当前位置： SCI文献检索 > CLINICAL AND EXPERIMENTAL IMMUNOLOGY期刊下所有文献 > Molecular basis for antibody cross-reactivity between the hepatitis C virus core protein and the host-derived GOR protein.

Molecular basis for antibody cross-reactivity between the hepatitis C virus core protein and the host-derived GOR protein.

Abstract：

:The presence of antibodies reactive to a recently cloned host-derived antigen GOR is highly correlated with the presence of antibodies to the hepatitis C virus (HCV). We explored the molecular basis for this observation, and address the following question: are antibodies reactive with GOR19-27 (QKAKSNPNR) a result of a cross-reactivity triggered by the antigenic region at residues 9-17 of HCV core (RKTKRNTNR)? We compared the relative antibody avidity between antibodies reactive to both regions, and determined the residues essential for antibody binding using substitution peptide analogues. Of 96 sera assayed, 60 were found positive for anti-HCV, and of these 55 were found to react with HCV core. Twenty-nine sera were found reactive to the GOR peptide, and these were all reactive to HCV core. In most cases the relative antibody avidity of antibodies reactive to GOR was higher for the HCV core peptide. In 21 of the GOR-reactive sera we were able to determine the essential residues for antibody binding. The essential residues in > 50% of all tested sera coincided with the well conserved residues Lys10, Lys12, Asn14, and Asn16. Also, reactivity to GOR was not related to any certain serotype of antibodies to HCV. Taken together, these findings explain at the molecular level the observed cross-reactivity between these two proteins, since sequence homology per se is not evidence for cross-reactivity.

journal_name

Clin Exp Immunol

journal_title

Clinical and experimental immunology

authors

Zhang ZX,Chen M,Wallhagen K,Trojnar J,Magnius LO,Wahren B,Sällberg M

doi

10.1111/j.1365-2249.1994.tb06042.x

subject

Has Abstract

pub_date

1994-06-01 00:00:00

pages

403-9

issue

3

eissn

0009-9104

issn

1365-2249

journal_volume

96

pub_type

杂志文章

相关文献

CLINICAL AND EXPERIMENTAL IMMUNOLOGY文献大全
  • Protein biochip array technology to monitor rituximab in rheumatoid arthritis.

    abstract：:In rheumatoid arthritis (RA) there are currently no good indicators to predict a clinical response to rituximab. The purpose of this study was to monitor and determine the role of peripheral blood cytokine profiling in differentiating between a good versus poor response to rituximab in RA. Blood samples were collected...

    journal_title：Clinical and experimental immunology

    pub_type： 杂志文章

    doi：10.1111/j.1365-2249.2008.03804.x

    authors： Fabre S,Guisset C,Tatem L,Dossat N,Dupuy AM,Cohen JD,Cristol JP,Daures JP,Jorgensen C

    更新日期：2009-03-01 00:00:00

  • Blocking lymphotoxin-beta receptor activation diminishes inflammation via reduced mucosal addressin cell adhesion molecule-1 (MAdCAM-1) expression and leucocyte margination in chronic DSS-induced colitis.

    abstract：:The lymphotoxin-beta receptor (LTbetaR) pathway is critical for maintenance of organized lymphoid structures and is involved in the development of colitis. To investigate the mechanisms by which LTbetaR activation contributes to the pathology of chronic inflammation we used a soluble LTbetaR-Ig fusion protein as a com...

    journal_title：Clinical and experimental immunology

    pub_type： 杂志文章

    doi：10.1111/j.1365-2249.2004.02402.x

    authors： Stopfer P,Obermeier F,Dunger N,Falk W,Farkas S,Janotta M,Möller A,Männel DN,Hehlgans T

    更新日期：2004-04-01 00:00:00

  • In vitro dendritic cell-induced T cell responses to B cell chronic lymphocytic leukaemia enhanced by IL-15 and dendritic cell-B-CLL electrofusion hybrids.

