phospholipid syndrome (APS) is characterized by arterial and/or venous thrombosis and pregnancy morbidity. It is well known that in these patients thrombosis may be the result of a hypercoagulable state related to anti-β2-glycoprotein I (β2-GPI) antibodies. Moreover, platelets may play a role in thrombotic manife...

journal_title：Clinical and experimental immunology

authors： Capozzi A,Manganelli V,Riitano G,Recalchi S,Truglia S,Alessandri C,Longo A,Garofalo T,Misasi R,Valesini G,Conti F,Sorice M

更新日期：2019-04-01 00:00:00

abstract：:Aspergillus fumigatus (Af) is a fungus associated with allergic bronchopulmonary aspergillosis (ABPA) and other allergic diseases. Immune responses in these diseases are due to T and B cell responses. T cell activation requires both Af-specific engagement of the T-cell-receptor as well as interaction of antigen indepe...

journal_title：Clinical and experimental immunology

authors： Barrios CS,Johnson BD,D Henderson J Jr,Fink JN,Kelly KJ,Kurup VP

更新日期：2005-11-01 00:00:00

abstract：:The specificities of a panel of erythrocyte-reactive MoAbs derived from NZB mice with autoimmune haemolytic anaemia (AIHA) were determined by immunoprecipitation and immunoblotting. Of the eight antibodies, two (IgG1 MoAb 105-2H and IgG2a MoAb 34-3C) immunoprecipitated a 105-kD component identified as the erythrocyte ...

journal_title：Clinical and experimental immunology

authors： de Sá Oliveira GG,Izui S,Ravirajan CT,Mageed RA,Lydyard PM,Elson CJ,Barker RN

更新日期：1996-08-01 00:00:00

abstract：:The aim of this study was to characterize the proinflammatory and T helper (Th)1/Th2 cytokine responses during acute parvovirus B19 (B19) infection and determine whether an imbalance of the Th1/Th2 cytokine pattern is related to persistent B19 infection. Cytokines were quantified by multiplex beads immunoassay in seru...

journal_title：Clinical and experimental immunology

authors： Isa A,Lundqvist A,Lindblom A,Tolfvenstam T,Broliden K

更新日期：2007-03-01 00:00:00

abstract：:Experimental autoimmune uveitis (EAU) is an organ-specific autoimmune disease and has served as a model of certain ocular inflammatory conditions in man. The present study was aimed at separating the effects of MHC and non-MHC genes on the development of EAU in the rat. EAU-susceptible LEW (RT1l), EAU-resistant WKAH (...

journal_title：Clinical and experimental immunology

authors： Hirose S,Ogasawara K,Natori T,Sasamoto Y,Ohno S,Matsuda H,Onoé K

更新日期：1991-12-01 00:00:00

abstract：:The CCL2/CCR2 chemokine/receptor axis directs the chemotaxis of infiltrating monocytes/macrophages and T cells and plays a pivotal role in tissue damage and fibrosis in kidney diseases. The eradication of the activated leucocytes should diminish the production of inflammatory mediators, limit tissue damage and amelior...

journal_title：Clinical and experimental immunology

authors： McIntosh LM,Barnes JL,Barnes VL,McDonald JR

更新日期：2009-02-01 00:00:00

abstract：:The concentration of immunoglobulins, anti-ssDNA, anti-dsDNA, anti-TNP antibodies, IgM rheumatoid factor, C3, immune complexes and serum amyloid P component (SAP), in the serum were measured in 68 male and female MRL/lpr/lpr mice, a strain affected with a systemic autoimmune disease. The degree of lymphoproliferation ...

journal_title：Clinical and experimental immunology

authors： Rordorf-Adam C,Serban D,Pataki A,Grüninger M

更新日期：1985-09-01 00:00:00

abstract：:Myeloid FcαRI, a receptor for immunoglobulin (Ig)A, mediates cell activation or inhibition depending on the type of ligand interaction, which can be either multivalent or monovalent. Anti-inflammatory signalling is triggered by monomeric targeting using anti-FcαRI Fab or IgA ligand binding, which inhibits immune and n...

journal_title：Clinical and experimental immunology

authors： Watanabe T,Kanamaru Y,Liu C,Suzuki Y,Tada N,Okumura K,Horikoshi S,Tomino Y

更新日期：2011-11-01 00:00:00

abstract：:Myeloid and plasmacytoid dendritic cells (DC) are present in cerebrospinal fluid (CSF) in non-inflammatory neurological diseases (NIND) and elevated in clinically definite multiple sclerosis (MS) and in early MS - acute monosymptomatic optic neuritis (ON). Here, we show that expression of CCR5, a chemokine receptor fo...

journal_title：Clinical and experimental immunology

authors： Pashenkov M,Teleshova N,Kouwenhoven M,Kostulas V,Huang YM,Soderstrom M,Link H

更新日期：2002-03-01 00:00:00

abstract：:In vitro inducible suppressor cell precursors were detected in the spleen of BALB/c but not in DBA/2 mice infected intraperitoneally with 10(8) Mycobacterium lepraemurium bacilli, thus suggesting that their development is genetically controlled. Two pairs of mouse strains congenic at the Ity/Lsh/Bcg locus (BALB/c-C.D2...

journal_title：Clinical and experimental immunology

authors： Gosselin D,Turcotte R,Lemieux S

更新日期：1994-05-01 00:00:00

abstract：:The complement system is an important part of the innate immune defence. It contributes not only to local inflammation, removal and killing of pathogens, but it also assists in shaping of the adaptive immune response. Besides a role in inflammation, complement is also involved in physiological processes such as waste ...

