Blood levels of transforming growth factor-beta 1 (TGF-beta1) are elevated in both relapsing remitting and chronic progressive multiple sclerosis (MS) patients and are further augmented by treatment with interferon-beta 1b (IFN-beta1b).

abstract：:Studies of patients with active tuberculosis (TB) and infected healthy individuals have shown that interferon (IFN)-gamma is present in sites of Mycobacterium tuberculosis infection in comparable levels. This suggests that there is a deficiency in the macrophage response to IFN-gamma in TB patients. We used recombinan...

journal_title：Clinical and experimental immunology

authors： Esquivel-Solís H,Quiñones-Falconi F,Zarain-Herzberg A,Amieva-Fernández RI,López-Vidal Y

更新日期：2009-10-01 00:00:00

abstract：:Salivary gland biopsies from 12 patients with primary Sjögren's syndrome and 10 controls were examined for Epstein-Barr virus (EBV) DNA by in-situ hybridization and for EBV proteins by immunofluorescence and peroxidase techniques. Viral DNA was found in biopsies from two out of 12 patients with primary Sjögren's syndr...

journal_title：Clinical and experimental immunology

authors： Venables PJ,Teo CG,Baboonian C,Griffin BE,Hughes RA

更新日期：1989-03-01 00:00:00

abstract：:The aim of this study was to evaluate prospectively cytokine levels and disease activity in juvenile idiopathic arthritis (JIA) patients treated with and without tumour necrosis factor (TNF)-α inhibitors. TNF-α inhibitor-naive JIA subjects were followed prospectively for 6 months. Cytokine levels of TNF-α, interleukin...

journal_title：Clinical and experimental immunology

authors： Walters HM,Pan N,Lehman TJ,Adams A,Kalliolias GD,Zhu YS,Santiago F,Nguyen J,Sitaras L,Cunningham-Rundles S,Walsh TJ,Toussi SS

更新日期：2016-06-01 00:00:00

abstract：:One of the hallmarks of coeliac disease, both active and treated, is an increased number and proportion of gamma/delta intraepithelial T lymphocytes in the small intestinal mucosa, and an increased number of gamma/delta T cells in the small intestinal mucosa of coeliac disease patients has been associated with the inh...

journal_title：Clinical and experimental immunology

authors： Holtmeier W,Rowell DL,Nyberg A,Kagnoff MF

更新日期：1997-01-01 00:00:00

abstract：:Antibodies against cytomegalovirus-specific early antigens (CMV-EA) were followed in sera, obtained from fifteen immunosuppressed renal-allograft recipients. Eight patients (sixty-two sera) showed seroconversion 47--137 days post-transplantation. Five patients (forty sera) with CMV antibodies at the moment of renal im...

journal_title：Clinical and experimental immunology

authors： The TH,Andersen HK,Spencer ES,Klein G

更新日期：1977-06-01 00:00:00

abstract：:Rheumatoid arthritis (RA), seronegative spondyloarthropathy (SA) and osteoarthritis (OA) patients receiving no steroid or disease-modifying therapy have been monitored, along with healthy controls, for their prevailing level of Epstein-Barr virus (EBV) infection using four independent indices of the EBV-host balance, ...

journal_title：Clinical and experimental immunology

authors： Yao QY,Rickinson AB,Gaston JS,Epstein MA

更新日期：1986-05-01 00:00:00

abstract：:Anti-phospholipid syndrome (APS) is characterized by arterial and/or venous thrombosis and pregnancy morbidity. It is well known that in these patients thrombosis may be the result of a hypercoagulable state related to anti-β2-glycoprotein I (β2-GPI) antibodies. Moreover, platelets may play a role in thrombotic manife...

journal_title：Clinical and experimental immunology

authors： Capozzi A,Manganelli V,Riitano G,Recalchi S,Truglia S,Alessandri C,Longo A,Garofalo T,Misasi R,Valesini G,Conti F,Sorice M

更新日期：2019-04-01 00:00:00

abstract：:In fifty-seven healthy individuals a significant correlation ( r = 0.3, P < 0.05) has been found between responses of their lymphocytes to stimulation by PHA and by pooled lymphocytes in MLC. It is suggested that these tests quantitate the general status of T cell reactivity of individuals, and may be used in conjunct...

journal_title：Clinical and experimental immunology

authors： Nanra SK,Boettcher B

更新日期：1980-07-01 00:00:00

abstract：:The incidence of circulating T lymphocytes (ET-RFC) and a sub-population of T lymphocytes (EE-RFC) were monitored in the blood of seventy-one cadaver renal allograft recipients for the first 2 months after transplantation. In patients with uneventful post-operative courses, the incidence of both ET-RFC and EE-RFC fell...

journal_title：Clinical and experimental immunology

authors： Kelly GE,Sheil AG

更新日期：1977-03-01 00:00:00

abstract：:Perivascular infiltrates of inflammatory cells are a hallmark of lesional skin in scleroderma. We have explored the potential for scleroderma fibroblasts to modulate mononuclear leucocyte migration across endothelial cell monolayers in tissue culture, and to regulate expression of endothelial cell adhesion molecules. ...

