T lymphocyte expression of complement receptor 2 (CR2/CD21): a role in adhesive cell-cell interactions and dysregulation in a patient with systemic lupus erythematosus (SLE).


:Complement receptor 2 (CR2, CD21), the receptor for both the C3d,g portion of human complement component C3 and the Epstein-Barr virus, has been recently described on peripheral T cells. By using dual stain flow cytometric analysis, we have also observed that a peripheral T lymphocyte subpopulation of normal healthy donors bears CR2 in a range varying from 1.1 to 23.2% (mean 12.6%) of total CD3+ cells. T lymphocytes from nine patients with inactive SLE expressed CR2 in a similar range. Three patients with active SLE were also studied. One of them, having neuropathy and glomerulonephritis, displayed an expansion of the CR2 T cell subpopulation which reached as much as 89% of total CD3+ cells. To examine potential functional roles of T cell CR2, cells from a Jurkat-derived CR2 expressing T cell line were found to bind in vitro to human CR2-, complement-coated K562 cell targets in a CR2- and complement-dependent fashion. Based on these studies, we hypothesize that CR2 might act to increase adherence of T cells to nucleated target cells bearing C3d,g, a function which may be relevant to cytotoxicity or other T cell activities requiring cell-cell interaction.


Clin Exp Immunol


Levy E,Ambrus J,Kahl L,Molina H,Tung K,Holers VM




Has Abstract


1992-11-01 00:00:00












  • CRP and neutrophils: functional effects and complex uptake.

    abstract::The uptake of C-reactive protein (CRP)-pneumococcal C-polysaccharide (CPS) complexes by neutrophils was studied. A specific CRP dependent mechanism of uptake was demonstrated. This promoted CPS (complexed to CRP) clearance which was further enhanced by additional complement activation. Physiological concentrations of ...

    journal_title:Clinical and experimental immunology

    pub_type: 杂志文章


    authors: Shephard EG,Anderson R,Strachan AF,Kühn SH,De Beer FC

    更新日期:1986-03-01 00:00:00

  • CD23/Fc epsilon R11 expression in contact sensitivity reactions: a comparison between aeroallergen patch test reactions in atopic dermatitis and the nickel patch test reaction in non-atopic individuals.

    abstract::The immunopathology of patch test reactions to aeroallergens in patients with atopic dermatitis (AD) has been compared to that of contact sensitivity reactions to nickel in non-atopic individuals. Both reactions were found to exhibit equivalent erythema and induration on gross examination at 48 h. Four millimetre punc...

    journal_title:Clinical and experimental immunology

    pub_type: 杂志文章


    authors: Buckley C,Ivison C,Poulter LW,Rustin MH

    更新日期:1993-03-01 00:00:00

  • Antibody-independent activation of the classical pathway of complement by Epstein-Barr virus.

    abstract::A purified preparation of Epstein-Barr virus (EBV) has been shown to activate the classical complement pathway by direct interaction with the first component of complement, C1, without the intervention of antibody. No evidence was found for activation of the alternative pathway. Following classical pathway activation ...

    journal_title:Clinical and experimental immunology

    pub_type: 杂志文章


    authors: Martin H,McConnell I,Gorick B,Hughes-Jones NC

    更新日期:1987-03-01 00:00:00

  • In vitro synthesis of IgG by peripheral blood lymphocytes in chronic liver disease.

    abstract::In vitro IgG synthesis by peripheral blood mononuclear cells (PBM) from patients with chronic liver disease (CLD) was studied. In addition, the effect of pokeweed mitogen (PWM), polyadenylic-polyuridylic acid complexes (poly A:U) and thymosin fraction 5 on IgG synthesis was determined. Unstimulated cultures of PBM fro...

    journal_title:Clinical and experimental immunology

    pub_type: 杂志文章


    authors: Mutchnick MG,Lederman HM,Missirian A,Johnson AG

    更新日期:1981-02-01 00:00:00

  • Secretory autoantibodies in primary biliary cirrhosis (PBC).

    abstract::It is unclear how breakdown in immune tolerance to the ubiquitous self-antigen pyruvate dehydrogenase complex (PDC), seen in the autoimmune liver disease PBC, gives rise to tissue damage with such a limited distribution (restricted to the liver and salivary and lachrymal glands). One property shared by these tissues i...

