当前位置： SCI文献检索 > CLINICAL AND EXPERIMENTAL IMMUNOLOGY期刊下所有文献 > A controlled trial of treatment of acquired immunodeficiency in severe measles with thymic humoral factor.

A controlled trial of treatment of acquired immunodeficiency in severe measles with thymic humoral factor.

Abstract：

:A randomized controlled trial of treatment with thymic humoral factor (THF) in 20 children with severe complicated acute measles infection, resulted in objective benefit as evidenced by improvement in the ESR and a fall in C-reactive protein, fewer complications and a reduced incidence of secondary herpes infection. An increased ratio of helper to suppressor T cells (OKT4/OKT8 ratio) and a greater lymphocyte transformation response to phytohaemagglutin was seen in those children receiving THF. We conclude that THF treatment helps to prevent the development of complications particularly secondary viral infections possibly by enhancing cell-mediated immune responses.

journal_name

Clin Exp Immunol

journal_title

Clinical and experimental immunology

authors

Beatty DW,Handzel ZT,Pecht M,Ryder CR,Hughes J,McCabe K,Trainin N

subject

Has Abstract

pub_date

1984-06-01 00:00:00

pages

479-85

issue

3

eissn

0009-9104

issn

1365-2249

journal_volume

56

pub_type

临床试验,杂志文章,随机对照试验

相关文献

CLINICAL AND EXPERIMENTAL IMMUNOLOGY文献大全
  • Immune response to rabbit liver-specific lipoprotein in acute viral hepatitis.

    abstract：:A serial prospective study of cell-mediated immunity to rabbit liver-specific lipoprotein (RLSP) has been done in 26 patients with acute viral hepatitis (AH) (18 HBsAg+ and eight HBsAg-) using a lymphocyte transformation test. An increased stimulation index was recorded in 56% of HBsAg+ cases and in 63% of the HBsAg- ...

    journal_title：Clinical and experimental immunology

    pub_type： 杂志文章

    doi：

    authors： Ortona L,Laghi V,Cauda R,Nervo P

    更新日期：1980-12-01 00:00:00

  • Acute-phase protein synthesis in human hepatoma cells: differential regulation of serum amyloid A (SAA) and haptoglobin by interleukin-1 and interleukin-6.

    abstract：:Interleukin-6 (IL-6, BSF-2 or IFN-beta 2) is thought to be the major regulator of the acute-phase protein response that follows tissue injury and inflammation, with interleukin-1 (IL-1), tumour necrosis factor and more recently, LIF or HSF III, slightly stimulatory on only certain acute phase proteins. The synthesis o...

    journal_title：Clinical and experimental immunology

    pub_type： 杂志文章

    doi：10.1111/j.1365-2249.1991.tb05666.x

    authors： Raynes JG,Eagling S,McAdam KP

    更新日期：1991-03-01 00:00:00

  • In vitro cellular immunity in Chagas' disease.

    abstract：:In vitro delayed hypersensitivity was studied in patients with either the chronic or the indeterminate phase of Chagas' disease. Normal healthy individuals were used as controls. The leucocyte migration inhibition test was applied using an antigen an extract of culture forms of T. cruzi or an extract of normal rat hea...

    journal_title：Clinical and experimental immunology

    pub_type： 杂志文章

    doi：

    authors： Toledo Barros MA,Amato Neto V,Mendes E,Mota I

    更新日期：1979-11-01 00:00:00

  • Defective low-density cells of dendritic morphology from the blood of patients with common variable hypogammaglobulinaemia: low immunoglobulin production on stimulation of normal B cells.

    abstract：:Low-density cells (LDC) of dendritic morphology from the blood of patients with common variable (late-onset) hypogammaglobulinaemia (CVH) did not induce allogeneic immunoglobulin production by normal B cells unlike LDC from normal blood. When LDC from patients were treated with pokeweed mitogen (PWM), a lower allogene...

    journal_title：Clinical and experimental immunology

    pub_type： 杂志文章

    doi：

    authors： Farrant J,Bryant AE,Lever AM,Edwards AJ,Knight SC,Webster AD

    更新日期：1985-07-01 00:00:00

  • Antibody-dependent cellular cytotoxicity of vascular endothelium: characterization and pathogenic associations in systemic sclerosis.

    abstract：:Ten sera from 48 patients with systemic sclerosis were found to be capable of producing cytotoxicity of human umbilical venous and arterial endothelium when co-cultured with peripheral blood mononuclear cells. Fractionation of sera on Ultrogel and the preparation of monomeric IgG by ion exchange and affinity chromatog...

