Nickel, cobalt, chromium, palladium and gold induce a mixed Th1- and Th2-type cytokine response in vitro in subjects with contact allergy to the respective metals.

abstract：:Natural killer (NK) cells mediate host defense against infections and are regulated by interleukin 2 (IL-2) and other factors. We studied NK cell function in burn patients using a 51Cr release assay with K562 target cells. We found that peripheral blood lymphocytes from burn patients had depressed NK activity (target ...

journal_title：Clinical and experimental immunology

authors： Bender BS,Winchurch RA,Thupari JN,Proust JJ,Adler WH,Munster AM

更新日期：1988-01-01 00:00:00

abstract：:The relationship between allergic airway inflammation and pneumococcal pneumonia is not well understood. We assessed susceptibility to experimental pneumococcal pneumonia in mice with and without allergic airway inflammation. Susceptibility to pneumococcal pneumonia was evaluated by challenging mice with a bioluminesc...

journal_title：Clinical and experimental immunology

authors： Kang CI,Rouse MS,Patel R,Kita H,Juhn YJ

更新日期：2009-06-01 00:00:00

abstract：:Activation of human peripheral blood lymphocytes from unsensitized donors by fractions of T.b rhodesiense has been demonstrated in vitro. Both T and B cells were stimulated to differentiate into blast cells. Purified T cells failed to proliferate, but did so when mitomycin C-treated non-T cells were added. Non-T cell ...

journal_title：Clinical and experimental immunology

authors： Selkirk ME,Ogilvie BM,Platts-Mills TA

更新日期：1981-09-01 00:00:00

abstract：:Kawasaki disease (KD) is a systemic vasculitis with cardiac and noncardiac complications. Anti--endothelial cell antibodies (AECA) are found among many patients with KD. The aim of this study was to investigate the pathogenic role of AECA in KD using in vitro and in vivo experimental models. F(ab)2 fragments of IgG-AE...

journal_title：Clinical and experimental immunology

authors： Grunebaum E,Blank M,Cohen S,Afek A,Kopolovic J,Meroni PL,Youinou P,Shoenfeld Y

更新日期：2002-11-01 00:00:00

abstract：:Anaemia of chronic disease (ACD) is frequently found in rheumatoid arthritis (RA). In the pathogenesis of ACD both cytokines, such as tumour necrosis factor-alpha (TNF-alpha), IL-1 and IL-6 as well as a relative deficiency of erythropoietin (EPO), are thought to play a key role. In the present study the role of IL-6 i...

journal_title：Clinical and experimental immunology

authors： Jongen-Lavrencic M,Peeters HR,Rozemuller H,Rombouts WJ,Martens AC,Vreugdenhil G,Pillay M,Cox PH,Bijser M,Brutel G,Breedveld FC,Swaak AJ

更新日期：1996-02-01 00:00:00

abstract：:Acute lung injury frequently develops following haemorrhage, and is characterized by increased proinflammatory cytokine levels and massive neutrophil accumulation in the lung. Blood loss produces rapid increases in tumour necrosis factor-alpha (TNF-alpha) mRNA expression among pulmonary cell populations which precede ...

journal_title：Clinical and experimental immunology

authors： Abraham E,Coulson WF,Schwartz MD,Allbee J

更新日期：1994-10-01 00:00:00

abstract：:Two patients with severe combined immunodeficiency disease (SCID) having variable B-cell development have been shown to have marrow precursors of lymphoid cells which can be induced in vitro by thymic factors to express certain T-cell surface characteristics (HTLA+ phenotypes). Their marrow cells could not, however, b...

journal_title：Clinical and experimental immunology

authors： Incefy GS,Grimes E,Kagan WA,Goldstein G,Smithwick E,O'Reilly R,Good RA

更新日期：1976-09-01 00:00:00

abstract：:Chronic bone infection is associated with bone resorption. From animal studies, CD3/CD28-activated T cells are known to enhance osteoclastogenesis and bone resorption. Because CD28 is expressed constitutively on T cells and its expression is down-regulated by chronic exposure to the inflammatory environment, we charac...

journal_title：Clinical and experimental immunology

authors： Kumar G,Roger PM,Ticchioni M,Trojani C,Bernard de Dompsur R,Bronsard N,Carles M,Bernard E

更新日期：2014-04-01 00:00:00

abstract：:In the present study we describe the in vitro transcription-translation of human melanocyte-specific protein Pmel17 cDNA and subsequent use of the resulting 35S-labelled Pmel17 in an RIA to analyse vitiligo sera for the presence of Pmel17 antibodies. Of 53 vitiligo sera examined in the assay, three (5.9%) were found t...

journal_title：Clinical and experimental immunology

authors： Kemp EH,Gawkrodger DJ,Watson PF,Weetman AP

更新日期：1998-12-01 00:00:00

abstract：:Primary immunodeficiencies (PIDs) are uncommon, chronic and severe disorders of the immune system in which patients cannot mount a sufficiently protective immune response, leading to an increased susceptibility to infections. The treatment of choice for PID patients with predominant antibody deficiency is intravenous ...

