A comparison of the effects of plasma exchange and immunoadsorption on anti-insulin antibody synthesis in rabbits.

abstract：:Reduced microbial exposure in early life may contribute to the increase of atopic diseases in 'westernized' societies but the underlying mechanisms remain elusive. The objective of this study was to examine how exposure to bacterial lipopolysaccharide (LPS) during early antigen encounter might influence the maturation...

journal_title：Clinical and experimental immunology

authors： Haddeland U,Sletten GB,Brandtzaeg P,Nakstad B

更新日期：2005-02-01 00:00:00

abstract：:The kinetics of efflux of calcium mobilized from intracellular stores following activation of human neutrophils with the synthetic chemotactic tripeptide, fMLP (1 microM), as well as that of the subsequent store-operated influx of this cation, has been measured by radiometric procedures using 45Ca. These procedures en...

journal_title：Clinical and experimental immunology

authors： Anderson R,Goolam Mahomed A

更新日期：1997-10-01 00:00:00

abstract：:An expanded T cell subpopulation (CD8+ Leu-7+) has previously been reported in the peripheral blood of patients with Crohn's disease. This subpopulation of T cells was associated with a 'covert suppressor' function, particularly in patients with mild/early Crohn's disease, suppressing immunoglobulin production in vitr...

journal_title：Clinical and experimental immunology

authors： Deem RL,Targan SR,Niederlehner A,Shanahan F

更新日期：1990-06-01 00:00:00

abstract：:Immune repopulation, despite virological failure, often occurs in children under highly active anti-retroviral therapy (HAART). The aim of this study was to analyse the characteristics of immune repopulation and activation in children with and without virological response to HAART. Fourteen human immunodeficiency viru...

journal_title：Clinical and experimental immunology

authors： Anselmi A,Vendrame D,Rampon O,Giaquinto C,Zanchetta M,De Rossi A

更新日期：2007-12-01 00:00:00

abstract：:A randomized controlled trial of treatment with thymic humoral factor (THF) in 20 children with severe complicated acute measles infection, resulted in objective benefit as evidenced by improvement in the ESR and a fall in C-reactive protein, fewer complications and a reduced incidence of secondary herpes infection. A...

journal_title：Clinical and experimental immunology

authors： Beatty DW,Handzel ZT,Pecht M,Ryder CR,Hughes J,McCabe K,Trainin N

更新日期：1984-06-01 00:00:00

abstract：:A peptide based on the complementarity determining region (CDR)1 of a human monoclonal anti-DNA autoantibody (hCDR1) was shown to either prevent or treat an already established murine lupus in systemic lupus erythematosus (SLE)-prone mice or in mice with induced experimental SLE. The present study was undertaken to de...

journal_title：Clinical and experimental immunology

authors： Mauermann N,Sthoeger Z,Zinger H,Mozes E

更新日期：2004-09-01 00:00:00

abstract：:Serum concentrations of C1q, C4, C4 binding protein (C4bp), C3 and C2 haemolytic activity have been measured in 110 samples from 20 patients with systemic lupus erythematosus (SLE). Significant reductions in comparison to normal levels were found in the mean serum concentrations of C4, C3 and C4bp as well as C2 haemol...

journal_title：Clinical and experimental immunology

authors： Daha MR,Hazevoet HM,Hermans J,van Es LA,Cats A

更新日期：1983-10-01 00:00:00

abstract：:We have studied the skin and nerve fibrosis in toxic oil syndrome by in situ hybridization using specific cDNA probes for types I, III, and IV collagens. Fibroblasts with high levels of type I and III collagen mRNA were observed in biopsies from fibrotic skin areas. Similarly, type IV collagen mRNA was abundant in cel...

journal_title：Clinical and experimental immunology

authors： Gomez-Reino JJ,Sandberg M,Carreira PE,Vuorio E

更新日期：1993-07-01 00:00:00

abstract：:In susceptible mice, the heavy metal ion mercury is able to induce a strong immune activation, which resembles a T helper 2 (Th2) type of immune response and is characterized by a polyclonal B cell activation, formation of high levels of IgG1 and IgE antibodies, production of autoantibodies of different specificities ...

journal_title：Clinical and experimental immunology

authors： Brenden N,Rabbani H,Abedi-Valugerdi M

更新日期：2001-08-01 00:00:00

abstract：:Splenectomized patients are highly susceptible to infections with capsulated bacteria and an impaired response to vaccination with bacterial polysaccharides has frequently been observed in these individuals. Based partly on experimental animal data, an important role for the spleen in the production of specific anti-c...

journal_title：Clinical and experimental immunology

authors： Hammarström L,Smith CI

更新日期：1986-11-01 00:00:00

abstract：:Post-kala-azar dermal leishmaniasis (PKDL) is a chronic dermal complication that occurs usually after recovery from visceral leishmaniasis (VL). The disease manifests into macular, papular and/or nodular clinical types with mono- or polymorphic presentations. Here, we investigated differences in immunological response...

