Progressive cellular immune impairment leading to development of AIDS: two-year prospective study of HIV infection in drug addicts.

abstract：:Regulatory B (Breg ) cells are characterized by various membrane markers and the secretion of different inhibitory cytokines. A new subset of Breg cells was identified as CD5hi Fas-ligand (FasL)hi . Their main reported role is to suppress anti-viral and anti-tumour immune responses, and, hence they have been dubbed 'k...

journal_title：Clinical and experimental immunology

authors： Eiza N,Zuckerman E,Carlebach M,Rainis T,Goldberg Y,Vadasz Z

更新日期：2018-08-01 00:00:00

abstract：:There is a link between increased allergy and a reduction of some infections in western countries. Epidemiological data also show that respiratory allergy is less frequent in people exposed to orofaecal and foodborne microbes such as Toxoplasma gondii. Infection with T. gondii induces a strong cell-mediated immunity w...

journal_title：Clinical and experimental immunology

authors： Fenoy I,Giovannoni M,Batalla E,Martin V,Frank FM,Piazzon I,Goldman A

更新日期：2009-02-01 00:00:00

abstract：:Bullous pemphigoid is a blistering skin disease characterized by autoantibodies against the NC16a domain of bullous pemphigoid 180. This study was performed to characterize and map the fine specificity of T cell responses to NC16a. Peripheral blood mononuclear cells (PBMC) from a total of 28 bullous pemphigoid patient...

journal_title：Clinical and experimental immunology

authors： Pickford WJ,Gudi V,Haggart AM,Lewis BJ,Herriot R,Barker RN,Ormerod AD

更新日期：2015-05-01 00:00:00

abstract：:Peptide immunotherapy is being explored to modulate varied disease states; however, the mechanism of action remains poorly understood. In this study, we investigated the ability of a subcutaneous peptide immunization schedule to induce of CD4(+) CD25(+) T regulatory cells. DO11.10 T cell receptor (TCR) transgenic mice...

journal_title：Clinical and experimental immunology

authors： Dahlberg PE,Schartner JM,Timmel A,Seroogy CM

更新日期：2007-08-01 00:00:00

abstract：:Secretory immunoglobulin A (IgA) was determined by means of an enzyme-linked immunosorbent assay (using as capture antibody an MoAb specific for secretory component) in saliva and serum from 46 patients with IgA mesangial nephritis (IgAGN), 36 with an idiopathic nephrotic syndrome (INS), 30 with an idiopathic membrano...

journal_title：Clinical and experimental immunology

authors： Rostoker G,Terzidis H,Petit-Phar M,Meillet D,Lang P,Dubert JM,Lagrue G,Weil B

更新日期：1992-11-01 00:00:00

abstract：:Ani s 7 is currently the most important excretory/secretory (ES) Anisakis simplex allergen, as it is the only one recognized by 100% of infected patients. The allergenicity of this molecule is due mainly to the presence of a novel CX(17-25)CX(9-22)CX(8)CX(6) tandem repeat motif not seen in any previously reported prot...

journal_title：Clinical and experimental immunology

authors： Anadón AM,Romarís F,Escalante M,Rodríguez E,Gárate T,Cuéllar C,Ubeira FM

更新日期：2009-06-01 00:00:00

abstract：:Inadequate apoptosis may contribute to the synovial hyperplasia associated with rheumatoid arthritis (RA). The Fas-associated death domain protein (FADD)-like interleukin (IL)-1beta-converting enzyme (FLICE)-inhibitory protein (FLIP), which is an apoptotic inhibitor, has been implicated in the resistance to Fas-mediat...

journal_title：Clinical and experimental immunology

authors： Kim WU,Yoo SA,Min SY,Park SH,Koh HS,Song SW,Cho CS

更新日期：2006-06-01 00:00:00

abstract：:Intestinal epithelial cell (IEC)-derived cytokines, such as stem cell factor (SCF), interleukin (IL)-7 and IL-15 are known to be required for the development of intestinal intraepithelial lymphocytes (IELs). A newly described cytokine, IL-18, has also been shown to be produced by intestinal epithelial cells. To demons...

journal_title：Clinical and experimental immunology

authors： Okazawa A,Kanai T,Nakamaru K,Sato T,Inoue N,Ogata H,Iwao Y,Ikeda M,Kawamura T,Makita S,Uraushihara K,Okamoto R,Yamazaki M,Kurimoto M,Ishii H,Watanabe M,Hibi T

更新日期：2004-05-01 00:00:00

abstract：:Clustering activity for neutrophil granulocytes was generated in pooled normal human serum (NHS) by incubation of the serum with preformed IgG aggregates, but not in heat-treated NHS (56 degrees C, 30 min), indicating that the function was complement-dependent. Judging from results of experiments with complement-defic...

journal_title：Clinical and experimental immunology

authors： Sturfelt G,Jonsson H,Hellmer G,Sjöholm AG

更新日期：1993-08-01 00:00:00

abstract：:HIV-2 is thought to have entered the human population in the 1930s through cross-species transmission of SIV from sooty mangabeys in West Africa. Unlike HIV-1, HIV-2 has not led to a global pandemic, and recent data suggest that HIV-2 prevalence is declining in some West African states where it was formerly endemic. A...