    journal_title:Clinical and experimental immunology

    pub_type: 杂志文章


    authors: Palmer JM,Doshi M,Kirby JA,Yeaman SJ,Bassendine MF,Jones DE

    更新日期:2000-12-01 00:00:00

  • Association of polymorphisms in DNMT1, DNMT3A, DNMT3B, MTHFR and MTRR genes with global DNA methylation levels and prognosis of autoimmune thyroid disease.

    abstract::To clarify the association between factors regulating DNA methylation and the prognosis of autoimmune thyroid diseases (AITDs), we genotyped single nucleotide polymorphisms in genes encoding DNA methyltransferase 1 (DNMT1), DNMT3A, DNMT3B, methylenetetrahydrofolate reductase (MTHFR) and methionine synthase reductase (...

    journal_title:Clinical and experimental immunology

    pub_type: 杂志文章


    authors: Arakawa Y,Watanabe M,Inoue N,Sarumaru M,Hidaka Y,Iwatani Y

    更新日期:2012-11-01 00:00:00

  • Serological and histological characterization of the new mutant strain of lpr mice, CBA/KlJms-lprcg/lprcg.

    abstract::CBA/KlJms-lprcg/lprcg mice with a novel mutation producing systemic lymphoproliferation were investigated for their serological and histological characteristics. The mutant mice showed elevated levels of serum immunoglobulin, C1q-binding immune complexes and antibodies to nuclear antigens such as dsDNA and ssDNA and p...

    journal_title:Clinical and experimental immunology

    pub_type: 杂志文章


    authors: Kimura M,Mohri H,Shimada K,Wakabayashi T,Kanai Y,Matsuzawa A

    更新日期:1990-01-01 00:00:00

  • Antibody-dependent and phytohaemagglutinin-induced lymphocyte cytotoxicity in systemic sclerosis.

    abstract::Cell-mediated cytotoxicity was examined in thirty-seven patients with systemic sclerosis using both whole blood and purified peripheral blood mononuclear cells (PBM) to measure antibody-dependent (ADCC) and phytohaemagglutinin (PHA) induced lymphocyte cytotoxicity to 51Cr-labelled Chang liver cells. In twenty-three mi...

    journal_title:Clinical and experimental immunology

    pub_type: 杂志文章


    authors: Wright JK,Hughes P,Rowell NR,Sneddon IB

    更新日期:1979-04-01 00:00:00

  • Molecular studies and NK cell function of a new case of TAP2 homozygous human deficiency.

    abstract::In this paper we describe the clinical and molecular features of a new case (GOR) of homozygous human TAP2 deficiency, analysing the phenotype and function of NK cells. The patient presented from infancy with recurrent sinopulmonary infections; a selective IgG2 deficiency, negative antibody response to polysaccharide ...

    journal_title:Clinical and experimental immunology

    pub_type: 杂志文章


    authors: Matamoros N,Milà J,Llano M,Balas A,Vicario JL,Pons J,Crespí C,Martinez N,Iglesias-Alzueta J,López-Botet M

    更新日期:2001-08-01 00:00:00

  • Mechanism of a lymphocyte abnormality associated with HLA-B8/DR3: role of interleukin-1.

    abstract::Lymphocytes from normal individuals with the histocompatibility antigens HLA-B8 and DR3 have impaired proliferative responses when stimulated with suboptimal concentrations of mitogens. We have previously shown that an important factor in the impaired response is a failure to produce normal quantities of interleukin-2...

    journal_title:Clinical and experimental immunology

    pub_type: 杂志文章


    authors: Hashimoto S,Michalski JP,Berman MA,McCombs C

    更新日期:1990-02-01 00:00:00

  • Nasal tolerance in experimental autoimmune myasthenia gravis (EAMG): induction of protective tolerance in primed animals.

    abstract::Nasal administration of microg doses of acetylcholine receptor (AChR) is effective in preventing the development of B cell-mediated EAMG in the Lewis rat, a model for human MG. In order to investigate whether nasal administration of AChR modulates ongoing EAMG, Lewis rats were treated nasally with AChR 2 weeks after i...

