Precipitable immune complexes in healthy homosexual men, acquired immune deficiency syndrome and the related lymphadenopathy syndrome.

Abstract:

:Increased levels of 3% PEG precipitable circulating immune complexes (CIC) were found in healthy homosexual men, in homosexual patients with the acquired immune deficiency syndrome (AIDS), and in the AIDS related lymphadenopathy syndrome (LAS). The degree of CIC elevation increases from healthy homosexual men to LAS and AIDS. Patients suffering from AIDS associated with opportunistic infections had a more pronounced increase in CIC than patients with AIDS associated Kaposi's sarcoma. In LAS and AIDS the amount of CIC correlated with the degree of inversion of the T4/T8 lymphocyte ratio, whereas in healthy homosexual men with increased levels of CIC the T4/T8 ratio was not significantly altered. Laser nephelometric partial components analysis revealed that these complexes were of a complement poor subtype with low component levels of C4, C1q and C3c. IgM and IgG were found to be the major components. It is suggested that these CIC might represent a marker of the total antigenic burden of the immune system. Possibly, they are of prognostic and monitoring value for clinical handling of patients at risk for AIDS.

journal_name

Clin Exp Immunol

authors

Euler HH,Kern P,Löffler H,Dietrich M

subject

Has Abstract

pub_date

1985-02-01 00:00:00

pages

267-75

issue

2

eissn

0009-9104

issn

1365-2249

journal_volume

59

pub_type

杂志文章
  • Characterization of hepatitis B surface antigen (HBsAg) induced interleukin-2 secretion in chronic asymptomatic carriers of HBsAg.

    abstract::Peripheral T lymphocytes from asymptomatic HBsAg carriers and hepatitis B (HB) immune (naturally acquired or vaccine induced) donors were induced into interleukin-2 (IL-2) secretion by plasma-derived HBsAg and the translational products of the S- and pre-S2+S gene of HB virus (HBV) in vitro. Biphasic time courses of I...

    journal_title:Clinical and experimental immunology

    pub_type: 杂志文章

    doi:

    authors: Sylvan SP,Hekkström UB

    更新日期:1989-11-01 00:00:00

  • Therapeutic effects of TACI-Ig on rat with adjuvant arthritis.

    abstract::Transmembrane activator and calcium modulator and cyclophilin ligand interactor-immunoglobulin (TACI-Ig) is a human fusion protein that binds and neutralizes both B lymphocyte stimulator (BLyS), a cytokine shown to be a key regulator of B cell maturation, proliferation and survival, and a proliferation-inducing ligand...

    journal_title:Clinical and experimental immunology

    pub_type: 杂志文章

    doi:10.1111/j.1365-2249.2010.04293.x

    authors: Wang D,Chang Y,Wu Y,Zhang L,Yan S,Xie G,Qin Q,Jin J,Wang W,Fang J,Wei W

    更新日期:2011-02-01 00:00:00

  • Changes in serum immunoglobulin patterns in adults with common variable immunodeficiency.

    abstract::Striking variations of serum immunoglobulin class and IgG subclass levels were observed in five patients with common variable immunodeficiency. They occurred mainly in untreated patients or, in those patients who received substitutive therapy, could not be merely due to replacement. They result in major changes in the...

    journal_title:Clinical and experimental immunology

    pub_type: 杂志文章

    doi:10.1111/j.1365-2249.1991.tb08118.x

    authors: Seligmann M,Aucouturier P,Danon F,Preud'Homme JL

    更新日期:1991-04-01 00:00:00

  • beta7 Integrin expression is not required for the localization of T cells to the intestine and colitis pathogenesis.

    abstract::beta7 Integrins have been shown to have an important role in the localization of T cells to the intestine. Utilizing two different experimental mouse models of inflammatory bowel disease (IBD), this study was undertaken to determine if beta7 integrin expression is critical for T cell localization to the intestine and ...

    journal_title:Clinical and experimental immunology

    pub_type: 杂志文章

    doi:10.1046/j.1365-2249.2002.01892.x

    authors: Sydora BC,Wagner N,Lohler J,Yakoub G,Kronenberg M,Muller W,Aranda R

    更新日期:2002-07-01 00:00:00

  • Difference in the cell proliferation and colony-forming ability of normal human T lymphocytes.

    abstract::Cell transfer experiments were carried out with phytohaemagglutinin-induced normal human T lymphocyte colonies after 2--10 days of primary colony growth. The cells gave a cloning efficiency of 15% after 2 days of incubation and this decreased to 0.2% with the progressive growth of the colonies. The primary colonies ha...