journal_title：Clinical and experimental immunology

authors： Kaushal H,Bras-Gonçalves R,Avishek K,Kumar Deep D,Petitdidier E,Lemesre JL,Papierok G,Kumar S,Ramesh V,Salotra P

更新日期：2016-07-01 00:00:00

abstract：:Pretreatment of guinea-pigs with cyclophosphamide (Cy) (300 mg/kg) 3 days before cutaneous infection with Leishmania enriettii caused an increased intensity of the lesion at the site of infection and an increase in the incidence of widespread metastases. Decreased levels of circulating antibody were found from the fir...

journal_title：Clinical and experimental immunology

authors： Belehu A,Poulter LW,Turk JL

更新日期：1976-04-01 00:00:00

abstract：:The regulatory effect of prostaglandin (PG) E2 and a cyclooxygenase (COX) inhibitor on Bacille Calmette-Guérin (BCG)-induced macrophage cytotoxicity in a bladder cancer cell, MBT-2, was studied in vitro. BCG stimulated thioglycollate-elicited murine peritoneal exudate cells (PEC) to induce cytotoxic activity and to pr...

journal_title：Clinical and experimental immunology

authors： Yamada H,Kuroda E,Matsumoto S,Matsumoto T,Yamada T,Yamashita U

更新日期：2002-04-01 00:00:00

abstract：:The production of anti-tetanus toxoid (TT) antibody and anti-anti-TT (auto-anti-Id) antibody has been measured in three young and three old persons. Both antibodies were measured using ELISA. We found that: (i) the anti-TT response of old subjects was lower than that of young subjects, (ii) serum auto-anti-Id antibody...

journal_title：Clinical and experimental immunology

authors： Arreaza EE,Gibbons JJ Jr,Siskind GW,Weksler ME

更新日期：1993-04-01 00:00:00

abstract：:Human thyroid epithelial cells (thyrocytes) express HLA Class II molecules in autoimmune thyroid diseases (ATD). Normal thyrocytes do not express Class II, but can be induced to do so by culture with interferon-gamma (gamma-IFN). We have examined HLA-D subregion expression in sections and monolayers of thyroid by indi...

journal_title：Clinical and experimental immunology

authors： Todd I,Pujol-Borrell R,Abdul-Karim BA,Hammond LJ,Feldmann M,Bottazzo GF

更新日期：1987-09-01 00:00:00

abstract：:The effect of anti-immunoglobulin (anti-Ig) on cultures of established human B-cell lines was studied to develop models for the initiation and regulation of immune responses. DNA synthesis in one line, BM, measured by [125I]iododeoxyuridine (IUdR) incorporation, was stimulated by anti-Ig when the continuously prolifer...

journal_title：Clinical and experimental immunology

authors： Kishimoto T,Ralph P,Good RA

更新日期：1977-10-01 00:00:00

abstract：:Gambian children with past or present Plasmodium falciparum malaria were investigated for the incidence of Coombs positivity using monospecific antisera. Approximately 50% were positive and the most frequent form of erythrocyte sensitization was with C3d. Other specificities, EIgG, EIgGC3d and EIgGC4bC3d were less com...

journal_title：Clinical and experimental immunology

authors： Facer CA,Bray RS,Brown J

更新日期：1979-01-01 00:00:00

abstract：:Myasthenia gravis (MG) is a debilitating and potentially fatal neuromuscular disease characterized by the generation of autoantibodies reactive with nicotinic acetylcholine receptors (AChR) that cause loss of AChR from the neuromuscular endplate with resultant failure of neuromuscular transmission. A role for compleme...

journal_title：Clinical and experimental immunology

authors： Chamberlain-Banoub J,Neal JW,Mizuno M,Harris CL,Morgan BP

更新日期：2006-11-01 00:00:00

abstract：:Mouse-rosette formation was investigated in a variety of leukaemias and lymphomas, and it was found that this phenomenon was restricted to the B lymphocytes of chronic lymphocytic leukaemia and hairy-cell leukaemia. Eighteen of nineteen cases of chronic lymphocytic leukaemia expressed the mouse receptor, but only eigh...

journal_title：Clinical and experimental immunology

authors： Burns GF,Cawley JC

更新日期：1980-01-01 00:00:00

abstract：:The presence of antibodies reactive to a recently cloned host-derived antigen GOR is highly correlated with the presence of antibodies to the hepatitis C virus (HCV). We explored the molecular basis for this observation, and address the following question: are antibodies reactive with GOR19-27 (QKAKSNPNR) a result of ...

journal_title：Clinical and experimental immunology

authors： Zhang ZX,Chen M,Wallhagen K,Trojnar J,Magnius LO,Wahren B,Sällberg M

更新日期：1994-06-01 00:00:00

abstract：:A technique is described which shows how to obtain a suspension of only progressively motile spermatozoa, from semen, by active penetration into an overlying buffer layer. About 60% of the number of motile spermatozoa in the original semen sample can be obtained as an output in the removed buffer layer. With this meth...

