Modification of cutaneous leishmaniasis in the guinea-pig by cyclophosphamide.

abstract：:A phenotypic and functional analysis of the circulating natural killer (NK) cell population was carried out in a series of patients with hairy cell leukaemia (HCL). The overall mean NK activity of both the mononuclear and T cell fractions was reduced compared to that of normal controls (466 lytic units (lu) v 573 lu a...

journal_title：Clinical and experimental immunology

authors： Foa R,Lauria F,Lusso P,Raspadori D,Fierro MT,Tazzari PL,Caudana L,Matera L

更新日期：1986-05-01 00:00:00

abstract：:Tolerogenic dendritic cells (DCs) play a critical role in the induction of regulatory T cells (Tregs ), which in turn suppress effector T cell responses. We have previously shown the induction of DCs from human and mouse monocytic cell lines, mouse splenocytes and human peripheral blood monocytes by a novel apolipopro...

journal_title：Clinical and experimental immunology

authors： Bellemore SM,Nikoopour E,Au BC,Krougly O,Lee-Chan E,Haeryfar SM,Singh B

更新日期：2014-09-01 00:00:00

abstract：:We have shown previously that IgG2a anti-Thy-1 MoAb (ER4G) induces apoptosis of rat mesangial cells (GMC) in vitro. Since the classical complement pathway plays an essential role in Thy-1 nephritis, we analysed whether C1q, a subunit of the first component of complement, enhances the ER4G-mediated apoptosis of rat GMC...

journal_title：Clinical and experimental immunology

authors： Sato T,van Dixhoorn MG,Heemskerk E,van Es LA,Daha MR

更新日期：1997-09-01 00:00:00

abstract：:It is unclear how breakdown in immune tolerance to the ubiquitous self-antigen pyruvate dehydrogenase complex (PDC), seen in the autoimmune liver disease PBC, gives rise to tissue damage with such a limited distribution (restricted to the liver and salivary and lachrymal glands). One property shared by these tissues i...

journal_title：Clinical and experimental immunology

authors： Palmer JM,Doshi M,Kirby JA,Yeaman SJ,Bassendine MF,Jones DE

更新日期：2000-12-01 00:00:00

abstract：:An immunoglobulin phage display library constructed from a tumour-associated pericolic lymph node was panned against the extracellular domain of the oncoprotein c-erbB-2. Sixteen independent clones were confirmed as positive binders based on ELISA analysis of soluble Fabs. Nucleotide sequencing demonstrated that the V...

journal_title：Clinical and experimental immunology

authors： Clark MA,Hawkins NJ,Papaioannou A,Fiddes RJ,Ward RL

更新日期：1997-07-01 00:00:00

abstract：:Experimental autoimmune uveitis (EAU) is an organ-specific autoimmune disease and has served as a model of certain ocular inflammatory conditions in man. The present study was aimed at separating the effects of MHC and non-MHC genes on the development of EAU in the rat. EAU-susceptible LEW (RT1l), EAU-resistant WKAH (...

journal_title：Clinical and experimental immunology

authors： Hirose S,Ogasawara K,Natori T,Sasamoto Y,Ohno S,Matsuda H,Onoé K

更新日期：1991-12-01 00:00:00

abstract：:The Km for AMP for 5' nucleotidase was increased in lymphocytes from patients with common variable (CVH) and sex linked (XLH) hypogammaglobulinaemia and from patients with chronic lymphatic leukaemia (CLL): the Vmax of the latter was low. The kinetic constants for cord blood lymphocytes are similar to adults and the K...

journal_title：Clinical and experimental immunology

authors： Shah T,Webster AD,Peters TJ

更新日期：1984-07-01 00:00:00

abstract：:Low concentrations of protease and trypsin reduced the electrophoretic mobility (EPM) of thymocytes; with higher concentrations it was normal or above. Differences in membrane structure of thymocytes, T and B cells was found as B cells showed no reduction while T cells gave intermediate values. Further the reduction w...

journal_title：Clinical and experimental immunology

authors： Wiig JN

更新日期：1975-10-01 00:00:00

abstract：:CD30 is a surface molecule which can be expressed by normal B and T lymphocytes. Our study focused on the CD30 expression and release compared with IL-4 expression as well as CD23-alpha/beta in peripheral blood mononuclear cells (PBMC) from atopic subjects and controls. Data showed a lack of CD30 mRNA expression in th...

journal_title：Clinical and experimental immunology

authors： Esnault S,Benbernou N,Lavaud F,Guenounou M

更新日期：1996-10-01 00:00:00

abstract：:Most patients with late-onset bypogammaglobulinaemia have normal numbers of B cells. In addition, some of these patients have been shown to have circulating T cells which suppress immunolobulin production in vitro. From our present studies on a large series of patients it appears that these two findings distinguish tw...

