Individual germinal centres of myasthenia gravis human thymuses contain polyclonal activated B cells that express all the Vh and Vk families.

Abstract:

:Using in situ hybridization, we analysed the immunoglobulin repertoire expressed by the B cells present in myasthenia gravis thymuses from four patients. B cells, mostly in activated state, were clustered in germinal centres, in which multiple isotypes were identified. A majority of cells expressed IgG as compared with IgM, with a roughly similar contribution of kappa and lambda chains. Hybridization with the six VH and the 4 VK human family probes was observed in serial sections, providing additional evidence that individual germinal centres were polyclonal. The thymic B cell repertoire closely reflected the VH and the VK family usage of normal peripheral blood lymphocytes with the preferential utilization of VH3, VK1 and VK3.

journal_name

Clin Exp Immunol

authors

Guigou V,Emilie D,Berrih-Aknin S,Fumoux F,Fougereau M,Schiff C

doi

10.1111/j.1365-2249.1991.tb05625.x

subject

Has Abstract

pub_date

1991-02-01 00:00:00

pages

262-6

issue

2

eissn

0009-9104

issn

1365-2249

journal_volume

83

pub_type

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