journal_title：Clinical and experimental immunology

authors： Hellema HW,Rümke P

更新日期：1978-01-01 00:00:00

abstract：:The BB rat is a well-known animal model for the study of autoimmune thyroid disease. Antithyroglobulin antibodies can be detected in the circulation from the age of 6 weeks onwards, and accumulations of lymphoid cells occurs in the thyroid of up to 60% of animals at the age of 20 weeks and over. The rat, however, stay...

journal_title：Clinical and experimental immunology

authors： Voorby HA,Van der Gaag RD,Jeucken PH,Bloot AM,Drexhage HA

更新日期：1989-05-01 00:00:00

abstract：:A solid-phase radioimmunoassay was developed to detect antibodies to liver membrane antigens in sera of patients with HBsAg-negative and -positive liver diseases and primary non-hepatic autoimmune diseases. Ten of fourteen patients with HBsAg-negative CAH had autoantibodies detected by RIA; negative results were obtai...

journal_title：Clinical and experimental immunology

authors： Manns M,Meyer zum Büschenfelde KH,Hütteroth TH,Hess G

更新日期：1980-11-01 00:00:00

abstract：:Toll-like receptors (TLRs) constitute an archetypal pattern recognition system. Their sophisticated biology underpins the ability of innate immunity to discriminate between highly diverse microbial pathogens and self. However, the remarkable progress made in describing this biology has also revealed new immunological ...

journal_title：Clinical and experimental immunology

authors： Hopkins PA,Sriskandan S

更新日期：2005-06-01 00:00:00

abstract：:Costimulation of T lymphocytes by the leucocyte surface molecules CD80 and CD86 expressed on antigen-presenting cells (APC) is required for the development of T cell responses. The CD28 and CTLA-4 molecules on T cells serve as receptors for the CD80 and CD86 costimulatory antigens. We have examined the frequency of ex...

journal_title：Clinical and experimental immunology

authors： Melichar B,Nash MA,Lenzi R,Platsoucas CD,Freedman RS

更新日期：2000-01-01 00:00:00

abstract：:Systemic lupus erythematosus (SLE) is an autoimmune disease characterized by extensive immune response, including over-activation of T and B cell development of pathogenic autoantibodies, organ damage induced by the formation and deposition of immune complex and the abnormal elevation of type I interferon. Semaphorin5...

journal_title：Clinical and experimental immunology

authors： Du Y,Wu X,Chen M,Wang W,Xv W,Ye L,Wu D,Xue J,Sun W,Luo J,Wu H

更新日期：2017-05-01 00:00:00

abstract：:Tolerance to lipopolysaccharide (LPS) constitutes a stress adaptation, in which a primary contact with LPS results in a minimal response when a second exposure with the same stimulus occurs. However, active important defence mechanisms are mounted during the tolerant state. Our aim was to assess the contribution of po...

journal_title：Clinical and experimental immunology

authors： Landoni VI,Chiarella P,Martire-Greco D,Schierloh P,van-Rooijen N,Rearte B,Palermo MS,Isturiz MA,Fernández GC

更新日期：2012-04-01 00:00:00

abstract：:Sjögren's syndrome (SS) is a chronic autoimmune disease that mainly damages the salivary and lacrimal glands. Immune complex (IC) formation triggers local inflammation through IC deposition and decreased antigen function. Some ICs can leak from the lesion and into the saliva but no salivary ICs have been reported to d...

journal_title：Clinical and experimental immunology

authors： Yamane K,Nakamura H,Hamasaki M,Minei Y,Aibara N,Shimizu T,Kawakami A,Nakashima M,Kuroda N,Ohyama K

更新日期：2021-01-12 00:00:00

abstract：:The murine antibody response to porcine insulin is controlled by immune response genes of the major histocompatibility complex. Animals of the one haplotype (H-2d) produce specific antibodies to pork insulin, while animals of other haplotypes do not. We analysed the antibody responses to purified pork insulin by anima...

journal_title：Clinical and experimental immunology

authors： Strayer DS,Kapp J

更新日期：1982-01-01 00:00:00

abstract：:Erythrocyte C3b receptors (ECR1) have been measured in 122 pairs of twins (60 monozygotic, 62 dizygotic) using an [125I]-labelled monoclonal antibody (E11). The range of ECR1 numbers was wide, 99-4179 sites/cell, with a log-normal distribution around a geometric mean of 837 sites/cell. The intra-pair variance in dizyg...

journal_title：Clinical and experimental immunology

authors： Fyfe A,Holme ER,McKay IC,Zoma A,Hunter J,Lucie NP,Whaley K

更新日期：1987-10-01 00:00:00