Heterogeneity of human Ro ribonucleoproteins (RNPS): nuclear retention of Ro RNPS containing the human hY5 RNA in human and mouse cells.

abstract：:CFA is an inflammatory condition of the lungs resulting in scarring, pulmonary failure and death. The etiology of the disease is unknown, but the pathogenesis is believed to involve a persistent immunological reaction to unidentified antigen in the lung resulting in tissue damage. Recent advances in our understanding ...

journal_title：Clinical and experimental immunology

authors： Wallace WA,Ramage EA,Lamb D,Howie SE

更新日期：1995-09-01 00:00:00

abstract：:The open reading frame of human proteinase 3 (PR3) without the prepro-peptide was cloned and expressed in Escherichia coli (rcPR3) and in Pichia pastoris (rpPR3). The 6-histidine tagged rpPR3 was efficiently secreted into culture supernatant from which it could be purified by immobilized metal chelate chromatography. ...

journal_title：Clinical and experimental immunology

authors： Harmsen MC,Heeringa P,van der Geld YM,Huitema MG,Klimp A,Tiran A,Kallenberg CG

更新日期：1997-11-01 00:00:00

abstract：:Using in situ hybridization, we analysed the immunoglobulin repertoire expressed by the B cells present in myasthenia gravis thymuses from four patients. B cells, mostly in activated state, were clustered in germinal centres, in which multiple isotypes were identified. A majority of cells expressed IgG as compared wit...

journal_title：Clinical and experimental immunology

authors： Guigou V,Emilie D,Berrih-Aknin S,Fumoux F,Fougereau M,Schiff C

更新日期：1991-02-01 00:00:00

abstract：:The presence of antibodies reactive to a recently cloned host-derived antigen GOR is highly correlated with the presence of antibodies to the hepatitis C virus (HCV). We explored the molecular basis for this observation, and address the following question: are antibodies reactive with GOR19-27 (QKAKSNPNR) a result of ...

journal_title：Clinical and experimental immunology

authors： Zhang ZX,Chen M,Wallhagen K,Trojnar J,Magnius LO,Wahren B,Sällberg M

更新日期：1994-06-01 00:00:00

abstract：:A method for the isolation of complement-fixing immune complexes from human serum and the separation of antigen from antibody is described. In order to isolate the complexes, we used soluble bovine conglutinin in a three-step procedure: (1) serum containing immune complexes is reacted with conglutinin in the presence ...

journal_title：Clinical and experimental immunology

authors： Gupta RC,Tan EM

更新日期：1981-10-01 00:00:00

abstract：:Bacille Calmette-Guérin (BCG), developed a century ago, is the only licensed tuberculosis (TB) vaccine in use to date. The protective efficacy of BCG against TB varies with no apparent protection in some population, and mechanisms of its immune protection is poorly known, and yet BCG is the most widely used vaccine, w...

journal_title：Clinical and experimental immunology

authors： Abebe F

更新日期：2012-09-01 00:00:00

abstract：:Rabbits were sensitized with Micropolyspora faeni by intratracheal inoculations and later challenged with the same antigen either with or without parenteral administration of cortisone acetate prior to challenge. Animals developed anti-M. faeni serum precipitins, M. faeni-induced alveolar macrophage migration inhibiti...

journal_title：Clinical and experimental immunology

authors： Cashner FM,Schuyler MR,Salvaggio JE

更新日期：1979-05-01 00:00:00

abstract：:Lupus nephritis (LN) is a major manifestation of systemic lupus erythematosus (SLE), causing morbidity and mortality in 40-60% of SLE patients. The pathogenic mechanisms of LN are not completely understood. Recent studies have demonstrated the presence of various immune cell populations in lupus nephritic kidneys of b...

journal_title：Clinical and experimental immunology

authors： Liao X,Ren J,Reihl A,Pirapakaran T,Sreekumar B,Cecere TE,Reilly CM,Luo XM

更新日期：2017-11-01 00:00:00

abstract：:It has been suggested that the immune system may be responsible for the destruction of insulin secreting cells in some types of diabetes. In order to test this hypothesis, we studied the consequences of immune-mediated reactions on the function of pancreatic islet cells in vitro. A model was set up in vitro where mous...

journal_title：Clinical and experimental immunology

authors： Boitard C,Saï P,Debray-Sachs M,Assan R,Hamburger J

更新日期：1984-03-01 00:00:00

abstract：:Thyroid peroxidase purified from porcine thyroid (pTPO) was found to induce an experimental murine thyroiditis with genetic restriction which was very different from that induced by mouse thyroglobulin (mTg). C57BL/6 and C57BL/10 (both H-2b) were good responders for thyroiditis, whereas A/J (H-2a), BALB/c (H-2d), DBA/...

