Circulating soluble selectins in Kawasaki disease.

abstract：:Sjögren's syndrome (SS) is an autoimmune disease characterized by T cell infiltration into the salivary and lacrimal glands (LG). Previous studies on T cell receptor (TCR) usage in the minor salivary glands (SG) have yielded controversial results. We studied TCR beta gene usage of the T cells infiltrating to LG, which...

journal_title：Clinical and experimental immunology

authors： Mizushima N,Kohsaka H,Tsubota K,Saito I,Miyasaka N

更新日期：1995-07-01 00:00:00

abstract：:Cell-mediated cytotoxicity (CTX) of meningioma patients was assessed postoperatively by a [3H]proline microcytotoxicity test. Autologous and allogeneic tumour cells were used for prelabelling with isotope and peripheral blood lymphocytes added in a ratio of 200:1. After 60 hg the plates were washed and residual CMP co...

journal_title：Clinical and experimental immunology

authors： Pees HW,Seidel B

更新日期：1976-05-01 00:00:00

abstract：:In patients with ANCA-associated vasculitis (AAV), CD25 expression is increased on circulating T cells. Although in animal experiments the role of CD4(+) CD25(+) T-regulatory-cells (T(reg)) in protection against autoimmunity is well established, the role of these cells in AAV is unknown. To investigate the hypothesis ...

journal_title：Clinical and experimental immunology

authors： Marinaki S,Neumann I,Kälsch AI,Grimminger P,Breedijk A,Birck R,Schmitt W,Waldherr R,Yard BA,Van Der Woude FJ

更新日期：2005-04-01 00:00:00

abstract：:The distribution of T lymphocyte subsets was assessed using monoclonal antibodies (MoAbs) in 44 untreated patients with multiple myeloma (MM) subdivided according to the clinical stage of the disease. A significant reduction (P less than 0.001) of T lymphocytes was observed only in stage II and III patients. The propo...

journal_title：Clinical and experimental immunology

authors： Lauria F,Foa R,Cavo M,Gobbi M,Raspadori D,Giubellino MC,Tazzari PL,Tura S

更新日期：1984-06-01 00:00:00

abstract：:Patients with common variable immunodeficiency (CVID) have reduced numbers and frequencies of dendritic cells (DCs) in blood, and there is also evidence for defective activation through Toll-like receptors (TLRs). Collectively, these observations may point to a primary defect in the generation of functional DCs. Here,...

journal_title：Clinical and experimental immunology

authors： Taraldsrud E,Fevang B,Aukrust P,Beiske KH,Fløisand Y,Frøland S,Rollag H,Olweus J

更新日期：2014-03-01 00:00:00

abstract：:Natural killer (NK) cytotoxic activity was simultaneously investigated in bone marrow mononuclear cells (BMMC) and peripheral blood lymphocytes (PBL) from nine Hodgkin's disease (HD) and 15 non-Hodgkin lymphoma (NHL) untreated patients. Twenty-five PBL samples and seven bone marrow specimens from healthy individuals w...

journal_title：Clinical and experimental immunology

authors： Caldera LH,Leon-Ponte M,Acquatella G,Bianco NE,Blanca I

更新日期：1992-04-01 00:00:00

abstract：:Intestinal epithelial cell (IEC)-derived cytokines, such as stem cell factor (SCF), interleukin (IL)-7 and IL-15 are known to be required for the development of intestinal intraepithelial lymphocytes (IELs). A newly described cytokine, IL-18, has also been shown to be produced by intestinal epithelial cells. To demons...

journal_title：Clinical and experimental immunology

authors： Okazawa A,Kanai T,Nakamaru K,Sato T,Inoue N,Ogata H,Iwao Y,Ikeda M,Kawamura T,Makita S,Uraushihara K,Okamoto R,Yamazaki M,Kurimoto M,Ishii H,Watanabe M,Hibi T

更新日期：2004-05-01 00:00:00

abstract：:Reduced B cell numbers and a mutation in Btk are considered sufficient to make the diagnosis of X-linked agammaglobulinaemia. In the process of conducting family studies, we identified a 58-year-old healthy man with an amino acid substitution, Y418H, in the adenosine-5'-triphosphate binding site of Btk. Immunofluoresc...

journal_title：Clinical and experimental immunology

authors： Conley ME,Farmer DM,Dobbs AK,Howard V,Aiba Y,Shurtleff SA,Kurosaki T

更新日期：2008-04-01 00:00:00

abstract：:The IgG subclass distribution of thyroglobulin antibodies (TgAb) has been studied in Hashimoto and Graves' patients by several investigators with conflicting results, in part explainable by methodological problems. We have recently developed a quantitative ELISA to measure in absolute terms the serum concentration of ...

journal_title：Clinical and experimental immunology

authors： Caturegli P,Kuppers RC,Mariotti S,Burek CL,Pinchera A,Ladenson PW,Rose NR

