Monoclonal antibodies to human leucocyte antigens in polymyositis and muscular dystrophy.

abstract：:The adenine nucleotide translocator protein (ANT) is the first well-characterized mitochondrial polypeptide to be identified as an antigen for antimitochondrial autoantibodies (AMA) in PBC sera. Because of the potential use for a highly purified antigen as a tool in studying the aetiology of PBC, we have undertaken an...

journal_title：Clinical and experimental immunology

authors： Mendel-Hartvig I,Frostell A,Nelson BD

更新日期：1986-11-01 00:00:00

abstract：:Peripheral blood leucocytes from multiple sclerosis (MS) patients and from normal individuals were tested for their interferon (IFN) producing capacity after stimulation in vitro with various lectins and viruses. The lectins, Con A, PHA and PWM, induced IFN-gamma. In a kinetic study, the response to Con A revealed its...

journal_title：Clinical and experimental immunology

authors： Vervliet G,Carton H,Meulepas E,Billiau A

更新日期：1984-10-01 00:00:00

abstract：:Toll-like receptors (TLRs) constitute an archetypal pattern recognition system. Their sophisticated biology underpins the ability of innate immunity to discriminate between highly diverse microbial pathogens and self. However, the remarkable progress made in describing this biology has also revealed new immunological ...

journal_title：Clinical and experimental immunology

authors： Hopkins PA,Sriskandan S

更新日期：2005-06-01 00:00:00

abstract：:Characterization of cold reactive lymphocytotoxic antibodies present in sera from Thai adults with malaria revealed that the antibodies are predominantly 19S (IgM), directed against both autologous and allogeneic mononuclear cells, complement-dependent, present in titres ranging from 1:2 to 1:16, and exhibit greater l...

journal_title：Clinical and experimental immunology

authors： Gilbreath MJ,Pavanand K,MacDermott RP,Wells RA,Ussery MA

更新日期：1983-02-01 00:00:00

abstract：:Monoclonal antibodies anti-Ly 1, anti-Ly 2 and GK1.5 were applied to determine phenotypes of T cells within granulomas formed as a result of infection of mice with the facultative intracellular bacterium Listeria monocytogenes. Early in granuloma formation, equal numbers of Ly 1+, Ly 2+ and L3T4+ cells were found, T c...

journal_title：Clinical and experimental immunology

authors： Näher H,Sperling U,Takacs L,Hahn H

更新日期：1985-06-01 00:00:00

abstract：:Extracorporeal photopheresis (ECP) is a widely used immunomodulatory therapy for the treatment of various T cell-mediated disorders such as cutaneous T cell lymphoma (CTCL), graft-versus-host disease (GvHD) or systemic sclerosis. Although clinical benefits of ECP are already well described, the underlying mechanism of...

journal_title：Clinical and experimental immunology

authors： Wiese F,Reinhardt-Heller K,Volz M,Gille C,Köstlin N,Billing H,Handgretinger R,Holzer U

更新日期：2019-03-01 00:00:00

abstract：:Stress known to stimulate sympathetic activity, as well as the hypothalamic-pituitary-adrenal axis (HPA), produces a significant increase in adrenomedullin (AdM) levels, suggesting a regulatory or protective role for AdM in countering HPA activation that follows a variety of stressors. Stressors can modulate the secre...

journal_title：Clinical and experimental immunology

authors： Yildirim NC,Yurekli M

更新日期：2010-07-01 00:00:00

abstract：:The production in vitro of antibody to hepatitis B surface antigen by peripheral blood mononuclear cells of healthy volunteers was studied after each of the three doses of hepatitis B vaccine. An in vitro hepatitis B surface antigen antibody response was successfully induced in 12% of the specimens taken over a 7 mont...

journal_title：Clinical and experimental immunology

authors： Filion LG,Saginur R

更新日期：1988-12-01 00:00:00

abstract：:A new, specific haemolytic assay for C2 is described using EAC43 (Antrypol) cells and serum deficient in C4 and C2 from a patient with hereditary angio-oedema. The method is simple and the results in pathological and normal sera correlate well with those obtained using the EA and C2-deficient serum method. ...

journal_title：Clinical and experimental immunology

authors： Naish PF,Barratt J,Collins C

更新日期：1976-09-01 00:00:00

abstract：:Previous studies have shown that the efficiency of phagocytosis is a function of cell cycle and that phagocytosis promotes cell cycle progression. Because phagocytosis is dependent on cellular receptors we hypothesized that Fcgamma receptors (FcgammaR) and complement receptors (CR) expression varied with cell cycle. C...