journal_title：Clinical and experimental immunology

authors： Ballow M,Notarangelo L,Grimbacher B,Cunningham-Rundles C,Stein M,Helbert M,Gathmann B,Kindle G,Knight AK,Ochs HD,Sullivan K,Franco JL

更新日期：2009-12-01 00:00:00

abstract：:The in-vivo clearance of Bordetella pertussis infections in murine models in naive mice and animals vaccinated with whole-cell vaccine is considered to be via a Th-1-dependent mechanism in which interleukin-12 (IL)-12 may play a prominent role. It has also been demonstrated clearly that the treatment of animals with m...

journal_title：Clinical and experimental immunology

authors： Carter CR,Dagg BM,Whitmore KM,Keeble JR,Asokanathan C,Xing D,Walker KB

更新日期：2004-02-01 00:00:00

abstract：:IgE was isolated from a patient with the hyper IgE, recurrent infection syndrome by immunoadsorption on sepharose bound goat anti-human IgE. Addition of this IgE to a monolayer culture of human monocytes resulted in a dose-dependent increase in PGE2 secretion. The addition of F(ab')2 fraction of goat anti-human IgE in...

journal_title：Clinical and experimental immunology

authors： Passwell JH,Geiger B,Levanon M,Davidsohn J,Cohen BE,Ramot B

更新日期：1984-12-01 00:00:00

abstract：:Even though the existence of phosphodiesterase (PDE) 7 in T cells has been proved, the lack of a selective PDE7 inhibitor has confounded an accurate assessment of PDE7 function in such cells. In order to elucidate the role of PDE7 in human T cell function, the effects of two PDE inhibitors on PDE7A activity, cytokine ...

journal_title：Clinical and experimental immunology

authors： Nakata A,Ogawa K,Sasaki T,Koyama N,Wada K,Kotera J,Kikkawa H,Omori K,Kaminuma O

更新日期：2002-06-01 00:00:00

abstract：:To elucidate the in vivo mechanisms involved in the impairment in pulmonary defence as the result of treatment with glucocorticoids, we established fatal pneumonia with bacteraemia in dexamethasone (DEX)-treated mice by means of an intratracheal challenge of Pseudomonas aeruginosa. An increased neutrophil influx was o...

journal_title：Clinical and experimental immunology

authors： Satoh S,Oishi K,Iwagaki A,Senba M,Akaike T,Akiyama M,Mukaida N,Atsushima KM,Nagatake T

更新日期：2001-11-01 00:00:00

abstract：:The Km for AMP for 5' nucleotidase was increased in lymphocytes from patients with common variable (CVH) and sex linked (XLH) hypogammaglobulinaemia and from patients with chronic lymphatic leukaemia (CLL): the Vmax of the latter was low. The kinetic constants for cord blood lymphocytes are similar to adults and the K...

journal_title：Clinical and experimental immunology

authors： Shah T,Webster AD,Peters TJ

更新日期：1984-07-01 00:00:00

abstract：:Immune complexes (IC) in sera and synovial fluid (SF) from patients with juvenile (rheumatoid) arthritis (JA) were isolated by making use of polyethylene glycol (PEG) to precipitate IC and then using staphylococcal protein A to separate the IC. The isolated IC were compared to IC in sera analysed by sucrose density gr...

journal_title：Clinical and experimental immunology

authors： Moore TL,Dorner RW,Sheridan PW,Zuckner J

更新日期：1984-05-01 00:00:00

abstract：:Anti-idiotypic antibodies (anti-Id Abs) are involved in the regulation of a number of immune responses including the IgE antibody production. In atopic patients, the increased synthesis of IgE antibodies could be related to a defective production of regulatory anti-Id Abs. In the present study, we first developed a se...

journal_title：Clinical and experimental immunology

authors： Hébert J,Bernier D,Mourad W

更新日期：1990-06-01 00:00:00

abstract：:There is currently scarce knowledge of the immunological profile of patients with latent autoimmune diabetes mellitus in the adult (LADA) when compared with healthy controls (HC) and patients with classical type 1 diabetes (T1D) and type 2 diabetes (T2D). The objective of this study was to investigate the cellular imm...

journal_title：Clinical and experimental immunology

authors： Singh K,Martinell M,Luo Z,Espes D,Stålhammar J,Sandler S,Carlsson PO

更新日期：2019-07-01 00:00:00

abstract：:In a family with partial or total adenine phosphoribosyl transferase (APRT) deficiency, T and B cell function was evaluated by counting rosette-forming cells, by investigating lymphocyte transformation to phytohaemagglutinin (PHA), concanavalin A (Con A) and pokeweed mitogen (PWM), by assaying serum immunoglobulins an...

journal_title：Clinical and experimental immunology

authors： Stevens WJ,Peetermans ME,Van Acker KJ

更新日期：1979-06-01 00:00:00

abstract：:Phytohaemagglutinin-induced lymphocyte transformation of four healthy adults and a child with kwashiorkor was performed in the presence of plasma from nineteen patients with protein energy malnutrition and a nutritionally normal child. Marked inhibition occurred in the presence of plasma from six patients who subseque...

