Soluble histocompatibility antigens in synovial fluids of patients with rheumatoid arthritis.

abstract：:Humoral and cell-mediated immune responses to Salmonella typhi were studied in 10 chronic typhoid carriers, and in healthy controls. Carriers showed impaired cellular reactivity to S. typhi antigens in the leucocyte migration inhibition test (LMI). Carriers did not show a generalized depression of cell-mediated immuni...

journal_title：Clinical and experimental immunology

authors： Dham SK,Thompson RA

更新日期：1982-10-01 00:00:00

abstract：:The relationship between allergic airway inflammation and pneumococcal pneumonia is not well understood. We assessed susceptibility to experimental pneumococcal pneumonia in mice with and without allergic airway inflammation. Susceptibility to pneumococcal pneumonia was evaluated by challenging mice with a bioluminesc...

journal_title：Clinical and experimental immunology

authors： Kang CI,Rouse MS,Patel R,Kita H,Juhn YJ

更新日期：2009-06-01 00:00:00

abstract：:Estimation of the concentration of C9, C-reactive protein (CRP) and alpha1-antitrypsin in forty sera from patients with Behcet's syndrome and recurrent oral ulcers showed significantly increased amounts of C9 and CRP in Behcet's syndrome. The concentration of C9 was also significantly raised in recurrent oral ulcerati...

journal_title：Clinical and experimental immunology

authors： Adinolfi M,Lehner T

更新日期：1976-07-01 00:00:00

abstract：:Patients with functional deficiency of C1-inhibitor (C1-INH) suffer from recurrent acute attacks (AA) of localized oedema associated with activation of the contact system, complement and fibrinolysis. To unravel further the role of coagulation and fibrinolysis in the pathophysiology of C1-INH deficiency, we performed ...

journal_title：Clinical and experimental immunology

authors： van Geffen M,Cugno M,Lap P,Loof A,Cicardi M,van Heerde W

更新日期：2012-03-01 00:00:00

abstract：:Circulating immunoglobulin (Ig)G antibodies against M(2) muscarinic acetylcholine receptors (M(2) mAChR) have been implicated in Chagas' disease (ChD) pathophysiology. These antibodies bind to and activate their target receptor, displaying agonist-like activity through an unclear mechanism. This study tested the abili...

journal_title：Clinical and experimental immunology

authors： Beltrame SP,Auger SR,Bilder CR,Waldner CI,Goin JC

更新日期：2011-05-01 00:00:00

abstract：:We investigated the role of inflammatory cytokines in a mouse model of chronic Pseudomonas aeruginosa infection mimicking diffuse panbronchiolitis (DPB), and determined the effects of clarithromycin therapy on the production of these cytokines. The concentrations of IL-1beta, IL-2, IL-4, IL-5, interferon-gamma (IFN-ga...

journal_title：Clinical and experimental immunology

authors： Yanagihara K,Tomono K,Kuroki M,Kaneko Y,Sawai T,Ohno H,Miyazaki Y,Higashiyama Y,Maesaki S,Kadota J,Kohno S

更新日期：2000-10-01 00:00:00

abstract：:Monocyte-depleted mononuclear cells (MNC) from healthy subjects synthesized IgM-class antibody to single-stranded DNA (anti-ssDNA) at significantly higher levels than unfractionated MNC. The increased production of IgM anti-ssDNA by monocyte-depleted normal MNC was inhibited to a greater degree than total IgM by addit...

journal_title：Clinical and experimental immunology

authors： Okawa-Takatsuji M,Aotsuka S,Uwatoko S,Kinoshita M,Yokohari R

更新日期：1989-09-01 00:00:00

abstract：:The introduction of 25 mg of a new protein antigen into the diets of mice produced transient increases in PVP clearance which reached a maximum 60 hr after the change of diet and had disappeared by 4 days. At the same time the immune responsiveness to unrelated antigens given parenterally was also raised transiently, ...

journal_title：Clinical and experimental immunology

authors： Newby TJ,Stokes CR,Bourne FJ

更新日期：1980-02-01 00:00:00

abstract：:In fifty-seven healthy individuals a significant correlation ( r = 0.3, P < 0.05) has been found between responses of their lymphocytes to stimulation by PHA and by pooled lymphocytes in MLC. It is suggested that these tests quantitate the general status of T cell reactivity of individuals, and may be used in conjunct...

journal_title：Clinical and experimental immunology

authors： Nanra SK,Boettcher B

更新日期：1980-07-01 00:00:00

abstract：:Specific assays for 5'-nucleotidase, adenosine diphosphatase (ADPase) and Mg2+-dependent adenosine triphosphatase (Mg2+-ATPase) have been optimized for human lymphocytes and their subcellular localizations determined by sucrose density gradient centrifugation. 5'-Nucleotidase was localized solely to the plasma membran...

