Abstract：
:Autoantibody production increases with ageing. However, the pathological significance of this increase as well as the corresponding underlying mechanisms are poorly understood. To further our understanding of the role that ageing plays in the development of autoantibody responses, we used a novel nonhuman primate model consisting of healthy baboons of ages representing the entire lifespan of this animal species. Results from this study indicate that production of antinuclear antibodies, anticell extract antibodies and natural autoantibodies gradually and significantly increases from young age to old age without a corresponding increase in neither serum immunoglobulin concentration nor in levels of selected markers of immune dysregulation (sTNF-RI, sTNF-RII, IL-2 sR alpha and IFN-gamma). Therefore, in the baboon model, autoantibodies may be produced in absence of recognizable pathological conditions of the ageing immune system.
journal_name
Clin Exp Immunoljournal_title
Clinical and experimental immunologyauthors
Attanasio R,Brasky KM,Robbins SH,Jayashankar L,Nash RJ,Butler TMdoi
10.1046/j.1365-2249.2001.01454.xsubject
Has Abstractpub_date
2001-03-01 00:00:00pages
361-5issue
3eissn
0009-9104issn
1365-2249pii
cei1454journal_volume
123pub_type
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