journal_title：Clinical and experimental immunology

authors： Luo Y,Cook E,Fries BC,Casadevall A

更新日期：2006-08-01 00:00:00

abstract：:A number of studies done in the last 10 years demonstrate the importance of iron in regulating the expression of T lymphoid cell surface markers, in influencing the expansion of different T cell subsets and in affecting different immune cell functions in vitro. It has been argued that some of the results obtained coul...

journal_title：Clinical and experimental immunology

authors： de Sousa M

更新日期：1989-01-01 00:00:00

abstract：:Autoantibody production increases with ageing. However, the pathological significance of this increase as well as the corresponding underlying mechanisms are poorly understood. To further our understanding of the role that ageing plays in the development of autoantibody responses, we used a novel nonhuman primate mode...

journal_title：Clinical and experimental immunology

authors： Attanasio R,Brasky KM,Robbins SH,Jayashankar L,Nash RJ,Butler TM

更新日期：2001-03-01 00:00:00

abstract：:Increased levels of 3% PEG precipitable circulating immune complexes (CIC) were found in healthy homosexual men, in homosexual patients with the acquired immune deficiency syndrome (AIDS), and in the AIDS related lymphadenopathy syndrome (LAS). The degree of CIC elevation increases from healthy homosexual men to LAS a...

journal_title：Clinical and experimental immunology

authors： Euler HH,Kern P,Löffler H,Dietrich M

更新日期：1985-02-01 00:00:00

abstract：:Skin nuclear speckled IgG deposition was noted in seven patients. The patients' clinical courses satisfied at least four of the preliminary criteria of the American Rheumatism Association for the diagnosis of systemic lupus erthematosus (SLE). Examination of approximately 700 additional biopsies from patiets with SLE,...

journal_title：Clinical and experimental immunology

authors： Shu S,Provost T,Croxdale MB,Reichlin M,Beutner EH

更新日期：1977-02-01 00:00:00

abstract：:Mucous membrane pemphigoid (MMP) (also known as cicatricial pemphigoid) is a rare autoimmune mucocutaneous blistering disease that affects mucous membranes derived from stratified squamous epithelium and the skin. A subset of MMP affects only the oral cavity and is referred to as the oral pemphigoid (OP). MMP and OP a...

journal_title：Clinical and experimental immunology

authors： Mignogna M,Lanza A,Rossiello L,Ruocco V,Ahmed AR

更新日期：2006-07-01 00:00:00

abstract：:In this study of protein composition of amyloid fibrils isolated from eight patients representative of the spectrum of amyloidosis found in Papua New Guinea has been investigated. All fibril preparations, including three from patients with amyloidosis secondary to lepromatous leprosy and one from an unusual juvenile c...

journal_title：Clinical and experimental immunology

authors： Anders RF,Price MA,Wilkey IS,Husby G,Takitaki F,Natvig JB,McAdam KP

更新日期：1976-04-01 00:00:00

abstract：:The effect of various exogenous cells on the in-vitro PWM stimulation of immunoglobulin synthesis by normal human peripheral blood mononuclear cells was investigated. The accessory cells tested were bovine and human endothelial cells, bovine and human fibroblasts, normal human monocytes, and a monocyte cell line U937....

journal_title：Clinical and experimental immunology

authors： King MA,Roche WR,Nelson DS

更新日期：1986-09-01 00:00:00

abstract：:Tumour-infiltrating lymphocytes (TIL) have been isolated from early primary melanoma (Clark level III) and expanded in vitro using culture conditions with low concentrations of IL-2 (50 U/ml). Immediately after isolation TIL consisted of mainly CD3+ T cells, and the portion of CD56+ natural killer (NK) cells was below...

journal_title：Clinical and experimental immunology

authors： Becker JC,Schwinn A,Dummer R,Burg G,Bröcker EB

更新日期：1993-01-01 00:00:00

abstract：:Patients with common variable immunodeficiency (CVID) have reduced numbers and frequencies of dendritic cells (DCs) in blood, and there is also evidence for defective activation through Toll-like receptors (TLRs). Collectively, these observations may point to a primary defect in the generation of functional DCs. Here,...

journal_title：Clinical and experimental immunology

authors： Taraldsrud E,Fevang B,Aukrust P,Beiske KH,Fløisand Y,Frøland S,Rollag H,Olweus J

更新日期：2014-03-01 00:00:00

abstract：:There have been many studies on the mechanisms of internalization of DNA-anti-DNA immune complexes by cells, including the one used for rheumatoid factor-expressing mouse B cells. In parallel, studies on the role of intracellular DNA sensors in the pathogenesis of systemic lupus erythematosus (SLE) have been conducted...