journal_title：Clinical and experimental immunology

authors： Boswell MT,Rowland-Jones SL

更新日期：2019-06-01 00:00:00

abstract：:Cell transfer experiments were carried out with phytohaemagglutinin-induced normal human T lymphocyte colonies after 2--10 days of primary colony growth. The cells gave a cloning efficiency of 15% after 2 days of incubation and this decreased to 0.2% with the progressive growth of the colonies. The primary colonies ha...

journal_title：Clinical and experimental immunology

authors： Smith SD,Sachs L

更新日期：1979-08-01 00:00:00

abstract：:A full-length cDNA coding a human beta 2-glycoprotein I (beta 2-GPI) was introduced into the baculovirus genome to construct a recombinant baculovirus. Spodoptera frugiperda (Sf9) cells were infected with the recombinant baculovirus. A protein (mol. wt 43,000) reactive with anti-beta 2-GPI antisera was produced in the...

journal_title：Clinical and experimental immunology

authors： Igarashi M,Matsuura E,Igarashi Y,Nagae H,Matsuura Y,Ichikawa K,Yasuda T,Voelker DR,Koike T

更新日期：1993-07-01 00:00:00

abstract：:The role of T cells in the pathophysiology of chronic obstructive pulmonary disease (COPD) is not yet certain, although varying reports have shown increases in T helper 1 (Th1) and/or Th2 cytokines in peripheral blood and bronchoalveolar lavage (BAL). No studies have examined cytokine production by intraepithelial T c...

journal_title：Clinical and experimental immunology

authors： Hodge G,Nairn J,Holmes M,Reynolds PN,Hodge S

更新日期：2007-10-01 00:00:00

abstract：:Peripheral blood mononuclear cells (PBMC) of normal human donors are spontaneously cytotoxic for certain tumour-derived and virus-infected target cells. This so-called natural killing (NK) can be augmented by the action of interferons (IFN) and by IFN-inducers. In this study, we have compared both endogenous and augme...

journal_title：Clinical and experimental immunology

authors： Neighbour PA,Grayzel AI,Miller AE

更新日期：1982-07-01 00:00:00

abstract：:The HLA phenotype of fifty-four patients with myasthenia gravis (MG) was compared to that of 600 controls. When male and female patients were compared separately with the control group, HLA-B12 was increased in MG males (P less than 0-023) and HLA-A1, B8 in MG females (P less than 0-023). In addition, HLA-A1, B8 was c...

journal_title：Clinical and experimental immunology

authors： Gross WL,Krüger J,Gröschel-Stewart U,Friedrich H,Kunze K

更新日期：1977-01-01 00:00:00

abstract：:We studied the relationship between the HLA specificities associated with multiple sclerosis (MS) susceptibility in southern Italy and the reactivity of the human myelin basic protein (hMBP) immunogenic peptides 84-98 and 143-168, using short-term T-cell lines established from 9 MS patients and from 8 healthy individu...

journal_title：Clinical and experimental immunology

authors： Montanaro D,Sanna V,Matarese G,Larby BB,Racioppi L,Carrieri PB,Bruno R,Davey NJ,Zappacosta S,Fontana S

更新日期：2001-02-01 00:00:00

abstract：:To clarify immunological differences among patients with Graves' disease (GD) and Hashimoto's disease (HD) at various levels of severity, we examined the expression of the CD154 molecules on peripheral T cells, which regulate B cell activation, B cell differentiation, and T-cell survival. We found decreases in the int...

journal_title：Clinical and experimental immunology

authors： Watanabe M,Yamamoto N,Matsuzuka F,Miyauchi A,Iwatani Y

更新日期：2004-06-01 00:00:00

abstract：:We recently separated a PG1828-encoded triacylated lipoprotein (Pg-LP), composed of two palmitoyl and one pentadecanoyl groups at the N-terminal of glycerocysteine from Porphyromonas gingivalis, a periodontopathic bacteria, and found that Pg-LP exhibited definite biological activities through Toll-like receptor (TLR) ...

journal_title：Clinical and experimental immunology

authors： Makimura Y,Asai Y,Taiji Y,Sugiyama A,Tamai R,Ogawa T

更新日期：2006-10-01 00:00:00

abstract：:Small molecule metabolites that are produced or altered by host-associated microbial communities are emerging as significant immune response modifiers. However, there is a key gap in our knowledge of how oral microbial metabolites affect the immune response. Here, we examined the effects of metabolites from five bacte...

journal_title：Clinical and experimental immunology

authors： Whiteson K,Agrawal S,Agrawal A

更新日期：2017-06-01 00:00:00

abstract：:Summary The interaction between stroma and blood cells in the human spleen has received little attention, despite their well-defined roles during blood cell development in bone marrow. We have reported previously that human spleen-derived fibroblasts display a differentiated myofibroblast phenotype and constitutively ...