    journal_title:Clinical and experimental immunology

    pub_type: 杂志文章

    doi:

    authors: Smith SD,Sachs L

    更新日期:1979-08-01 00:00:00

  • Enhanced apoptosis of T cells in common variable immunodeficiency (CVID): role of defective CD28 co-stimulation.

    abstract::CVID is a primary immune disorder in which hypogammaglobulinaemia may be associated with a number of T cell defects including lymphopenia, anergy, impaired lymphocyte proliferation and deficient cytokine secretion. In this study we show that T cells of CVID subjects, in comparison with control T cells, undergo spontan...

    journal_title:Clinical and experimental immunology

    pub_type: 杂志文章

    doi:10.1046/j.1365-2249.2000.01239.x

    authors: Di Renzo M,Zhou Z,George I,Becker K,Cunningham-Rundles C

    更新日期:2000-06-01 00:00:00

  • Amelioration of lupus manifestations by a peptide based on the complementarity determining region 1 of an autoantibody in severe combined immunodeficient (SCID) mice engrafted with peripheral blood lymphocytes of systemic lupus erythematosus (SLE) patient

    abstract::A peptide based on the complementarity determining region (CDR)1 of a human monoclonal anti-DNA autoantibody (hCDR1) was shown to either prevent or treat an already established murine lupus in systemic lupus erythematosus (SLE)-prone mice or in mice with induced experimental SLE. The present study was undertaken to de...

    journal_title:Clinical and experimental immunology

    pub_type: 杂志文章

    doi:10.1111/j.1365-2249.2004.02559.x

    authors: Mauermann N,Sthoeger Z,Zinger H,Mozes E

    更新日期:2004-09-01 00:00:00

  • Proliferation and production of interferon-gamma (IFN-gamma) and IL-4 in response to Staphylococcus aureus and staphylococcal superantigen in childhood atopic dermatitis.

    abstract::We have examined the cell-mediated immunity (CMI) to Staphylococcus aureus (S. aureus) and Staphylococcal enterotoxin B (SEB) in peripheral blood mononuclear cells (PBMC) from children with atopic dermatitis (AD) and from non-atopic child controls by measurement of proliferative responses and production of the cytokin...

    journal_title:Clinical and experimental immunology

    pub_type: 杂志文章

    doi:10.1111/j.1365-2249.1997.278-ce1172.x

    authors: Campbell DE,Kemp AS

    更新日期:1997-02-01 00:00:00

  • Activation of the lectin pathway of complement by cardiopulmonary bypass contributes to the development of systemic inflammatory response syndrome after paediatric cardiac surgery.

    abstract::The systemic inflammatory response is a challenge in the management of paediatric patients undergoing cardiac surgery. Although multi-factorial, a contribution by the lectin pathway of complement activation has been postulated. We therefore investigated the changes in serum levels of mannose binding lectin (MBL) and a...

    journal_title:Clinical and experimental immunology

    pub_type: 杂志文章

    doi:10.1111/cei.12763

    authors: Pągowska-Klimek I,Świerzko AS,Michalski M,Głowacka E,Szala-Poździej A,Sokołowska A,Moll M,Krajewski WR,Romak J,Cedzyński M

    更新日期:2016-05-01 00:00:00

  • Suppression of autologous peripheral blood mononuclear cell proliferation by alveolar macrophages from young infants.

    abstract::Maintenance of lung homeostasis involves a complex interaction between T lymphocytes and alveolar macrophages (AM), in which AM suppress pulmonary T cell proliferation to antigenic stimuli. To assess whether AM-mediated suppression is attenuated in healthy young infants, AM and peripheral blood mononuclear cells (PBMC...

    journal_title:Clinical and experimental immunology

    pub_type: 杂志文章

    doi:10.1046/j.1365-2249.2002.01848.x

    authors: Bunn HJ,Hewitt CR,Grigg J

    更新日期:2002-05-01 00:00:00

  • The fine specificity of human T cell lines towards myelin basic protein peptides in southern Italian multiple sclerosis patients.

    abstract::We studied the relationship between the HLA specificities associated with multiple sclerosis (MS) susceptibility in southern Italy and the reactivity of the human myelin basic protein (hMBP) immunogenic peptides 84-98 and 143-168, using short-term T-cell lines established from 9 MS patients and from 8 healthy individu...

