Abstract:
:Several parameters of lymphocyte interleukin 2 receptor (IL-2R) expression in response to tetanus toxoid (TT) were monitored using a receptor-specific monoclonal antibody and flow cytometry in patients with acquired immunodeficiency syndrome (AIDS, n = 6), AIDS-related complex (ARC, n = 8), or lymphadenopathy syndrome (LAS, n = 9). These parameters, measured on days 6 and 7 of culture, included (a) the percentage of recovered lymphocytes expressing IL-2R, (b) the number of IL-2R-positive cells/lymphocyte trigger region (a relative measure of the number of IL-2R-positive cells per culture), and (c) mean fluorescence intensity of IL-2R-positive cells. Data were then assessed in relation to DNA synthesis on day 7 of culture. Normal DNA synthesis was observed in nine patients (Pt-N group), and the mean values for all three IL-2R expression parameters in this group did not significantly differ from those of the healthy control group (n = 20). In contrast, 14 patients exhibited low proliferation (Pt-L group) and mean values for all three parameters were significantly lower in this group compared to both the Pt-N and control groups. When considering individual patient values, day 7 IL-2R+ cell number proved the best predictor of DNA synthesis results: all 14 patients in the Pt-L group exhibited low IL-2R+ cell number, while seven of nine patients in the Pt-N group exhibited normal IL-2R+ cell number. Thus, low TT-induced lymphocyte proliferation in AIDS and related disorders is associated with defective IL-2R expression. Further, assessment of IL-2R+ cell number appears to be a valid alternative assay for monitored antigen-induced T cell proliferation in vitro.
journal_name
Clin Exp Immunoljournal_title
Clinical and experimental immunologyauthors
Prince HE,John JKsubject
Has Abstractpub_date
1987-01-01 00:00:00pages
59-65issue
1eissn
0009-9104issn
1365-2249journal_volume
67pub_type
杂志文章abstract::Changes were assessed in lymphocyte sub-populations in various stages of human pregnancy. The percentage and absolute number of E-RFC decreased during pregnancy. There was a concomitant rise in the percentages of EAC-RFC and cells bearing SmIg with little change in their absolute numbers. EAC-RFC continued to rise pos...
journal_title:Clinical and experimental immunology
pub_type: 杂志文章
doi:
更新日期:1977-05-01 00:00:00
abstract::Capsular polysaccharide from Actinobacillus actinomycetemcomitans Y4 (Y4 CP) induces bone resorption in a mouse organ culture system and osteoclast formation in mouse bone marrow cultures, as reported in previous studies. We also found that Y4 CP inhibits the release of interleukin (IL)-6 and IL-8 from human gingival ...
journal_title:Clinical and experimental immunology
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journal_title:Clinical and experimental immunology
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pub_type: 杂志文章
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journal_title:Clinical and experimental immunology
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journal_title:Clinical and experimental immunology
pub_type: 杂志文章
doi:
更新日期:1986-11-01 00:00:00
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journal_title:Clinical and experimental immunology
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pub_type: 杂志文章
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pub_type: 杂志文章,评审
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journal_title:Clinical and experimental immunology
pub_type: 杂志文章
doi:
更新日期:1988-09-01 00:00:00
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pub_type: 杂志文章
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journal_title:Clinical and experimental immunology
pub_type: 杂志文章
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pub_type: 杂志文章
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更新日期:1994-08-01 00:00:00
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journal_title:Clinical and experimental immunology
pub_type: 杂志文章
doi:
更新日期:1977-04-01 00:00:00
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pub_type: 杂志文章
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journal_title:Clinical and experimental immunology
pub_type: 杂志文章
doi:
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journal_title:Clinical and experimental immunology
pub_type: 杂志文章
doi:
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pub_type: 临床试验,杂志文章,多中心研究
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journal_title:Clinical and experimental immunology
pub_type: 杂志文章
doi:
更新日期:1979-01-01 00:00:00
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journal_title:Clinical and experimental immunology
pub_type: 评论,杂志文章,评审
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journal_title:Clinical and experimental immunology
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pub_type: 临床试验,杂志文章
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更新日期:2006-01-01 00:00:00
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journal_title:Clinical and experimental immunology
pub_type: 杂志文章
doi:
更新日期:1984-05-01 00:00:00
abstract::Natural autoantibodies (NaAb) and IgG antibodies to tetanus toxoid (TT) were analysed in the sera of 38 children with active visceral leishmaniasis (VL) previously vaccinated with TT and in 30 healthy controls matched for sex and age. Patients exhibited high levels of NaAb to a panel of self antigens (tubulin, myosin,...
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pub_type: 杂志文章
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