Pre-neutralization of C5a-mediated effects by the monoclonal antibody 137-26 reacting with the C5a moiety of native C5 without preventing C5 cleavage.

abstract：:The sera of patients with histologically proven carcinomata of the gastrointestinal tract were fractionated by gel filtration and the fractions assayed for the presence of free carcinoembryonic antigen (CEA) binding immunoglobulins and CEA immune complexes by radioimmuno-double-diffusion, using 125I-CEA as a marker. I...

journal_title：Clinical and experimental immunology

authors： Kapsopoulou-Dominos K,Anderer FA

更新日期：1979-02-01 00:00:00

abstract：:Rheumatoid arthritis (RA) is a chronic inflammatory disease that develops as a result of the interaction between genetic and environmental risk factors. Although increasing evidence shows the importance of genes in determining the risk of RA, it is clear that environmental factors also have a vital role. Studies to da...

journal_title：Clinical and experimental immunology

authors： Colebatch AN,Edwards CJ

更新日期：2011-01-01 00:00:00

abstract：:Mercuric chloride (HgCl2)-induced autoimmunity in Brown Norway (BN) rats is a highly polarized polyclonal Th2-driven autoimmune response with increased IgE production, lymphoproliferation, vasculitis and proteinuria. The increase in serum IgE concentration is clearly measurable by day 4 after the first HgCl2 injection...

journal_title：Clinical and experimental immunology

authors： Macphee IA,Turner DR,Yagita H,Oliveira DB

更新日期：2002-09-01 00:00:00

abstract：:Solubilization of an immune precipitate by serum is a complement function mediated by the alternative pathway and enhanced by the classical pathway--it therefore provides the basis of a simple quantitative assessment of the integrity of complement function. Using a preformed radiolabelled precipitate of BSA-alpha BSA ...

journal_title：Clinical and experimental immunology

authors： Schifferli JA,Morris SM,Dash A,Peters DK

更新日期：1981-12-01 00:00:00

abstract：:Intravenous immune globulin (IVIG) preparations are efficacious and safe products in use world-wide. Although rare, side-effects of IVIG may be serious, even life-threatening, and clinicians should be aware of their potential occurrence. This article summarizes most of the adverse experiences with IVIG reported in the...

journal_title：Clinical and experimental immunology

authors： Duhem C,Dicato MA,Ries F

更新日期：1994-07-01 00:00:00

abstract：:We describe a system for studying the interaction of human, single donor platelets and aggregated human IgG adherent to erythrocyte stroma (ES/Agg IgG) and report the role of monomeric IgG and C1q in this interaction. Monomeric IgG inhibits platelet aggregation by the ES/Agg IgG and acts on the platelet surface. Compl...

journal_title：Clinical and experimental immunology

authors： Vollertsen RS,McDuffie FC,Bowie EJ

更新日期：1983-05-01 00:00:00

abstract：:Goodpasture (GP) antigens, protein components reactive with human autoantibodies against glomerular basement membrane (GBM), were identified in human alveolar basement membrane (ABM) using an enzyme-linked immunoassay (ELISA), Western blotting and immunoprecipitation. All six anti-GBM antisera studied, three obtained ...

journal_title：Clinical and experimental immunology

authors： Yoshioka K,Iseki T,Okada M,Morimoto Y,Eryu N,Maki S

更新日期：1988-12-01 00:00:00

abstract：:Sjögren's syndrome (SS) is an autoimmune disease characterized by clonal B cell attack of the exocrine glands and dysregulated expression of B cell-activating factor (BAFF). Based upon the current data of increased rates of lymphoid malignancy, as non-Hodgkin's lymphoma (NHL) is associated with SS, we propose the dete...

journal_title：Clinical and experimental immunology

authors： Guzmán LM,Castillo D,Aguilera SO

更新日期：2010-07-01 00:00:00

abstract：:Antibody-dependent cellular cytotoxicity (ADCC) of peripheral blood lymphocytes against chicken red blood cells (ChRBC) in the presence of specific antiserum has been studied in normal subjects and in patients with acute hepatitis B and with chronic active hepatitis (CAH). ADCC was significantly reduced in patients wi...

journal_title：Clinical and experimental immunology

authors： Bortolotti F,Realdi G,Diodati G,Fattovich G

更新日期：1978-08-01 00:00:00

abstract：:Antibody responses in immunoglobulin G1, G2, G3, G4, A (IgA1) and M isotypes were studied in 10 patients with an acute influenza A and in another 10 patients with a parainfluenza type 1 virus infection using radioimmunoassay with standardized monoclonal anti-immunoglobulins. A four-fold or greater increase of antibody...

journal_title：Clinical and experimental immunology

authors： Julkunen I,Hovi T,Seppälä I,Mäkelä O

更新日期：1985-04-01 00:00:00

abstract：:In rheumatoid arthritis peripheral cartilaginous joints are inflamed and eroded. One driving factor may be an immune response towards proteins in the cartilage. Here it is shown that cartilage oligomeric matrix protein (COMP), expressed specifically in cartilage, is arthritogenic in the rat. Both native and denatured ...

