Antibodies to a non-repeat region of Plasmodium falciparum antigen Pf155/RESA in individuals from malaria-endemic areas.

abstract：:A peptide based on the complementarity determining region (CDR)1 of a human monoclonal anti-DNA autoantibody (hCDR1) was shown to either prevent or treat an already established murine lupus in systemic lupus erythematosus (SLE)-prone mice or in mice with induced experimental SLE. The present study was undertaken to de...

journal_title：Clinical and experimental immunology

authors： Mauermann N,Sthoeger Z,Zinger H,Mozes E

更新日期：2004-09-01 00:00:00

abstract：:Previous studies have shown that male mice of strains with high target organ responsiveness to androgen, the C57L/J and RF/J, have lower plasma immunoglobulin levels and weaker antibody responses to protein and polysaccharide antigens than mice of low androgen responder (LAR) strains, the A/J and 129/J. In the current...

journal_title：Clinical and experimental immunology

authors： Cohn DA

更新日期：1986-01-01 00:00:00

abstract：:Antibodies against cytomegalovirus-specific early antigens (CMV-EA) were followed in sera, obtained from fifteen immunosuppressed renal-allograft recipients. Eight patients (sixty-two sera) showed seroconversion 47--137 days post-transplantation. Five patients (forty sera) with CMV antibodies at the moment of renal im...

journal_title：Clinical and experimental immunology

authors： The TH,Andersen HK,Spencer ES,Klein G

更新日期：1977-06-01 00:00:00

abstract：:Previous studies have shown that an optimal humoral response to a primary protein antigen requires C3 and CR2 (CD21). Sera from non-immunized donors contain natural IgM and IgG antibodies to the primary antigen keyhole limpet haemocyanin (KLH), and these have been previously shown to form immune complexes (IC) that ac...

journal_title：Clinical and experimental immunology

authors： Thornton BP,Vetvicka V,Ross GD

更新日期：1996-06-01 00:00:00

abstract：:Because activation of the alternative pathway (AP) of the complement system is an important aspect of both age-related macular degeneration (AMD) and rheumatoid arthritis (RA), we wished to address the question whether genetic risk factors of the AP inhibitor complement factor H (CFH) for AMD would also be risk factor...

journal_title：Clinical and experimental immunology

authors： Trouw LA,Böhringer S,Daha NA,Stahl EA,Raychaudhuri S,Kurreeman FA,Stoeken-Rijsbergen G,Houwing-Duistermaat JJ,Huizinga TW,Toes RE

更新日期：2011-12-01 00:00:00

abstract：:Superantigens (SAgs) are potent stimulators of T cells bearing specific Vbeta T cell receptors (TCR) and may play a role in the pathogenesis of Kawasaki syndrome (KS), although despite 15 years of intense study this area remains controversial. Because SAgs can cause Vbeta restricted T cell activation in the absence of...

journal_title：Clinical and experimental immunology

authors： Brogan PA,Shah V,Clarke LA,Dillon MJ,Klein N

更新日期：2008-02-01 00:00:00

abstract：:Factor H and the FHL-1/reconectin protein are two human plasma proteins that act as important regulators of the alternative complement pathway. Each protein is encoded by a unique transcript, but both mRNAs are derived from the factor H gene by means of alternative processing. In order to address potential functional ...

journal_title：Clinical and experimental immunology

authors： Friese MA,Hellwage J,Jokiranta TS,Meri S,Müller-Quernheim HJ,Peter HH,Eibel H,Zipfel PF

更新日期：2000-08-01 00:00:00

abstract：:The role of suppressive anti-retroviral therapy (ART) in eliciting restoration of dysregulated immune function remains unclear in HIV-1 infection. Also, due to tailoring of therapeutic regimens towards HIV-1, this possible impairment of therapy may be even more pronounced in HIV-2 and dual (HIV-D) infection. Thus, we ...

journal_title：Clinical and experimental immunology

authors： Salwe S,Padwal V,Nagar V,Patil P,Patel V

更新日期：2019-11-01 00:00:00

abstract：:We describe two brothers with marked leucopenia, lymphopenia, no immunologicl response to infections (no Ig production, negative PHA response and very low number of T and B lymphocytes in peripheral blood) and hypocellular marrow. They died at 12 and 8 days of life with infection (E. coli and Klebsiella, respectively)...

journal_title：Clinical and experimental immunology

authors： Español T,Compte J,Alvarez C,Tallada N,Laverde R,Peguero G

更新日期：1979-12-01 00:00:00

abstract：:The intestinal population of gamma delta T cell receptor (TCR)-bearing cells was characterized with regard to V delta and V gamma subtype expression. For this purpose, we utilized V gene-specific PCR of mRNA prepared from intestinal biopsies. Predominant expression of the V delta 1 subtype was demonstrated in the smal...

journal_title：Clinical and experimental immunology

authors： Bucht A,Söderström K,Esin S,Grunewald J,Hagelberg S,Magnusson I,Wigzell H,Grönberg A,Kiessling R