更新日期：1994-12-01 00:00:00

abstract：:The spot-ELISA technique has been used to enumerate the frequency of cells secreting tumor necrosis factor-alpha (TNF-alpha) and interferon-gamma (IFN-gamma), isolated from biopsies of normal intestine and from biopsies of children with inflammatory bowel disease. TNF-alpha production was undetectable in six out of 12...

journal_title：Clinical and experimental immunology

authors： MacDonald TT,Hutchings P,Choy MY,Murch S,Cooke A

更新日期：1990-08-01 00:00:00

abstract：:Linomide (quinoline-3-carboxamide) is a synthetic immunomodulator that suppresses several experimental autoimmune diseases. Here we report the effects of Linomide on experimental autoimmune neuritis (EAN), a CD4+ T cell-mediated animal model of acute Guillain-Barré syndrome (GBS) in humans. EAN induced in Lewis rats b...

journal_title：Clinical and experimental immunology

authors： Zhu J,Bai XF,Hedlund G,Björk J,Bakhiet M,Van Der Meide PH,Link H

更新日期：1999-01-01 00:00:00

abstract：:Endogenous retrovirus-3 (ERV-3) is an endogenous retrovirus encoding an open reading frame for an envelope protein expressed in placenta. In this study we also found high levels of expression in fetal heart, with peak expression occurring between 11 and 17 weeks of gestation. Antibodies to a peptide corresponding to a...

journal_title：Clinical and experimental immunology

authors： Li JM,Fan WS,Horsfall AC,Anderson AC,Rigby S,Larsson E,Venables PJ

更新日期：1996-06-01 00:00:00

abstract：:One of the hallmarks of coeliac disease, both active and treated, is an increased number and proportion of gamma/delta intraepithelial T lymphocytes in the small intestinal mucosa, and an increased number of gamma/delta T cells in the small intestinal mucosa of coeliac disease patients has been associated with the inh...

journal_title：Clinical and experimental immunology

authors： Holtmeier W,Rowell DL,Nyberg A,Kagnoff MF

更新日期：1997-01-01 00:00:00

abstract：:Anti-endothelial cell antibodies (AECA) have been frequently detected in systemic vasculitis, which affects blood vessels of various sizes. To understand the pathogenic roles of AECA in systemic vasculitis, we attempted to identify target antigens for AECA comprehensively by a proteomic approach. Proteins extracted fr...

journal_title：Clinical and experimental immunology

authors： Karasawa R,Kurokawa MS,Yudoh K,Masuko K,Ozaki S,Kato T

更新日期：2010-09-01 00:00:00

abstract：:The humoral immune response, especially IgG and IgA, is considered to be protective in the pathogenesis of periodontal disease, but the precise mechanisms are still unknown. Immunoglobulins arriving at the periodontal lesion are from both systemic and local tissue sources. In order to understand better the local immun...

journal_title：Clinical and experimental immunology

authors： Kinane DF,Lappin DF,Koulouri O,Buckley A

更新日期：1999-03-01 00:00:00

abstract：:The murine immune system is not necessarily identical to it human counterpart, which has led to the construction of humanized mice. The current study analysed whether or not a human immune system contained within the non-obese diabetic (NOD)-Rag1(null) -γ chain(null) (NRG) mouse model was an accurate representation of...

journal_title：Clinical and experimental immunology

authors： Harris DT,Badowski M,Balamurugan A,Yang OO

更新日期：2013-12-01 00:00:00

abstract：:Ws/Ws rats have a small deletion of the c-kit gene, and are deficient in both mucosal and connective tissue-type mast cells. In this study, the role of mucosal type mast cells (MMC) in the development of intestinal ischaemia-reperfusion injury was investigated in Ws/Ws rats. Autoperfused segments of the jejunum were e...

journal_title：Clinical and experimental immunology

authors： Andoh A,Kimura T,Fukuda M,Araki Y,Fujiyama Y,Bamba T

更新日期：1999-04-01 00:00:00

abstract：:Studies in humans and murine disease models have clearly shown dietary fish oil to possess anti-inflammatory properties, apparently mediated by the n-3 polyunsaturated fatty acids, eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA). To determine the mechanisms by which dietary EPA and DHA modulate mouse T-cell...

journal_title：Clinical and experimental immunology

authors： Arrington JL,Chapkin RS,Switzer KC,Morris JS,McMurray DN

更新日期：2001-09-01 00:00:00

abstract：:Anticardiolipin antibodies (ACA) belong to a heterogeneous group of antibodies directed against negatively charged phospholipids. In patients with rheumatic disorders, their presence has been correlated to the occurrence of thromboembolic complications, thrombocytopenia, abortions and other disease manifestations. Sev...

journal_title：Clinical and experimental immunology

authors： Rubbert A,Bock E,Schwab J,Marienhagen J,Nüsslein H,Wolf F,Kalden JR

更新日期：1994-12-01 00:00:00

abstract：:Plasma exchange (PE) and ex vivo immunoadsorption (IA) may be applicable to the removal of anti-insulin antibodies (AI-Ab) from diabetic patients. However, the removal of antibodies may prompt an increase in their rate of synthesis and an overshoot of antibody levels which may be deleterious to the patient. The effect...

