Abstract:
:Functional impairments of polymorphonuclear granulocytes (PMN) are believed to contribute to hampered inflammation and host defence in alcoholics. We studied effects of i.v. ethanol administration on PMN responses in rabbits during induction of a knee-joint synovitis. The synovitis conferred systemic effects, since chemiluminescent responses of peripheral blood PMN to opsonized zymosan and phorpbol myristate acetate (PMA) increased 6.4- and 17.9-fold, respectively. Chemiluminescent responses of synovial PMN were further amplified. This up-regulation was reduced to 33% in rabbits treated with ethanol when opsonized zymosan was used as the PMN stimulus; in contrast, PMA responses were unaffected. The appearance and migration of PMN to the synovitis joint were normal despite a blood ethanol concentration of 0.5%. Thus, ethanol impaired release of oxygen metabolites from PMN, but not the delivery of cells at an inflammatory site.
journal_name
Clin Exp Immunoljournal_title
Clinical and experimental immunologyauthors
Nilsson E,Thomsen P,Ericson L,Palmblad Jdoi
10.1111/j.1365-2249.1995.tb06647.xsubject
Has Abstractpub_date
1995-10-01 00:00:00pages
137-43issue
1eissn
0009-9104issn
1365-2249journal_volume
102pub_type
杂志文章abstract::The potential value of interleukin 1 (IL-1) containing supernatants as a radioprotective agent was evaluated. It was found that the response of irradiated thymocytes to mitogens was partially restored if IL-1 containing supernatants was included in the culture medium immediately after irradiation. A delay of 24 h in t...
journal_title:Clinical and experimental immunology
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