更新日期：1995-01-01 00:00:00

abstract：:In this study, we hypothesized that the granulomatous disorder sarcoidosis is not caused by a single pathogen, but rather results from abnormal responses of Toll-like receptors (TLRs) to conserved bacterial elements. Unsorted bronchoalveolar lavage (BAL) cells from patients with suspected pulmonary sarcoidosis and hea...

journal_title：Clinical and experimental immunology

authors： Gabrilovich MI,Walrath J,van Lunteren J,Nethery D,Seifu M,Kern JA,Harding CV,Tuscano L,Lee H,Williams SD,Mackay W,Tomashefski JF Jr,Silver RF

更新日期：2013-09-01 00:00:00

abstract：:Reliable risk assessment for biotherapeutics requires accurate evaluation of risk factors associated with immunogenicity. Immunogenicity risk assessment tools were developed and applied to investigate the immunogenicity of a fully human therapeutic monoclonal antibody, ATR-107 [anti-interleukin (IL)-21 receptor] that ...

journal_title：Clinical and experimental immunology

authors： Xue L,Hickling T,Song R,Nowak J,Rup B

更新日期：2016-01-01 00:00:00

abstract：:Calculated globulin (total protein - albumin) is usually tested as part of a liver function test profile in both primary and secondary care and determines the serum globulin concentration, of which immunoglobulins are a major component. The main use hitherto of calculated globulin is to detect paraproteins when the le...

journal_title：Clinical and experimental immunology

authors： Jolles S,Borrell R,Zouwail S,Heaps A,Sharp H,Moody M,Selwood C,Williams P,Phillips C,Hood K,Holding S,El Shanawany T

更新日期：2014-09-01 00:00:00

abstract：:The influence of human seminal plasma (SP) and whole semen (S) on the expression of natural cytotoxicity by human peripheral blood mononuclear cells (PBMNC) was examined. Marked suppression of natural cytotoxicity against K562 targets was observed when effectors were pre-treated for 1 h with SP or S diluted up to 1:40...

journal_title：Clinical and experimental immunology

authors： Rees RC,Vallely P,Clegg A,Potter CW

更新日期：1986-03-01 00:00:00

abstract：:Neutrophil activation is thought to play a crucial role in the pathogenesis of sepsis. During activation, neutrophils adhere to and migrate through the endothelium. Therefore, the amount of circulating neutrophils does not adequately reflect the total amount of neutrophils that are involved in the pathophysiologic pro...

journal_title：Clinical and experimental immunology

authors： Muller Kobold AC,Zijlstra JG,Koene HR,de Haas M,Kallenberg CG,Tervaert JW

更新日期：1998-11-01 00:00:00

abstract：:The present report concerns the site of synthesis of alpha 1-anti-trypsin (alpha 1 AT). In this study circulating cells and tissue fragments were incubated with radioactive amino acids to be incorporated during protein synthesis. The de novo synthesis of proteins was demonstrated by autoradiography of the immunoelectr...

journal_title：Clinical and experimental immunology

authors： van Furth R,Kramps JA,Diesselhof-den Dulk MM

更新日期：1983-03-01 00:00:00

abstract：:Bronchiolitis obliterans syndrome (BOS) is characterized by persistent alloreactive, infective and non-specific epithelial injury, loss of epithelial integrity and dysregulated repair. We have reported increased apoptosis of epithelial cells collected from the large airway in lung transplant recipients. As part of the...

journal_title：Clinical and experimental immunology

authors： Hodge S,Hodge G,Ahern J,Liew CL,Hopkins P,Chambers DC,Reynolds PN,Holmes M

更新日期：2009-11-01 00:00:00

abstract：:Significant numbers of syncytial cells were observed in the bronchoalveolar lavage fluid (BALF) of a 42-year-old patient who had SLE with interstitial pneumonia. Electron microscopic study of the BALF cells and positive reverse transcriptase activity in the supernatant of the cultured cells revealed unknown retroviral...

journal_title：Clinical and experimental immunology

authors： Tamura N,Sekigawa I,Hashimoto H,Yamamoto N,Kira S

更新日期：1997-03-01 00:00:00

abstract：:During 25 years of research since HIV-1 was first identified in Paris, there have been great advances in our understanding of the virus and of the immune system. Practical advances include the early development of diagnostic tests of infection that made blood donation safe, and since 1996, combination anti-retroviral ...

journal_title：Clinical and experimental immunology

authors： Weiss RA

更新日期：2008-05-01 00:00:00

abstract：:Booster immunization of normal individuals with soluble tetanus toxoid (TT) produced significant levels of plasma anti-tetanus IgG and IgM detectable by an enzyme linked immunosorbent assay (ELISA). Similar changes in circulating anti-TT antibody were found in mice following primary immunization. There was. however, n...