    journal_title:Clinical and experimental immunology

    pub_type: 杂志文章

    doi:10.1046/j.1365-2249.2001.01457.x

    authors: Montanaro D,Sanna V,Matarese G,Larby BB,Racioppi L,Carrieri PB,Bruno R,Davey NJ,Zappacosta S,Fontana S

    更新日期:2001-02-01 00:00:00

  • Monocyte chemoattractant protein-1 (MCP-1) inhibits the intestinal-like differentiation of monocytes.

    abstract::Monocytes (MO) migrating into normal, non-inflamed intestinal mucosa undergo a specific differentiation resulting in a non-reactive, tolerogenic intestinal macrophage (IMAC). Recently we demonstrated the differentiation of MO into an intestinal-like macrophage (MAC) phenotype in vitro in a three-dimensional cell cultu...

    journal_title:Clinical and experimental immunology

    pub_type: 杂志文章

    doi:10.1111/j.1365-2249.2006.03113.x

    authors: Spoettl T,Hausmann M,Herlyn M,Gunckel M,Dirmeier A,Falk W,Herfarth H,Schoelmerich J,Rogler G

    更新日期:2006-07-01 00:00:00

  • Up-regulation of CCL11 and CCL26 is associated with activated eosinophils in bullous pemphigoid.

    abstract::Eosinophils contribute to the pathogenesis of bullous pemphigoid (BP) by secretion of proinflammatory cytokines and proteases. Trafficking of eosinophils into tissue in animal models and asthma depends on interleukin-5 and a family of chemokines named eotaxins, comprising CCL11, CCL24 and CCL26. Up-regulation of CCL11...

    journal_title:Clinical and experimental immunology

    pub_type: 杂志文章

    doi:10.1111/j.1365-2249.2011.04464.x

    authors: Günther C,Wozel G,Meurer M,Pfeiffer C

    更新日期:2011-11-01 00:00:00

  • Programmed death-1 ligands 1 and 2 expression in cutaneous squamous cell carcinoma and their relationship with tumour- infiltrating dendritic cells.

    abstract::The programmed death-1 (PD-1) receptor ligands, PD-L1 and PD-L2, are co-stimulatory molecules that contribute to the negative regulation of T lymphocyte activation. It is still unclear whether there is correlation between PD-L1 or PD-L2 and tumour-infiltrating dendritic cells (TIDCs) in cutaneous squamous cell carcino...

    journal_title:Clinical and experimental immunology

    pub_type: 杂志文章

    doi:10.1111/cei.12921

    authors: Jiao Q,Liu C,Li W,Li W,Fang F,Qian Q,Zhang X

    更新日期:2017-06-01 00:00:00

  • Altered innate immune response of plasmacytoid dendritic cells in multiple sclerosis.

    abstract::Plasmacytoid dendritic cells (pDCs) are of crucial importance in immune regulation and response to microbial factors. In multiple sclerosis (MS), pDCs from peripheral blood showed an immature phenotype, but its role in susceptibility to MS is not determined. Because infectious diseases are established triggers of exac...

    journal_title:Clinical and experimental immunology

    pub_type: 杂志文章

    doi:10.1111/j.1365-2249.2009.03964.x

    authors: Bayas A,Stasiolek M,Kruse N,Toyka KV,Selmaj K,Gold R

    更新日期:2009-09-01 00:00:00

  • Benznidazole, a drug employed in the treatment of Chagas' disease, down-regulates the synthesis of nitrite and cytokines by murine stimulated macrophages.

    abstract::Benznidazole (BZL) is a nitroheterocyclic drug employed in the chemotherapy of Chagas' disease, a protozoan disease caused by Trypanosoma cruzi. Because this parasite mostly replicates in macrophages, we investigated whether BZL was likely to modify the synthesis of macrophage mediators such as nitrite, tumour necrosi...

    journal_title:Clinical and experimental immunology

    pub_type: 杂志文章

    doi:10.1046/j.1365-2249.1999.01053.x

    authors: Revelli S,Le Page C,Piaggio E,Wietzerbin J,Bottasso O

    更新日期:1999-11-01 00:00:00

  • Lung cell responses to M. tuberculosis in genetically susceptible and resistant mice following intratracheal challenge.

    abstract::One approach to study the role of distinct cellular mechanisms in susceptibility/resistance to tuberculosis (TB) is to compare parameters of response to infection in the lungs of mouse strains exhibiting genetically determined differences in TB susceptibility/severity. Interstrain differences in antimycobacterial macr...