    journal_title：Clinical and experimental immunology

    pub_type： 杂志文章

    doi：

    authors： Holt CM,Lindsey N,Moult J,Malia RG,Greaves M,Hume A,Rowell NR,Hughes P

    更新日期：1989-12-01 00:00:00

  • Anti-proteinase 3 antibodies, their characterization and disease associations.

    abstract：:Anti-proteinase 3 antibodies are a subgroup of anti-neutrophil cytoplasmic antibodies (ANCA), and we have established an ELISA for their detection using high performance liquid chromatography (HPLC)-purified protein. This assay is sensitive and specific: inhibition studies have shown that despite the homology between ...

    journal_title：Clinical and experimental immunology

    pub_type： 杂志文章

    doi：10.1111/j.1365-2249.1994.tb06519.x

    authors： Jennings JG,Chang L,Savige JA

    更新日期：1994-02-01 00:00:00

  • Cell-mediated immunity in patients with chronic fatigue syndrome, healthy control subjects and patients with major depression.

    abstract：:The chronic fatigue syndrome (CFS) is characterized by severe persistent fatigue and neuropsychiatric symptoms. It has been proposed that the abnormalities in cell-mediated immunity which have been documented in patients with CFS may be attributable to a clinical depression, prevalent in patients with this disorder. C...

    journal_title：Clinical and experimental immunology

    pub_type： 杂志文章

    doi：10.1111/j.1365-2249.1992.tb06416.x

    authors： Lloyd A,Hickie I,Hickie C,Dwyer J,Wakefield D

    更新日期：1992-01-01 00:00:00

  • Cytotoxic effects of antibodies to proteinase 3 (C-ANCA) on human endothelial cells.

    abstract：:Autoantibodies directed against cytoplasmic antigens of neutrophils (ANCA), especially those with specificity for proteinase 3 (PR-3) and myeloperoxidase, are valuable markers for differential diagnosis and monitoring of disease activity in Wegener's granulomatosis (WG) and other vasculitides. Till now, several concep...

    journal_title：Clinical and experimental immunology

    pub_type： 杂志文章

    doi：10.1111/j.1365-2249.1994.tb06110.x

    authors： Mayet WJ,Schwarting A,Meyer zum Büschenfelde KH

    更新日期：1994-09-01 00:00:00

  • Autoimmunity to endometrium and ovary in endometriosis.

    abstract：:Antibody titres to whole ovary, theca cells, granulosa cells and endometrium were determined by passive haemagglutination and immunofluorescence assays in sera and in cervical and vaginal secretions from 13 patients with endometriosis. Antibody titres to endometrium (mean log2 +/- s.e.m., 7.08 +/- 0.80; P less than 0....

    journal_title：Clinical and experimental immunology

    pub_type： 杂志文章

    doi：

    authors： Mathur S,Peress MR,Williamson HO,Youmans CD,Maney SA,Garvin AJ,Rust PF,Fudenberg HH

    更新日期：1982-11-01 00:00:00

  • Interleukin-2 activated peripheral blood lymphocytes and the correlation of lytic activity and peanut agglutinin receptor expression on malignant cells.

    abstract：:The possibility that the peanut agglutinin (PNA) receptor and/or its co-ordinate structures on the surface of leukaemia cells might be recognized by lectin free crude interleukin-2 (IL-2) activated human peripheral blood lymphocytes (LAK) was investigated. Analysis was undertaken of the correlation between the sensiti...

    journal_title：Clinical and experimental immunology

    pub_type： 杂志文章

    doi：

    authors： Gotoh YI,Minegishi M,Yamaguchi Y,Konno T,Tada K

    更新日期：1984-09-01 00:00:00

  • Cellular autoreactivity against heat shock protein 60 in renal transplant patients: peripheral and graft-infiltrating responses.

    abstract：:Autoreactivity to heat shock protein 60 (Hsp60) has been implicated in the pathogenesis and regulation of chronic inflammation, especially in autoimmune diseases. In transplantation, there is a lack of information regarding the cytokine profile and specificity of cells that recognize self-Hsp60 as well as the kinetics...

    journal_title：Clinical and experimental immunology

    pub_type： 杂志文章

    doi：10.1111/j.1365-2249.2006.03195.x

    authors： Caldas C,Luna E,Spadafora-Ferreira M,Porto G,Iwai LK,Oshiro SE,Monteiro SM,Fonseca JA,Lemos F,Hammer J,Ho PL,Kalil J,Coelho V