journal_title：Clinical and experimental immunology

authors： Kotani T,Umeki K,Hirai K,Ohtaki S

更新日期：1990-04-01 00:00:00

abstract：:To gain insight into possible determinants of in vivo polyclonal B cell activation seen in rheumatoid arthritis (RA), we enumerated immunoglobulin secreting cells appearing in cultures of peripheral blood mononuclear cells that were stimulated with pokeweed mitogen (PWM) or a newly described polyclonal B cell activato...

journal_title：Clinical and experimental immunology

authors： Pardo I,Carafa C,Dziarski R,Levinson AI

更新日期：1984-05-01 00:00:00

abstract：:Serum levels and liver expression of CCL2 are increased in patients with alcoholic hepatitis (AH). In an experimental model of alcoholic liver disease (ALD), CCL2 was implicated in proinflammatory cytokines activation and hepatic lipid metabolism, but its role in human disease is currently unknown. In a large cohort o...

journal_title：Clinical and experimental immunology

authors： Degré D,Lemmers A,Gustot T,Ouziel R,Trépo E,Demetter P,Verset L,Quertinmont E,Vercruysse V,Le Moine O,Devière J,Moreno C

更新日期：2012-09-01 00:00:00

abstract：:Immunofluorescence (IF) to detect HCV antigens and non-isotopic in situ hybridization (NISH) to detect HCV RNA genome were carried out on bone marrow (BM) and peripheral blood (PB) mononuclear cells (MC) of 11 chronically HCV-infected patients. In four patients (36.4%) HCV antigens were detected in monocytes/macrophag...

journal_title：Clinical and experimental immunology

authors： Sansonno D,Iacobelli AR,Cornacchiulo V,Iodice G,Dammacco F

更新日期：1996-03-01 00:00:00

abstract：:The potential value of interleukin 1 (IL-1) containing supernatants as a radioprotective agent was evaluated. It was found that the response of irradiated thymocytes to mitogens was partially restored if IL-1 containing supernatants was included in the culture medium immediately after irradiation. A delay of 24 h in t...

journal_title：Clinical and experimental immunology

authors： Manori I,Kushilevsky A,Weinstein Y

更新日期：1986-03-01 00:00:00

abstract：:Previous studies have shown that an optimal humoral response to a primary protein antigen requires C3 and CR2 (CD21). Sera from non-immunized donors contain natural IgM and IgG antibodies to the primary antigen keyhole limpet haemocyanin (KLH), and these have been previously shown to form immune complexes (IC) that ac...

journal_title：Clinical and experimental immunology

authors： Thornton BP,Vetvicka V,Ross GD

更新日期：1996-06-01 00:00:00

abstract：:Epigenetic studies reveal how our genes (nature) are influenced by environment (nurture) leading to wide variability in clinical presentations, especially in autoimmune diseases. Patients with C1-inhibitor deficiency, even within the same family, have diverse clinical presentations that may reflect epigenetic control ...

journal_title：Clinical and experimental immunology

authors： Khan S,Longhurst H

更新日期：2020-11-01 00:00:00

abstract：:We report the immunological studies on three transplantable lymphoma lines that developed when CAF1 mice were injected with busulfan and chloramphenicol. The lymphoma cells displayed Thy-1.2, brain associated antigen, and H-2d alloantigen. They were negative for surface IgM and Ia antigens. Expression of T cell differ...

journal_title：Clinical and experimental immunology

authors： Bhoopalam N,Price K,Norgello H,Barone-Varelas J,Fried W

更新日期：1986-06-01 00:00:00

abstract：:Suppression of the lymphocyte response to concanavalin A (Con A), phytohaemagglutinin (PHA) and protein A from Staphylococcus aureus (SpA) by Con A-induced suppressor cells was measured in twenty-four patients with recently active-recovering multiple sclerosis (MS), twelve with inactive MS and twenty-three healthy con...

journal_title：Clinical and experimental immunology

authors： Gonzalez RL,Dau PC,Spitler LE

更新日期：1979-04-01 00:00:00

abstract：:A study was conducted to quantify soluble IL-2 receptor (sIL-2R) levels in sera of 57 chronic plaque psoriasis patients and correlate these measurements with disease activity and the number of IL-2R-positive (CD25+) lymphocytes in lesional biopsies of 11 cyclosporin A (CsA) and 13 psoralen plus ultraviolet radiation (...

journal_title：Clinical and experimental immunology

authors： Duncan JI,Horrocks C,Ormerod AD,Powles AV,Whiting PH,Fry L,Thomson AW

更新日期：1991-08-01 00:00:00

abstract：:The aim of this study was to evaluate prospectively cytokine levels and disease activity in juvenile idiopathic arthritis (JIA) patients treated with and without tumour necrosis factor (TNF)-α inhibitors. TNF-α inhibitor-naive JIA subjects were followed prospectively for 6 months. Cytokine levels of TNF-α, interleukin...

journal_title：Clinical and experimental immunology

authors： Walters HM,Pan N,Lehman TJ,Adams A,Kalliolias GD,Zhu YS,Santiago F,Nguyen J,Sitaras L,Cunningham-Rundles S,Walsh TJ,Toussi SS

