Spontaneous CD30 mRNA expression in peripheral blood mononuclear cells from atopic patients with high IgE serum levels.

abstract：:Five out of 51 sera (10%) from patients with progressive systemic sclerosis reacted by immunoblotting with tissue concanavalin A binding glycoproteins of 50 kD and 45 kD Mr, whereas only one out of 133 control sera gave the same reaction (P less than 0.001). The antigens were localized to the microsomal fractions of t...

journal_title：Clinical and experimental immunology

authors： Alderuccio F,Witherden D,Toh BH,Barnett A

更新日期：1989-10-01 00:00:00

abstract：:Peripheral blood natural killer (NK) activity was analysed from 32 asthma patients and 13 control donors. Male patients and female patients with atopic asthma had significantly stronger NK activity against the leukaemic cell line K-562. Fractionation of patient mononuclear cells by discontinuous density gradient centr...

journal_title：Clinical and experimental immunology

authors： Timonen T,Stenius-Aarniala B

更新日期：1985-01-01 00:00:00

abstract：:Patients with IgA deficiency often demonstrate circulating antibodies against IgA, which have been suggested to be associated with transfusion reactions. Sera from three patients with common variable immunodeficiency (CVID) and one with a selective IgA deficiency with anti-IgA antibodies receiving subcutaneous gammagl...

journal_title：Clinical and experimental immunology

authors： Sundin U,Nava S,Hammarström L

更新日期：1998-05-01 00:00:00

abstract：:Monocytes and endothelial cells were stimulated in co-culture with allogeneic lymphocytes to produce thromboplastin (TPL). The induction was biphasic, an early response (8-24 h) was greatly augmented by cyclosporin A (CS) (0.5-5 micrograms/ml) whereas the late response (day 3-4) was inhibited. Prednisolone inhibited b...

journal_title：Clinical and experimental immunology

authors： Carlsen E,Gaudernack G,Filion-Myklebust C,Pettersen KS,Prydz H

更新日期：1989-06-01 00:00:00

abstract：:A soluble form of CD23 (sCD23) was found in the urine from 12 normal individuals but was not present in 20 normal sera, suggesting that sCD23 produced by cells in tissues is eliminated in the urine. The sCD23 from urine differed in physicochemical properties from the sCD23 found in supernates from B-lymphoblastoid cel...

journal_title：Clinical and experimental immunology

authors： Ling NR,Stevenson FK,Brown B

更新日期：1991-12-01 00:00:00

abstract：:Lupus nephritis (LN) is a major manifestation of systemic lupus erythematosus (SLE), causing morbidity and mortality in 40-60% of SLE patients. The pathogenic mechanisms of LN are not completely understood. Recent studies have demonstrated the presence of various immune cell populations in lupus nephritic kidneys of b...

journal_title：Clinical and experimental immunology

authors： Liao X,Ren J,Reihl A,Pirapakaran T,Sreekumar B,Cecere TE,Reilly CM,Luo XM

更新日期：2017-11-01 00:00:00

abstract：:Premature atherosclerosis has been observed during the course of different systemic inflammatory diseases such as rheumatoid arthritis and sytemic lupus erythematosus. Remarkably, relatively few studies have been published on the occurrence of accelerated atherosclerosis in patients with vasculitis. In giant cell arte...

journal_title：Clinical and experimental immunology

authors： Tervaert JW

更新日期：2009-06-01 00:00:00

abstract：:In ANCA-associated vasculitis the activation of primed leucocytes by autoantibodies with subsequent release of proteases such as myeloperoxidase (MPO), proteinase 3 (PR3) and elastase is thought to play an important pathogenetic role. Whether these proteases contribute to the vascular lesions by stimulating the procoa...

journal_title：Clinical and experimental immunology

authors： Haubitz M,Gerlach M,Kruse HJ,Brunkhorst R

更新日期：2001-12-01 00:00:00

abstract：:For 'the total population of patients with sepsis, sepsis syndrome or SIRS', the question of whether intravenous immune globulin (IVIG) reduces mortality is neither proved nor disproved. For the sepsis subgroups 'postoperative sepsis with a sepsis score more than 19' and 'endotoxaemic, early septic shock', a significa...

journal_title：Clinical and experimental immunology

authors： Werdan K,Pilz G

更新日期：1996-05-01 00:00:00

abstract：:Autoantibodies to the intermediate filament proteins vimentin and keratin were studied in sera of 50 Caribbean patients with Schistosoma mansoni infection and 50 control subjects. Autoantibodies were detected by indirect immunofluorescence on HEp-2 cells pretreated with colchicine. The incidence of anti-vimentin antib...

journal_title：Clinical and experimental immunology

authors： Boehme MW,Kataaha PK,Holborow EJ

更新日期：1989-08-01 00:00:00

abstract：:The incidence of circulating T lymphocytes (ET-RFC) and a sub-population of T lymphocytes (EE-RFC) were monitored in the blood of seventy-one cadaver renal allograft recipients for the first 2 months after transplantation. In patients with uneventful post-operative courses, the incidence of both ET-RFC and EE-RFC fell...

