Immunity to schistosomiasis mansoni in guinea-pigs vaccinated with radiation-attenuated cercariae: I. Humoral responses against skin-stage schistosomula.

abstract：:Macaques provide important animal models in biomedical research into infectious and chronic inflammatory disease. Therefore, a proper understanding of the similarities and differences in immune function between macaques and humans is needed for adequate interpretation of the data and translation to the human situation...

journal_title：Clinical and experimental immunology

authors： Koopman G,Beenhakker N,Burm S,Bouwhuis O,Bajramovic J,Sommandas V,Mudde G,Mooij P,'t Hart BA,Bogers WM

更新日期：2013-10-01 00:00:00

abstract：:Systemic autoimmune diseases, such as systemic lupus erythematosus (SLE), are often characterized by a failure of self-tolerance and result in an uncontrolled activation of B cells and effector T cells. Interleukin (IL)-2 critically maintains homeostasis of regulatory T cells (T(reg)) and effector T cells in the perip...

journal_title：Clinical and experimental immunology

authors： Ohl K,Wiener A,Schippers A,Wagner N,Tenbrock K

更新日期：2015-07-01 00:00:00

abstract：:Atopic disorders are caused by disregulated activation of T helper 2 (Th2) cells that produce IL-4 and IL-5. Because the presence of IL-4 potently augments the differentiation of naive T cells into Th2 cells, it is important to seek the cell population which provides IL-4 for naive T cells. Recently, a unique subpopul...

journal_title：Clinical and experimental immunology

authors： Oishi Y,Sakamoto A,Kurasawa K,Nakajima H,Nakao A,Nakagawa N,Tanabe E,Saito Y,Iwamoto I

更新日期：2000-03-01 00:00:00

abstract：:Functional impairments of polymorphonuclear granulocytes (PMN) are believed to contribute to hampered inflammation and host defence in alcoholics. We studied effects of i.v. ethanol administration on PMN responses in rabbits during induction of a knee-joint synovitis. The synovitis conferred systemic effects, since ch...

journal_title：Clinical and experimental immunology

authors： Nilsson E,Thomsen P,Ericson L,Palmblad J

更新日期：1995-10-01 00:00:00

abstract：:Systemic lupus erythematosus (SLE) is an autoimmune disease characterized by extensive immune response, including over-activation of T and B cell development of pathogenic autoantibodies, organ damage induced by the formation and deposition of immune complex and the abnormal elevation of type I interferon. Semaphorin5...

journal_title：Clinical and experimental immunology

authors： Du Y,Wu X,Chen M,Wang W,Xv W,Ye L,Wu D,Xue J,Sun W,Luo J,Wu H

更新日期：2017-05-01 00:00:00

abstract：:Two facts support the definition of idiopathic thrombocytopenic purpura (ITP) as an immune disorder. First, antibodies against platelets, which often appear after a viral infection, provoke the increased elimination of these cells. Viral disease may change the complex immune response of the host at different levels. I...

journal_title：Clinical and experimental immunology

authors： Imbach PA

更新日期：1994-07-01 00:00:00

abstract：:Lewis rats were immunized with bee venom allergen in Freund's complete adjuvant (FCA) or with FCA only. Animals immunized with bee venom developed specific IgG antibodies but no specific IgE antibodies were detected. Lymphocytes from lymph nodes when cultured with antigen in vitro showed an increased stimulation index...

journal_title：Clinical and experimental immunology

authors： Schneider H,Urbanek R

更新日期：1984-08-01 00:00:00

abstract：:A study was conducted to quantify soluble IL-2 receptor (sIL-2R) levels in sera of 57 chronic plaque psoriasis patients and correlate these measurements with disease activity and the number of IL-2R-positive (CD25+) lymphocytes in lesional biopsies of 11 cyclosporin A (CsA) and 13 psoralen plus ultraviolet radiation (...

journal_title：Clinical and experimental immunology

authors： Duncan JI,Horrocks C,Ormerod AD,Powles AV,Whiting PH,Fry L,Thomson AW

更新日期：1991-08-01 00:00:00

abstract：:Patients with chronic granulomatous disease (CGD) suffer from recurrent, life-threatening bacterial and fungal infections of the skin, the airways, the lymph nodes, liver, brain and bones. Frequently found pathogens are Staphylococcus aureus, Aspergillus species, Klebsiella species, Burkholderia cepacia and Salmonella...

journal_title：Clinical and experimental immunology

authors： Roos D,de Boer M

更新日期：2014-02-01 00:00:00

abstract：:There is growing speculation about the meaning of reported imbalances in subpopulations of T lymphocytes in patients with chronic lymphocytic leukaemia (CLL). This study compared two techniques for producing T cell enriched subpopulations from both patients with CLL and normal individuals and the effects of these tech...