journal_title：Clinical and experimental immunology

authors： Charlton B,Antony G,Cooper SG,Schindhelm K

更新日期：1988-05-01 00:00:00

abstract：:The uptake of C-reactive protein (CRP)-pneumococcal C-polysaccharide (CPS) complexes by neutrophils was studied. A specific CRP dependent mechanism of uptake was demonstrated. This promoted CPS (complexed to CRP) clearance which was further enhanced by additional complement activation. Physiological concentrations of ...

journal_title：Clinical and experimental immunology

authors： Shephard EG,Anderson R,Strachan AF,Kühn SH,De Beer FC

更新日期：1986-03-01 00:00:00

abstract：:Activation of human umbilical vein endothelial (HUVE) cells with the inflammatory mediators tumour necrosis factor-alpha (TNF), interleukin-1 (IL-1), lipopolysaccharide (LPS) and phorbol esters enhanced their adhesiveness for leucocytes. The appearance of an activation antigen ELAM-1, recognized by a monoclonal antibo...

journal_title：Clinical and experimental immunology

authors： Leeuwenberg JF,Jeunhomme GM,Buurman WA

更新日期：1990-09-01 00:00:00

abstract：:In this study we have looked at the effect of lipopolysaccharide (LPS) on the surface antigen expression of cultured monocytes. Monocytes were purified from peripheral blood mononuclear cells (PBMC) and cultured in the presence or absence of LPS. The cultured cells were then stained with anti-MO3, anti-IL-2R and anti-...

journal_title：Clinical and experimental immunology

authors： Neate EV,Greenhalgh AM,McPhee DA,Crowe SM

更新日期：1992-12-01 00:00:00

abstract：:Biopsy specimens from patients with treated or untreated polymyositis and muscular dystrophy controls were examined by indirect immunoperoxidase staining with a panel of monoclonal antibodies to human leucocyte antigens. In untreated polymyositis, helper/inducer T cells were the predominant T cell subset. In treated c...

journal_title：Clinical and experimental immunology

authors： Rowe D,Isenberg DA,Beverley PC

更新日期：1983-11-01 00:00:00

abstract：:Ulcerative colitis (UC) and Crohn's disease (CD) are considered to be immunologically mediated disorders that share certain features with murine models of colitis. Whether any of these models are physiologically relevant to the human condition remains controversial. The hypothesis is that increased amounts of antibodi...

journal_title：Clinical and experimental immunology

authors： Ebert EC,Panja A,Das KM,Praveen R,Geng X,Rezac C,Bajpai M

更新日期：2009-01-01 00:00:00

abstract：:To define glucocorticoid (GC)-regulated genes contributing to the anti-inflammatory and immunosuppressive effects of GC, previous work from our laboratory revealed up-regulation of transcripts from endogenous type B mouse mammary tumour virus (Mtv) and type C murine leukaemia virus (Emv) loci by high dose GC treatment...

journal_title：Clinical and experimental immunology

authors： Fiegl M,Strasser-Wozak E,Geley S,Gsur A,Drach J,Kofler R

更新日期：1995-08-01 00:00:00

abstract：:The modulatory effect of human milk proteins from colostrum and late milk on the proliferative response of human T lymphocytes activated by mitogens (OKT3 and leucoagglutinin from Phaseolus vulgaris) and alloantigens was studied. High concentrations (10-100 micrograms/ml) of crude colostral milk proteins had an inhibi...

journal_title：Clinical and experimental immunology

authors： Mincheva-Nilsson L,Hammarström ML,Juto P,Hammarström S

更新日期：1990-03-01 00:00:00

abstract：:A method enabling direct enumeration of mouse T and B cells from cytocentrifuged cell smears is described. The acid alpha-naphthyl acetate esterase (ANAE) staining was used as marker for T cells. The distribution of the ANAE marker-carrying lymphocytes closely followed the percentual distribution of T cells in spleen ...

journal_title：Clinical and experimental immunology

authors： Ranki A,Tötterman TH,Häyry P

更新日期：1976-12-01 00:00:00

abstract：:Tumour necrosis factor (TNF)-alpha and interferon (IFN)-gamma exert detrimental effects in organ-specific autoimmune disease, while both destructive and protective roles have been demonstrated for interleukin (IL)-10, IL-4 and IL-5. We examined the production of these cytokines by peripheral blood mononuclear cells (P...

journal_title：Clinical and experimental immunology

authors： Nielsen CH,Hegedüs L,Rieneck K,Moeller AC,Leslie RG,Bendtzen K

更新日期：2007-02-01 00:00:00

abstract：:F-42, an autoantibody found in the sera of some patients with systemic lupus erythematosus, was isolated from sera of seven different patients. By binding of the autoantibodies to cell bound C42, the autoantibodies were purified to homogeneity and radiolabelled with 125I. Purified preparations of 125I-F-42 were bound ...

journal_title：Clinical and experimental immunology

authors： Daha MR,Hazevoet HM,van Es LA

更新日期：1984-06-01 00:00:00