    更新日期：2006-10-01 00:00:00

  • Relationships between humoral factors in HIV-1-infected mothers and the occurrence of HIV infection in their infants.

    abstract：:Based on what is known about the biology of HIV-1 vertical transmission, the HIV burden of the mother, maternal immune factors and the integrity of the placental barrier are likely to play major roles. We therefore sought to determine whether the presence of antibodies in sera from 47 HIV-1-infected mothers, including...

    journal_title：Clinical and experimental immunology

    pub_type： 杂志文章

    doi：10.1111/j.1365-2249.1995.tb03840.x

    authors： Mabondzo A,Rouvier P,Raoul H,Le Naour R,Courpotin C,Hervé F,Parnet-Mathieu F,Lasfargues G,Dormont D

    更新日期：1995-12-01 00:00:00

  • Trypanosoma cruzi: immunological consequences of parasite modification of host cells.

    abstract：:Parasite antigens released from Trypanosoma cruzi-infected cells were adsorbed to infected and uninfected mammalian cells thus rendering them susceptible to immune lysis by antibody and cell-mediated immunity directed against the parasite. BALB/c mice infected with T. cruzi for 15 days developed cytotoxic T lymphocyte...

    journal_title：Clinical and experimental immunology

    pub_type： 杂志文章

    doi：

    authors： Ribeiro Dos Santos R,Hudson L

    更新日期：1980-04-01 00:00:00

  • Differences in modifications of cytoplasmic free Ca2+ concentration and 86Rb+ influx in human neoplastic B cells by antibodies to mu- relative to delta-Ig heavy chains.

    abstract：:Cytoplasmic free Ca2+ concentration and influx of 86Rb+ (K+ analogue) were determined during the first minutes after stimulation of neoplastic human B cells and B cell lines by antibodies to surface Ig. The Ca2+ concentration increased in the great majority of samples (41 of 48). All of four B cell lines also responde...

    journal_title：Clinical and experimental immunology

    pub_type： 杂志文章

    doi：

    authors： Heikkilä R,Ruud E,Funderud S,Godal T

    更新日期：1985-03-01 00:00:00

  • Reconstitution of Semliki forest virus infected mice, induces immune mediated pathological changes in the CNS.

    abstract：:Reconstitution of Semliki forest virus infected nude mice with spleen cells from their immunocompetent nu/+ litter mates resulted in an abolition of the otherwise persistent brain virus, production of anti-SFV IgG, and development of normally absent brain pathology. The brain pathological changes, including demyelinat...

    journal_title：Clinical and experimental immunology

    pub_type： 杂志文章

    doi：

    authors： Fazakerley JK,Amor S,Webb HE

    更新日期：1983-04-01 00:00:00

  • Effects of therapy with highly active anti-retroviral therapy (HAART) and IL-2 on CD4+ and CD8+ lymphocyte apoptosis in HIV+ patients.

    abstract：:The kinetics and effects of in vivo spontaneous apoptosis and activation-induced cell death (AICD) upon CD4+ and CD8+ lymphocyte subsets and CD4 naive cell numbers were studied in HIV+ subjects with CD4 pretreatment values > 200/mm3, who were subsequently treated for 48 weeks with HAART alone or in combination with si...

    journal_title：Clinical and experimental immunology

    pub_type： 临床试验,杂志文章,随机对照试验

    doi：10.1046/j.1365-2249.2000.01187.x

    authors： Caggiari L,Zanussi S,Bortolin MT,D'andrea M,Nasti G,Simonelli C,Tirelli U,De Paoli P

    更新日期：2000-04-01 00:00:00

  • T- and B-lymphocyte subpopulations in the tropical splenomegaly syndrome (TSS).

    abstract：:Lymphocyte subpopulations in thirty-nine patients with the tropical splenomegaly syndrome (TSS) were studied using the E-rosette, EAC rosette and direct immunofluorescent staining techniques. In the peripheral blood a decrease in the percentage of T-lymphocytes was found which was accompanied by an increase in the per...

    journal_title：Clinical and experimental immunology

    pub_type： 杂志文章

    doi：

    authors： Fakunle YM,Oduloju AJ,Greenwood BM

    更新日期：1978-08-01 00:00:00

  • Two novel cationic staphylococcal proteins induce IL-2 secretion, proliferation and immunoglobulin synthesis in peripheral blood mononuclear cells (PBMC) of both healthy controls and patients with common variable immunodeficiency (CVID).