journal_title：Clinical and experimental immunology

authors： Denton CP,Shi-Wen X,Sutton A,Abraham DJ,Black CM,Pearson JD

更新日期：1998-11-01 00:00:00

abstract：:Significant numbers of syncytial cells were observed in the bronchoalveolar lavage fluid (BALF) of a 42-year-old patient who had SLE with interstitial pneumonia. Electron microscopic study of the BALF cells and positive reverse transcriptase activity in the supernatant of the cultured cells revealed unknown retroviral...

journal_title：Clinical and experimental immunology

authors： Tamura N,Sekigawa I,Hashimoto H,Yamamoto N,Kira S

更新日期：1997-03-01 00:00:00

abstract：:T helper type 17 (Th17) cells play a pathogenic role in autoimmune disease, while interleukin (IL)-10-producing Th10 cells serve a protective role. The balance between the two subsets is regulated by the local cytokine milieu and by the relative expression of intact forkhead box protein 3 (FoxP3) compared to FoxP3Δ2, ...

journal_title：Clinical and experimental immunology

authors： Kristensen B,Hegedüs L,Madsen HO,Smith TJ,Nielsen CH

更新日期：2015-04-01 00:00:00

abstract：:Complement C6 has a common charge polymorphism designated A and B with gene frequencies of 0.65 and 0.35. The probable molecular basis for this is a Glu (C6A) for Ala (C6B) substitution at amino acid position 98, and is detected by digestion with the restriction enzyme Dde I of a polymerase chain reaction (PCR)-amplif...

journal_title：Clinical and experimental immunology

authors： Fernie BA,Hobart MJ,Delbridge G,Potter PC,Orren A,Lachmann PJ

更新日期：1994-02-01 00:00:00

abstract：:The repeated administration of a monoclonal anti-Sm antibody (KSml) resulted in a significant prolongation of life in MRL-lpr/lpr lupus mice with a 50% mortality of 36 weeks compared with 18-24 weeks in the control groups. Control animals injected with APC11 (a myeloma protein of the same isotype) lived no longer than...

journal_title：Clinical and experimental immunology

authors： Brennan FM,Williams DG,Bovill D,Stocks MR,Maini RN

更新日期：1986-07-01 00:00:00

abstract：:The lymphotoxin-beta receptor (LTbetaR) pathway is critical for maintenance of organized lymphoid structures and is involved in the development of colitis. To investigate the mechanisms by which LTbetaR activation contributes to the pathology of chronic inflammation we used a soluble LTbetaR-Ig fusion protein as a com...

journal_title：Clinical and experimental immunology

authors： Stopfer P,Obermeier F,Dunger N,Falk W,Farkas S,Janotta M,Möller A,Männel DN,Hehlgans T

更新日期：2004-04-01 00:00:00

abstract：:Two DNA-binding monoclonal antibodies (MoAb) derived from lupus mice were examined for their effects on kidney function. Antibody IV-228, reactive with single-stranded DNA (ssDNA) but not double-stranded DNA (dsDNA) significantly altered kidney function in some MRL/Mp-lpr/lpr (MRL/lpr) mice with lupus glomerulonephrit...

journal_title：Clinical and experimental immunology

authors： Lake RA,Staines NA

更新日期：1988-07-01 00:00:00

abstract：:Dendritic cells (DCs) were prepared from human bronchoalveolar lavage (BAL) cells. We previously reported that, in particular, the CD1a fraction of the low autofluorescent (LAF) cells contains the precursors for DCs: after overnight culture, 40% of the LAF cells change into functionally and phenotypically prototypic d...

journal_title：Clinical and experimental immunology

authors： Verhoeven GT,Van Haarst JM,De Wit HJ,Simons PJ,Hoogsteden HC,Drexhage HA

更新日期：2000-11-01 00:00:00

abstract：:Regulatory B (Breg ) cells are characterized by various membrane markers and the secretion of different inhibitory cytokines. A new subset of Breg cells was identified as CD5hi Fas-ligand (FasL)hi . Their main reported role is to suppress anti-viral and anti-tumour immune responses, and, hence they have been dubbed 'k...

journal_title：Clinical and experimental immunology

authors： Eiza N,Zuckerman E,Carlebach M,Rainis T,Goldberg Y,Vadasz Z

更新日期：2018-08-01 00:00:00

abstract：:Mouse-rosette formation was investigated in a variety of leukaemias and lymphomas, and it was found that this phenomenon was restricted to the B lymphocytes of chronic lymphocytic leukaemia and hairy-cell leukaemia. Eighteen of nineteen cases of chronic lymphocytic leukaemia expressed the mouse receptor, but only eigh...

journal_title：Clinical and experimental immunology

authors： Burns GF,Cawley JC

更新日期：1980-01-01 00:00:00

abstract：:Human peripheral blood lymphocytes injected intradermally into X-ray immunosuppressed mice were tested for angiogenesis-inducing capacity. Both T and B lymphocytes evoked angiogenesis of the same intensity. The total T cell population was fractionated into three subpopulations on the basis of their different affinitie...