journal_title：Clinical and experimental immunology

authors： Ershler WB,Moore AL,Hacker MP

更新日期：1982-09-01 00:00:00

abstract：:Chronic, remittent, erosive arthritis was produced in rats by a single intraperitoneal injection of an aqueous suspension of cell wall fragments isolated from group A streptococci. Arthritis could be induced in rats which had been immunologically compromised by neonatal thymectomy. Delayed hypersensitivity to cell wal...

journal_title：Clinical and experimental immunology

authors： Hunter N,Anderle SK,Brown RR,Dalldorf FG,Clark RL,Cromartie WJ,Schwab JH

更新日期：1980-12-01 00:00:00

abstract：:Live Mycobacterium lepraemurium or 60Co-gamma-irradiated organisms stimulated a very weak oxidative burst compared with similar numbers of heat-killed organisms or with live M. microti. This was found to reflect the poor uptake of the living organisms rather than an absolute failure to stimulate an oxidative burst. It...

journal_title：Clinical and experimental immunology

authors： Brett SJ,Butler R

更新日期：1988-01-01 00:00:00

abstract：:Ro ribonucleoproteins (RNPs) are autoantigens that result from the association of a 60-kDa protein (Ro60) with a small RNA (hY1, hY3, hY4 or hY5 in humans, mY1 or mY3 in mice). Previous studies localized Ro RNPs to the cytoplasm. Because Ro RNPs containing hY5 RNA (Ro(hY5) RNPs) have unique biochemical and immunologic...

journal_title：Clinical and experimental immunology

authors： Gendron M,Roberge D,Boire G

更新日期：2001-07-01 00:00:00

abstract：:Primary immunodeficiencies (PIDs) are uncommon, chronic and severe disorders of the immune system in which patients cannot mount a sufficiently protective immune response, leading to an increased susceptibility to infections. The treatment of choice for PID patients with predominant antibody deficiency is intravenous ...

journal_title：Clinical and experimental immunology

authors： Ballow M,Notarangelo L,Grimbacher B,Cunningham-Rundles C,Stein M,Helbert M,Gathmann B,Kindle G,Knight AK,Ochs HD,Sullivan K,Franco JL

更新日期：2009-12-01 00:00:00

abstract：:Sjögren's syndrome (SS) is an autoimmune disease characterized by T cell infiltration into the salivary and lacrimal glands (LG). Previous studies on T cell receptor (TCR) usage in the minor salivary glands (SG) have yielded controversial results. We studied TCR beta gene usage of the T cells infiltrating to LG, which...

journal_title：Clinical and experimental immunology

authors： Mizushima N,Kohsaka H,Tsubota K,Saito I,Miyasaka N

更新日期：1995-07-01 00:00:00

abstract：:The objective of the study was to determine the diagnostic value for rheumatoid arthritis (RA) of anti-filaggrin autoantibodies (autoAb) recognizing citrullinated recombinant rat filaggrin (ACRF) in community cases of very early arthritis. To evaluate the diagnostic value of ACRF, were studied sera from patients with ...

journal_title：Clinical and experimental immunology

authors： Vittecoq O,Incaurgarat B,Jouen-Beades F,Legoedec J,Letourneur O,Rolland D,Gervasi G,Ménard JF,Gayet A,Fardellone P,Daragon A,Jolivet M,le Loët X,Tron F

更新日期：2004-01-01 00:00:00

abstract：:Patients with IgA deficiency often demonstrate circulating antibodies against IgA, which have been suggested to be associated with transfusion reactions. Sera from three patients with common variable immunodeficiency (CVID) and one with a selective IgA deficiency with anti-IgA antibodies receiving subcutaneous gammagl...

journal_title：Clinical and experimental immunology

authors： Sundin U,Nava S,Hammarström L

更新日期：1998-05-01 00:00:00

abstract：:Complement receptor 2 (CR2, CD21), the receptor for both the C3d,g portion of human complement component C3 and the Epstein-Barr virus, has been recently described on peripheral T cells. By using dual stain flow cytometric analysis, we have also observed that a peripheral T lymphocyte subpopulation of normal healthy d...

journal_title：Clinical and experimental immunology

authors： Levy E,Ambrus J,Kahl L,Molina H,Tung K,Holers VM

更新日期：1992-11-01 00:00:00

abstract：:Leishmania parasites are the causative agents of leishmaniasis, a neglected tropical disease that causes substantial morbidity and considerable mortality in many developing areas of the world. Recent estimates suggest that roughly 10 million people suffer from cutaneous leishmaniasis (CL), and approximately 76,000 are...

journal_title：Clinical and experimental immunology

authors： Carlsen ED,Liang Y,Shelite TR,Walker DH,Melby PC,Soong L

更新日期：2015-11-01 00:00:00

abstract：:T and B cell function, in particular IgD production in vitro, were studied across the spectrum of HIV infection in homosexual men and compared with seronegative homosexual and heterosexual male controls. Proliferation to phytohaemagglutinin (PHA) was reduced most strikingly in symptomatic HIV infection; it was also im...

journal_title：Clinical and experimental immunology

authors： Rogers LA,Forster SM,Pinching AJ

更新日期：1989-01-01 00:00:00