journal_title：Clinical and experimental immunology

authors： Carlsén S,Hansson AS,Olsson H,Heinegård D,Holmdahl R

更新日期：1998-12-01 00:00:00

abstract：:Malignant rabbit fibroma virus (MV) directly suppresses generation of antibody responses and mitogen induced T and B lymphocyte proliferation. We investigated whether this phenomenon required expression of the complete viral genome. Phosphonoacetic acid (PAA) inhibits poxvirus specific DNA polymerases. Adding PAA to c...

journal_title：Clinical and experimental immunology

authors： Strayer DS,Skaletsky E,Leibowitz JL

更新日期：1986-10-01 00:00:00

abstract：:We assessed whether complement and its factor C4 or abnormal immunoglobulin levels are associated with chronic or recurrent rhinosinusitis. We used multiple patient and control groups to obtain clinically meaningful data. Adult chronic or recurrent rhinosinusitis and acute purulent rhinosinusitis patients were compare...

journal_title：Clinical and experimental immunology

authors： Seppänen M,Suvilehto J,Lokki ML,Notkola IL,Järvinen A,Jarva H,Seppälä I,Tahkokallio O,Malmberg H,Meri S,Valtonen V

更新日期：2006-08-01 00:00:00

abstract：:Even though the existence of phosphodiesterase (PDE) 7 in T cells has been proved, the lack of a selective PDE7 inhibitor has confounded an accurate assessment of PDE7 function in such cells. In order to elucidate the role of PDE7 in human T cell function, the effects of two PDE inhibitors on PDE7A activity, cytokine ...

journal_title：Clinical and experimental immunology

authors： Nakata A,Ogawa K,Sasaki T,Koyama N,Wada K,Kotera J,Kikkawa H,Omori K,Kaminuma O

更新日期：2002-06-01 00:00:00

abstract：:There is increasing interest in the role of T cell exhaustion and it is well known that the natural history of chronic hepatitis C virus infection (HCV) is modulated by CD8(+) T cell immunobiology. There are many pathways that alter the presence of exhaustive T cells and, in particular, they are functionally impaired ...

journal_title：Clinical and experimental immunology

authors： Sumida K,Shimoda S,Iwasaka S,Hisamoto S,Kawanaka H,Akahoshi T,Ikegami T,Shirabe K,Shimono N,Maehara Y,Selmi C,Gershwin ME,Akashi K

更新日期：2013-10-01 00:00:00

abstract：:Individuals with a negative intradermal reaction to tuberculin PPD have long been described in the Mycobacterium tuberculosis exposed, immune-competent population. Here, we studied PPD-specific blood T lymphocytes from these subjects for phenotypic markers relevant to skin migration, including the expression of the sk...

journal_title：Clinical and experimental immunology

authors： Magnani ZI,Confetti C,Besozzi G,Codecasa LR,Panina-Bordignon P,Lang R,Rossi GA,Pardi R,Burastero SE

更新日期：2000-01-01 00:00:00

abstract：:The transferrin receptors which appear on mitogen-activated human peripheral blood lymphocytes were found by the use of immunofluorescence techniques to display temperature-dependent patching and capping reactions upon binding of transferrin. Lateral mobility of ligand-occupied membrane sites was accompanied by both s...

journal_title：Clinical and experimental immunology

authors： Galbraith GM,Galbraith RM

更新日期：1980-11-01 00:00:00

abstract：:IgA nephropathy (IgAN) is the most common primary glomerulonephritis, with various pathological phenotypes. Our previous study suggested that aberrant glycosylation of serum IgA1 was associated with different pathological phenotypes of IgAN, and substantial evidence indicated that deglycosylated IgA1 had an increased ...

journal_title：Clinical and experimental immunology

authors： Yan Y,Xu LX,Zhang JJ,Zhang Y,Zhao MH

更新日期：2006-04-01 00:00:00

abstract：:We have investigated the T-cell antigen receptor constant beta and alpha chain genes (TCR-C beta, -C alpha) and the immunoglobulin (Ig) heavy chain switch regions of patients with Graves' disease (GD) using restriction fragment length polymorphism (RFLP) analysis. No significant associations were found with RFLPs of e...

journal_title：Clinical and experimental immunology

authors： Demaine AG,Ratanachaiyavong S,Pope R,Ewins D,Millward BA,McGregor AM

更新日期：1989-07-01 00:00:00

abstract：:Sjögren's syndrome (SS) is an autoimmune disease characterized by T cell infiltration into the salivary and lacrimal glands (LG). Previous studies on T cell receptor (TCR) usage in the minor salivary glands (SG) have yielded controversial results. We studied TCR beta gene usage of the T cells infiltrating to LG, which...