journal_title：Clinical and experimental immunology

authors： Kamiński MJ,Nowacyk M,Skopińska-Rozewska E,Kamińska G,Bem W

更新日期：1981-11-01 00:00:00

abstract：:T cells from systemic lupus erythematosus (SLE) patients display a wide array of anomalies in peripheral immune tolerance mechanisms. The role of ubiquitin ligases such as Cbl-b has been described recently in these phenomena. However, its role in resistance to suppression phenotype in SLE has not been characterized, w...

journal_title：Clinical and experimental immunology

authors： Romo-Tena J,Rajme-López S,Aparicio-Vera L,Alcocer-Varela J,Gómez-Martín D

更新日期：2018-01-01 00:00:00

abstract：:Lysinuric protein intolerance (LPI) is characterized by defective cellular transport of the dibasic amino acids, secondary dysfunction of the urea cycle, aversion to dietary protein, failure to thrive, hepatosplenomegaly and osteoporosis. Because several patients have suffered from recurrent respiratory infections and...

journal_title：Clinical and experimental immunology

authors： Lukkarinen M,Parto K,Ruuskanen O,Vainio O,Käyhty H,Olander RM,Simell O

更新日期：1999-06-01 00:00:00

abstract：:Reduced B cell numbers and a mutation in Btk are considered sufficient to make the diagnosis of X-linked agammaglobulinaemia. In the process of conducting family studies, we identified a 58-year-old healthy man with an amino acid substitution, Y418H, in the adenosine-5'-triphosphate binding site of Btk. Immunofluoresc...

journal_title：Clinical and experimental immunology

authors： Conley ME,Farmer DM,Dobbs AK,Howard V,Aiba Y,Shurtleff SA,Kurosaki T

更新日期：2008-04-01 00:00:00

abstract：:Mannose-binding lectin (MBL) is an innate immune molecule present in blood and some mucosal tissues, which can influence microbial attachment and inflammatory responses of host cells during infection. In this study MBL was found to be present at a low concentration in semen samples in the range 1.2-24.9 ng/ml. Co-incu...

journal_title：Clinical and experimental immunology

authors： Wing JB,Jack DL,Lee ME,Pacey AA,Kinghorn GR,Read RC

更新日期：2009-09-01 00:00:00

abstract：:Adjuvant arthritis in Lewis rats is a model of T cell-mediated autoimmune arthritis resembling human rheumatoid arthritis. A nonapeptide from the 65-kD heat-shock protein of Mycobacterium bovis BCG, amino acid sequence 180-188, has been described to carry the dominant immunogenic epitope(s) for both arthritis-protecti...

journal_title：Clinical and experimental immunology

authors： Yang XD,Gasser J,Feige U

更新日期：1990-08-01 00:00:00

abstract：:Monoclonal antibodies anti-Ly 1, anti-Ly 2 and GK1.5 were applied to determine phenotypes of T cells within granulomas formed as a result of infection of mice with the facultative intracellular bacterium Listeria monocytogenes. Early in granuloma formation, equal numbers of Ly 1+, Ly 2+ and L3T4+ cells were found, T c...

journal_title：Clinical and experimental immunology

authors： Näher H,Sperling U,Takacs L,Hahn H

更新日期：1985-06-01 00:00:00

abstract：:The effect of anti-immunoglobulin (anti-Ig) on cultures of established human B-cell lines was studied to develop models for the initiation and regulation of immune responses. DNA synthesis in one line, BM, measured by [125I]iododeoxyuridine (IUdR) incorporation, was stimulated by anti-Ig when the continuously prolifer...

journal_title：Clinical and experimental immunology

authors： Kishimoto T,Ralph P,Good RA

更新日期：1977-10-01 00:00:00

abstract：:Cell transfer experiments were carried out with phytohaemagglutinin-induced normal human T lymphocyte colonies after 2--10 days of primary colony growth. The cells gave a cloning efficiency of 15% after 2 days of incubation and this decreased to 0.2% with the progressive growth of the colonies. The primary colonies ha...

journal_title：Clinical and experimental immunology

authors： Smith SD,Sachs L

更新日期：1979-08-01 00:00:00

abstract：:The binding of anti-DNA antibodies to the endothelial cell is mediated through DNA, which forms a bridge between the immunoglobulin and the plasma membrane. We have shown that 32P-labelled DNA bound to the plasma membrane of human umbilical vein endothelial cells (HUVEC) by a saturable process, which could be competit...

journal_title：Clinical and experimental immunology

authors： Chan TM,Frampton G,Cameron JS

更新日期：1993-01-01 00:00:00

abstract：:A full-length cDNA coding a human beta 2-glycoprotein I (beta 2-GPI) was introduced into the baculovirus genome to construct a recombinant baculovirus. Spodoptera frugiperda (Sf9) cells were infected with the recombinant baculovirus. A protein (mol. wt 43,000) reactive with anti-beta 2-GPI antisera was produced in the...

journal_title：Clinical and experimental immunology

authors： Igarashi M,Matsuura E,Igarashi Y,Nagae H,Matsuura Y,Ichikawa K,Yasuda T,Voelker DR,Koike T

更新日期：1993-07-01 00:00:00