journal_title：Clinical and experimental immunology

authors： Smith GP,Shah T,Webster AD,Peters TJ

更新日期：1982-08-01 00:00:00

abstract：:It has been demonstrated immunohistologically using cryostat sections that the lectins PHA and Con A bind to human placentae. Both lectins stain trophoblastic basement membrane (TBM), perivascular tissue and stroma. No staining of trophoblasts was observed. It has been shown by blocking experiments that the lectin bin...

journal_title：Clinical and experimental immunology

authors： Johnson PM,Faulk WP

更新日期：1976-06-01 00:00:00

abstract：:Secretory IgA antibody responses such as those directed against respiratory and enteric pathogens, may be impaired in protein-calorie malnutrition. In previous studies using a rat model of the mucosal immune response to cholera toxin, as little as 2 weeks of severe protein deprivation markedly impaired mucosal anti-to...

journal_title：Clinical and experimental immunology

authors： Koster F,Pierce NF

更新日期：1985-04-01 00:00:00

abstract：:Clearance rates in the guinea pig were determined for intact guinea pig and human C1 inhibitor, the complexes of both inhibitors with human Cls, beta factor XIIa and kallikrein, and for each inhibitor cleaved at its reactive centre with trypsin. Intact human and guinea pig C1 inhibitor were cleared from the circulatio...

journal_title：Clinical and experimental immunology

authors： Malek R,Aulak KS,Davis AE 3rd

更新日期：1996-07-01 00:00:00

abstract：:Five patients with no detectable serum IgA (less than 20 mug/ml) and one patient with low serum IgA were compared to normal subjects. The number of circulating E-RFC was normal as was the lymphocyte DNA synthesis induced by PHA, Con A, and streptokinase-streptodornase. The patients had normal numbers of IgA-bearing ly...

journal_title：Clinical and experimental immunology

authors： Delespesse G,Gausset P,Cauchie C,Govaerts A

更新日期：1976-05-01 00:00:00

abstract：:C3b-coated immune complexes adhere to the complement receptor 1 (CR1, CD35) on human erythrocytes. This multi-valent binding might be favoured by the known clustering of CR1 and by the multiple C3b-binding sites on each CR1. The size of the CR1 clusters correlates directly with the number of CR1/erythrocytes, and the ...

journal_title：Clinical and experimental immunology

authors： Madi N,Paccaud JP,Steiger G,Schifferli JA

更新日期：1991-04-01 00:00:00

abstract：:Clinically, corticosteroids (CS) are among the first line drugs in the therapy of autoimmune and allergic diseases and potently inhibit the activation of immune cells. However, due to their pleiotropic mode of action, the prolonged use of CS is generally associated with a range of undesirable side-effects. In this stu...

journal_title：Clinical and experimental immunology

authors： Kalthoff FS,Chung J,Musser P,Stuetz A

更新日期：2003-09-01 00:00:00

abstract：:We have shown that immunization with dendritic cells (DCs) pulsed with hepatitis B virus core antigen virus-like particles (HBc-VLP) packaging with cytosine-guanine dinucleotide (CpG) (HBc-VLP/CpG) alone were able to delay melanoma growth but not able to eradicate the established tumour in mice. We tested whether, by ...

journal_title：Clinical and experimental immunology

authors： Song S,Zhang K,You H,Wang J,Wang Z,Yan C,Liu F

更新日期：2010-10-01 00:00:00

abstract：:The systemic inflammatory response is a challenge in the management of paediatric patients undergoing cardiac surgery. Although multi-factorial, a contribution by the lectin pathway of complement activation has been postulated. We therefore investigated the changes in serum levels of mannose binding lectin (MBL) and a...

journal_title：Clinical and experimental immunology

authors： Pągowska-Klimek I,Świerzko AS,Michalski M,Głowacka E,Szala-Poździej A,Sokołowska A,Moll M,Krajewski WR,Romak J,Cedzyński M

更新日期：2016-05-01 00:00:00

abstract：:Antigen- and mitogen-stimulated cytokine production by peripheral blood mononuclear cells (PBMC) of 50 pregnant women and 31 age- and sex-matched non-pregnant controls were analysed to determine whether changes in cytokine production occur during normal and pathologic human gestation. The pregnant women, consecutively...

journal_title：Clinical and experimental immunology

authors： Marzi M,Vigano A,Trabattoni D,Villa ML,Salvaggio A,Clerici E,Clerici M

更新日期：1996-10-01 00:00:00

abstract：:In autoimmune diseases, mitogen-induced IL-2 production in vitro is generally considered to be diminished despite evidence of lymphoid hyperactivity in vivo. HgCl2 is known to cause T-dependent polyclonal B cell activation in Brown-Norway (BN) rats, resulting in autoimmune disease. We show here that the IL-2 producing...

journal_title：Clinical and experimental immunology

authors： Baran D,Lantz O,Dosquet P,Sfaksi A,Druet P

更新日期：1988-09-01 00:00:00

abstract：:Recently we showed the in vivo relevance of chemokines in cases of bacterial peritonitis in continuous ambulatory peritoneal dialysis (CAPD) patients. Mesothelial cells, the most numerous cells in the peritoneal cavity, are hypothesized to function as a main source of chemokine production. We investigated the time- an...