    journal_title:Clinical and experimental immunology

    pub_type: 杂志文章


    authors: Shi FD,Bai XF,Li HL,Huang YM,Van der Meide PH,Link H

    更新日期:1998-03-01 00:00:00

  • Identification of autoantigens in canine autoimmune haemolytic anaemia.

    abstract::Autoantigens in canine autoimmune haemolytic anaemia (AIHA) were identified by immunoprecipitation using autoantibody eluted from the erythrocytes of affected dogs. At least three patterns of precipitated antigen were identified in six cases of AIHA. The most commonly precipitated antigen pattern was a combination of ...

    journal_title:Clinical and experimental immunology

    pub_type: 杂志文章


    authors: Barker RN,Gruffydd-Jones TJ,Stokes CR,Elson CJ

    更新日期:1991-07-01 00:00:00

  • Specific stimulation of peripheral blood mononuclear cells from patients with acute myocarditis by peptide-bound flavin adenine dinucleotide (FAD), a naturally occurring autologous hapten.

    abstract::The tryptic FAD-peptide carrying the flavin in 8alpha-(N3)histidyl linkage as natural hapten was isolated by HPLC from the bacterial enzyme 6-hydroxy-d-nicotine oxidase. The same flavin protein linkage is found in the mitochondrial succinate dehydrogenase flavoprotein subunit, the predominant flavoprotein with covalen...

    journal_title:Clinical and experimental immunology

    pub_type: 杂志文章


    authors: Cicek G,Schiltz E,Staiger J,Neumann FJ,Melchers I,Brandsch R

    更新日期:2003-05-01 00:00:00

  • Tumour cell binding by a human monoclonal IgM antibody from the spleen of a non-tumour-associated patient is due to somatic mutations in the VH gene.

    abstract::Recently we described the occurrence of B cells producing polyspecific natural IgM with anti-tumour specificity in the spleen of non-tumour-bearing individuals as well as in fetal organisms. Immunoprecipitation and 2-D electrophoresis showed the binding of such antibodies to a 55-kD (pI 6.0) membrane surface glycoprot...

    journal_title:Clinical and experimental immunology

    pub_type: 杂志文章


    authors: Bohn J,Niemann B,Roggenbuck D,Döcke W,Jahn S

    更新日期:1995-03-01 00:00:00

  • Natural killer cell activity in asthma.

    abstract::Peripheral blood natural killer (NK) activity was analysed from 32 asthma patients and 13 control donors. Male patients and female patients with atopic asthma had significantly stronger NK activity against the leukaemic cell line K-562. Fractionation of patient mononuclear cells by discontinuous density gradient centr...

    journal_title:Clinical and experimental immunology

    pub_type: 杂志文章


    authors: Timonen T,Stenius-Aarniala B

    更新日期:1985-01-01 00:00:00

  • H-ferritin and CD68(+) /H-ferritin(+) monocytes/macrophages are increased in the skin of adult-onset Still's disease patients and correlate with the multi-visceral involvement of the disease.

    abstract::Adult-onset Still's disease (AOSD) patients may show an evanescent salmon-pink erythema appearing during febrile attacks and reducing without fever. Some patients may experience this eruption for many weeks. During AOSD, exceptionally high serum levels of ferritin may be observed; it is an iron storage protein compose...

    journal_title:Clinical and experimental immunology

    pub_type: 杂志文章


    authors: Ruscitti P,Cipriani P,Ciccia F,Di Benedetto P,Liakouli V,Berardicurti O,Carubbi F,Guggino G,Di Bartolomeo S,Triolo G,Giacomelli R

    更新日期:2016-10-01 00:00:00

  • Wild isolates of Plasmodium falciparum malaria show decreased sensitivity to in vitro inhibition of parasite growth mediated by autologous host antibodies.

    abstract::Antigenic diversity in field populations of Plasmodium falciparum parasites may delay the acquisition of protective immunity to malaria, the development of which may thus require repeated exposure to infection over a prolonged period of time. In this study we show that P. falciparum parasites may vary in their sensiti...

    journal_title:Clinical and experimental immunology

    pub_type: 杂志文章


    authors: Flyg BW,Perlmann H,Perlmann P,Esposito F,Berzins K

    更新日期:1997-02-01 00:00:00

  • Factors associated with CD4 lymphocyte counts in HIV-negative Senegalese individuals.