journal_title：Clinical and experimental immunology

authors： Platts-Mills TA,De Gast GC,Webster AD,Asherson GL,Wilkins SR

更新日期：1981-05-01 00:00:00

abstract：:Endothelial cells (ECs) are a target in inflammation, and the death of EC is regulated by various factors. Although intravenous immunoglobulin (IVIG) preparations are known to be beneficial therapeutic agents for the treatment of autoimmune diseases and systemic inflammatory disorders, their mechanism of action have n...

journal_title：Clinical and experimental immunology

authors： Nakatani K,Takeshita S,Tsujimoto H,Sekine I

更新日期：2002-03-01 00:00:00

abstract：:The c-Jun N-terminal kinase (JNK) participates in intracellular signalling cascades that mediate inflammatory responses. Therefore, the JNK signalling may be involved in gastric injury and inhibition of this pathway may form the basis of a new strategy for the treatment of gastric injury. The aim of this study was to ...

journal_title：Clinical and experimental immunology

authors： Mitsuyama K,Tsuruta O,Matsui Y,Harada K,Tomiyasu N,Suzuki A,Takaki K,Masuda J,Handa K,Satoh Y,Bennett BL,Toyonaga A,Sata M

更新日期：2006-01-01 00:00:00

abstract：:Mice were immunized with the cell wall of BCG suspended in an oil-in-saline emulsion, and examined against time for the emergence of T cell-mediated acquired immunity. Evidence is presented that shows that levels of acquired resistance expressed in these animals over the first month following inoculation, and which en...

journal_title：Clinical and experimental immunology

authors： Orme IM

更新日期：1988-03-01 00:00:00

abstract：:In order to define the optimal conditions for detection of microbial antigens in urine, urinary HBsAg excreted during hepatitis B was chosen as a model. Using commercial kits, which mainly involve anti-discontinuous epitopes, we found urinary HBsAg in only 50% of patients with HBsAg in their sera. In contrast, with an...

journal_title：Clinical and experimental immunology

authors： Badur S,Grangeot-Keros L,Pillot J

更新日期：1992-02-01 00:00:00

abstract：:Complement C6 has a common charge polymorphism designated A and B with gene frequencies of 0.65 and 0.35. The probable molecular basis for this is a Glu (C6A) for Ala (C6B) substitution at amino acid position 98, and is detected by digestion with the restriction enzyme Dde I of a polymerase chain reaction (PCR)-amplif...

journal_title：Clinical and experimental immunology

authors： Fernie BA,Hobart MJ,Delbridge G,Potter PC,Orren A,Lachmann PJ

更新日期：1994-02-01 00:00:00

abstract：:A large series of leukaemias (1,512 cases) and leukaemic cell lines (40) have been tested for selective expression of a monomorphic HLR-DR determinant using a monoclonal antibody (DA2). Relatively mature myeloid leukaemias (APML, CGL) and erythroid leukemias are DR-, in contrast to most (72% leukaemias of myeloid prec...

journal_title：Clinical and experimental immunology

authors： Newman RA,Greaves MF

更新日期：1982-10-01 00:00:00

abstract：:Complement receptor 2 (CR2, CD21), the receptor for both the C3d,g portion of human complement component C3 and the Epstein-Barr virus, has been recently described on peripheral T cells. By using dual stain flow cytometric analysis, we have also observed that a peripheral T lymphocyte subpopulation of normal healthy d...

journal_title：Clinical and experimental immunology

authors： Levy E,Ambrus J,Kahl L,Molina H,Tung K,Holers VM

更新日期：1992-11-01 00:00:00

abstract：:The spontaneous lysis of target cells sensitive to natural killer (NK) activity is accomplished in two distinct phases: (i) binding between target and effector cells and (ii) post-binding events leading to target cell destruction. To test the hypothesis that cell surface carbohydrate(s) might be involved in recognitiv...

journal_title：Clinical and experimental immunology

authors： Vose BM,Harding M,White W,Moore M,Gallagher J

更新日期：1983-03-01 00:00:00

abstract：:Synovial tissues from fifteen patients with psoriatic arthritis were investigated with direct immunofluorescence staining for immunoglobulins (IgG, IgA, and IgM) and from eigth patients for complement component C3. As control groups, there were synovial tissues from seven patients with seropositive rheumatoid arthriti...

journal_title：Clinical and experimental immunology

authors： Fyrand O,Mellbye OJ,Natvig JB

更新日期：1977-09-01 00:00:00

abstract：:The programmed death-1 (PD-1) receptor ligands, PD-L1 and PD-L2, are co-stimulatory molecules that contribute to the negative regulation of T lymphocyte activation. It is still unclear whether there is correlation between PD-L1 or PD-L2 and tumour-infiltrating dendritic cells (TIDCs) in cutaneous squamous cell carcino...

journal_title：Clinical and experimental immunology

authors： Jiao Q,Liu C,Li W,Li W,Fang F,Qian Q,Zhang X

更新日期：2017-06-01 00:00:00

abstract：:Significant numbers of syncytial cells were observed in the bronchoalveolar lavage fluid (BALF) of a 42-year-old patient who had SLE with interstitial pneumonia. Electron microscopic study of the BALF cells and positive reverse transcriptase activity in the supernatant of the cultured cells revealed unknown retroviral...