更新日期：2016-06-01 00:00:00

abstract：:Activation of the interferon (IFN) system is an early defence mechanism against viral infections. The virus stimulates production of IFN by nucleated cells including the peripheral blood mononuclear cells (PBMC), and this IFN in turn activates several IFN-dependent immune mechanisms including the induction of an anti-...

journal_title：Clinical and experimental immunology

authors： Levin S,Hahn T

更新日期：1985-05-01 00:00:00

abstract：:The production of interleukin-2 (IL-2) by Con A-activated spleen cells (SC) progressively declined and reached negligible values during the course of infection of C57BL/6 mice with Mycobacterium lepraemurium. In addition, the capacity of cultured SC to utilize IL-2 was highly reduced, as demonstrated by the accumulati...

journal_title：Clinical and experimental immunology

authors： Turcotte R,Lemieux S

更新日期：1989-04-01 00:00:00

abstract：:The synthesis of some class 1 acute-phase proteins (APP), including C-reactive protein (CRP) and serum amyloid A (SAA) protein is completely blocked by the IL-1 receptor antagonist (IL-1Ra), whereas the production of fibrinogen, a class 2 APP, is increased by IL-1Ra in hepatoma cells, but this has never been tested in...

journal_title：Clinical and experimental immunology

authors： Gabay C,Genin B,Mentha G,Iynedjian PB,Roux-Lombard P,Guerne PA

更新日期：1995-05-01 00:00:00

abstract：:Tolerogenic dendritic cells (DCs) play a critical role in the induction of regulatory T cells (Tregs ), which in turn suppress effector T cell responses. We have previously shown the induction of DCs from human and mouse monocytic cell lines, mouse splenocytes and human peripheral blood monocytes by a novel apolipopro...

journal_title：Clinical and experimental immunology

authors： Bellemore SM,Nikoopour E,Au BC,Krougly O,Lee-Chan E,Haeryfar SM,Singh B

更新日期：2014-09-01 00:00:00

abstract：:While most of our understanding of immune dysfunction in dialysis patients involves alterations in CD28-CD80/86 signalling, nothing is known of CD46-mediated co-stimulation of T cells in these patients. Because C3b/C4b bind to CD46 and complement activation occurs during haemodialysis (HD), we addressed whether CD46-m...

journal_title：Clinical and experimental immunology

authors： Brinkkoetter PT,Marinaki S,Gottmann U,Fleckenstein S,Stump C,Van Der Woude FJ,Braun C,Yard BA

更新日期：2005-03-01 00:00:00

abstract：:A purified preparation of Epstein-Barr virus (EBV) has been shown to activate the classical complement pathway by direct interaction with the first component of complement, C1, without the intervention of antibody. No evidence was found for activation of the alternative pathway. Following classical pathway activation ...

journal_title：Clinical and experimental immunology

authors： Martin H,McConnell I,Gorick B,Hughes-Jones NC

更新日期：1987-03-01 00:00:00

abstract：:Nickel (Ni), the main cause of contact allergy to metals, induces in vitro production of both Th1- and Th2-type cytokines in peripheral blood mononuclear cells (PBMC) from allergic subjects. Because the knowledge of the cellular immune response to other metals involved in contact allergy has been limited, we investiga...

journal_title：Clinical and experimental immunology

authors： Minang JT,Areström I,Troye-Blomberg M,Lundeberg L,Ahlborg N

更新日期：2006-12-01 00:00:00

abstract：:Disseminated infection with virulent Mycobacterium avium in C57Bl/6 (B6) mice leads to severe lymphocyte depletion in secondary lymphoid organs. In this study, we found an up-regulation of caspase-8 activity in spleen cell extracts from M. avium 25291-infected B6 mice compared to non-infected mice. The activation of t...

journal_title：Clinical and experimental immunology

authors： Borges M,Rosa GT,Appelberg R

更新日期：2011-06-01 00:00:00

abstract：:Human thymoma is a thymic epithelial cell tumour which often contains a large number of immature T cells and is frequently associated with autoimmune diseases. Since thymic epithelial cells play key roles in the development and selection of T cells in the normal thymus, we hypothesized that the neoplastic thymic epith...

journal_title：Clinical and experimental immunology

authors： Inoue M,Fujii Y,Okumura M,Takeuchi Y,Shiono H,Miyoshi S,Matsuda H,Shirakura R

更新日期：1998-06-01 00:00:00

abstract：:The immune and bone systems maintain homeostasis by interacting closely with each other. Rheumatoid arthritis is a pathological consequence of their interplay, as activated T cell immune responses result in osteoclast-mediated bone erosion. An imbalance between forkhead box protein 3 (Foxp3)+ regulatory T (Treg ) cell...

journal_title：Clinical and experimental immunology

authors： Komatsu N,Takayanagi H

更新日期：2018-10-01 00:00:00