    abstract：:HLA class II-restricted proliferative and cytotoxic T cell (CTL) responses to B cell chronic lymphocytic leukaemia (B-CLL) can be generated using autologous dendritic cells (DCs) pulsed with tumour cell lysate. In this study a number of different approaches were used to optimize further the in vitro system. First, the...

    journal_title：Clinical and experimental immunology

    pub_type： 杂志文章

    doi：10.1046/j.1365-2249.2003.02047.x

    authors： Goddard RV,Prentice AG,Copplestone JA,Kaminski ER

    更新日期：2003-01-01 00:00:00

  • CD4+ T cells from HIV-1-infected patients recognize wild-type and mutant human immunodeficiency virus-1 protease epitopes.

    abstract：:Human immunodeficiency virus (HIV)-1 protease is a known target of CD8+ T cell responses, but it is the only HIV-1 protein in which no fully characterized HIV-1 protease CD4 epitopes have been identified to date. We investigated the recognition of HIV-1 protease by CD4+ T cells from 75 HIV-1-infected, protease inhibit...

    journal_title：Clinical and experimental immunology

    pub_type： 杂志文章

    doi：10.1111/j.1365-2249.2011.04319.x

    authors： Muller NG,Alencar R,Jamal L,Hammer J,Sidney J,Sette A,Brindeiro RM,Kalil J,Cunha-Neto E,Moraes SL

    更新日期：2011-04-01 00:00:00

  • Incidence of arthritis and autoreactivity of anti-collagen antibodies after immunization of DBA/1 mice with heterologous and autologous collagen II.

    abstract：:Native type II collagens of rat, chick, bovine, human and murine origin have been used for immunization of male and female DBA/1 mice of different ages. The four heterologous collagens were able to induce arthritis in both male and female mice although the incidence of arthritis was higher in males. The onset of arthr...

    journal_title：Clinical and experimental immunology

    pub_type： 杂志文章

    doi：

    authors： Holmdahl R,Jansson L,Gullberg D,Rubin K,Forsberg PO,Klareskog L

    更新日期：1985-12-01 00:00:00

  • Stimulation by means of dendritic cells followed by Epstein-Barr virus-transformed B cells as antigen-presenting cells is more efficient than dendritic cells alone in inducing Aspergillus f16-specific cytotoxic T cell responses.

    abstract：:Adoptive immunotherapy with in vitro expanded antigen-specific cytotoxic T lymphocytes (CTLs) may be an effective approach to prevent, or even treat, Aspergillus (Asp) infections. Such lines can be generated using monocyte-derived dendritic cells (DC) as antigen-presenting cells (APC) but requires a relatively high vo...

    journal_title：Clinical and experimental immunology

    pub_type： 杂志文章

    doi：10.1111/j.1365-2249.2007.03544.x

    authors： Zhu F,Ramadan G,Davies B,Margolis DA,Keever-Taylor CA

    更新日期：2008-02-01 00:00:00

  • Impaired activation of Stat1 and c-Jun as a possible defect in macrophages of patients with active tuberculosis.

    abstract：:Studies of patients with active tuberculosis (TB) and infected healthy individuals have shown that interferon (IFN)-gamma is present in sites of Mycobacterium tuberculosis infection in comparable levels. This suggests that there is a deficiency in the macrophage response to IFN-gamma in TB patients. We used recombinan...

    journal_title：Clinical and experimental immunology

    pub_type： 杂志文章

    doi：10.1111/j.1365-2249.2009.03985.x

    authors： Esquivel-Solís H,Quiñones-Falconi F,Zarain-Herzberg A,Amieva-Fernández RI,López-Vidal Y

    更新日期：2009-10-01 00:00:00

  • Role of membrane-associated lymphotoxin (mLT) in the killing activity of lymphokine-activated killer (LAK) cells towards various tumour cell lines.

