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Relative importance of C4 binding protein in the modulation of the classical pathway C3 convertase in patients with systemic lupus erythematosus.

Abstract：

:Serum concentrations of C1q, C4, C4 binding protein (C4bp), C3 and C2 haemolytic activity have been measured in 110 samples from 20 patients with systemic lupus erythematosus (SLE). Significant reductions in comparison to normal levels were found in the mean serum concentrations of C4, C3 and C4bp as well as C2 haemolytic activities. For patients serum concentrations of C4 correlated with C2 haemolytic activities (r = 0.91) and C4bp (r = 0.79); the C2 haemolytic levels correlated with the concentration of C4b (r = 0.72). It is concluded that serum concentrations of the complement components C4 and C2, which are the constituents of the classical pathway C3 convertase, are regulated by C4bp in vivo. Further metabolic studies are required to determine the causes of decreased serum concentrations of C4bp in patients with SLE.

journal_name

Clin Exp Immunol

journal_title

Clinical and experimental immunology

authors

Daha MR,Hazevoet HM,Hermans J,van Es LA,Cats A

subject

Has Abstract

pub_date

1983-10-01 00:00:00

pages

248-52

issue

1

eissn

0009-9104

issn

1365-2249

journal_volume

54

pub_type

杂志文章

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