journal_title：Clinical and experimental immunology

authors： Kelly GE,Sheil AG

更新日期：1977-03-01 00:00:00

abstract：:Immune complexes (IC) in sera and synovial fluid (SF) from patients with juvenile (rheumatoid) arthritis (JA) were isolated by making use of polyethylene glycol (PEG) to precipitate IC and then using staphylococcal protein A to separate the IC. The isolated IC were compared to IC in sera analysed by sucrose density gr...

journal_title：Clinical and experimental immunology

authors： Moore TL,Dorner RW,Sheridan PW,Zuckner J

更新日期：1984-05-01 00:00:00

abstract：:Chronic pulmonary infection is known to constitute a major complication of cystic fibrosis (CF). In order to determine whether a defect of antibody formation is associated with this clinical finding, we have investigated antibody production on the cellular level by using a haemolytic plaque forming cell (PFC) assay. T...

journal_title：Clinical and experimental immunology

authors： Götz M,Zielinski CC,Ahmad R,Eibl M

更新日期：1982-10-01 00:00:00

abstract：:In recent years galectin-3 has gained attention as a signalling molecule, mainly in inflammatory diseases. Data on galectin-3 expression in neonates, however, are limited, and expression of this lectin in cord blood has not yet been reported. The aim of this study was to determine galectin-3 levels in cord blood of te...

journal_title：Clinical and experimental immunology

authors： Demmert M,Faust K,Bohlmann MK,Tröger B,Göpel W,Herting E,Härtel C

更新日期：2012-02-01 00:00:00

abstract：:Hepatitis C virus (HCV) is an RNA virus which is estimated to persistently infect about 170 million people worldwide. After acute infection, there is an initial period during which long-term outcome is decided. There is strong evidence that the cellular immune responses, involving both CD4+ and CD8+ T lymphocytes, are...

journal_title：Clinical and experimental immunology

authors： Ward S,Lauer G,Isba R,Walker B,Klenerman P

更新日期：2002-05-01 00:00:00

abstract：:Chronic obstructive pulmonary disease (COPD) is characterized by an abnormal regulatory T cell (T(reg)) response and increases in T helper type 1 (Th1) and Th17 cell responses. It is unclear if dysregulation of microRNAs (miRNA) within T(reg) cells contributes to the abnormal inflammatory response in COPD. In this stu...

journal_title：Clinical and experimental immunology

authors： Chatila WM,Criner GJ,Hancock WW,Akimova T,Moldover B,Chang JK,Cornwell W,Santerre M,Rogers TJ

更新日期：2014-07-01 00:00:00

abstract：:The kinetics and effects of in vivo spontaneous apoptosis and activation-induced cell death (AICD) upon CD4+ and CD8+ lymphocyte subsets and CD4 naive cell numbers were studied in HIV+ subjects with CD4 pretreatment values > 200/mm3, who were subsequently treated for 48 weeks with HAART alone or in combination with si...

journal_title：Clinical and experimental immunology

authors： Caggiari L,Zanussi S,Bortolin MT,D'andrea M,Nasti G,Simonelli C,Tirelli U,De Paoli P

更新日期：2000-04-01 00:00:00

abstract：:Mice were immunized with the cell wall of BCG suspended in an oil-in-saline emulsion, and examined against time for the emergence of T cell-mediated acquired immunity. Evidence is presented that shows that levels of acquired resistance expressed in these animals over the first month following inoculation, and which en...

journal_title：Clinical and experimental immunology

authors： Orme IM

更新日期：1988-03-01 00:00:00

abstract：:Immunoregulation was examined in normal controls and in patients with immune complex glomerulonephritis and lupus nephritis (SLE) using OKT monoclonal anti-bodies against helper (OKT4) and suppressor (OKT8) T cell subsets. Functional studies assessed T cell control of in vitro immunoglobulin synthesis by cultured peri...

journal_title：Clinical and experimental immunology

authors： Bannister KM,Drew PA,Clarkson AR,Woodroffe AJ

更新日期：1983-08-01 00:00:00

abstract：:We have previously found that isolated B-CLL cells from progressive disease produce less interleukin-1 beta (IL-1 beta) as compared with cells from patients with indolent disease. Here we extend that finding to include measurements of IL-1 beta mRNA and secretion of IL-1 alpha and interleukin-6 (IL-6). As before, a lo...

journal_title：Clinical and experimental immunology

authors： Aguilar-Santelises M,Magnusson R,Svenson SB,Loftenius A,Andersson B,Mellstedt H,Jondal M