journal_title：Clinical and experimental immunology

authors： Briard D,Azzarone B,Brouty-Boyé D

更新日期：2005-05-01 00:00:00

abstract：:Nephrosis is characterized by glomerular epithelial cell injury and a decrease in the glomerular basement membrane (GBM) proteoglycan content. Although CsA is a useful treatment for a group of patients with this disease, its mechanism of action is unclear. We have previously shown that in experimental nephrosis there ...

journal_title：Clinical and experimental immunology

authors： Bustos C,González-Cuadrado S,Ruiz-Ortega M,Gómez-Guerrero C,González E,Plaza JJ,Egido J

更新日期：1995-12-01 00:00:00

abstract：:Wiskott-Aldrich syndrome (WAS) is an X-linked platelet/immunodeficiency disease. The affected gene encodes WASP, a multidomain protein that regulates cytoskeletal assembly in blood cells. Patients have recurring infections, and their lymphocytes exhibit deficient proliferative responses in vitro. We report an evaluati...

journal_title：Clinical and experimental immunology

authors： Park JY,Kob M,Prodeus AP,Rosen FS,Shcherbina A,Remold-O'Donnell E

更新日期：2004-04-01 00:00:00

abstract：:An expanded T cell subpopulation (CD8+ Leu-7+) has previously been reported in the peripheral blood of patients with Crohn's disease. This subpopulation of T cells was associated with a 'covert suppressor' function, particularly in patients with mild/early Crohn's disease, suppressing immunoglobulin production in vitr...

journal_title：Clinical and experimental immunology

authors： Deem RL,Targan SR,Niederlehner A,Shanahan F

更新日期：1990-06-01 00:00:00

abstract：:A preparation of the putative antibody in HN (Heymann's nephritis) lacking preformed immune complexes, obtained from the acid eluates of kidneys with HN, purified through ion exchange and gel-filtration chromatography, characterized by immunoelectrophoresis, sucrose density-gradient ultracentrifugation, 125I-Clq assay...

journal_title：Clinical and experimental immunology

authors： Makker SP,Kirson IJ,Moorthy B

更新日期：1982-02-01 00:00:00

abstract：:In patients with ANCA-associated vasculitis (AAV), CD25 expression is increased on circulating T cells. Although in animal experiments the role of CD4(+) CD25(+) T-regulatory-cells (T(reg)) in protection against autoimmunity is well established, the role of these cells in AAV is unknown. To investigate the hypothesis ...

journal_title：Clinical and experimental immunology

authors： Marinaki S,Neumann I,Kälsch AI,Grimminger P,Breedijk A,Birck R,Schmitt W,Waldherr R,Yard BA,Van Der Woude FJ

更新日期：2005-04-01 00:00:00

abstract：:Patients with recurrent miscarriage (RM) show up-regulated cytotoxic natural killer (NK) cells that are suspected to play a causal role in abortion. In the present study, we investigated counter-regulating inhibitory mechanisms and compared the results in RM patients with those of healthy controls (HC), patients with ...

journal_title：Clinical and experimental immunology

authors： Zhu L,Aly M,Wang H,Karakizlis H,Weimer R,Morath C,Kuon RJ,Toth B,Ekpoom N,Opelz G,Daniel V

更新日期：2018-08-01 00:00:00

abstract：:Monocyte-depleted mononuclear cells (MNC) from healthy subjects synthesized IgM-class antibody to single-stranded DNA (anti-ssDNA) at significantly higher levels than unfractionated MNC. The increased production of IgM anti-ssDNA by monocyte-depleted normal MNC was inhibited to a greater degree than total IgM by addit...

journal_title：Clinical and experimental immunology

authors： Okawa-Takatsuji M,Aotsuka S,Uwatoko S,Kinoshita M,Yokohari R

更新日期：1989-09-01 00:00:00

abstract：:Human peripheral blood lymphocytes were examined for rosette formation with autologous erythrocytes. When normal human lymphocytes were stimulated with phorbol myristate acetate (PMA) in the presence of autologous serum, the levels of autorosette forming cells (ARFC) were strongly enhanced. Pre-culture was necessary f...

journal_title：Clinical and experimental immunology

authors： Sakano T,Hyodo S,Kittaka E,Tanaka Y,Usui T

更新日期：1982-09-01 00:00:00

abstract：:A rabbit antiserum has been prepared using peripheral mononuclear cells from a patient with common variable hypogammaglobulinaemia (CVH) who had demonstrable suppressor cells in vitro. This antiserum (anti-Ck), after absorption with pooled normal glass-non-adherent cells and platelets, showed selective reactivity with...

journal_title：Clinical and experimental immunology

authors： Rizzoli AJ,Bankhurst AD

更新日期：1981-12-01 00:00:00

abstract：:The serum levels of TGF-beta1, measured by solid-phase ELISA, were determined to be significantly augmented in patients with both relapsing remitting (RR) and secondary chronic progressive (CP) MS compared with sex- and age-matched healthy controls. Moreover, in RR MS patients, the blood levels of the cytokine were fu...

journal_title：Clinical and experimental immunology

authors： Nicoletti F,Di Marco R,Patti F,Reggio E,Nicoletti A,Zaccone P,Stivala F,Meroni PL,Reggio A

更新日期：1998-07-01 00:00:00