Abstract:
:The production of anti-tetanus toxoid (TT) antibody and anti-anti-TT (auto-anti-Id) antibody has been measured in three young and three old persons. Both antibodies were measured using ELISA. We found that: (i) the anti-TT response of old subjects was lower than that of young subjects, (ii) serum auto-anti-Id antibody concentration was higher in old compared with young humans before boosting with TT, and (iii) anti-TT antibodies from different humans shared Id cross-reactivity when tested with a rabbit anti-Id antibody. Thus, the serum anti-TT antibody response to boosting was inversely correlated with the serum level of auto-anti-Id. This conclusion is consistent with the view that the higher level of auto-anti-antibody in older subjects contributes to their impaired antibody response to TT.
journal_name
Clin Exp Immunoljournal_title
Clinical and experimental immunologyauthors
Arreaza EE,Gibbons JJ Jr,Siskind GW,Weksler MEdoi
10.1111/j.1365-2249.1993.tb05965.xsubject
Has Abstractpub_date
1993-04-01 00:00:00pages
169-73issue
1eissn
0009-9104issn
1365-2249journal_volume
92pub_type
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