journal_title：Clinical and experimental immunology

authors： Tamura N,Sekigawa I,Hashimoto H,Yamamoto N,Kira S

更新日期：1997-03-01 00:00:00

abstract：:The supernatants of hybrids produced by fusion of splenocytes from normal, germ free, nude and neonatal BALB/c mice with mouse NS-1 myeloma cells were examined for immunofluorescence reactivity with viable and acetone fixed monolayers of syngeneic mouse fibroblasts and mouse 3T3 cells and with viable cell suspensions ...

journal_title：Clinical and experimental immunology

authors： Underwood JR,Pedersen JS,Chalmers PJ,Toh BH

更新日期：1985-05-01 00:00:00

abstract：:In the present study we attempted to clarify the effects of anti-beta 2-microglobulin (a-beta 2m) on lymphocyte activation. Neither a-beta 2m IgG fraction nor F(ab')2 had a mitogenic effect on either highly purified T or B lymphocytes alone, while their mitogenic effect was observed when T and B lymphocytes were appro...

journal_title：Clinical and experimental immunology

authors： Kin K,Kasahara T,Itoh Y,Sakurabayashi I,Kawai T,Morita K

更新日期：1979-05-01 00:00:00

abstract：:Bronchoalveolar washings (BAW) were obtained from rats primarily infected with N. brasiliensis during the early infection stage that coincides with the lung passage of the parasite and the recruitment of inflammatory cells. BAW were tested for IL-1, IL-6 and tumour necrosis factor (TNF) activities. We found that IL-1 ...

journal_title：Clinical and experimental immunology

authors： Benbernou N,Matsiota-Bernard P,Jolivet C,Ougen P,Guenounou M

更新日期：1992-05-01 00:00:00

abstract：:Sepsis is associated with depression of T cell-dependent immune reactivity with proinflammatory cytokines, such as tumour necrosis factor (TNF)-alpha, playing an important role. Recent investigations describe an association between these immunological alterations and disturbances of the endocrine system, related most ...

journal_title：Clinical and experimental immunology

authors： Hildebrand F,Pape HC,Harwood P,Wittwer T,Krettek C,van Griensven M

更新日期：2004-11-01 00:00:00

abstract：:Perforin, one of the cytotoxic proteins of the immune system, plays a prominent role in protection against viral and bacterial infections. We investigated its expression in PBL and their CD3+, CD4+, CD8+ and CD16+ and/or CD56+ subpopulations in endurance athletes before and after a triathlon. Lymphocyte subpopulations...

journal_title：Clinical and experimental immunology

authors： Staats R,Balkow S,Sorichter S,Northoff H,Matthys H,Luttmann W,Berg A,Virchow JC

更新日期：2000-06-01 00:00:00

abstract：:Complement C5a is aetiologically linked to inflammatory tissue damage in conditions like septicaemia, immune complex diseases and ischaemia-reperfusion injury. We here describe a monoclonal antibody (mAb), 137-26, that binds to the C5a moiety of human C5 and neutralizes the effects of C5a without interfering with C5 c...

journal_title：Clinical and experimental immunology

authors： Fung M,Lu M,Fure H,Sun W,Sun C,Shi NY,Dou Y,Su J,Swanson X,Mollnes TE

更新日期：2003-08-01 00:00:00

abstract：:The uptake of C-reactive protein (CRP)-pneumococcal C-polysaccharide (CPS) complexes by neutrophils was studied. A specific CRP dependent mechanism of uptake was demonstrated. This promoted CPS (complexed to CRP) clearance which was further enhanced by additional complement activation. Physiological concentrations of ...

journal_title：Clinical and experimental immunology

authors： Shephard EG,Anderson R,Strachan AF,Kühn SH,De Beer FC

更新日期：1986-03-01 00:00:00

abstract：:A positive Mitsuda skin test for delayed type hypersensitivity to Mycobacterium leprae is associated with a high level of protection against lepromatous leprosy, while the value of tuberculin sensitivity in leprosy is less pronounced. Cutaneous lymphocytes, isolated from the Mitsuda reaction of a PPD-positive individu...

journal_title：Clinical and experimental immunology

authors： Roberts PP,Dockrell HM,McAdam KP

更新日期：1988-06-01 00:00:00

abstract：:Cytokines have been extensively studied in coeliac disease, but cytokine release related to exposure to gluten and associated symptoms has only recently been described. Prominent, early elevations in serum interleukin (IL)-2 after gluten support a central role for T cell activation in the clinical reactions to gluten ...

journal_title：Clinical and experimental immunology

authors： Goel G,Daveson AJM,Hooi CE,Tye-Din JA,Wang S,Szymczak E,Williams LJ,Dzuris JL,Neff KM,Truitt KE,Anderson RP

更新日期：2020-01-01 00:00:00