    abstract：:Two cationic proteins, a neutral phosphatase (NP-tase) and a 70-kD protein (p70) were isolated from Staphylococcus aureus by ion exchange chromatography. We compared their properties to those of the well established B cell mitogen of whole, fixed Staph. aureus strain Cowan I cells (SAC). Both purified proteins were ab...

    journal_title：Clinical and experimental immunology

    pub_type： 杂志文章

    doi：10.1111/j.1365-2249.1995.tb03714.x

    authors： Jahreis A,Yousif Y,Rump JA,Dräger R,Vogt A,Peter HH,Schlesier M

    更新日期：1995-06-01 00:00:00

  • Increased levels of IL-13 mRNA, but not IL-4 mRNA, are found in vivo in peripheral blood mononuclear cells (PBMC) of patients with atopic dermatitis (AD).

    abstract：:Previous studies using in vitro systems with various stimuli have shown that PBMC from patients with AD show increased levels of IL-4 but decreased levels of interferon-gamma (IFN-gamma) compared with PBMC from normal controls. However, in vitro conditions do not always mimic the in vivo condition. We therefore believ...

    journal_title：Clinical and experimental immunology

    pub_type： 杂志文章

    doi：10.1046/j.1365-2249.1997.d01-1015.x

    authors： Katagiri K,Itami S,Hatano Y,Takayasu S

    更新日期：1997-05-01 00:00:00

  • Increased killer B cells in chronic HCV infection may lead to autoimmunity and increased viral load.

    abstract：:Regulatory B (Breg ) cells are characterized by various membrane markers and the secretion of different inhibitory cytokines. A new subset of Breg cells was identified as CD5hi Fas-ligand (FasL)hi . Their main reported role is to suppress anti-viral and anti-tumour immune responses, and, hence they have been dubbed 'k...

    journal_title：Clinical and experimental immunology

    pub_type： 杂志文章

    doi：10.1111/cei.13139

    authors： Eiza N,Zuckerman E,Carlebach M,Rainis T,Goldberg Y,Vadasz Z

    更新日期：2018-08-01 00:00:00

  • Spontaneous lymphocyte proliferation and depressed cellular immunity in Hodgkin's disease.

    abstract：:Patients with Hodgkin's disease have increased numbers of spontaneously proliferating circulating lymphocytes. In order to test the relationship between this phenomenon and the in vitro mitogenic response, both spontaneous lymphocyte proliferation and the response to stimulation with phytohaemagglutinin were quantifie...

    journal_title：Clinical and experimental immunology

    pub_type： 杂志文章

    doi：

    authors： Shiftan TA,Caviles AP Jr,Mendelsohn J

    更新日期：1978-04-01 00:00:00

  • Polymorphisms in STAT-4, IL-10, PSORS1C1, PTPN2 and MIR146A genes are associated differently with prognostic factors in Italian patients affected by rheumatoid arthritis.

    abstract：:Rheumatoid arthritis (RA) is a systemic autoimmune disease resulting in chronic inflammation of the synovium and consequent cartilage and bone erosion. RA is associated strongly with the presence of rheumatoid factor (RF), and consists of clinical subsets of anti-citrullinated protein antibody (ACPA)-positive and -neg...

    journal_title：Clinical and experimental immunology

    pub_type： 杂志文章

    doi：10.1111/cei.12831

    authors： Ciccacci C,Conigliaro P,Perricone C,Rufini S,Triggianese P,Politi C,Novelli G,Perricone R,Borgiani P

    更新日期：2016-11-01 00:00:00

  • Production of tumour necrosis factors by human T cells stimulated by a superantigen, toxic shock syndrome toxin-1.

    abstract：:The capacity of human T cell subsets, CD4+ or CD8+ T cells, to produce tumour necrosis factors (TNF-alpha and TNF-beta) upon stimulation with toxic shock syndrome toxin-1 (TSST-1) and the requirement for MHC class II molecules on accessory cells (AC) in the response were investigated. The capacity of CD4+ T cells was ...

    journal_title：Clinical and experimental immunology

    pub_type： 杂志文章

    doi：10.1111/j.1365-2249.1994.tb06045.x

    authors： Akatsuka H,Imanishi K,Inada K,Yamashita H,Yoshida M,Uchiyama T

    更新日期：1994-06-01 00:00:00

  • The potentiating, mitogenic and inhibitory effects on lymphocytes in vitro, of macrophages in the lymph nodes of mice 'overloaded' with mycobacterial products.