    abstract：:Human lymphokine-activated killer (LAK) cells developed by an incubation of peripheral mononuclear cells with IL-2 express the membrane-associated lymphotoxin (LT)-related molecule (mLT). By a further cultivation of mLT expressing (mLT-positive) LAK cells for 24 h without IL-2, mLT disappears (mLT-negative LAK cells)....

    journal_title：Clinical and experimental immunology

    pub_type： 杂志文章

    doi：10.1111/j.1365-2249.1994.tb06245.x

    authors： Horiuchi A,Abe Y,Miyake M,Kimura K,Hitsumoto Y,Takeuchi N,Kimura S

    更新日期：1994-04-01 00:00:00

  • Studies on J chain and binding site for secretory component in circulating human B cells.

    abstract：:Lymphocyte-enriched mononuclear cell fractions were obtained from the peripheral blood of four healthy young adults. Living B cells with membrane immunoglobulin (Ig) were studied by immunofluorescence to reveal exposed J-chain determinants or surface affinity for the secretory component (SC). Alcohol-fixed cell smears...

    journal_title：Clinical and experimental immunology

    pub_type： 杂志文章

    doi：

    authors： Brandtzaeg P

    更新日期：1976-07-01 00:00:00

  • Late diagnosis of chronic granulomatous disease.

    abstract：:Modern era advancements in medical care, with improved treatment of infections, can result in delayed diagnosis of congenital immunodeficiencies. In this study we present a retrospective cohort of 16 patients diagnosed with Chronic Granulomatous Disease (CGD) at adulthood. Some of the patients had a milder clinical ph...

    journal_title：Clinical and experimental immunology

    pub_type： 杂志文章

    doi：10.1111/cei.13474

    authors： Barkai T,Somech R,Broides A,Gavrieli R,Wolach B,Marcus N,Hagin D,Stauber T

    更新日期：2020-09-01 00:00:00

  • Increased natural killer cell subsets with inhibitory cytokines and inhibitory surface receptors in patients with recurrent miscarriage and decreased or normal subsets in kidney transplant recipients late post-transplant.

    abstract：:Patients with recurrent miscarriage (RM) show up-regulated cytotoxic natural killer (NK) cells that are suspected to play a causal role in abortion. In the present study, we investigated counter-regulating inhibitory mechanisms and compared the results in RM patients with those of healthy controls (HC), patients with ...

    journal_title：Clinical and experimental immunology

    pub_type： 杂志文章

    doi：10.1111/cei.13142

    authors： Zhu L,Aly M,Wang H,Karakizlis H,Weimer R,Morath C,Kuon RJ,Toth B,Ekpoom N,Opelz G,Daniel V

    更新日期：2018-08-01 00:00:00

  • Translational mini-review series on immunology of vascular disease: accelerated atherosclerosis in vasculitis.

    abstract：:Premature atherosclerosis has been observed during the course of different systemic inflammatory diseases such as rheumatoid arthritis and sytemic lupus erythematosus. Remarkably, relatively few studies have been published on the occurrence of accelerated atherosclerosis in patients with vasculitis. In giant cell arte...

    journal_title：Clinical and experimental immunology

    pub_type： 杂志文章,评审

    doi：10.1111/j.1365-2249.2009.03885.x

    authors： Tervaert JW

    更新日期：2009-06-01 00:00:00

  • Paneth cell granule depletion in the human small intestine under infective and nutritional stress.

    abstract：:Paneth cells are important contributors to the intestinal antimicrobial barrier through synthesis and release of antimicrobial peptides and proteins. Animal studies indicate that Paneth cell numbers, location and granule morphology are altered by infection and zinc status. We examined human tissue to determine whether...

    journal_title：Clinical and experimental immunology

    pub_type： 杂志文章

    doi：10.1111/j.1365-2249.2004.02374.x

    authors： Kelly P,Feakins R,Domizio P,Murphy J,Bevins C,Wilson J,McPhail G,Poulsom R,Dhaliwal W