journal_title：Clinical and experimental immunology

authors： Inoue K,Ishizawa M,Kubota T

更新日期：2020-02-01 00:00:00

abstract：:The cytotoxic functions of highly purified blood lymphocytes from patients with breast cancer were studied before and after radiotherapy. Addition of PHA or of rabbit antibodies to target cells (chicken erythrocytes) were chosen as two means of inducing lymphocyte cytotoxicity in vitro. The proportion of T and non-T-l...

journal_title：Clinical and experimental immunology

authors： Wasserman J,Melén B,Blomgren H,Glas U,Perlmann P

更新日期：1975-11-01 00:00:00

abstract：:Transfer of contact sensitivity (CS) responses by immune lymphoid cells was the first finding that distinguished cellular from humoral immunity. CS has remained the most studied T cell reaction in vivo, and is the prototype for a variety of delayed-type hypersensitivity (DTH) responses. DTH in essence is the recruitme...

journal_title：Clinical and experimental immunology

authors： Askenase PW

更新日期：2001-09-01 00:00:00

abstract：:We studied the interaction of two different forms of immune glomerular damage occurring simultaneously: anti-glomerular basement membrane (GBM) antibody fixation and immune elimination of bovine serum albumin (BSA). 125I-radiolabelled BSA anti-BSA immune complexes, formed in response to a single small intravenous dose...

journal_title：Clinical and experimental immunology

authors： Trevillian P,Cameron JS

更新日期：1979-03-01 00:00:00

abstract：:Ulcerative colitis (UC) and Crohn's disease (CD) are considered to be immunologically mediated disorders that share certain features with murine models of colitis. Whether any of these models are physiologically relevant to the human condition remains controversial. The hypothesis is that increased amounts of antibodi...

journal_title：Clinical and experimental immunology

authors： Ebert EC,Panja A,Das KM,Praveen R,Geng X,Rezac C,Bajpai M

更新日期：2009-01-01 00:00:00

abstract：:Expression of the adhesion molecule, CD146/MCAM/MelCAM, on T cells has been associated with recent activation, memory subsets and T helper type 17 (Th17) effector function, and is elevated in inflammatory arthritis. Th17 cells have been implicated in the pathogenesis of rheumatoid arthritis (RA) and spondyloarthritide...

journal_title：Clinical and experimental immunology

authors： Wu C,Goodall JC,Busch R,Gaston JS

更新日期：2015-03-01 00:00:00

abstract：:Rabbits were sensitized with Micropolyspora faeni by intratracheal inoculations and later challenged with the same antigen either with or without parenteral administration of cortisone acetate prior to challenge. Animals developed anti-M. faeni serum precipitins, M. faeni-induced alveolar macrophage migration inhibiti...

journal_title：Clinical and experimental immunology

authors： Cashner FM,Schuyler MR,Salvaggio JE

更新日期：1979-05-01 00:00:00

abstract：:Hybridization of peripheral blood lymphocytes from patients with rheumatoid arthritis has yielded 14 monoclonal antibodies which react with cultured human epithelial cells. Immunofluorescence staining identifies at last five different types of antibody. Solid phase immunosorbent assays show a variety of cross-reaction...

journal_title：Clinical and experimental immunology

authors： Haskard DO,Gul V,Morgan A,Kataaha P,Staines NA,Archer JR

更新日期：1985-09-01 00:00:00

abstract：:The clinical use of dendritic cells (DCs) to induce antigen-specific immune tolerance has been hampered by the lack of a widely acknowledged method for generating human regulatory DCs but even more so by the non-existence of reliable markers. Thus, we set out to find reliable markers that can be measured with simple m...

journal_title：Clinical and experimental immunology

authors： Pedersen AW,Holmstrøm K,Jensen SS,Fuchs D,Rasmussen S,Kvistborg P,Claesson MH,Zocca MB

更新日期：2009-07-01 00:00:00

abstract：:Environmental factors such as diet are known to play important roles in inflammatory bowel disease (IBD). Epidemiological studies have indicated that a high-fat diet is a risk factor for IBD. In addition, the balance between effector T cells (T(eff)) and regulatory T cells (T(reg)) contributes to the pathogenesis of m...

journal_title：Clinical and experimental immunology

authors： Ma X,Torbenson M,Hamad AR,Soloski MJ,Li Z

更新日期：2008-01-01 00:00:00

abstract：:The scaffold protein caspase recruitment domain-containing protein 11 (CARD11) is implicated in the regulation of inflammation and autoimmunity. The present study aimed to explore the role of CARD11 in the pathogenesis of rheumatoid arthritis (RA). Mice with collagen-induced arthritis (CIA) were treated with either CA...

journal_title：Clinical and experimental immunology

authors： Wang H,Zhao J,Zhang H,Huang Y,Wang S,Tu Q,Yang N

更新日期：2014-05-01 00:00:00