journal_title：Clinical and experimental immunology

authors： Mizushima N,Kohsaka H,Tsubota K,Saito I,Miyasaka N

更新日期：1995-07-01 00:00:00

abstract：:Anti-CD2 MoAbs have previously been shown to induce tolerance and to block B cell differentiation, T cell and monocyte activation. Since these immune functions are important in joint inflammation, we asked whether administration of the anti-CD2 MoAb OX34 has a beneficial effect on established rat adjuvant arthritis, a...

journal_title：Clinical and experimental immunology

authors： Hoffmann JC,Herklotz C,Zeidler H,Bayer B,Westermann J

更新日期：1997-10-01 00:00:00

abstract：:We explored the effects of local anaesthetics, which are proposed to affect the plasma membrane, on human natural killer (NK) cells. Human NK cell activity was inhibited by lidocaine and procaine in a dose-dependent manner. Procaine inhibited not only NK cytolysis but also the binding of NK cells to target cells when ...

journal_title：Clinical and experimental immunology

authors： Takagi S,Kitagawa S,Oshimi K,Takaku F,Miura Y

更新日期：1983-08-01 00:00:00

abstract：:Measles-specific IgA antibody titres were determined by radioimmunoassay (RIA) for serial serum, saliva and tear samples obtained from 21 children with measles infection, from onset of rash until up to 14 months later. Serum IgA titres rose rapidly after onset of illness and remained detectable throughout the follow-u...

journal_title：Clinical and experimental immunology

authors： Friedman MG,Phillip M,Dagan R

更新日期：1989-01-01 00:00:00

abstract：:A system has been established to produce in vitro IgG specific for cell wall determinants of S. aureus by human peripheral blood mononuclear cells (PBMC). PBMC of healthy individuals, of patients with S. aureus infections and of patients with other bacterial infections were cultured for 12 days. In the culture superna...

journal_title：Clinical and experimental immunology

authors： Hauser C,Wilhelm JA,Matter L,Schopfer K

更新日期：1984-07-01 00:00:00

abstract：:Anti-proteinase 3 antibodies are a subgroup of anti-neutrophil cytoplasmic antibodies (ANCA), and we have established an ELISA for their detection using high performance liquid chromatography (HPLC)-purified protein. This assay is sensitive and specific: inhibition studies have shown that despite the homology between ...

journal_title：Clinical and experimental immunology

authors： Jennings JG,Chang L,Savige JA

更新日期：1994-02-01 00:00:00

abstract：:alpha 1-Microglobulin (alpha 1-m) was purified by column chromatography from a supernatant fluid of cultured T and B lymphocytes stimulated with mitogens. This protein had a molecular weight of 33,000 as determined by sodium dodecyl sulphate (SDS) polyacrylamide gel electrophoresis, migrated in the alpha 1-region on i...

journal_title：Clinical and experimental immunology

authors： Itoh Y,Kin K,Kasahara T,Sakurabayashi I,Kawai T,Shiori-Nakano K,Takagi K

更新日期：1979-07-01 00:00:00

abstract：:Salivary gland biopsies from 12 patients with primary Sjögren's syndrome and 10 controls were examined for Epstein-Barr virus (EBV) DNA by in-situ hybridization and for EBV proteins by immunofluorescence and peroxidase techniques. Viral DNA was found in biopsies from two out of 12 patients with primary Sjögren's syndr...

journal_title：Clinical and experimental immunology

authors： Venables PJ,Teo CG,Baboonian C,Griffin BE,Hughes RA

更新日期：1989-03-01 00:00:00

abstract：:Muscle is an attractive target for gene therapy and for immunization with DNA vaccines and is also the target of immunological injury in myositis. It is important therefore to understand the immunologic capabilities of muscle cells themselves. In this study, we show that proinflammatory stimuli induce the expression o...

journal_title：Clinical and experimental immunology

authors： Nagaraju K,Raben N,Merritt G,Loeffler L,Kirk K,Plotz P

更新日期：1998-09-01 00:00:00

abstract：:Using quantitative morphometric analysis of immunohistochemically stained tissue sections we compared hypertrophic obstructive adenoids (HOA, n = 10) from children without middle ear disease with chronically infected adenoids (CIA, n = 10) from children with middle ear disease. gamma delta T cell receptor (TCR)+ cells...

journal_title：Clinical and experimental immunology

authors： Olofsson K,Hellström S,Hammarström ML

更新日期：1996-11-01 00:00:00

abstract：:Five patients with no detectable serum IgA (less than 20 mug/ml) and one patient with low serum IgA were compared to normal subjects. The number of circulating E-RFC was normal as was the lymphocyte DNA synthesis induced by PHA, Con A, and streptokinase-streptodornase. The patients had normal numbers of IgA-bearing ly...

journal_title：Clinical and experimental immunology

authors： Delespesse G,Gausset P,Cauchie C,Govaerts A

更新日期：1976-05-01 00:00:00