    更新日期：2004-02-01 00:00:00

  • The role of anti-endothelial cell antibodies in Kawasaki disease - in vitro and in vivo studies.

    abstract：:Kawasaki disease (KD) is a systemic vasculitis with cardiac and noncardiac complications. Anti--endothelial cell antibodies (AECA) are found among many patients with KD. The aim of this study was to investigate the pathogenic role of AECA in KD using in vitro and in vivo experimental models. F(ab)2 fragments of IgG-AE...

    journal_title：Clinical and experimental immunology

    pub_type： 杂志文章

    doi：10.1046/j.1365-2249.2002.02000.x

    authors： Grunebaum E,Blank M,Cohen S,Afek A,Kopolovic J,Meroni PL,Youinou P,Shoenfeld Y

    更新日期：2002-11-01 00:00:00

  • Pre-incubation with interleukin-4 mediates a direct protective effect against the loss of pancreatic beta-cell viability induced by proinflammatory cytokines.

    abstract：:Loss of pancreatic beta-cells in type I diabetes is associated with an increase in T helper 1 (Th1) proinflammatory cytokines in the islet milieu, with a concomitant reduction in Th2 anti-inflammatory cytokines. In animal models, manoeuvres designed to polarize Th1 responses towards Th2, particularly involving interle...

    journal_title：Clinical and experimental immunology

    pub_type： 杂志文章

    doi：10.1111/j.1365-2249.2007.03375.x

    authors： Kaminski A,Kaminski ER,Morgan NG

    更新日期：2007-06-01 00:00:00

  • Production of complement components by cells of the immune system.

    abstract：:The complement system is an important part of the innate immune defence. It contributes not only to local inflammation, removal and killing of pathogens, but it also assists in shaping of the adaptive immune response. Besides a role in inflammation, complement is also involved in physiological processes such as waste ...

    journal_title：Clinical and experimental immunology

    pub_type： 杂志文章,评审

    doi：10.1111/cei.12952

    authors： Lubbers R,van Essen MF,van Kooten C,Trouw LA

    更新日期：2017-05-01 00:00:00

  • Regulation of the primary in vitro antibody response in human peripheral blood lymphocytes: different effects of mitogen-induced and spontaneous T suppressor cells.

    abstract：:The specific response of human peripheral blood lymphocyte cultures to TNP-polyacrylamide was suppressed by the addition of concanavalin A (Con A). A dose of Con A (0.5 microgram/ml) could be selected, which induced a reproducible but incomplete suppression independent of the magnitude of the anti-TNP response. Con A-...

    journal_title：Clinical and experimental immunology

    pub_type： 杂志文章

    doi：

    authors： Galanaud P,Crevon MC,Delfraissy JF,Segond P,Wallon C,Dormont J

    更新日期：1979-10-01 00:00:00

  • Impaired natural killer cell-induced antibody-dependent cell-mediated cytotoxicity is associated with human immunodeficiency virus-1 disease progression.

    abstract：:This study evaluates the correlation between natural killer (NK) cell function and human immunodeficiency virus (HIV)-1 disease progression in 133 untreated HIV-1 positive Chinese subjects, including 41 former plasma donors (FPDs) and 92 men who have sex with men, and 35 HIV-negative controls. Flow cytometry was used ...

    journal_title：Clinical and experimental immunology

    pub_type： 杂志文章

    doi：10.1111/j.1365-2249.2012.04672.x

    authors： Jia M,Li D,He X,Zhao Y,Peng H,Ma P,Hong K,Liang H,Shao Y

    更新日期：2013-01-01 00:00:00

  • Soluble complement receptor type 1 (sCR1) in chronic liver diseases: serum levels at different stages of liver diseases.

    abstract：:Complement receptor type 1 (CR1) is an integral membrane protein of many haematopoietic cells and plays an important role in the clearance of complement-associated immune complexes, favouring their transport to liver and spleen macrophages. A small amount of soluble CR1 (sCR1) is also found in plasma and might origina...