    journal_title:Clinical and experimental immunology

    pub_type: 杂志文章

    doi:10.1111/j.1365-2249.2004.02328.x

    authors: Eruslanov EB,Majorov KB,Orlova MO,Mischenko VV,Kondratieva TK,Apt AS,Lyadova IV

    更新日期:2004-01-01 00:00:00

  • Lack of complement activation by human IgA immune complexes.

    abstract::Complement activation may play an important role in renal injury associated with glomerular deposition of IgA immune complexes. The ability of naturally occurring human IgA immune complexes (IgA-IC) and covalently cross-linked human IgA oligomers (X-IgA) to activate complement were examined in vitro and in vivo. Large...

    journal_title:Clinical and experimental immunology

    pub_type: 杂志文章

    doi:

    authors: Imai H,Chen A,Wyatt RJ,Rifai A

    更新日期:1988-09-01 00:00:00

  • Fungal-derived cues promote ocular autoimmunity through a Dectin-2/Card9-mediated mechanism.

    abstract::Uveitis (intraocular inflammation) is a leading cause of loss of vision. Although its aetiology is largely speculative, it is thought to arise from complex genetic-environmental interactions that break immune tolerance to generate eye-specific autoreactive T cells. Experimental autoimmune uveitis (EAU), induced by imm...

    journal_title:Clinical and experimental immunology

    pub_type: 杂志文章

    doi:10.1111/cei.13021

    authors: Brown BR,Lee EJ,Snow PE,Vance EE,Iwakura Y,Ohno N,Miura N,Lin X,Brown GD,Wells CA,Smith JR,Caspi RR,Rosenzweig HL

    更新日期:2017-12-01 00:00:00

  • In vivo anti-nuclear antibodies in epithelial biopsies in SLE and other connective tissue diseases.

    abstract::In vivo anti-nuclear antibody (ANA) was observed by direct immunofluorescence microscopy in epithelial cell nuclei in forty-four biopsies from thirty-three patients. The tissue containing the ANA was macroscopically normal in twenty-seven patients. The thirty-three patients with in vivo biopsy ANA included twenty-thre...

    journal_title:Clinical and experimental immunology

    pub_type: 杂志文章

    doi:

    authors: Wells JV,Webb J,Van Deventer M,Fry B,Pollard KM,Raftos J,Monk W,Nelson DS

    更新日期:1979-12-01 00:00:00

  • Antibodies selectively reactive to autologous and host-type platelets are obtained following interspecies immunizations in marmosets.

    abstract::Interspecies immunization of marmosets with platelets leads to an acute thrombocytopenia which appears to be immunologically mediated. The thrombocytopenia is preceded by the formation of antibodies to the donor platelet antigen and deposition of IgG on the host's platelets. Examination of sera obtained from these ani...

    journal_title:Clinical and experimental immunology

    pub_type: 杂志文章

    doi:

    authors: Gengozian N,Annostby D

    更新日期:1981-01-01 00:00:00

  • Identification of mononuclear cells in human blood. I. Qualitative and quantitative data on surface markers after formaldehyde fixation of the cells.

    abstract::The technical details of a fixation procedure with formaldehyde which was applied in a direct membrane immunofluorescence technique to mononuclear cells from normal human blood are described. After separation of the cells with Ficoll--Isopaque according to Böyum (1963) they were washed and fixed with 0 . 04% formaldeh...

    journal_title:Clinical and experimental immunology

    pub_type: 杂志文章

    doi:

    authors: Schuit HR,Hijmans W,Asma GE

    更新日期:1980-09-01 00:00:00

  • Decreased expression of complement receptor type 2 (CR2) on neoplastic B cells of chronic lymphocytic leukaemia.

    abstract::Neoplastic cells from 49 patients with B cell chronic lymphocytic leukaemia (B-CLL) were studied and compared with normal peripheral and tonsillar B cells using CD21 monoclonal antibodies. Membrane expression of CR2 was quantified by calibrated flow cytometry and by binding analysis with radiolabelled antibody. Both a...

    journal_title:Clinical and experimental immunology

    pub_type: 杂志文章

    doi:10.1111/j.1365-2249.1991.tb05655.x

    authors: Tooze JA,Bevan DH

    更新日期:1991-03-01 00:00:00

  • CD5-positive B cells after T cell depleted bone marrow transplantation.

    abstract::CD5 is an antigen normally found on T cells and on a minority subpopulation of B cells in fetal spleen and tonsil and on the majority of cells in B-chronic lymphocytic leukaemia. Recent reports described the occurrence of large numbers of CD5-positive B cells in the peripheral blood after bone marrow transplantation (...