    abstract::CD4+ lymphocytes are a primary target of the human immunodeficiency virus (HIV), and CD4 counts are one of the factors used to measure disease progression in HIV-positive individuals. CD4 counts vary in uninfected individuals and across populations due to a variety of demographic, environmental, immunological and gene...

    journal_title:Clinical and experimental immunology

    pub_type: 杂志文章,多中心研究


    authors: Mair C,Hawes SE,Agne HD,Sow PS,N'doye I,Manhart LE,Fu PL,Gottlieb GS,Kiviat NB

    更新日期:2008-03-01 00:00:00

  • IL-12 protects mice against pulmonary and disseminated infection caused by Cryptococcus neoformans.

    abstract::We examined the role of IL-12 in host resistance to Cryptococcus neoformans using a murine model of pulmonary and disseminated infection. In this model, mice were infected intratracheally with viable yeast cells. Mice untreated with IL-12 allowed an uncontrolled multiplication of yeast cells in the lung with infiltrat...

    journal_title:Clinical and experimental immunology

    pub_type: 杂志文章


    authors: Kawakami K,Tohyama M,Xie Q,Saito A

    更新日期:1996-05-01 00:00:00

  • Low molecular weight proteins of outer membrane of Salmonella typhimurium are immunogenic in Salmonella induced reactive arthritis revealed by proteomics.

    abstract::In patients with reactive arthritis (ReA)/undifferentiated spondyloarthropathy (uSpA), synovial fluid mononuclear cells (SFMC) show proliferation to bacterial antigens that trigger ReA, i.e. Chlamydia, Yersinia, Campylobactor, Shigella and Salmonella species. We have shown previously that SFMC proliferate significantl...

    journal_title:Clinical and experimental immunology

    pub_type: 杂志文章


    authors: Singh R,Shasany AK,Aggarwal A,Sinha S,Sisodia BS,Khanuja SP,Misra R

    更新日期:2007-06-01 00:00:00

  • Enhancement of in situ immune complex formation in isolated perfused kidneys in Heymann's nephritis.

    abstract::A preparation of the putative antibody in HN (Heymann's nephritis) lacking preformed immune complexes, obtained from the acid eluates of kidneys with HN, purified through ion exchange and gel-filtration chromatography, characterized by immunoelectrophoresis, sucrose density-gradient ultracentrifugation, 125I-Clq assay...

    journal_title:Clinical and experimental immunology

    pub_type: 杂志文章


    authors: Makker SP,Kirson IJ,Moorthy B

    更新日期:1982-02-01 00:00:00

  • Limitations of the semisynthetic library approach for obtaining human monoclonal autoantibodies to the thyrotropin receptor of Graves' disease.

    abstract::Graves' disease (GD) is characterized by the presence of autoantibodies against the TSH-receptor (TSH-R) which are pathogenic and, upon binding to the receptor, trigger intracellular signal transduction. The autoantibodies are oligoclonal and as they are responsible for disease activity, their characterization would l...

    journal_title:Clinical and experimental immunology

    pub_type: 杂志文章


    authors: Van Der Heijden JH,De Bruin TW,Glaudemans KA,De Kruif J,Banga JP,Logtenberg T

    更新日期:1999-11-01 00:00:00

  • High levels of glucocorticoid receptors in patients with active Crohn's disease may predict steroid resistance.

    abstract::Up to 20% of Crohn's disease (CD) patients respond poorly to glucocorticoids (GC). A product of an alternative splicing of the glucocorticoid receptor (GR) premRNA, GRbeta, may play a role as a dominant inhibitor of the glucocorticoid response. Increasing evidence suggests that inflammatory cytokines such as interleuk...

    journal_title:Clinical and experimental immunology

    pub_type: 杂志文章


    authors: Towers R,Naftali T,Gabay G,Carlebach M,Klein A,Novis B

    更新日期:2005-08-01 00:00:00

  • CD56(+dim) and CD56(+bright) cell activation and apoptosis in hepatitis C virus infection.

    abstract::CD3- CD56(+dim) natural killer (NK) cells, which are cytotoxic against virally infected cells, may be important in hepatitis C virus (HCV)-infected patients who are successfully treated with pegylated interferon (PEG-IFN)-alpha. We used flow cytometry to enumerate activated (CD69+) and apoptotic (annexin-V+) dim (CD3-...

