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Chronology of halothane-induced antigen expression in halothane-exposed rabbits.

Abstract：

:Multiple halothane exposures in rabbits generate modified liver proteins or antigens that appear to incorporate the metabolic intermediate of halothane, trifluoroacetyl halide (TFA), as identified by specific anti-TFA antibody. These halothane-induced antigens are most prevalent throughout the second to fourth days following a single halothane exposure and are in highest concentration after the second and third exposure. In addition, five consecutive halothane exposures at 2-week intervals caused the sustained expression of these halothane-induced antigens throughout the first 4 days following the last exposure. By the seventh day, however, antigen expression began to decline. Although there is great heterogeneity in the molecular weights of the halothane-induced antigens, the predominant proteins appear to be 85k, 58k, 53k, 37k and 24k. These liver proteins could reflect self proteins altered by trifluoroacetylation by halothane metabolites and may be potential immunogens in the initiation of a halothane-induced immune response.

journal_name

Clin Exp Immunol

journal_title

Clinical and experimental immunology

authors

Roth TP,Hubbard AK,Gandolfi AJ,Brown BR

subject

Has Abstract

pub_date

1988-05-01 00:00:00

pages

330-6

issue

2

eissn

0009-9104

issn

1365-2249

journal_volume

72

pub_type

杂志文章

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