journal_title：Clinical and experimental immunology

authors： Dickinson AM,George S,Proctor SJ

更新日期：1983-11-01 00:00:00

abstract：:Characterization of cold reactive lymphocytotoxic antibodies present in sera from Thai adults with malaria revealed that the antibodies are predominantly 19S (IgM), directed against both autologous and allogeneic mononuclear cells, complement-dependent, present in titres ranging from 1:2 to 1:16, and exhibit greater l...

journal_title：Clinical and experimental immunology

authors： Gilbreath MJ,Pavanand K,MacDermott RP,Wells RA,Ussery MA

更新日期：1983-02-01 00:00:00

abstract：:Clinical investigations of recombinant human acid alpha-glucosidase for the treatment of Pompe disease often reveal the appearance of therapy-specific antibodies. These antibodies could potentially interfere with recombinant human acid alpha-glucosidase efficacy and induce immunological consequences. Several immunosup...

journal_title：Clinical and experimental immunology

authors： Joseph A,Munroe K,Housman M,Garman R,Richards S

更新日期：2008-04-01 00:00:00

abstract：:The molecular basis of common variable immunodeficiency (CVID) is undefined, and diagnosis requires exclusion of other diseases including X-linked lymphoproliferative disease (XLP). This rare disorder of immunedysregulation presents typically after Epstein-Barr virus infection and results from defects in the SAP (SLAM...

journal_title：Clinical and experimental immunology

authors： Eastwood D,Gilmour KC,Nistala K,Meaney C,Chapel H,Sherrell Z,Webster AD,Davies EG,Jones A,Gaspar HB

更新日期：2004-09-01 00:00:00

abstract：:Lymphocytes and plasma cells in the peripheral blood and bone marrow of patients with multiple myeloma, benign monoclonal gammopathy and Waldenström's macroglobulinaemia were investigated for their cytoplasmic immunoglobulin distribution. Anti-idiotypic sera were used as markers for monoclonality. Double-wavelength fl...

journal_title：Clinical and experimental immunology

authors： Van Camp B,Reynaert P,Broodtaerts L

更新日期：1981-04-01 00:00:00

abstract：:The proliferative response of preparations of whole PBMC populations from 20 healthy individuals and 28 multiple sclerosis (MS) patients to purified protein derivative (PPD) and myelin basic protein (MBP) was monitored in a kinetic assay over a period of up to 10 days. PPD produced a classical secondary response in bo...

journal_title：Clinical and experimental immunology

authors： Ponsford M,Mazza G,Coad J,Campbell MJ,Zajicek J,Wraith DC

更新日期：2001-05-01 00:00:00

abstract：:Studies in experimental animals suggest that antibody responses to certain polysaccharide antigens may be restricted in IgG subclass distribution. To determine if human antibodies to pneumococcal polysaccharides are similarly restricted we measured the IgG subclass specific response to immunization with purified polyv...

journal_title：Clinical and experimental immunology

authors： Barrett DJ,Ayoub EM

更新日期：1986-01-01 00:00:00

abstract：:Although both envelope glycoproteins of the hepatitis C virus, E1 and E2/NS1, show a high degree of sequence variation, the E1 protein includes a well conserved domain, which may be functionally important. We have analysed the human B cell response to a peptide fragment from amino acid residues 314-330 (EP3) covering ...

journal_title：Clinical and experimental immunology

authors： Siemoneit K,Cardoso Mda S,Koerner K,Wölpl A,Kubanek B

更新日期：1995-08-01 00:00:00

abstract：:The effect of administration of 0-2 mg of epinephrine (Parke-Davis) on circulatory lymphocytes was investigated in fifteen normal subjects. Blood samples were taken prior to, 10 and 20 min after, subcutaneous injections. Thymus-derived (T) cells were assayed by sheep red blood cell rosettes, bone marrow-derived (B) ce...

journal_title：Clinical and experimental immunology

authors： Yu DT,Clements PJ

更新日期：1976-09-01 00:00:00

abstract：:Nucleotide-binding, oligomerization domain (NOD)-like receptor family, pyrin domain containing 3 (NLRP3) gene polymorphism was reported to be associated with susceptibility, disease activity or anti-tumour necrosis factor (TNF) treatment response in rheumatoid arthritis (RA). However, the roles of NLRP3 inflammasome i...

journal_title：Clinical and experimental immunology

authors： Guo C,Fu R,Wang S,Huang Y,Li X,Zhou M,Zhao J,Yang N

更新日期：2018-11-01 00:00:00

abstract：:The synthesis of some class 1 acute-phase proteins (APP), including C-reactive protein (CRP) and serum amyloid A (SAA) protein is completely blocked by the IL-1 receptor antagonist (IL-1Ra), whereas the production of fibrinogen, a class 2 APP, is increased by IL-1Ra in hepatoma cells, but this has never been tested in...