    journal_title:Clinical and experimental immunology

    pub_type: 杂志文章


    authors: Lin AW,Gonzalez SA,Cunningham-Rundles S,Dorante G,Marshall S,Tignor A,Ha C,Jacobson IM,Talal AH

    更新日期:2004-08-01 00:00:00

  • Anti-DNA antibody derived from a systemic lupus erythematosus (SLE) patient forms histone-DNA-anti-DNA complexes that bind to rat glomeruli in vivo.

    abstract::Histone can mediate the binding of both free DNA and DNA complexed to anti-DNA antibody to the glomerular capillary wall. We tested whether performed histone-DNA-anti-DNA immune complexes (IC) could bind to the glomerular capillary wall. The immune complex, generated with anti-DNA antibody derived from an SLE patient ...

    journal_title:Clinical and experimental immunology

    pub_type: 杂志文章


    authors: Morioka T,Fujigaki Y,Batsford SR,Woitas R,Oite T,Shimizu F,Vogt A

    更新日期:1996-04-01 00:00:00

  • Development of anti-polysaccharide antibodies in asplenic children.

    abstract::Splenectomized patients are highly susceptible to infections with capsulated bacteria and an impaired response to vaccination with bacterial polysaccharides has frequently been observed in these individuals. Based partly on experimental animal data, an important role for the spleen in the production of specific anti-c...

    journal_title:Clinical and experimental immunology

    pub_type: 杂志文章


    authors: Hammarström L,Smith CI

    更新日期:1986-11-01 00:00:00

  • Metabolic and cytoskeletal modulation of transferrin receptor mobility in mitogen-activated human lymphocytes.

    abstract::The transferrin receptors which appear on mitogen-activated human peripheral blood lymphocytes were found by the use of immunofluorescence techniques to display temperature-dependent patching and capping reactions upon binding of transferrin. Lateral mobility of ligand-occupied membrane sites was accompanied by both s...

    journal_title:Clinical and experimental immunology

    pub_type: 杂志文章


    authors: Galbraith GM,Galbraith RM

    更新日期:1980-11-01 00:00:00

  • Disordered Toll-like receptor 2 responses in the pathogenesis of pulmonary sarcoidosis.

    abstract::In this study, we hypothesized that the granulomatous disorder sarcoidosis is not caused by a single pathogen, but rather results from abnormal responses of Toll-like receptors (TLRs) to conserved bacterial elements. Unsorted bronchoalveolar lavage (BAL) cells from patients with suspected pulmonary sarcoidosis and hea...

    journal_title:Clinical and experimental immunology

    pub_type: 杂志文章


    authors: Gabrilovich MI,Walrath J,van Lunteren J,Nethery D,Seifu M,Kern JA,Harding CV,Tuscano L,Lee H,Williams SD,Mackay W,Tomashefski JF Jr,Silver RF

    更新日期:2013-09-01 00:00:00

  • Natural thymocytotoxic autoantibodies in non-obese diabetic (NOD) mice: characterization and fine specificity.

    abstract::The NOD mouse is a model of human juvenile type I diabetes mellitus. As in humans and in the BB rat model, the development of diabetes in NOD mice is accompanied by evident manifestations of cell-mediated and humoral autoimmunity. Beside autoantibodies directed at putative islet cell antigens, NOD sera contain antibod...

    journal_title:Clinical and experimental immunology

    pub_type: 杂志文章


    authors: Lehuen A,Altman J,Bach JF,Carnaud C

    更新日期:1990-09-01 00:00:00

  • Endothelial cell enhancement of PWM induced immunoglobulin synthesis by peripheral blood mononuclear cells.

    abstract::The effect of various exogenous cells on the in-vitro PWM stimulation of immunoglobulin synthesis by normal human peripheral blood mononuclear cells was investigated. The accessory cells tested were bovine and human endothelial cells, bovine and human fibroblasts, normal human monocytes, and a monocyte cell line U937....

    journal_title:Clinical and experimental immunology

    pub_type: 杂志文章


    authors: King MA,Roche WR,Nelson DS

    更新日期:1986-09-01 00:00:00