    journal_title：Clinical and experimental immunology

    pub_type： 杂志文章

    doi：10.1046/j.1365-2249.1998.00707.x

    authors： Di Bona D,Montalto G,Clemenza L,Bascone F,Accardo P,Bellavia D,Craxì A,Brai M

    更新日期：1998-10-01 00:00:00

  • Fluorescent probes to detect lymphocyte activation.

    abstract：:Fluorescent probes can monitor events in lymphocytes stimulated by mitogens and antigens. Early activation is associated with conformational changes in membrane macromolecules, and has been studied by measurement of fluorescence intensity or polarization of the membrane-localizing probes ANS, NPN, DPH and TMRITC. Subs...

    journal_title：Clinical and experimental immunology

    pub_type： 杂志文章,评审

    doi：

    authors： Nairn RC,Rolland JM

    更新日期：1980-01-01 00:00:00

  • Induction of cutaneous graft-versus-host disease by local injection of unprimed T cells.

    abstract：:The skin is a major target organ in human graft-versus-host disease (GVHD) after bone-marrow transplantation. GVHD can be induced in mice by i.v. injection of T cells into unirradiated semi-allogeneic or lethally irradiated allogeneic recipients. However, in the murine systemic GVHD model, cutaneous lesions occur only...

    journal_title：Clinical and experimental immunology

    pub_type： 杂志文章

    doi：10.1111/j.1365-2249.1991.tb08173.x

    authors： Kawai K,Matsumoto Y,Watanabe H,Ito M,Fujiwara M

    更新日期：1991-05-01 00:00:00

  • Structural relationship of kappa-type light chains with AL amyloidosis: multiple deletions found in a VkappaIV protein.

    abstract：:Two amyloidogenic Bence Jones proteins (Am37 VkappaIV and NIG1 VkappaI) and one non-amyloidogenic protein (NIG26 VkappaIII) were characterized. The protein Am37 had four deletions when compared with the translated germ-line gene sequence: two Ser residues following position 27 (27e, 27f) in CDR1 and two amino acids Pr...

    journal_title：Clinical and experimental immunology

    pub_type： 杂志文章

    doi：10.1046/j.1365-2249.1999.00939.x

    authors： Alim MA,Yamaki S,Hossain MS,Takeda K,Kozima M,Izumi T,Takashi I,Shinoda T

    更新日期：1999-12-01 00:00:00

  • Impaired CD4 and CD8 T cell phenotype and reduced chemokine secretion in recent-onset type 1 diabetic children.

    abstract：:Although the role of the T cell-mediated autoimmune reaction in type 1 diabetes (T1D) is conclusive, studies including data from human circulating CD4(+) and CD8(+) lymphocytes subsets during the disease onset and posterior development are scarce. Further, chemokines and chemokine receptors are key players in the migr...

    journal_title：Clinical and experimental immunology

    pub_type： 杂志文章,多中心研究

    doi：10.1111/j.1365-2249.2008.03720.x

    authors： Hedman M,Faresjö M,Axelsson S,Ludvigsson J,Casas R

    更新日期：2008-09-01 00:00:00

  • C1-inhibitor efficiently inhibits Escherichia coli-induced tissue factor mRNA up-regulation, monocyte tissue factor expression and coagulation activation in human whole blood.

    abstract：:Both the complement system and tissue factor (TF), a key initiating component of coagulation, are activated in sepsis, and cross-talk occurs between the complement and coagulation systems. C1-inhibitor (C1-INH) can act as a regulator in both systems. Our aim in this study was to examine this cross-talk by investigatin...

    journal_title：Clinical and experimental immunology

    pub_type： 杂志文章

    doi：10.1111/cei.12098

    authors： Landsem A,Nielsen EW,Fure H,Christiansen D,Ludviksen JK,Lambris JD,Østerud B,Mollnes TE,Brekke OL

