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Production of complement components by cells of the immune system.

Abstract：

:The complement system is an important part of the innate immune defence. It contributes not only to local inflammation, removal and killing of pathogens, but it also assists in shaping of the adaptive immune response. Besides a role in inflammation, complement is also involved in physiological processes such as waste disposal and developmental programmes. The complement system comprises several soluble and membrane-bound proteins. The bulk of the soluble proteins is produced mainly by the liver. While several complement proteins are produced by a wide variety of cell types, other complement proteins are produced by only a few related cell types. As these data suggest that local production by specific cell types may have specific functions, more detailed studies have been employed recently analysing the local and even intracellular role of these complement proteins. Here we review the current knowledge about extrahepatic production and/or secretion of complement components. More specifically, we address what is known about complement synthesis by cells of the human immune system.

journal_name

Clin Exp Immunol

journal_title

Clinical and experimental immunology

authors

Lubbers R,van Essen MF,van Kooten C,Trouw LA

doi

10.1111/cei.12952

subject

Has Abstract

pub_date

2017-05-01 00:00:00

pages

183-194

issue

2

eissn

0009-9104

issn

1365-2249

journal_volume

188

pub_type

杂志文章,评审

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