更新日期：1991-06-01 00:00:00

abstract：:Human antibodies to the repeat regions of the Plasmodium falciparum asexual blood stage antigen Pf155/RESA interfere with parasite growth in vitro, but the significance in this respect of antibodies to non-repetitive epitopes is less clear. In this study the levels of antibodies to a non-repetitive part of Pf155/RESA ...

journal_title：Clinical and experimental immunology

authors： Siddique AB,Ahlborg N,Warsame M,Perlmann P,Berzins K

更新日期：1999-06-01 00:00:00

abstract：:This study presents data on more than 300 RA and allergic patients analysed for their serum levels of anti-immunoglobulin isotype autoantibodies and IgE. We observed high levels of IgE in sera of RA and allergic patients. Interestingly, we measured significantly higher specific IgE levels against Alternaria but not ag...

journal_title：Clinical and experimental immunology

authors： Millauer N,Zuercher AW,Miescher SM,Gerber HA,Seitz M,Stadler BM

更新日期：1999-01-01 00:00:00

abstract：:Soluble histocompatibility antigens of the class II region have been detected in synovial fluids obtained from patients with rheumatoid arthritis. A capture immunoassay involving two monoclonal antibodies was used; interference by rheumatoid factor, which is a feature of such assays, was overcome by mild pretreatment ...

journal_title：Clinical and experimental immunology

authors： Stevenson FK,Douglass WA,Spellerberg MB,Walters MT,Cawley MI

更新日期：1990-04-01 00:00:00

abstract：:Mice with SCID disease have previously been successfully engrafted with human peripheral blood mononuclear cells (PBMC) obtained from normal individuals and from patients with various diseases. To determine whether SCID mice engrafted with SLE PBMC produced autoantibodies with specificities similar to those in the SLE...

journal_title：Clinical and experimental immunology

authors： Ashany D,Hines J,Gharavi A,Mouradian J,Elkon KB

更新日期：1992-04-01 00:00:00

abstract：:Type I diabetes (T1D) is a T cell-mediated autoimmune disease characterized by loss of tolerance to islet autoantigens, leading to the destruction of insulin-producing beta cells. Peripheral tolerance to self is maintained in health through several regulatory mechanisms, including a population of CD4+CD25hi naturally ...

journal_title：Clinical and experimental immunology

authors： Lawson JM,Tremble J,Dayan C,Beyan H,Leslie RD,Peakman M,Tree TI

更新日期：2008-12-01 00:00:00

abstract：:The purpose of the present study was to elucidate the role of oestrogen in the pathogenesis of Mycobacterium avium complex (MAC) pulmonary disease, which occurs most frequently in postmenopausal women. The study was carried out in a murine infectious model using ovariectomized DBA/2 female mice. Infection with MAC was...

journal_title：Clinical and experimental immunology

authors： Tsuyuguchi K,Suzuki K,Matsumoto H,Tanaka E,Amitani R,Kuze F

更新日期：2001-03-01 00:00:00

abstract：:Several parameters of lymphocyte interleukin 2 receptor (IL-2R) expression in response to tetanus toxoid (TT) were monitored using a receptor-specific monoclonal antibody and flow cytometry in patients with acquired immunodeficiency syndrome (AIDS, n = 6), AIDS-related complex (ARC, n = 8), or lymphadenopathy syndrome...

journal_title：Clinical and experimental immunology

authors： Prince HE,John JK

更新日期：1987-01-01 00:00:00

abstract：:The capacity of peripheral blood mononuclear (PBM) cells from patients with leprosy to generate immunoglobulin-secreting cells in response to pokeweed mitogen (PWM) was evaluated by a reverse haemolytic plaque forming cell (PFC) assay. The PFC responses of PBM cells from patients with lepromatous (Lpr) leprosy were si...

journal_title：Clinical and experimental immunology

authors： Bullock WE,Watson S,Nelson KE,Schauf V,Makonkawkeyoon S,Jacobson RR

更新日期：1982-07-01 00:00:00

abstract：:Since thyroid follicular epithelial cells (thyrocytes) have been shown to express a number of functions similar to monocytes, they were further examined for their potency in secreting thymocyte-stimulating activity (TSA). Although spontaneous production of TSA could not be detected when thyrocytes were cultured in the...

journal_title：Clinical and experimental immunology

authors： Hirose W,Kawagoe M,Hara M,Kitani A,Hirose T,Norioka K,Harigai M,Nakamura H

更新日期：1987-10-01 00:00:00

abstract：:Mercuric chloride (HgCl2)-induced autoimmunity in Brown Norway (BN) rats is a highly polarized polyclonal Th2-driven autoimmune response with increased IgE production, lymphoproliferation, vasculitis and proteinuria. The increase in serum IgE concentration is clearly measurable by day 4 after the first HgCl2 injection...

journal_title：Clinical and experimental immunology

authors： Macphee IA,Turner DR,Yagita H,Oliveira DB

更新日期：2002-09-01 00:00:00