journal_title：Clinical and experimental immunology

authors： Heyworth B,Moore DL,Brown J

更新日期：1975-10-01 00:00:00

abstract：:IgE rheumatoid factor activity was found to be significantly elevated (P less than 0.01) using an ELISA assay when paired synovial fluid and sera from 13 patients with active RA were compared to ten control samples. Synovial fluid IgE RF activity was higher than predicted by diffusion alone in 7/11 (64%) of the RA syn...

journal_title：Clinical and experimental immunology

authors： Gruber B,Ballan D,Gorevic PD

更新日期：1988-02-01 00:00:00

abstract：:To investigate the significance of circulating adhesion molecules associated with leucocyte-endothelial cell interaction in Kawasaki disease (KD), serum levels of soluble E-, P-, L-selectin (sE-, sP-, sL-selectin), and vascular cell adhesion molecule-1 (VCAM-1) were measured in 16 patients with KD, eight with other fe...

journal_title：Clinical and experimental immunology

authors： Takeshita S,Dobashi H,Nakatani K,Koike Y,Tsujimoto H,Hirayama K,Kawamura Y,Mori K,Sekine I,Yoshioka S

更新日期：1997-06-01 00:00:00

abstract：:The search for novel chemical classes of anti-malarial compounds to cope with the current state of chemoresistance of malaria parasites has led to the identification of Plasmodium falciparum aminopeptidase 1 (PfA-M1) as a new therapeutic target. PfA-M1, known to be involved in the hemoglobin digestion cascade which he...

journal_title：Clinical and experimental immunology

authors： Oyegue-Liabagui SL,Imboumy-Limoukou RK,Kouna CL,Bangueboussa F,Schmitt M,Florent I,Lekana-Douki JB

更新日期：2020-06-01 00:00:00

abstract：:The F1 hybrid mouse strain, from B10Q and DBA/1 parentals (the QD strain), is highly susceptible to induction of type II collagen-induced arthritis, an experimental model for rheumatoid arthritis. Males are more susceptible than females. Oophorectomy enhances susceptibility to arthritis and treatment with physiologica...

journal_title：Clinical and experimental immunology

authors： Jansson L,Holmdahl R

更新日期：1992-09-01 00:00:00

abstract：:Soluble histocompatibility antigens of the class II region have been detected in synovial fluids obtained from patients with rheumatoid arthritis. A capture immunoassay involving two monoclonal antibodies was used; interference by rheumatoid factor, which is a feature of such assays, was overcome by mild pretreatment ...

journal_title：Clinical and experimental immunology

authors： Stevenson FK,Douglass WA,Spellerberg MB,Walters MT,Cawley MI

更新日期：1990-04-01 00:00:00

abstract：:A solid-phase radioimmunoassay was developed to detect antibodies to liver membrane antigens in sera of patients with HBsAg-negative and -positive liver diseases and primary non-hepatic autoimmune diseases. Ten of fourteen patients with HBsAg-negative CAH had autoantibodies detected by RIA; negative results were obtai...

journal_title：Clinical and experimental immunology

authors： Manns M,Meyer zum Büschenfelde KH,Hütteroth TH,Hess G

更新日期：1980-11-01 00:00:00

abstract：:Recently we reported that monocyte phagocytosis and chemotaxis are impaired in X-linked agammaglobulinaemia (XLA) and common variable immunodeficiency (CVI) patients. Few data exist on the in vivo expression of receptors for the constant region of immunoglobulin (IgG) (Fc gammaR) and complement receptors (CR) in these...

journal_title：Clinical and experimental immunology

authors： Amoras AL,da Silva MT,Zollner RL,Kanegane H,Miyawaki T,Vilela MM

更新日期：2007-12-01 00:00:00

abstract：:Cyclosporin A (Cy A) enhances immunoglobulin (Ig) production by EB virus stimulated peripheral blood lymphocytes from normal subjects with prior immunity to EB virus. In 11 normal adults, this enhancement of Ig production correlated with T cell-mediated cytotoxic regression. Cultures from normal healthy adults without...

journal_title：Clinical and experimental immunology

authors： Pereira RS,Gear AJ,Doré CJ,Webster AD

更新日期：1983-07-01 00:00:00

abstract：:The reproducibility of a simplified, sensitive and rapid agarose-cell droplet assay for leucocyte migration inhibition factor (LIF) activity was studied. Removal of T cells with anti-T-cell serum eliminated LIF activity, indicating that in humans it is probably the T cell that produces LIF. Cord blood lymphocytes prod...

journal_title：Clinical and experimental immunology

authors： Hahn T,Levin S,Handzel ZT

更新日期：1976-06-01 00:00:00

abstract：:A method is described which can be used to quantitate class II MHC antigens (HLA-DR) expressed by cells within tissue sections. A mouse anti-human HLA-DR monoclonal antibody is directly conjugated to the fungal enzyme glucose oxidase. The enzyme, in the presence of its substrate can be used to reduce tetrazolium salts...

journal_title：Clinical and experimental immunology

authors： Collings LA,Tidman N,Poulter LW

更新日期：1985-07-01 00:00:00