    更新日期：2013-08-01 00:00:00

  • Contrasting activity of cytosin-guanosin dinucleotide oligonucleotides in mice with experimental colitis.

    abstract：:Intestinal inflammation in inflammatory bowel disease (IBD) and experimental models of colitis is characterized by a dysregulated intestinal immune response with elevated levels of Th1 cytokines. The luminal flora has been implicated as a major factor contributing to the initiation and perpetuation of inflammation in ...

    journal_title：Clinical and experimental immunology

    pub_type： 杂志文章

    doi：10.1046/j.1365-2249.2003.02288.x

    authors： Obermeier F,Dunger N,Strauch UG,Grunwald N,Herfarth H,Schölmerich J,Falk W

    更新日期：2003-11-01 00:00:00

  • Lymphocyte expression of a 90 kD brush border antigen.

    abstract：:This study analyses the expression by rat lymphocytes of six renal brush border (BB) antigens defined by a set of monoclonal antibodies and demonstrates that a 90 kD protein (gp 90), synthesized by BB and glomeruli is found on the surface of T and B cells. The other antigens, including the 330 kD protein involved in H...

    journal_title：Clinical and experimental immunology

    pub_type： 杂志文章

    doi：

    authors： Van Leer EH,Moullier P,Ronco P,Verroust P

    更新日期：1987-03-01 00:00:00

  • T cell regulation of the chronic peritoneal neutrophilia during mycobacterial infections.

    abstract：:Intraperitoneal infection of mice with mycobacteria induces the persistent mobilization of neutrophils to the infected peritoneal cavities. The recruitment of the neutrophils was mediated by the immune system since it was enhanced by immunization and reduced in T cell-deficient nude and SCID mice. Anti-mitotic treatme...

    journal_title：Clinical and experimental immunology

    pub_type： 杂志文章

    doi：10.1111/j.1365-2249.1992.tb06889.x

    authors： Appelberg R

    更新日期：1992-07-01 00:00:00

  • Experimental autoimmune thyroiditis: attempt to correlate disease development with lymphocyte subset changes.

    abstract：:An attempt was made to correlate lymphocyte subset abnormalities with the development of experimental autoimmune thyroiditis (EAIT) in thymectomized and irradiated rats of five inbred strains. The peripheral blood subpopulations were analysed using the fluorescence-activated cell sorter (FACS-IV). A significant lympho...

    journal_title：Clinical and experimental immunology

    pub_type： 杂志文章

    doi：

    authors： Smith E,Behan WM,Menzies CB,Behan PO

    更新日期：1987-02-01 00:00:00

  • Adverse reactions to nitrofurantoin in relation to cellular and humoral immune responses.

    abstract：:Eighteen patients showing hypersensitivity to nitrofurantoin with symptoms like sudden fever, malaise, cough, pleuritis, leucocytosis and sometimes eosinophilia were analysed for immune reactions, i.e. lymphocyte transformation and specific antibodies. In addition, thirty-three individuals treated with the drug but wi...

    journal_title：Clinical and experimental immunology

    pub_type： 杂志文章

    doi：

    authors： Bäck O,Lidén S,Ahlstedt S

    更新日期：1977-06-01 00:00:00

  • Increased IgE-dependent cytotoxicity by blood mononuclear cells of allergic patients.

    abstract：:Peripheral blood mononuclear cells from 14 healthy donors and 22 allergic patients were incubated with 51Cr-labelled chicken erythrocytes coated with an IgE myeloma protein or rabbit IgG antibodies. Mononuclear cells from patients with severe atopic disorders released a significantly greater percentage of 51Cr (P less...

    journal_title：Clinical and experimental immunology

    pub_type： 杂志文章

    doi：

    authors： Melewicz FM,Zeiger RS,Mellon MH,O'Connor RD,Spiegelberg HL

    更新日期：1981-03-01 00:00:00