    journal_title:Clinical and experimental immunology

    pub_type: 杂志文章

    doi:

    authors: Drexler HG,Brenner MK,Wimperis JZ,Gignac SM,Janossy G,Prentice HG,Hoffbrand AV

    更新日期:1987-06-01 00:00:00

  • T cell receptor gamma delta bearing cells are decreased in the peripheral blood of patients with atopic diseases.

    abstract::The biological role of T cell receptor (TCR) gamma delta bearing cells is currently not fully understood. Recently, a monoclonal antibody (TCR delta 1) reacting against the whole molecule became available which facilitates the direct analysis of TCR-gamma delta+ cells. We studied 11 children with atopic dermatitis, 20...

    journal_title:Clinical and experimental immunology

    pub_type: 杂志文章

    doi:10.1111/j.1365-2249.1991.tb02950.x

    authors: Schauer U,Dippel E,Gieler U,Bräuer J,Jung T,Heymanns J,Rieger CH

    更新日期:1991-12-01 00:00:00

  • Dancing with the enemy: the interplay of herpes simplex virus with dendritic cells.

    abstract::Summary Herpes simplex virus (HSV) represents a smart pathogen, which displays both lytic and latent modes of interaction with its natural human host. In order to be optimally equipped for immune evasion and to reply to any attacks of the host during reactivation, HSV has developed a multitude of cleverly devised defe...

    journal_title:Clinical and experimental immunology

    pub_type: 杂志文章,评审

    doi:10.1111/j.1365-2249.2005.02927.x

    authors: Novak N,Peng WM

    更新日期:2005-12-01 00:00:00

  • Fractalkine functions as a chemoattractant for osteoarthritis synovial fibroblasts and stimulates phosphorylation of mitogen-activated protein kinases and Akt.

    abstract::Fractalkine (FKN/CX3CL1) has been detected in synovial fluids from osteoarthritis (OA) patients. Additionally, low-level expression of the FKN receptor, CX3CR1, has been demonstrated in OA synovial lining. This study aimed to determine a biological function for this ligand/receptor pair in OA and to assess a potential...

    journal_title:Clinical and experimental immunology

    pub_type: 杂志文章

    doi:10.1111/j.1365-2249.2009.03903.x

    authors: Klosowska K,Volin MV,Huynh N,Chong KK,Halloran MM,Woods JM

    更新日期:2009-05-01 00:00:00

  • Chronology of halothane-induced antigen expression in halothane-exposed rabbits.

    abstract::Multiple halothane exposures in rabbits generate modified liver proteins or antigens that appear to incorporate the metabolic intermediate of halothane, trifluoroacetyl halide (TFA), as identified by specific anti-TFA antibody. These halothane-induced antigens are most prevalent throughout the second to fourth days fo...

    journal_title:Clinical and experimental immunology

    pub_type: 杂志文章

    doi:

    authors: Roth TP,Hubbard AK,Gandolfi AJ,Brown BR

    更新日期:1988-05-01 00:00:00

  • Cell-mediated immune response during experimental arthritis induced in rats with streptococcal cell walls.

    abstract::Chronic, remittent, erosive arthritis was produced in rats by a single intraperitoneal injection of an aqueous suspension of cell wall fragments isolated from group A streptococci. Arthritis could be induced in rats which had been immunologically compromised by neonatal thymectomy. Delayed hypersensitivity to cell wal...

    journal_title:Clinical and experimental immunology

    pub_type: 杂志文章

    doi:

    authors: Hunter N,Anderle SK,Brown RR,Dalldorf FG,Clark RL,Cromartie WJ,Schwab JH

    更新日期:1980-12-01 00:00:00

  • Interferon-gamma and tumour necrosis factor-alpha production by CD4+ T and CD8+ T lymphocytes in AIDS patients with tuberculosis.

    abstract::Tuberculosis (TB) is usually more severe in HIV-infected patients, and the immune derangement found in co-infected patients may differ from that in each isolated disease. Following mitogen stimulation of peripheral blood mononuclear cells (PBMC), interferon (IFN)-gamma and tumour necrosis factor (TNF)-alpha production...

    journal_title:Clinical and experimental immunology

    pub_type: 杂志文章

    doi:10.1111/j.1365-2249.2005.02796.x

    authors: de Castro Cunha RM,Kallas EG,Rodrigues DS,Nascimento Burattini M,Salomao R

    更新日期:2005-06-01 00:00:00