journal_title：Clinical and experimental immunology

authors： Visser CE,Tekstra J,Brouwer-Steenbergen JJ,Tuk CW,Boorsma DM,Sampat-Sardjoepersad SC,Meijer S,Krediet RT,Beelen RH

更新日期：1998-05-01 00:00:00

abstract：:Human red cells (RBC) coated with IgG anti-D are cleared from the circulation to the spleen by macrophages which express IgG receptors (Fcgamma R). Polymorphisms of Fcgamma RIIa and Fcgamma RIIIa affect IgG binding in vitro, and may alter the efficiency of clearance of immune complexes in vivo. In a RBC clearance stud...

journal_title：Clinical and experimental immunology

authors： Kumpel BM,De Haas M,Koene HR,Van De Winkel JG,Goodrick MJ

更新日期：2003-04-01 00:00:00

abstract：:The presence of antibodies reactive to a recently cloned host-derived antigen GOR is highly correlated with the presence of antibodies to the hepatitis C virus (HCV). We explored the molecular basis for this observation, and address the following question: are antibodies reactive with GOR19-27 (QKAKSNPNR) a result of ...

journal_title：Clinical and experimental immunology

authors： Zhang ZX,Chen M,Wallhagen K,Trojnar J,Magnius LO,Wahren B,Sällberg M

更新日期：1994-06-01 00:00:00

abstract：:There is no information available about immunological interactions between the synovial tissue compartment and systemic immunity in health and in disease. The aim of the present study was to evaluate effects of intra-articular immunization on the systemic immune responses in humans. Control subjects were immunized wit...

journal_title：Clinical and experimental immunology

authors： Trollmo C,Carlsten H,Tarkowski A

更新日期：1990-11-01 00:00:00

abstract：:Circulating immune complexes (CIC) were detected by a solid-phase radioassay in 34% of fifty-three insulin-dependent diabetics (IDD) as compared to 18% of forty-five non-insulin-dependent diabetics (NIDD) and 14% of 173 control subjects. In control subjects, the prevalence of CIC increased with age and was higher in m...

journal_title：Clinical and experimental immunology

authors： Delespesse G,Gausset P,Sarfati M,Dubi-Rucquoy M,Debisschop MJ,van Haelst L

更新日期：1980-04-01 00:00:00

abstract：:Using an experimental contact sensitivity model in guinea-pigs, evidence is presented that hapten (DNCB or oxazolone) specific T lymphocytes may persist for several months in previous sites of inflammation. Immunological memory, revealed by accelerated contact skin reactions upon retesting with the hapten, was limited...

journal_title：Clinical and experimental immunology

authors： Scheper RJ,von Blomberg M,Boerrigter GH,Bruynzeel D,van Dinther A,Vos A

更新日期：1983-01-01 00:00:00

abstract：:Two models of murine graft-versus-host disease (GVHD) were studied with respect to autoantibody production and development of systemic lupus erythematosus (SLE) like disease. One model was induced by injection of (B10.A(4R) x B10.A(2R]F1 mice with parental (B10.A(4R] spleen and lymph node cells (groups I GVHD), the ot...

journal_title：Clinical and experimental immunology

authors： van Dam AP,Meilof JF,van den Brink HG,Smeenk RJ

更新日期：1990-07-01 00:00:00

abstract：:The ability of lymphocytes from a patient suffering from the acquired immune deficiency syndrome (AIDS) to produce interleukin-2 (IL-2) was found to be comparable to that of his healthy sex partner and to that of a normal control. Addition of exogenous IL-2 to lymphocyte cultures did not improve the poor mitogen respo...

journal_title：Clinical and experimental immunology

authors： Hauser GJ,Bino T,Rosenberg H,Zakuth V,Geller E,Spirer Z

更新日期：1984-04-01 00:00:00

abstract：:There is increasing interest in the role of T cell exhaustion and it is well known that the natural history of chronic hepatitis C virus infection (HCV) is modulated by CD8(+) T cell immunobiology. There are many pathways that alter the presence of exhaustive T cells and, in particular, they are functionally impaired ...

journal_title：Clinical and experimental immunology

authors： Sumida K,Shimoda S,Iwasaka S,Hisamoto S,Kawanaka H,Akahoshi T,Ikegami T,Shirabe K,Shimono N,Maehara Y,Selmi C,Gershwin ME,Akashi K

更新日期：2013-10-01 00:00:00

abstract：:A retrospective chart review was conducted at a single centre, capturing data on 173 primary immunodeficiency disease (PIDD) patients, including 40 obese patients, using subcutaneous administration of immunoglobulin (Ig) (SCIG) (16 or 20%) delivered by infusion pump or subcutaneous (s.c.) rapid push. Patients previous...

journal_title：Clinical and experimental immunology

authors： Shapiro R

更新日期：2013-08-01 00:00:00