    abstract：:The lymph nodes of mice overloaded with mycobacterial products, either by the injection of whole or ultrasonicated organisms, or as a consequence of severe infection with Mycobacterium ulcerans, contain phagocytic cells which cause spontaneous transformation of the lymph node cells in a low volume, high cell density c...

    journal_title：Clinical and experimental immunology

    pub_type： 杂志文章

    doi：

    authors： Rook GA

    更新日期：1975-07-01 00:00:00

  • Triggering receptor expressed on myeloid cells-1 (TREM-1) expression on gastric epithelium: implication for a role of TREM-1 in Helicobacter pylori infection.

    abstract：:In Helicobacter pylori gastritis gastric epithelium plays a central role in the innate immunity to H. pylori. However, epithelial receptors interacting with H. pylori have been poorly characterized so far. Recently a new triggering receptor expressed on myeloid cells-1 (TREM-1) has been identified on human neutrophils...

    journal_title：Clinical and experimental immunology

    pub_type： 杂志文章

    doi：10.1111/j.1365-2249.2008.03608.x

    authors： Schmausser B,Endrich S,Beier D,Moran AP,Burek CJ,Rosenwald A,Rieckmann P,Müller-Hermelink HK,Eck M

    更新日期：2008-04-01 00:00:00

  • Subcutaneous immunoglobulin (16 or 20%) therapy in obese patients with primary immunodeficiency: a retrospective analysis of administration by infusion pump or subcutaneous rapid push.

    abstract：:A retrospective chart review was conducted at a single centre, capturing data on 173 primary immunodeficiency disease (PIDD) patients, including 40 obese patients, using subcutaneous administration of immunoglobulin (Ig) (SCIG) (16 or 20%) delivered by infusion pump or subcutaneous (s.c.) rapid push. Patients previous...

    journal_title：Clinical and experimental immunology

    pub_type： 杂志文章

    doi：10.1111/cei.12099

    authors： Shapiro R

    更新日期：2013-08-01 00:00:00

  • Efficacy of HIV-specific and 'antibody-independent' mechanisms for complement activation by HIV-infected cells.

    abstract：:Previous studies in this laboratory have shown that efficient activation of complement (C) on HIV isolates and HIV-infected cells requires the binding of specific anti-HIV antibodies, while other investigators have observed 'antibody-independent' C activation. In an attempt to clarify these disparate findings, we inve...

    journal_title：Clinical and experimental immunology

    pub_type： 杂志文章

    doi：10.1111/j.1365-2249.1995.tb05531.x

    authors： Saarloos MN,Lint TF,Spear GT

    更新日期：1995-02-01 00:00:00

  • The effect of anti-neutrophil cytoplasm autoantibodies on the signal transduction in human neutrophils.

    abstract：:The effect of anti-neutrophil cytoplasm autoantibodies (ANCA) on neutrophil activation was studied by pre-incubating neutrophils with IgG and F(ab')2 prepared from ANCA patients with Wegener's granulomatosis or microscopic polyarteritis. We measured the generation of inositol triphosphate (IP3) (a product of hydrolysi...

    journal_title：Clinical and experimental immunology

    pub_type： 杂志文章

    doi：10.1111/j.1365-2249.1991.tb05738.x

    authors： Lai KN,Lockwood CM

    更新日期：1991-09-01 00:00:00

  • NLRP3 inflammasome activation contributes to the pathogenesis of rheumatoid arthritis.

    abstract：:Nucleotide-binding, oligomerization domain (NOD)-like receptor family, pyrin domain containing 3 (NLRP3) gene polymorphism was reported to be associated with susceptibility, disease activity or anti-tumour necrosis factor (TNF) treatment response in rheumatoid arthritis (RA). However, the roles of NLRP3 inflammasome i...

    journal_title：Clinical and experimental immunology

    pub_type： 杂志文章

    doi：10.1111/cei.13167

    authors： Guo C,Fu R,Wang S,Huang Y,Li X,Zhou M,Zhao J,Yang N

    更新日期：2018-11-01 00:00:00

  • Humoral immune responses in periodontal disease may have mucosal and systemic immune features.

    abstract：:The humoral immune response, especially IgG and IgA, is considered to be protective in the pathogenesis of periodontal disease, but the precise mechanisms are still unknown. Immunoglobulins arriving at the periodontal lesion are from both systemic and local tissue sources. In order to understand better the local immun...

    journal_title：Clinical and experimental immunology

    pub_type： 杂志文章

    doi：10.1046/j.1365-2249.1999.00819.x

    authors： Kinane DF,Lappin DF,Koulouri O,Buckley A

    更新日期：1999-03-01 00:00:00