journal_title：Clinical and experimental immunology

authors： Gabay C,Genin B,Mentha G,Iynedjian PB,Roux-Lombard P,Guerne PA

更新日期：1995-05-01 00:00:00

abstract：:Excessive T helper type 1 (Th1) cell activity has been reported in Behçet's disease (BD). Recently, association of Th17 cells with certain autoimmune diseases was reported, and we thus investigated circulating Th17 cells in BD. CD4(+) CD45RO(-) (naive) T cells were cultured with Th0-, Th1-, Th2- and Th17-related cyto...

journal_title：Clinical and experimental immunology

authors： Shimizu J,Takai K,Fujiwara N,Arimitsu N,Ueda Y,Wakisaka S,Yoshikawa H,Kaneko F,Suzuki T,Suzuki N

更新日期：2012-04-01 00:00:00

abstract：:The effect of low-density lipoprotein (LDL) on the binding of DNA and DNA-anti-DNA immune complexes to cultured human skin fibroblasts was examined. Using radioisotope analysis, ELISA and indirect immunofluorescent staining, a correlation between plasma membrane-bound DNA or DNA-anti-DNA immune complexes and cell-asso...

journal_title：Clinical and experimental immunology

authors： Kabakov AE,Saenko VA,Poverenny AM

更新日期：1991-03-01 00:00:00

abstract：:Serum cytokine levels and peripheral T cell subpopulations of HIV-1-infected patients before, during and after active visceral leishmaniasis (VL) were analysed and compared with appropriate controls. At VL diagnosis, co-infected patients showed higher serum levels of interferon-gamma (IFN-gamma) than matched HIV-1 con...

journal_title：Clinical and experimental immunology

authors： Medrano FJ,Rey C,Leal M,Cañavate C,Rubio A,Sánchez-Quijano A,Alvar J,Lissen E

更新日期：1998-12-01 00:00:00

abstract：:Patients with IgA deficiency often demonstrate circulating antibodies against IgA, which have been suggested to be associated with transfusion reactions. Sera from three patients with common variable immunodeficiency (CVID) and one with a selective IgA deficiency with anti-IgA antibodies receiving subcutaneous gammagl...

journal_title：Clinical and experimental immunology

authors： Sundin U,Nava S,Hammarström L

更新日期：1998-05-01 00:00:00

abstract：:Low-density cells (LDC) of dendritic morphology from the blood of patients with common variable (late-onset) hypogammaglobulinaemia (CVH) did not induce allogeneic immunoglobulin production by normal B cells unlike LDC from normal blood. When LDC from patients were treated with pokeweed mitogen (PWM), a lower allogene...

journal_title：Clinical and experimental immunology

authors： Farrant J,Bryant AE,Lever AM,Edwards AJ,Knight SC,Webster AD

更新日期：1985-07-01 00:00:00

abstract：:The production in vitro of antibody to hepatitis B surface antigen by peripheral blood mononuclear cells of healthy volunteers was studied after each of the three doses of hepatitis B vaccine. An in vitro hepatitis B surface antigen antibody response was successfully induced in 12% of the specimens taken over a 7 mont...

journal_title：Clinical and experimental immunology

authors： Filion LG,Saginur R

更新日期：1988-12-01 00:00:00

abstract：:Human polymorphonuclear cells (PMN) were found to adhere to a novel model of blood vessel wall-associated IgG. The internal surfaces of cellulose acetate hollow fibres, of comparable internal diameter to small blood vessels, were coated with normal serum human IgG, heat-aggregated IgG (HAIgG), laminin or fibrinogen. U...

journal_title：Clinical and experimental immunology

authors： D'Arrigo C,Candal-Couto JJ,Greer M,Veale DJ,Woof JM

更新日期：1995-04-01 00:00:00

abstract：:Circulating levels of eosinophil cationic protein (ECP), an eosinophil specific granule protein, and numbers of peripheral eosinophils were determined in 42 patients with rheumatoid arthritis. At the time of the investigation the patients were without drug treatment. They had normal blood counts of eosinophils but on ...

journal_title：Clinical and experimental immunology

authors： Hällgren R,Feltelius N,Svenson K,Venge P

更新日期：1985-03-01 00:00:00

abstract：:The lymph nodes of mice overloaded with mycobacterial products, either by the injection of whole or ultrasonicated organisms, or as a consequence of severe infection with Mycobacterium ulcerans, contain phagocytic cells which cause spontaneous transformation of the lymph node cells in a low volume, high cell density c...

journal_title：Clinical and experimental immunology

authors： Rook GA

更新日期：1975-07-01 00:00:00

abstract：:Native human CRP in solution formed complexes with the abnormal lipoprotein beta-VLDL in serum of patients with type III hyperlipoproteinaemia. CRP also formed complexes in sera from individuals with type IV and type V hyperlipoproteinaemia. The binding was calcium-dependent and inhibitable by free phosphoryl choline....

journal_title：Clinical and experimental immunology

authors： Rowe IF,Soutar AK,Trayner IM,Thompson GR,Pepys MB

更新日期：1984-10-01 00:00:00