journal_title：Clinical and experimental immunology

authors： Lubbers R,van Essen MF,van Kooten C,Trouw LA

更新日期：2017-05-01 00:00:00

abstract：:Amyloid obtained from the myocardium of a patient (Han) with familial amyloid cardiomyopathy of Danish origin was studied. Gel filtration and electrophoresis of purified and denatured amyloid fibrils Han revealed various fractions ranging in mol. wt from 40,000 to 8,000 daltons. Amyloid Han and fractions reacted with ...

journal_title：Clinical and experimental immunology

authors： Husby G,Ranløv PJ,Sletten K,Marhaug G

更新日期：1985-04-01 00:00:00

abstract：:Presence of antibodies directed against replication protein A (RPA), a DNA binding protein complex composed of three subunits (RPA-70, RPA-32 and RPA-14) was investigated among patients with SLE and other autoimmune diseases using immunoblot analysis to RPA-70 and RPA-32 recombinant proteins. Anti-RPA antibodies were ...

journal_title：Clinical and experimental immunology

authors： Garcia-Lozano R,Wichmann I,Garcia A,Sanchez-Roman J,Gonzalez-Escribano F,Nuñez-Roldan A

更新日期：1996-01-01 00:00:00

abstract：:Insufficient stimulatory capacities of autologous dendritic cells (DC) may contribute in part to impaired T cell stimulation and therefore viral persistence in patients with chronic hepatitis B virus (HBV) infection. In order to characterize the antigen presenting functions of DC from chronic HBV carriers and controls...

journal_title：Clinical and experimental immunology

authors： Löhr HF,Pingel S,Böcher WO,Bernhard H,Herzog-Hauff S,Rose-John S,Galle PR

更新日期：2002-10-01 00:00:00

abstract：:Tuberculosis is a worldwide health problem, and multidrug-resistant (MDR) and extensively multidrug-resistant (XMDR) strains are rapidly emerging and threatening the control of this disease. These problems motivate the search for new treatment strategies. One potential strategy is immunotherapy using cationic anti-mic...

journal_title：Clinical and experimental immunology

authors： Rivas-Santiago CE,Rivas-Santiago B,León DA,Castañeda-Delgado J,Hernández Pando R

更新日期：2011-04-01 00:00:00

abstract：:In order to study T-cell function related to the production of autoimmune nephropathy, we immunized random-bred mice, homozygous athymic nude (nu/nu) mice and heterozygous hairy (nu/+) mice with human glomeruli contained in Freund's complete adjuvant. The random-bred and heterozygous hairy mice developed circulating a...

journal_title：Clinical and experimental immunology

authors： Bolton WK,Benton FR,Lobo PI

更新日期：1978-09-01 00:00:00

abstract：:In this study which included 16 patients with inflammatory or non-inflammatory arthropathies, human granulocyte-macrophage colony-stimulating activity was detected in synovial fluid. This was attributable to the presence of colony-stimulating factor(s) (CSF), as a direct action on human bone marrow progenitor cells wa...

journal_title：Clinical and experimental immunology

authors： Williamson DJ,Begley CG,Vadas MA,Metcalf D

更新日期：1988-04-01 00:00:00

abstract：:Extracorporeal photopheresis (ECP) is a widely used immunomodulatory therapy for the treatment of various T cell-mediated disorders such as cutaneous T cell lymphoma (CTCL), graft-versus-host disease (GvHD) or systemic sclerosis. Although clinical benefits of ECP are already well described, the underlying mechanism of...

journal_title：Clinical and experimental immunology

authors： Wiese F,Reinhardt-Heller K,Volz M,Gille C,Köstlin N,Billing H,Handgretinger R,Holzer U

更新日期：2019-03-01 00:00:00

abstract：:IFN-gamma is known to be a major inhibitor of IgE synthesis in vitro. Recent studies demonstrating reduced production of IFN-gamma in children and adults with atopic dermatitis and elevated serum IgE suggest a similar role for this cytokine in vivo. The reasons for this reduced IFN-gamma production are not known. One ...

journal_title：Clinical and experimental immunology

authors： Tang M,Kemp A

更新日期：1994-01-01 00:00:00

abstract：:We have investigated the expression of chemokines and their receptors in leprosy skin lesions using immunohistochemistry. Skin biopsies from 25 leprosy patients across the leprosy spectrum, 11 patients undergoing type I reversal reactions and four normal donors were immunostained by ABC peroxidase method using antibod...

journal_title：Clinical and experimental immunology

authors： Kirkaldy AA,Musonda AC,Khanolkhar-Young S,Suneetha S,Lockwood DN

更新日期：2003-12-01 00:00:00

abstract：:Lyme borreliosis is a complex infection, where some individuals develop so-called 'chronic borreliosis'. The pathogenetic mechanisms are unknown, but the type of immune response is probably important for healing. A strong T helper cell type 1 (Th1)-like response has been suggested as crucial for eradication of Borreli...

journal_title：Clinical and experimental immunology

authors： Ekerfelt C,Andersson M,Olausson A,Bergström S,Hultman P

更新日期：2007-10-01 00:00:00

abstract：:The anti-schistosomular humoral responses of guinea-pigs vaccinated with radiation-attenuated cercariae of Schistosoma mansoni have been investigated in vitro. The sera of vaccinated animals contain schistosomulicidal complement-fixing antibodies which peak in titre at week 5 after vaccination and predominantly consis...

journal_title：Clinical and experimental immunology

authors： Gordon JR,McLaren DJ

更新日期：1987-02-01 00:00:00